Pancreas transplantation from donors after cardiac death: an update of the UNOS database.


OBJECTIVE:There is reluctance to use donation after cardiac death (DCD) organs for fear of worse outcomes due to increased warm ischemia time. Extensive evidence to confirm the quality of DCD pancreas transplants is not manifest. METHODS:A united network for organ sharing database review of pancreas transplants performed between 1996 and 2012 was conducted. We compared outcomes and all demographic variables between donors after cardiac death and donors after brain death in pancreas transplantation. RESULTS:There were 320 DCD pancreas transplants and 20,448 donation after brain death pancreas transplants performed in the United States between 1996 and 2012. There was no statistically significant difference in graft survival or patient survival in pancreas transplantation in DCD versus donation after brain death donors measured at 1-year, 3-year, 5-year, 10-year, and 15-year intervals. There was no significant difference between donor and recipient age, race, sex, and body mass index (BMI) between the groups. There was no significant difference between the recipient ethnicity or time on wait list between the groups. CONCLUSIONS:Pancreata procured by DCD have comparable outcomes to those procured after brain death. Donation after cardiac death pancreas transplant is a viable method of increasing the donor pool, decreasing wait list mortality, and improving the quality of life for type 1 diabetic patients.






Siskind E,Akerman M,Maloney C,Huntoon K,Alex A,Siskind T,Bhaskeran M,Ali N,Basu A,Molmenti E,Ortiz J




Has Abstract


2014-05-01 00:00:00














  • Intrinsic nerves of the pancreas after celiac and superior mesenteric ganglionectomy in rats: a morphologic study of acetylcholinesterase activity and catecholamine histofluorescence.

    abstract::The effect of surgical celiac and superior mesenteric ganglionectomy (GGX) on intrinsic pancreatic innervation was studied in male Wistar rats. Neurons were stained in the pancreas of control and ganglionectomized rats with histochemical methods evidencing the acetylcholinesterase (AChE) activity and the induced fluor...


    pub_type: 杂志文章


    authors: Anglade P,Michel C,Rozé C

    更新日期:1987-01-01 00:00:00

  • Atrial natriuretic factor and exocrine pancreas: autoradiographic localization of binding sites and ultrastructural evidence for internalization of endogenous ANF.

    abstract::Atrial natriuretic factor (ANF) binding sites in adult rat exocrine pancreas were studied by autoradiography using slide-mounted frozen tissue sections with mono-iodinated ANF (101-126) as the tracer. Radiolabel was displaced by unlabeled atrial peptide (IC50 = 2 X 10(-11) M). High specific labeling was found in pancr...


    pub_type: 杂志文章


    authors: Chabot JG,Morel G,Kopelman H,Belles-Isles M,Heisler S

    更新日期:1987-01-01 00:00:00

  • Mitochondrial transcription factor a worsens the clinical course of patients with pancreatic cancer through inhibition of apoptosis of cancer cells.

    abstract:OBJECTIVE:Mitochondrial transcription factor A (mtTFA) is mandatory for both the transcription and maintenance of mitochondrial DNA. This study aimed to investigate the significance of mtTFA expression in pancreatic ductal adenocarcinoma (PDAC). METHODS:Surgical specimens from 93 patients with PDAC who all underwent p...


    pub_type: 杂志文章


    authors: Yamauchi M,Nakayama Y,Minagawa N,Torigoe T,Shibao K,Yamaguchi K

    更新日期:2014-04-01 00:00:00

  • Acute Pancreatitis and Use of Pancreatitis-Associated Drugs: A 10-Year Population-Based Cohort Study.

    abstract:OBJECTIVES:To assess the use of acute pancreatitis (AP)-associated drugs in patients with AP, the relation between sales of these drugs and the incidence of AP, and the potential impact on AP severity and recurrence. METHODS:All patients with incident AP between 2003 and 2012, in a well-defined area, were retrospectiv...


    pub_type: 杂志文章


    authors: Bertilsson S,Kalaitzakis E

    更新日期:2015-10-01 00:00:00

  • Increased expression of glutathione S-transferase-pi in the islets of patients with primary chronic pancreatitis but not secondary chronic pancreatitis.

