Pain and opioid use in chronic pancreatitis.

abstract：OBJECTIVES:Clinical and morphological criteria are not precise enough to diagnose early chronic pancreatitis (CP). We investigated if short endoscopic pancreas function testing as a part of routine upper endoscopy could improve clinical diagnostics. METHODS:Patients with suspected CP underwent modified secretin-stimul...

journal_title：Pancreas

authors： Erchinger F,Engjom T,Tjora E,Hoem D,Hausken T,Gilja OH,Dimcevski G

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVES:Studies show an increased incidence of adult acute pancreatitis (AP) in recent decades. The aim was to review pediatric AP incidence. METHODS:Retrospective review of computerized databases at the Children's Hospital of Pittsburgh from 1993 to 2004. The International Classification of Diseases, Ninth Revisio...

journal_title：Pancreas

authors： Morinville VD,Barmada MM,Lowe ME

更新日期：2010-01-01 00:00:00

abstract：:To evaluate the effect of the prostaglandin inhibitor acetylsalicylic acid (ASA) on rat exocrine pancreas secretion, three groups of rats were administered ASA by infusion: Groups 1-3, 50, 100, and 200 mg/kg body wt, respectively; Group 4 received saline. Twenty minutes later these ASA-pretreated groups were given int...

journal_title：Pancreas

authors： Fabris C,Munaretto S,Basso D,Dodi G,Infantino A,Piccoli A,Meggiato T,Fogar P,Panozzo MP,Del Favero G

更新日期：1993-07-01 00:00:00

abstract：:Pancreatic cystic insulinoma is an uncommon tumor. Perioperative localization remained challenging if the tumor is atypical with cystic feature or in small size. Near-infrared (NIR) imaging is a technique by injecting fluorescent dye intravenously, which accumulates to the target lesion and creating signal by laser so...

journal_title：Pancreas

authors： Kou HW,Yu MC,Chong SW,Hsu HY,Chou HH,Lee CW,Chen TC,Huang SF

更新日期：2020-11-01 00:00:00

abstract：INTRODUCTION:Islet cell transplantation offers a new approach for the treatment of diabetes. Before transplantation, immunomodulation procedures are conducted to reduce the immunogenicity of the pancreatic islets. AIM:To study the effect of cyclophosphamide pretreatment and culture on the xenograft survival of monkey ...

journal_title：Pancreas

authors： Mythili MD,Ramakrishna B,Gunasekaran S

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVES:Despite decades of effort, the 5-year overall survival rate of pancreatic cancer (PC) remains at only approximately 5%. Until now, no detailed knowledge regarding the worldwide research architecture of PC has yet been established. METHODS:Hence, we conducted this scientometric analysis to quantify the globa...

journal_title：Pancreas

authors： Schöffel N,Krempel M,Bundschuh M,Bendels MH,Brüggmann D,Groneberg DA

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:The present study screened the SMAD4 gene in an Indian population of patients with pancreatic ductal adenocarcinoma (PDAC) for the presence of homozygous deletions and mutations. The effect of these genetic alterations on Smad4 protein expression and patient survival was also evaluated. METHODS:This study w...

journal_title：Pancreas

authors： Singh P,Srinivasan R,Wig JD

更新日期：2012-05-01 00:00:00

abstract：:Pancreatic duct bicarbonate secretion is mediated primarily by secretin-induced elevation of intracellular cyclic AMP, although little is known of the effects of other physiological regulators on pancreatic duct cyclic AMP metabolism. We investigated the effects of secretin and several other potential agonists on cycl...

journal_title：Pancreas

authors： de Ondarza J,Hootman SR

更新日期：1995-10-01 00:00:00

abstract：OBJECTIVES:The aims of this study were to evaluate diagnostic value of endoscopic ultrasound strain ratio elastography in patients with focal pancreatic masses and to determine the cutoff value between the pancreatic malignancies and inflammatory pancreatic masses using reference areas different than those used by othe...

journal_title：Pancreas

authors： Rustemović N,Kalauz M,Grubelić Ravić K,Iveković H,Bilić B,Ostojić Z,Opačić D,Ledinsky I,Majerović M,Višnjić A

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to determine if there had been any change in the number of solid-pseudopapillary neoplasm (SPN) cases detected and their evaluation or management over time. METHODS:A systematic review of SPN was performed of all articles published in English in PubMed and Scopus. RESULTS:A total of...

journal_title：Pancreas

authors： Law JK,Ahmed A,Singh VK,Akshintala VS,Olson MT,Raman SP,Ali SZ,Fishman EK,Kamel I,Canto MI,Dal Molin M,Moran RA,Khashab MA,Ahuja N,Goggins M,Hruban RH,Wolfgang CL,Lennon AM

更新日期：2014-04-01 00:00:00

abstract：UNLABELLED:Total pancreatectomy is considered the final resort in the treatment of chronic pancreatitis; however, here we show that simultaneous islet autotransplantation can abrogate the onset of diabetes. METHODS:: In Leicester, 46 patients have now undergone total pancreatectomy with immediate islet auto transplant...

