Abstract:
:Utilizing scanning electron microscopy and isolated, vascularly perfused rat pancreas, we studied the angioarchitecture and the effect of the insulinotropic hormone, gastric inhibitory polypeptide (GIP), on cholecystokinin (CCK)-stimulated exocrine secretion. We tried to correlate the microcirculation with the physiological effect of insulin on the pancreatic secretion in the same species. We found a vascular pattern consisting of direct insuloacinar connections, a venous drainage system of islets, and a direct arterial supply of acini. GIP at a concentration as low as 2 ng/ml or exogenous rat insulin potentiated CCK-stimulated pancreatic enzyme secretion. To have similar effects as insulin which is endogenously released by GIP, about 30 times more exogenous rat insulin has to be infused. We conclude that based on the angioarchitecture, insulinotropic hormones like GIP could link the metabolic and the digestive function of the pancreas.
journal_name
Pancreasjournal_title
Pancreasauthors
Mueller MK,Scheck T,Dreesmann V,Miodonski A,Goebell Hdoi
10.1097/00006676-198701000-00016subject
Has Abstractpub_date
1987-01-01 00:00:00pages
106-13issue
1eissn
0885-3177issn
1536-4828journal_volume
2pub_type
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