    abstract::The mechanism of tissue alteration in chronic pancreatitis (CP) is still unclear. Different hypotheses have been discussed, including increasing oxidant stress in the acinar cells, often as a result of exposure to xenobiotics. To evaluate the role of oxidative stress in CP, the authors investigated the expression of t...


    pub_type: 杂志文章


    authors: Ulrich AB,Schmied BM,Matsuzaki H,Lawson TA,Friess H,Andrén-Sandberg A,Büchler MW,Pour PM

    更新日期:2001-05-01 00:00:00

  • Reported findings on endoscopic ultrasound examinations for chronic pancreatitis: toward establishing an endoscopic ultrasound quality benchmark.

    abstract:OBJECTIVES:Endoscopic ultrasound (EUS) quality benchmarks for pancreatic disease previously focused on maintaining thresholds of diagnostic accuracy for fine-needle aspiration and measuring complications. We aimed to evaluate quality indicators when performing EUS specifically for the diagnosis of chronic pancreatitis ...


    pub_type: 杂志文章


    authors: Gardner TB,Taylor DJ,Gordon SR

    更新日期:2014-01-01 00:00:00

  • Effect of verapamil on the cyclic AMP-mediated pathway for amylase secretion in rat pancreatic acini.

    abstract::In dispersed acini from rat pancreas, verapamil (a phenylalkylamine calcium channel blocker) potentiated amylase secretion stimulated by vasoactive intestinal peptide (VIP), secretin, peptide histidine isoleucine, helodermin, forskolin, and 8-bromocyclic AMP. The action of verapamil on VIP-stimulated amylase secretion...


    pub_type: 杂志文章


    authors: Slimak GG,Stark HA,Egan JJ,Jensen RT,Gardner JD

    更新日期:1993-03-01 00:00:00

  • Effectiveness of discriminant analysis of serum CA 19-9 and elastase 1 in diagnosis of pancreatic carcinoma.

    abstract::The accuracies of assays of serum CA 19-9 and elastase 1 in the diagnosis of pancreatic carcinoma were investigated by the cutoff method and discriminant analysis of data on 98 patients with pancreatitis, 65 patients with pancreatic carcinoma, 107 patients with benign diseases of other organs, and 108 patients with ca...


    pub_type: 杂志文章


    authors: Yamamura H,Tatsuta M,Ito M,Iishi H,Noguchi S,Okuda S,Yoshida M

    更新日期:1989-01-01 00:00:00

  • Effect of the cholecystokinin receptor antagonist loxiglumide on pancreatic exocrine function in rats after acute pancreatitis.

    abstract::Recent studies have demonstrated that cholecystokinin (CCK) receptor antagonists not only reduce the severity of pancreatitis but also inhibit pancreatic regeneration after pancreatitis. This study was undertaken, therefore, to examine the effects of the CCK receptor antagonist loxiglumide on the exocrine pancreas whe...


    pub_type: 杂志文章


    authors: Nakano S,Tachibana I,Otsuki M

    更新日期:1995-04-01 00:00:00

  • Inhibition of pancreatic and liver carcinogenesis in rats by retinoid- and selenium-supplemented diets.

    abstract::Chemoprevention by a synthetic retinoid, selenium, and these agents in combination during the postinitiation stages of carcinogenesis induced in rats by azaserine was evaluated. Male Lewis rats were given three weekly injections of 30 mg/kg azaserine while being fed a purified diet. One week after completion of carcin...


    pub_type: 杂志文章


    authors: Curphey TJ,Kuhlmann ET,Roebuck BD,Longnecker DS

    更新日期:1988-01-01 00:00:00

  • Proceedings of the 3rd International Conference for Cancer Metabolism and Therapy, October 12-14, 2018, Shanghai, China.

    abstract::The 3 International Conference for Cancer Metabolism and Therapy was successfully held at the South Hospital Conference Center of Shanghai First People's Hospital, nearly 200 international experts from the field of cancer metabolism and therapy and about two thousand local scientists attended the conference. The confe...


