Abstract:
OBJECTIVES:The circulating neutrophil-lymphocyte ratio (NLR) has been shown to be a prognostic factor for a variety of tumors. In this study, we evaluated the prognostic significance of NLR in a large cohort of Chinese patients with pancreatic ductal adenocarcinomas (PDACs). METHODS:A total of 381 patients with PDAC who underwent potentially curative surgery were recruited from 2 centers in Shanghai, China, between January 2004 and September 2011. Analysis of overall survival (OS) was performed using the Kaplan-Meier and log-rank tests and the Cox proportional hazards regression model. RESULTS:The most optimal cutoff of NLR was NLR 2.0 or greater, and the NLR was divided into 2 groups: high (≥ 2.0) and low (< 2.0). The high NLR (≥ 2.0) was associated with advanced UICC (Union for International Cancer Control) stages, p T stage, lymphoid node invasion, and poorer tumor differentiation. Multivariate analysis identified increased NLR as an independent prognostic factor for OS (hazard ratio = 1.51; 95 % confidence interval, 1.15-1.99; P = 0.003). Furthermore, neutrophil counts rather than lymphocyte counts were associated with OS of PDAC. CONCLUSIONS:The pretreatment NLR is a simple and useful potential biomarker for OS in patients with PDAC after curative resection.
journal_name
Pancreasjournal_title
Pancreasauthors
Ben Q,An W,Wang L,Wang W,Yu L,Yuan Ydoi
10.1097/MPA.0000000000000271subject
Has Abstractpub_date
2015-04-01 00:00:00pages
471-7issue
3eissn
0885-3177issn
1536-4828journal_volume
44pub_type
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