Abstract:
:A comparative study of antibacterial activity of pancreatic juice was conducted on six mammalian species. Pancreatic juice collections were conducted as acute (rabbit, guinea pig, rat) and chronic (pig, sheep, cattle) experiments, in the former before and after stimulation [cholecystokinin (CCK) and secretin] and in the latter under basal conditions alone. Antibacterial activity was tested on Micrococcus pyogenes and compared with that of neomycin. The samples were tested under normal conditions and after heating and dilution. The pancreatic juice of rat showed no activity against Micrococcus pyogenes. The antibacterial activity of rabbit and guinea pig pancreatic juice under basal conditions was similar within the group but significantly higher than that of pig, sheep and cattle which also did not differ significantly within the group. On stimulation with CCK and secretin, no significant change could be observed in the potency of antimicrobial activity of pancreatic juice in the rabbit and guinea pig. The antibacterial activity remained unchanged after heating to 65 degrees C and upon dilution to 1:10.
journal_name
Pancreasjournal_title
Pancreasauthors
Pierzynowski SG,Sharma P,Sobczyk J,Garwacki S,Barej W,Weström Bdoi
10.1097/00006676-199309000-00003subject
Has Abstractpub_date
1993-09-01 00:00:00pages
546-50issue
5eissn
0885-3177issn
1536-4828journal_volume
8pub_type
杂志文章相关文献
PANCREAS文献大全abstract::We demonstrated dynamic aspects of granulocyte activation in rat severe acute pancreatitis, which was induced by cerulein and aggravated following lipopolysaccharide (LPS) injection. Pancreatitis induced by cerulein increased intracellular elastase activity of granulocytes in the blood. However, significant systemic c...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200308000-00004
更新日期:2003-08-01 00:00:00
abstract:OBJECTIVES:To evaluate the systemic effects of moderate hypothermia (MH) and the timing of induction on acute pancreatitis (AP) and endotoxemia in rats. METHODS:The effects of MH were compared in 4 groups, that is, sham group (38 degrees C), control group (38 degrees C), early MH group (32 degrees C on administration ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318162cb26
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVES:Cyclooxygenase 2 (COX-2) and vascular endothelial growth factor (VEGF), often coexpressed in cancer, are associated with poor prognosis. However, results from pancreatic cancer trials of their inhibitors were disappointing. This study delineated the role of COX-2 and nonsteroidal anti-inflammatory drugs in a...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181c6575d
更新日期:2010-07-01 00:00:00
abstract:UNLABELLED:Serum adiponectin (ADP) levels are reported inversely related to the risk in breast, endometrial cancer, and gastric cancer. Serum ADP as a potential marker compared with CA-19-9 in pancreatic carcinoma (PC) and chronic pancreatitis (CP) was studied. Adiponectin and CA-19-9 levels were examined at the time o...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3180547709
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVE:Postoperative pancreatic fistula (POPF) and readmission remain the significant sources of morbidity after distal pancreatectomy (DP). We describe a technique of drainage and postoperation management to prevent severe POPF and readmission. METHODS:A retrospective analysis of 57 patients who underwent DP from ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000072
更新日期:2014-05-01 00:00:00
abstract::To evaluate the effect of the prostaglandin inhibitor acetylsalicylic acid (ASA) on rat exocrine pancreas secretion, three groups of rats were administered ASA by infusion: Groups 1-3, 50, 100, and 200 mg/kg body wt, respectively; Group 4 received saline. Twenty minutes later these ASA-pretreated groups were given int...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199307000-00003
更新日期:1993-07-01 00:00:00
abstract:OBJECTIVES:To determine if RNA collected from pancreatic tissue, without the use of RNAlater, is useful for RNA sequencing (RNA-seq) despite degradation, and if so, then, via RNA-seq analysis, how does gene expression vary between pancreatitis etiologies. METHODS:Data were assessed in 2 dimensions, based on RNA-seq si...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001607
更新日期:2020-09-01 00:00:00
abstract::The in vitro incorporation of [35S]cysteine into lipase, colipase, amylase, procarboxypeptidase A and B, and the serine proteases and total proteins was studied in pancreatic lobules isolated from normal and diabetic rats with or without insulin treatment. The incorporation of [35S]cysteine into total proteins was 65%...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199003000-00003
更新日期:1990-03-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to establish a minimally invasive and simple screening test for detection of pancreatic ductal adenocarcinoma (PDAC) using duodenal juice (DJ). METHODS:Duodenal juice was collected prospectively before endoscopic retrograde cholangiopancreatography in 46 patients. A protease inhibi...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3182649979
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVES:Association between acute pancreatitis and acute viral hepatitis (AVH) is more frequent than previously thought. Most cases are hepatitis A or B virus related. Only 6 cases of acute pancreatitis with acute hepatitis E virus (HEV)-related hepatitis has been reported so far. METHODS:We analyzed the hospital r...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31815d9d53
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVES:The circulating neutrophil-lymphocyte ratio (NLR) has been shown to be a prognostic factor for a variety of tumors. In this study, we evaluated the prognostic significance of NLR in a large cohort of Chinese patients with pancreatic ductal adenocarcinomas (PDACs). METHODS:A total of 381 patients with PDAC w...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000271
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVES:Pancreatic cancer (PC), a common cause of cancer death, is rarely diagnosed at an early stage. Early detection of PC may improve outcomes in affected patients. This study evaluated the utility of screening of high-risk individuals (HRIs) using an endoscopic ultrasound (EUS)-only approach to detect early mali...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001038
更新日期:2018-05-01 00:00:00
abstract::Type I diabetes is characterized by destruction of insulin-producing beta-islet cells in the pancreas resulting in hyperglycemia and associated morbidity. The successful treatment of diabetes by transplanted islets has resulted in renewed efforts to identify methods to augment islet availability. One approach is to id...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200407000-00064