    pub_type: 杂志文章


    authors: Xiao GG,Zhang Z,Lu B,Wang H,Fan TW,Boros LG,Gao P,Pan Y,Go VLW

    更新日期:2020-02-01 00:00:00

  • Successful Localization and Resection of Small Pancreatic Cystic Insulinoma Using Intraoperative Near-Infrared Fluorescence Imaging: A Case Report and Literature Review.

    abstract::Pancreatic cystic insulinoma is an uncommon tumor. Perioperative localization remained challenging if the tumor is atypical with cystic feature or in small size. Near-infrared (NIR) imaging is a technique by injecting fluorescent dye intravenously, which accumulates to the target lesion and creating signal by laser so...


    pub_type: 杂志文章


    authors: Kou HW,Yu MC,Chong SW,Hsu HY,Chou HH,Lee CW,Chen TC,Huang SF

    更新日期:2020-11-01 00:00:00

  • Sensitivity of endoscopic ultrasound, multidetector computed tomography, and magnetic resonance cholangiopancreatography in the diagnosis of pancreas divisum: a tertiary center experience.

    abstract:OBJECTIVES:There are limited data comparing imaging modalities in the diagnosis of pancreas divisum. We aimed to: (1) evaluate the sensitivity of endoscopic ultrasound (EUS), magnetic resonance cholangiopancreatography (MRCP), and multidetector computed tomography (MDCT) for pancreas divisum; and (2) assess interobserv...


    pub_type: 杂志文章


    authors: Kushnir VM,Wani SB,Fowler K,Menias C,Varma R,Narra V,Hovis C,Murad FM,Mullady DK,Jonnalagadda SS,Early DS,Edmundowicz SA,Azar RR

    更新日期:2013-04-01 00:00:00

  • Effects of parathyroid hormone on pancreatic exocrine secretion.

    abstract::The role of parathyroid hormone (PTH) and calcium on pancreatic exocrine secretion were observed using sham-operated and parathyroidectomized dogs. First, exocrine secretion of the pancreas stimulated with secretin and cholecystokinin octapeptide (CCK-8) was examined in vivo 3 weeks after parathyroidectomy. Secondly, ...


    pub_type: 杂志文章


    authors: Kuroda T,Shiohara E,Haba Y,Kaneko G,Hanazaki K,Kajikawa S,Iida F

    更新日期:1993-11-01 00:00:00

  • Standard Operating Procedures for Biospecimen Collection, Processing, and Storage: From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer.

    abstract::High-quality and well-annotated biorepositories are needed to better understand the pathophysiology and biologic mechanisms of chronic pancreatitis (CP) and its consequences. We report a methodology for the development of a robust standard operating procedure (SOP) for a biorepository based on the experience of the cl...


    pub_type: 杂志文章


    authors: Fisher WE,Cruz-Monserrate Z,McElhany AL,Lesinski GB,Hart PA,Ghosh R,Van Buren G,Fishman DS,Rinaudo JAS,Serrano J,Srivastava S,Mace T,Topazian M,Feng Z,Yadav D,Pandol SJ,Hughes SJ,Liu RY,Lu E,Orr R,Whitcomb DC,Ab

    更新日期:2018-11-01 00:00:00

  • Personalized Pancreatic Cancer Management: A Systematic Review of How Machine Learning Is Supporting Decision-making.

    abstract::This review critically analyzes how machine learning is being used to support clinical decision-making in the management of potentially resectable pancreatic cancer. Following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guidelines, electronic searches of MEDLINE, Embase, PubMed, and Coc...


    pub_type: 杂志文章


    authors: Bradley A,van der Meer R,McKay C

    更新日期:2019-05-01 00:00:00

  • Expression of ATM protein and its relationship with p53 in pancreatic carcinoma with tissue array.

    abstract::ATM protein anticipates in the initiation of the DNA repair signal pathway and also mediates cell cycle arrest and repair. ATM deficiency predictably results in radiosensitivity, germ cell degeneration, chromosomal instability, immunodeficiency, and an extreme predisposition to tumors. Moreover, studies found that ATM...


