Abstract:
OBJECTIVE:Pancreatic ductal carcinoma frequently recurs postoperatively, and we analyzed clinicopathological features of patients treated by surgical resection to find predictors of postoperative recurrence. METHODS:A retrospective cohort study was performed that included 69 patients between 1985 and 2003. Clinicopathologic factors were evaluated for tumor recurrences by univariate and multivariate analyses. RESULTS:Mean survival time and actuarial 5-year disease-specific survival were significantly lower in cases of hepatic metastasis (13 months, 0%) and in cases of peritoneal carcinomatosis (15 months, 6.8%) than in cases of local retroperitoneal recurrence (30 months, 21%). Univariate and logistic regression analyses showed undifferentiated adenocarcinoma to be independently associated with hepatic metastasis (odds ratio, 7.4; 95% confidence interval, 1.5-37.0) and invasion of the portal vein to be independently associated with peritoneal carcinomatosis (odds ratio, 4.0; 95% confidence interval, 1.2-12.8). Multivariate analysis showed undifferentiated adenocarcinoma, invasion of the anterior capsule, and invasion of the portal vein to be independent prognostic factors. CONCLUSION:Undifferentiated adenocarcinoma and invasion of the portal vein are predictors of poor outcome and are related to hepatic metastasis and peritoneal carcinomatosis, respectively. Postoperative adjuvant chemotherapy, including intra-arterial chemotherapy, should be selected according to prediction of the patterns of recurrence.
journal_name
Pancreasjournal_title
Pancreasauthors
Shibata K,Matsumoto T,Yada K,Sasaki A,Ohta M,Kitano Sdoi
10.1097/01.mpa.0000166998.04266.88subject
Has Abstractpub_date
2005-07-01 00:00:00pages
69-73issue
1eissn
0885-3177issn
1536-4828pii
00006676-200507000-00056journal_volume
31pub_type
杂志文章相关文献
PANCREAS文献大全abstract:OBJECTIVES:Endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) is the main diagnostic modality for pancreatic mass lesions. However, cytology is often indeterminate, leading to repeat FNAs and delay in care. Here, we evaluate whether combining routine cytology with fluorescence in situ hybridization (FISH) ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3182200201
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:This study aimed to develop target-specific binding agents for in vitro and in vivo imaging of human pancreatic cancer. METHODS:A monoclonal neutrophil gelatinase-associated lipocalin (NGAL)-specific antibody and a peptide specific for matrix metalloproteinase (MMP) were labeled with a near-infrared dye for...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31821f6b14
更新日期:2011-07-01 00:00:00
abstract::A comparative study of antibacterial activity of pancreatic juice was conducted on six mammalian species. Pancreatic juice collections were conducted as acute (rabbit, guinea pig, rat) and chronic (pig, sheep, cattle) experiments, in the former before and after stimulation [cholecystokinin (CCK) and secretin] and in t...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199309000-00003
更新日期:1993-09-01 00:00:00
abstract:OBJECTIVES:Scutellaria baicalensis has been a subject of research interest due to its potential multiple therapeutic benefits. This study was to examine the distribution of baicalein, wogonin, oroxylin A and their glucuronide/sulfate-conjugated metabolites in plasma, colon, small intestine, lung, liver, pancreas, kidne...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318232e130
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVES:The present study screened the SMAD4 gene in an Indian population of patients with pancreatic ductal adenocarcinoma (PDAC) for the presence of homozygous deletions and mutations. The effect of these genetic alterations on Smad4 protein expression and patient survival was also evaluated. METHODS:This study w...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318247d6af
