Interplay Between Gemcitabine and Erlotinib Over Pancreatic Adenocarcinoma Cells.

abstract：:The prognosis of patients with alpha-fetoprotein (AFP)-producing pancreatic cancer is generally very poor. We, however, present a case of a 33-year-old man who survived AFP-producing pancreatic cancer and its metachronous liver metastasis. The patient had undergone a curative total pancreatectomy for AFP-producing pan...

journal_title：Pancreas

authors： Natsume T,Watanabe Y,Maruyama T,Tanaka H,Sunouchi K,Tohma T,Noju M,Muto Y,Tohnosu N,Uehara T,Shimizu S,Ochiai T,Nabeya Y

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVES:Presentation of pancreatic adenocarcinoma (PC) as acute pancreatitis (AP), association of chronic pancreatitis (CP) with PC, and role of inflammation in PC carcinogenesis are well recognized. We hypothesized that inflammatory changes associated with remote history of AP (≥2 years before PC diagnosis) would r...

journal_title：Pancreas

authors： Phillips AE,Shah N,Borhani AA,Yadav D,Brand RE

更新日期：2018-11-01 00:00:00

abstract：:Dithizone (DTZ) is a selective stain for pancreatic islets which facilitates their identification, being of special interest in human islet isolation assessment. Nevertheless, there are few studies concerning its potential toxic effects on islet function. In our study, we have evaluated the effects of DTZ (dissolved i...

journal_title：Pancreas

authors： Conget JI,Sarri Y,González-Clemente JM,Casamitjana R,Vives M,Gomis R

更新日期：1994-03-01 00:00:00

abstract：:In the present study, antibodies directed against clathrin light (33 kDa-36 kDa) and heavy (180 kDa) chains were used to confirm, by immunocytochemistry, that coated vesicles increase in number in the exocrine cells of pancreatic lobules incubated under anoxic (N2) conditions. The same antibodies were used to check wh...

journal_title：Pancreas

authors： Merisko EM,Farquhar MG,Palade GE

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVES:Our aim was to establish and characterize a novel pancreatic ductal adenocarcinoma cell line from a patient in whom the origin of the invasive carcinoma could be traced back to the intraductal papillary mucinous neoplasm (IPMN) precursor lesion. METHODS:The primary patient-derived tumor was propagated in im...

journal_title：Pancreas

authors： Heller A,Angelova AL,Bauer S,Grekova SP,Aprahamian M,Rommelaere J,Volkmar M,Janssen JW,Bauer N,Herr I,Giese T,Gaida MM,Bergmann F,Hackert T,Fritz S,Giese NA

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to identify differentially expressed proteins in the pancreatic tissue of hepatic alcohol dehydrogenase-deficient deer mice fed ethanol to understand metabolic basis and mechanism of alcoholic chronic pancreatitis. METHODS:Mice were fed liquid diet containing 3.5 g% ethanol daily f...

journal_title：Pancreas

authors： Bhopale KK,Amer SM,Kaphalia L,Soman KV,Wiktorowicz JE,Shakeel Ansari GA,Kaphalia BS

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVES:Acute pancreatitis (AP) is a leading cause of hospitalization for a gastrointestinal illness in the United States. We hypothesized that enhanced recovery approaches may lead to earlier time to refeeding in patients with AP. METHODS:We performed a double-blind, randomized controlled trial of patients admitte...

journal_title：Pancreas

authors： Dong E,Chang JI,Verma D,Butler RK,Villarin CK,Kwok KK,Chen W,Wu BU

更新日期：2019-02-01 00:00:00

abstract：:OBJECTIVES: The purpose of this study was to determine whether the choice for performance of endoscopic retrograde pancreatography (ERP) could be tailored to findings on computed tomography (CT) in patients with suspected autoimmune pancreatitis (AIP). METHODS: Eighty-four AIP patients and 73 pathology-proven pancreat...

journal_title：Pancreas

authors： Kim JH,Kim MH,Byun JH,Lee SS,Lee SJ,Park SH,Lee SK,Park DH,Lee MG,Moon SH

更新日期：2012-05-01 00:00:00

abstract：:We performed molecular biological studies as well as immunohistochemical analysis of three cases of giant cell carcinoma of the pancreas. Histologically, one case was a pleomorphic giant cell carcinoma consisting of pleomorphic giant/ small cells and spindle cells, one an osteoclast-like giant cell tumor composed of o...

journal_title：Pancreas

authors： Imai Y,Morishita S,Ikeda Y,Toyoda M,Ashizawa T,Yamamoto K,Inoue T,Ishikawa T

更新日期：1999-04-01 00:00:00

abstract：OBJECTIVES:This case-control study was performed to evaluate the association between a specific caspase-9 polymorphism as well as the genetic polymorphism -31G/C located in the cycle-dependent elements/cell cycle homology regions repressor element of the human survivin promoter and the risk of pancreatic cancer. METHO...