    pub_type: 杂志文章


    authors: Yu G,Zhu MH,Zhu Z,Ni CR,Zheng JM,Li FM

    更新日期:2004-05-01 00:00:00

  • Protein kinase C: a target for therapy in pancreatic cancer.

    abstract:OBJECTIVES:Protein kinase C (PKC) is involved in tumor growth and apoptosis and hence represents a potential target for cancer therapy. This study investigated the expression of PKC in pancreatic tumor tissue in comparison to adjacent normal tissue and determined the modulation of PKC by bryostatin-1 (BRYO) on pancreat...


    pub_type: 杂志文章


    authors: El-Rayes BF,Ali S,Philip PA,Sarkar FH

    更新日期:2008-05-01 00:00:00

  • Matrix metalloproteinase-1 and cytokines in patients with acute pancreatitis.

    abstract:INTRODUCTION:Hypercytokinemia is known to occur in severe acute pancreatitis, suggesting that the production, deposition, and degradation of the extracellular matrix (ECM) occur actively as a result of the actions of the complicated cytokine network. AIMS AND METHODOLOGY:To examine the influence of cytokines and growt...


    pub_type: 杂志文章


    authors: Nakae H,Endo S,Inoue Y,Fujino Y,Wakabayashi G,Inada K,Sato S

    更新日期:2003-03-01 00:00:00

  • Understanding the Pathophysiology of Psychological Distress and Pancreatic Cancer: A Systematic Review.

    abstract:BACKGROUND:Psychological distress is highly prevalent in patients with pancreatic cancer (PC), yet little is known about the pathophysiology underlying the relationship between these 2 diseases. Our aim was to systematically review the evidence examining the pathophysiological mechanisms of the association between PC a...


    pub_type: 杂志文章,评审


    authors: Bettison TM,Nahm CB,Gill AJ,Mittal A,Malhi GS,Samra JS

    更新日期:2018-04-01 00:00:00

  • Protective effect of misoprostol, a synthetic prostaglandin E1 analog, on cerulein-induced acute pancreatitis in rats.

    abstract::This study was performed to assess the effects of misoprostol, a synthetic prostaglandin E1 analog, on cerulein-induced pancreatitis. Per group of 10 each, male Wistar rats received either cerulein (2.5 micrograms/kg/h subcutaneously), cerulein and misoprostol (500 micrograms/kg intraperitoneally at 0 and 4 h), or sal...


    pub_type: 杂志文章


    authors: Buscail L,Bussenot I,Bouisson M,Sénégas-Balas F,Bertrand C,Balas D,Vaysse N,Ribet A

    更新日期:1990-03-01 00:00:00

  • Pancreatic acinar cells in adult human islets of Langerhans.

    abstract::Pancreatic acinar cells within the islets of Langerhans in human pancreas were investigated both histopathologically and electron microscopically. Acinar cells inside the islets of Langerhans were observed in all 50 adult cases investigated. Between such acinar cells and endocrine tissues, no reticular fiber was obser...


    pub_type: 杂志文章


    authors: Suda K,Hosokawa Y,Kuroda J,Yuminamochi T,Ishii Y,Nakazawa K

    更新日期:1994-09-01 00:00:00

  • Deleterious effect of dithizone-DMSO staining on insulin secretion in rat and human pancreatic islets.

    abstract::Dithizone (DTZ) is a selective stain for pancreatic islets which facilitates their identification, being of special interest in human islet isolation assessment. Nevertheless, there are few studies concerning its potential toxic effects on islet function. In our study, we have evaluated the effects of DTZ (dissolved i...


    pub_type: 杂志文章


    authors: Conget JI,Sarri Y,González-Clemente JM,Casamitjana R,Vives M,Gomis R

    更新日期:1994-03-01 00:00:00

  • Effects of early ductal decompression in human biliary acute pancreatitis.