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to identify differentially expressed proteins in the pancreatic tissue of hepatic alcohol dehydrogenase-deficient deer mice fed ethanol to understand metabolic basis and mechanism of alcoholic chronic pancreatitis. METHODS:Mice were fed liquid diet containing 3.5 g% ethanol daily f...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000835
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVES:Endoscopic ultrasound (EUS) may offer a diagnostic tool through the combination of imaging and guided fine-needle aspiration of pancreatic cysts. The purpose of this investigation was to determine the most accurate test for differentiating mucinous from nonmucinous cysts. METHODS:The results of EUS imaging,...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31821bd62f
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:This analysis investigated nomogram use to evaluate metastatic pancreatic cancer prognosis. METHODS:Thirty-four baseline factors were examined in the Metastatic Pancreatic Adenocarcinoma Clinical Trial (MPACT) (nab-paclitaxel plus gemcitabine vs gemcitabine) data set. Factors significantly (P < 0.1) associa...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001563
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVES:Many patients with recurrent acute and chronic pancreatitis who are candidates for total pancreatectomy and islet cell autotransplantation (TPIAT) undergo endoscopic retrograde cholangiopancreatography (ERCP). However, little is known on the impact of ERCP on TPIAT outcomes. We aimed to explore the effect of...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001188
更新日期:2019-01-01 00:00:00
abstract::The accuracies of assays of serum CA 19-9 and elastase 1 in the diagnosis of pancreatic carcinoma were investigated by the cutoff method and discriminant analysis of data on 98 patients with pancreatitis, 65 patients with pancreatic carcinoma, 107 patients with benign diseases of other organs, and 108 patients with ca...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198908000-00002
更新日期:1989-01-01 00:00:00
abstract:INTRODUCTION:Peroxisome proliferator-activated receptors (PPARs) are a family of ligand-activated nuclear transcription factors belonging to the nuclear hormone receptors. Troglitazone, a specific ligand for PPAR-gamma is shown to regulate not only lipids and glucose metabolism, but also cell cycle, differentiation, an...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200204000-00015
更新日期:2002-04-01 00:00:00
abstract:INTRODUCTION:Proinflammatory cytokines play an important role in the development of type 1 diabetes. Lisofylline (LSF) is a novel anti-inflammatory compound that specifically inhibits proinflammatory cytokine production and action. AIM:To investigate the effect of LSF on diabetes prevention. METHODOLOGY:A mouse with ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200305000-00021
更新日期:2003-05-01 00:00:00
abstract::We collected pure pancreatic juice during an entire day and examined pancreatic secretory changes induced by ordinary meals in a male patient having an external drainage of the main pancreatic duct. The ingestion of breakfast, lunch, and dinner each caused a marked increase in pancreatic secretion above basal levels. ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198709000-00020
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVE:All forms of commonly practiced enteral feeding techniques stimulate pancreatic secretion, and only intravenous feeding avoids it. In this study, we explored the possibility of more distal enteral infusions of tube feeds to see whether activation of the ileal brake mechanism can result in enteral feeding with...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000183374.11919.e5
更新日期:2005-11-01 00:00:00
abstract::Adenocarcinoma of the pancreas is one of most catastrophic and least understood of cancers. Evidence from clinical studies indicates that the development of pancreas cancer progresses over many years before symptoms appear. Most people with pancreatic cancer die within six months of diagnosis. The lack of early diseas...