journal_title：Pancreas

authors： Theodoropoulos GE,Michalopoulos NV,Panoussopoulos SG,Taka S,Gazouli M

更新日期：2010-10-01 00:00:00

abstract：:Monoclonal antibodies (McAbs) to pancreatic cancer were developed by fusing SP2/0 cells and splenocytes from Balb/c mice immunized with CH-2 cells. The specific binding rates of McAb P1 and P2 were 40.1 and 43.8%, respectively, shown by binding radioreactivity assay in vitro, which were in sharp contrast with those of...

journal_title：Pancreas

authors： Yao CZ,Poston GJ,Ishizuka J,Townsend CM Jr,Thompson JC

更新日期：1993-05-01 00:00:00

abstract：OBJECTIVE:There is reluctance to use donation after cardiac death (DCD) organs for fear of worse outcomes due to increased warm ischemia time. Extensive evidence to confirm the quality of DCD pancreas transplants is not manifest. METHODS:A united network for organ sharing database review of pancreas transplants perfor...

journal_title：Pancreas

authors： Siskind E,Akerman M,Maloney C,Huntoon K,Alex A,Siskind T,Bhaskeran M,Ali N,Basu A,Molmenti E,Ortiz J

更新日期：2014-05-01 00:00:00

abstract：:Chemoprevention by a synthetic retinoid, selenium, and these agents in combination during the postinitiation stages of carcinogenesis induced in rats by azaserine was evaluated. Male Lewis rats were given three weekly injections of 30 mg/kg azaserine while being fed a purified diet. One week after completion of carcin...

journal_title：Pancreas

authors： Curphey TJ,Kuhlmann ET,Roebuck BD,Longnecker DS

更新日期：1988-01-01 00:00:00

abstract：:Islet amyloid polypeptide (IAPP) has been recently identified as the principal constituent of amyloid deposits in pancreatic islets of patients with type 2 (non-insulin-dependent) diabetes mellitus and causes insulin resistance in some target cells. In addition, glucose-induced insulin secretion is inhibited by IAPP. ...

journal_title：Pancreas

authors： Chuang LM,Wu HP,Jou TS,Tai TY,Lin BJ

更新日期：1992-01-01 00:00:00

abstract：:Radical pancreaticoduodenectomy was performed for cancer of the head of the pancreas in a 65-year-old male patient with congenital celiac occlusion. Preoperative angiography revealed that the arterial flow to the liver, spleen, and stomach was supplied via the pancreaticoduodenal arcade and that the dorsal pancreatic ...

journal_title：Pancreas

authors： Manabe T,Baba N,Setoyama H,Ohshio G,Tobe T

更新日期：1991-05-01 00:00:00

abstract：OBJECTIVES:Regeneration of the pancreas is initiated by the tubular complexes that consist of a cluster of epithelia surrounded by the mesenchymal cells. They have the potential to become pancreatic lobes, but their growth stops before the complete regeneration of the organ. To elucidate the possibility that we could p...

journal_title：Pancreas

authors： Kitamura T,Asanuma N,Inaba M,Otsuki M,Kasayama S,Kouhara H,Kawase I

更新日期：2005-03-01 00:00:00

abstract：AIM:To assess the feasibility and usefulness of secretin-enhanced magnetic resonance cholangiopancreatography (S-MRCP) for evaluation of pancreatic exocrine function. METHODOLOGY:S-MRCP was performed in 20 patients with mild (n = 8) or severe (n = 12) chronic pancreatitis (according to the grade of exocrine pancreatic...

journal_title：Pancreas

authors： Czakó L,Endes J,Takács T,Boda K,Lonovics J

更新日期：2001-10-01 00:00:00

abstract：:A procedure is described for the isolation and growth in vitro of epithelial cells from the duct network of human pancreas, referred to as DEC. A significant advantage of our procedure over previously published procedures is that it enables the isolation of DEC from small pieces of pancreas tissue (< 5 g) and, also, f...

journal_title：Pancreas

authors： Kolar C,Caffrey T,Hollingsworth M,Scheetz M,Sutherlin M,Weide L,Lawson T

更新日期：1997-10-01 00:00:00

abstract：OBJECTIVE:To develop a ¹³C-labeled substrate breath test by defining the optimal ¹³C-labeled substrate, substrate dose, test meal, and duration of the test and evaluating its accuracy for the diagnosis of pancreatic exocrine insufficiency (PEI) in chronic pancreatitis (CP). METHODS:Five consecutive prospective compara...

journal_title：Pancreas

authors： Domínguez-Muñoz JE,Nieto L,Vilariño M,Lourido MV,Iglesias-García J

更新日期：2016-02-01 00:00:00

abstract：:Periodic oscillation of insulin and glucagon by isolated mice islets has been studied. Pulsatile secretion of insulin and glucagon was observed at all glucose concentrations tested. The frequency of oscillation per 20 min for glucagon was 5.0 +/- 0.26 and for insulin 4.0 +/- 0.26 (n = 6), approximating to periodicitie...