    abstract::It was recently demonstrated in experimental models that, after pancreatic outflow obstruction, serum amylase levels first increase and then progressively decline regardless of whether the obstruction was maintained or relieved. Furthermore, early decompression of the ductal biliary system may prevent the progression ...


    pub_type: 杂志文章


    authors: Pezzilli R,Billi P,Barakat B,Baroncini D,D'Imperio N,Miglio F

    更新日期:1998-03-01 00:00:00

  • Does prophylactic administration of somatostatin decrease the rates of complications after pancreatic resection?: A clinical and electron microscopy study.

    abstract:OBJECTIVES:The postoperative morbidity after pancreatectomy remains high. The role of somatostatin and its analogs in reducing complications after pancreatic resection is controversial. The aim of the study was to evaluate the ability of somatostatin to influence pancreatic cell's function with consequence the decrease...


    pub_type: 杂志文章,随机对照试验


    authors: Katsourakis A,Zezos P,Noussios G,Kouklakis G,Chatzitheoklitos E,Simopoulos K,Pitiakoudis M

    更新日期:2013-01-01 00:00:00

  • Effects of Prophylactic Antibiotics on Length of Stay and Total Costs for Pediatric Acute Pancreatitis: A Nationwide Database Study in Japan.

    abstract:OBJECTIVES:Acute pancreatitis (AP) guidelines for adult patients do not recommend routine prophylactic use of antibiotics because of no clinical merit on mortality, infectious complications, or length of stay. Although the mortality of pediatric AP is low, no studies have explored the rationale for antibiotic use in pe...


    pub_type: 杂志文章


    authors: Ikeda Kurakawa K,Okada A,Jo T,Ono S,Bessho K,Michihata N,Matsui H,Yamaguchi S,Fushimi K,Kadowaki T,Yasunaga H

    更新日期:2020-11-01 00:00:00

  • Suppression of human pancreatic carcinoma cell growth and invasion by epigallocatechin-3-gallate.

    abstract:INTRODUCTION:The consumption of green tea is associated with a lower risk of several types of human carcinomas. A number of studies have focused on the possible mechanisms of cancer prevention by tea extracts, especially polyphenols such as epigallocatechin-3-gallate (EGCG). AIMS AND METHODOLOGY:Green tea-derived EGCG...


    pub_type: 杂志文章


    authors: Takada M,Nakamura Y,Koizumi T,Toyama H,Kamigaki T,Suzuki Y,Takeyama Y,Kuroda Y

    更新日期:2002-07-01 00:00:00

  • Enhanced Krev-1 expression inhibits the growth of pancreatic adenocarcinoma cells.

    abstract::Pancreatic ductal adenocarcinoma is characterized by a high rate of activating mutations involving codon 12 of the K-ras protooncogene. As a means of ras-targeted intervention, the effects of enhanced Krev-1 gene expression on the growth and tumorigenicity of the hamster pancreatic adenocarcinoma cell line PC-1 were e...


    pub_type: 杂志文章


    authors: Leach SD,Berger DH,Davidson BS,Curley SA,Tainsky MA

    更新日期:1998-05-01 00:00:00

  • Postoperative pancreatic fistula in distal pancreatectomy: experience from 1 institution.

    abstract:OBJECTIVE:Postoperative pancreatic fistula (POPF) and readmission remain the significant sources of morbidity after distal pancreatectomy (DP). We describe a technique of drainage and postoperation management to prevent severe POPF and readmission. METHODS:A retrospective analysis of 57 patients who underwent DP from ...


    pub_type: 杂志文章


    authors: Wang H,Xiu D,Jiang B,Ma C,Yuan C

    更新日期:2014-05-01 00:00:00

  • Pancreatic imaging: current and emerging technologies.

    abstract::This review discusses the current imaging modalities for the diagnosis and staging of solid and cystic pancreatic lesions and for the assessment of acute and chronic pancreatitis, and the future role of emerging technologies in the management of pancreatic diseases. Multidetector row spiral computed tomography is supe...


    pub_type: 杂志文章,评审


    authors: Nichols MT,Russ PD,Chen YK

    更新日期:2006-10-01 00:00:00