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVES:C-terminal tensin-like gene (CTEN, also known as TNS4) localizes to focal adhesions and is reported to function as an oncogene in colonic, breast, lung, and gastric cancers. Its role in pancreatic cancer is unknown and was thus investigated in this study. METHODS:C-terminal tensinlike gene expression was ev...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3182557ceb
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:Amylase level in drains (ALD) has been proposed as a predictor for the development of a clinically significant pancreatic fistula (CS-PF) in patients undergoing a major pancreatic surgery. This study aimed to determine if the ALD in patients who developed a CS-PF after pancreatoduodenectomy is higher than th...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000060
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVES:This study aimed to compare severity of acute pancreatitis (AP) and mortality rates between transferred and nontransferred patients and to determine the factors that influence the decision to transfer. METHODS:A retrospective analysis coding a statewide administrative database in Maryland was conducted. Sev...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000179
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:Opioid therapy for pain in chronic pancreatitis (CP) is associated with tolerance and possibly opioid-induced hyperalgesia. We thus examined opioid use and pain rating in CP patients. METHODS:Medical records of patients with established CP treated at the University of Pittsburgh Medical Center's Digestive Di...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318224056f
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVES:In injury conditions, myofibroblasts are induced to lay down matrix proteins and support the repair process. In this study, we investigated the role of myofibroblasts, particularly stellate cells, in the growth and regeneration of pancreatic β cells. METHODS:We used both in vitro and in vivo approaches to a...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000431
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVES:Despite a lack of evidence, gabexate mesylate (GM) is routinely used for the treatment of acute pancreatitis (AP) in some countries. The present study examined the effect and cost of GM for AP treatment using the Japanese Diagnosis Procedure Combination database. METHODS:We performed a propensity score anal...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31826495a0
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:Emphysematous pancreatitis is characterized by the presence of intraparenchymal pancreatic air in the setting of necrotizing pancreatitis. Mortality and morbidity rates approach approximately 40% and 100%, respectively. Traditionally, emphysematous pancreatitis was an indication for surgical intervention. The...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/MPA.0b013e3181a9f12a
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVE:The indolent nature and expression of progesterone receptor (PR), a well-known estrogen-induced gene, in a subset of pancreatic neuroendocrine tumors (PanNETs), raise the possibility of hormonal regulation in these tumors. METHODS:Immunohistochemical expression of estrogen receptors (ERs) α and β as well as ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000203
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVES:Tumor necrosis is often found in pancreatic ductal adenocarcinoma (PDAC). Objective histological assessment and adequate radiological detection of necrosis could be used as biomarkers for therapeutic decision. However, standardized clinical utility of necrosis remains unknown. Here, we aimed to determine the...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001539
更新日期:2020-05-01 00:00:00
abstract::The risk of developing postoperative complications following pancreatic resection depends mainly on how difficult it is to perform a proper pancreaticointestinal anastomosis. We have evaluated the serum pancreolauryl test, a rapid tubeless pancreatic function test, as a simple preoperative predictor of the degree of p...
journal_title:Pancreas
pub_type: 杂志文章
doi:
更新日期:1996-08-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate whether 6 candidate serum miRNAs and their interactions with serum folate level were associated with the risk for pancreatic cancer (PC). METHOD:A hospital-based case-control study including 74 incident PC cases and 74 controls was conducted. Serum folate and miRNAs ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000204
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:We evaluated how well phase II trials in locally advanced and metastatic pancreatic cancer (LAMPC) meet current recommendations for trial design. METHODS:We conducted a systematic review of phase II first-line treatment trial for LAMPC. We assessed baseline characteristics, type of comparison, and primary e...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001429
更新日期:2019-11-01 00:00:00
abstract::The effects of manganese (Mn2+) on phosphorylation activity in the rat pancreas were examined in an in vitro phosphorylation assay and by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) of endogenous proteins. Several histones were phosphorylated in the presence of pancreatic supernatant obtained ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199009000-00015
更新日期:1990-09-01 00:00:00
abstract:OBJECTIVES:The aim of this prospective study was to evaluate the diagnostic value of the rapid urinary trypsinogen-2 test strip in post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. METHODS:A total of 150 patients were tested with the urinary trypsinogen-2 test strip and serum levels of amylase a...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31821fcdcf
更新日期:2011-11-01 00:00:00
abstract::To confirm the accuracy of guided percutaneous aspiration (GPA) in distinguishing sterile from infected pancreatic necrosis, we have performed Brown-Brenn tissue Gram stains on pancreatic and peripancreatic necrotic tissue removed operatively in 15 patients. In eight patients judged to have sterile necrosis on the bas...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199005000-00013
更新日期:1990-05-01 00:00:00
abstract::A 50-year-old female was referred to our hospital because of postprandial epigastric pain and pancreatic head mass. On admission, an elastic hard mass with tenderness was palpable in the epigastric region. Laboratory findings showed no abnormalities, except for a slightly elevated C-reactive protein value and iron def...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000236730.08747.69
更新日期:2006-11-01 00:00:00
abstract::It has recently been shown that the infusion of oleic acid into the rat pancreaticobiliary duct causes a reproducible and long-lasting atrophy of the exocrine pancreas. The effects of this pancreatic atrophy on non-invasive pancreatic function tests have not been fully characterized. This study was undertaken to deter...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199309000-00015
更新日期:1993-09-01 00:00:00