journal_title：Pancreas

authors： Opara EC,Atwater I,Go VL

更新日期：1988-01-01 00:00:00

abstract：:A case of relapsing pancreatitis in a young man is presented. Stenosis of the main duct and cystic lesions of the tail of the pancreas were shown by ultrasonography, CT scan, and endoscopic retrograde cholangiopancreatography (ERCP). After a wrong diagnosis of cancer, the pathological examination demonstrated an eosin...

journal_title：Pancreas

authors： Bastid C,Sahel J,Choux R,Payan MJ,Sarles H

更新日期：1990-01-01 00:00:00

abstract：:A 50-year-old female was referred to our hospital because of postprandial epigastric pain and pancreatic head mass. On admission, an elastic hard mass with tenderness was palpable in the epigastric region. Laboratory findings showed no abnormalities, except for a slightly elevated C-reactive protein value and iron def...

journal_title：Pancreas

authors： Taguchi M,Nishikawa S,Matsuoka H,Narita R,Abe S,Fukuda K,Miyamoto H,Taniguchi H,Otsuki M

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVES:Currently available pancreatic enzyme products are crude porcine products with few data available regarding their efficacy, safety, and manufacture. We conducted a phase 1 study of a novel pancreatic enzyme product, TheraCLEC-Total (TCT), a proprietary formulation of microbial-derived lipase, protease, and a...

journal_title：Pancreas

authors： Borowitz D,Goss CH,Stevens C,Hayes D,Newman L,O'Rourke A,Konstan MW,Wagener J,Moss R,Hendeles L,Orenstein D,Ahrens R,Oermann CM,Aitken ML,Mahl TC,Young KR Jr,Dunitz J,Murray FT

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVE:Members of the transient receptor potential (TRP) channels are involved in mediating the electrical excitability and stimulus-secretion coupling in the pancreatic β-cells. The expression and the relative abundance of different TRP channels in the human β-cells are unknown. The objective of this study was to e...

journal_title：Pancreas

authors： Marabita F,Islam MS

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:To investigate the expression of thioredoxin-interacting protein (TXNIP) during hypoxia and its dependency on hypoxia-inducible factor 1alpha (HIF-1alpha) in pancreatic cancer cell lines. METHODS:MiaPaCa-2 pancreatic cancer cells were transiently transfected with siRNA to HIF-1alpha and TXNIP protein measure...

journal_title：Pancreas

authors： Baker AF,Koh MY,Williams RR,James B,Wang H,Tate WR,Gallegos A,Von Hoff DD,Han H,Powis G

更新日期：2008-03-01 00:00:00

abstract：:Pancreatic insufficiency was induced in rats by a single injection of 50 microliter oleic acid into the pancreatic duct over a period of 3 min. Exocrine tissue was destroyed within 3-6 days, and after 6 weeks the remaining pancreas equaled 2.7% of the original organ. The rats showed retardation of body weight in spite...

journal_title：Pancreas

authors： Mundlos S,Adler G,Schaar M,Koop I,Arnold R

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVES:Infected necrotizing pancreatitis represents a serious and therapeutically challenging complication. Percutaneous drainage of infected pancreatic necrosis is often unsuccessful. Alternatively, open necrosectomies are associated with high morbidity. Recently, minimally invasive necrosectomy techniques have be...

journal_title：Pancreas

authors： Bucher P,Pugin F,Morel P

更新日期：2008-03-01 00:00:00

abstract：INTRODUCTION:We recently established a method of isolation and primary monolayer culture of porcine pancreatic endocrine cells that involves the use of nicotinamide. AIM:To obtain genetic information on cultured porcine endocrine cells and to examine cell function in relation to insulin secretion during long-term cult...

journal_title：Pancreas

authors： Tsuchiya M,Tsuchiya K,Iwami Y,Ohgawara H

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVES:Literature addressing the significance of lymph node positivity in the management of nonfunctional pancreatic neuroendocrine tumors (PNETs) is conflicting. METHODS:The National Cancer Data Base was queried for patients who underwent surgical resection of nonfunctional PNETs between 1998 and 2011. Clinical d...

journal_title：Pancreas

authors： Jutric Z,Grendar J,Hoen HM,Cho SW,Cassera MA,Newell PH,Hammill CW,Hansen PD,Wolf RF

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVES:Hypertriglyceridemia-induced pancreatitis is an important cause of acute pancreatitis (AP) in children, which lacks established guidelines. The aim of this study was to review management approaches at a single pediatric center. METHODS:This retrospective study included all inpatients younger than 21 years w...

journal_title：Pancreas

authors： Ippisch HM,Alfaro-Cruz L,Fei L,Zou Y,Thompson T,Abu-El-Haija M

更新日期：2020-03-01 00:00:00