journal_title:Pancreas
pub_type:
doi:10.1097/00006676-200311000-00014
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to evaluate the relevance of defining borderline resectable (BR) pancreatic cancer as a distinct entity in the treatment scheme of pancreatic cancer as proposed by the National Comprehensive Cancer Network. METHODS:Among 375 patients with pancreatic cancer, 137 patients were ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31827b2d7c
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:Multiple organ failure because of systemic inflammatory response in the early phase and sepsis in the late phase is the main contributor to high mortality in severe acute pancreatitis (SAP). High-mobility group box chromosomal protein 1 (HMGB1) was recently identified as a potent proinflammatory mediator and ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000236741.15477.8b
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVES:This study aimed to investigate the frequency, predictors, and management of relapse of type 1 autoimmune pancreatitis (AIP) after steroid treatment. METHODS:One hundred one patients with type 1 AIP receiving steroid as initial treatment were enrolled. Predictors were identified by multivariate analysis usi...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001147
更新日期:2018-10-01 00:00:00
abstract::The involvement of endogenous prostaglandins (PGs) in pancreatic endocrine and exocrine secretion was investigated, using the isolated and perfused dog pancreas. Spontaneous production of both PGE2 and 6-keto-PGF1 alpha was recorded in venous effluent. Prostaglandin production increased following stimulation with both...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198912000-00008
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE:In 2003, the American Diabetes Association recommended that the lower limit for the diagnosis of impaired fasting glucose (IFG) should be reduced from 110 to 100 mg/dL in the analysis of the associated risk factors of IFG. It has been proposed that liver dysfunction may contribute to the development of type 2...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/mpa.0b013e31811f44fd
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVES:Ecological studies support the hypothesis that there is an association between vitamin D and pancreatic cancer (PaCa) mortality, but observational studies are somewhat conflicting. We sought to contribute further data to this issue by analyzing the differences in PaCa mortality across the eastern states of A...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31819975f4
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVES:The aims of this study were to evaluate diagnostic value of endoscopic ultrasound strain ratio elastography in patients with focal pancreatic masses and to determine the cutoff value between the pancreatic malignancies and inflammatory pancreatic masses using reference areas different than those used by othe...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000758
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVES:In the hamster model, pancreatic ductal adenocarcinoma develops after treatment with N-nitrosobis-(2-oxopropyl)amino (BOP). In this model, Langerhans islets play a central role in carcinogenesis. In contrast, treatment with BOP in rats and mice did not result in cancer development. We investigated whether pa...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3182016a08
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to determine the accuracy of cytology, carcinoembryonic antigen (CEA), and amylase levels in the preoperative diagnosis of intraductal papillary mucinous neoplasms (IPMNs). METHODS:An international registry was started in 2005 and included patients with clinically suspected IPMNs. ...
journal_title:Pancreas
pub_type: 杂志文章,多中心研究
doi:10.1097/MPA.0000000000000559
更新日期:2016-07-01 00:00:00
abstract::Clinical, histopathologic, immunohistochemical, and genetic analyses of 2 osteoclastic giant cell tumors of the pancreas are presented. The neoplasms were composed of osteoclastic giant cells and pleomorphic cells (PCs). The tissue-specific markers gave evidence of mesenchymal nature of the osteoclastic giant cells, a...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000202951.10612.fa
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVES:Patients with chronic pancreatitis are managed by extracorporeal shock wave lithotripsy (ESWL) for pancreatic stones. Stone density on noncontrast computed tomography (NCCT) is used to predict stone composition and fragility, but no report investigating the pancreatic stone density has been documented. We ai...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000277
更新日期:2015-04-01 00:00:00
abstract::Ornithine decarboxylase (ODC) is the rate-limiting enzyme in polyamine biosynthesis. We examined circadian variations in pancreatic ODC activity and time-course effects of caerulein in fed and fasted rats. Significant circadian variations in amount of ODC activity were observed. The highest values were obtained during...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199109000-00006
更新日期:1991-09-01 00:00:00
abstract:OBJECTIVE:Beacon gene expression is elevated in the hypothalamus of the Israeli sand rat (Psammomys obesus), an animal that is used as a polygenic animal model of obesity and NIDDM. We performed studies aimed at investigating the expression of beacon mRNA and protein in pancreatic islets of the rat and the possible bea...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200408000-00003
更新日期:2004-08-01 00:00:00
abstract::The influence of the neuropeptide galanin, present in intrapancreatic nerve endings, on the endocrine pancreas is well known. The most potent effect of galanin is inhibition of insulin release. Little is known of its effect on the exocrine pancreas. Whether galanin plays a role in the regulation of exocrine pancreatic...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199211000-00001
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:Pancreatic stellate cells (PSCs) are important players in pancreatic fibrosis and are major contributors to the extracellular matrix proteins observed with the stromal response characteristic of pancreatic ductal adenocarcinoma (PDAC). Pancreatic stellate cells are also believed to secrete soluble factors tha...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318214efaf
更新日期:2011-05-01 00:00:00