journal_title：Pancreas

authors： Webb MA,Illouz SC,Pollard CA,Gregory R,Mayberry JF,Tordoff SG,Bone M,Cordle CJ,Berry DP,Nicholson ML,Musto PP,Dennison AR

更新日期：2008-10-01 00:00:00

abstract：INTRODUCTION AND AIMS:It has been proposed that distinct tertiary structures of the C-terminus of CCK-8 and CCK-58 result in differences in stimulation of pancreatic amylase secretion. Binding of CCK-8 and CCK-58 to CCK-A and CCK-B receptors and stability to enzymatic digestion were used as independent probes for terti...

journal_title：Pancreas

authors： Reeve JR Jr,McVey DC,Bunnett NW,Solomon TE,Keire DA,Ho FJ,Davis MT,Lee TD,Shively JE,Vigna SR

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVES:To analyze the expression modulation of pancreatic protein tyrosine phosphatase (PTP)1B during the development of cerulein (Cer)-induced acute pancreatitis (AP) and the effect of inhibition of type 4 phosphodiesterase and c-Jun N-terminal kinase and extracellular signal-regulated kinase 1/2 on its expression...

journal_title：Pancreas

authors： Sarmiento N,Sánchez-Bernal C,Pérez N,Sardina JL,Mangas A,Calvo JJ,Sánchez-Yagüe J

更新日期：2010-07-01 00:00:00

abstract：:Pseudocysts and post-necrotic collections of the pancreas are sometimes treated by percutaneous drainage. In cases of post-necrotic collection, intractable pancreatic juice fistula is often formed by disruption of the main pancreatic duct in the necrotized region. We radically treated intractable pancreatic juice fist...

journal_title：Pancreas

authors： Hirota M,Kamekawa K,Tashima T,Mizumoto M,Ohara C,Beppu T,Shimada S,Yamaguchi Y,Ogawa M

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVES:After standardization of the perioperative management of pancreaticoduodenectomy, we retrospectively compared results in nonstented pancreaticojejunostomy with external-stented pancreaticojejunostomy. METHODS:The study population included 129 consecutive patients who underwent pancreaticoduodenectomy betwee...

journal_title：Pancreas

authors： Satoi S,Toyokawa H,Yanagimoto H,Yamamoto T,Hirooka S,Yui R,Yamaki S,Takahashi K,Matsui Y,Mergental H,Kwon AH

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to identify differentially expressed proteins among various stages of pancreatic ductal adenocarcinoma (PDAC) by shotgun proteomics using nano-liquid chromatography coupled tandem mass spectrometry and stable isotope dimethyl labeling. METHODS:Differentially expressed proteins were...

journal_title：Pancreas

authors： Kuo KK,Kuo CJ,Chiu CY,Liang SS,Huang CH,Chi SW,Tsai KB,Chen CY,Hsi E,Cheng KH,Chiou SH

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:The authors investigated if timing of medical treatment is associated with the analgesic effect of pregabalin or placebo in patients with chronic pancreatitis (CP). METHODS:Sixty-four patients received pregabalin (150-300 mg twice a day) or matching placebo for 3 consecutive weeks. Responders to treatment w...

journal_title：Pancreas

authors： Olesen SS,Graversen C,Bouwense SA,Wilder-Smith OH,van Goor H,Drewes AM

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to observe the role of nucleotide-binding and oligomerization domain (NOD)-like receptors (NLR) in intestinal injury of severe acute pancreatitis (SAP) in rats. METHODS:Severe acute pancreatitis was induced by retrograde infusion of sodium taurocholate into the biliopancreatic duct....

journal_title：Pancreas

authors： Xu S,Wei S,Guo Y,Cui D,Yao J

更新日期：2018-02-01 00:00:00

abstract：UNLABELLED:OBJECTDIVES: Mouse double minute 2 is a key negative regulator of the p53 protein, a central node in the mediation of tumor suppression. The MDM2 gene contains 2 differently regulated promoters, MDM2-P1 and MDM2-P2, which differ strongly in their biological and clinical importance. METHODS:We assess the cli...

journal_title：Pancreas

authors： Grochola LF,Taubert H,Greither T,Bhanot U,Udelnow A,Würl P

更新日期：2011-03-01 00:00:00

abstract：:It was reported that free fatty acids degraded from triglycerides by lipase may play a major role in acute necrotizing or hyperlipidemia-induced pancreatitis. We hypothesized that this injury may be related to the peroxidation of cell membrane phospholipids and tested this hypothesis using isolated pancreatic acini. P...

journal_title：Pancreas

authors： Morita Y,Yoshikawa T,Takeda S,Matsuyama K,Takahashi S,Yoshida N,Clemens MG,Kondo M

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVES:Rare cases of pancreatic neuroendocrine tumors (PNETs) that produce only proinsulin (PI) and manifest with hypoglycemia have been reported. Proinsulin expression in PNET has not been systematically studied, and the clinicopathologic features of such tumors remain unknown. METHODS:We studied expression of PI...

journal_title：Pancreas

authors： Celli R,Tang LH,Cai G,Freedman-Weiss M,Colunga M,Salem RR,Majumdar S,Jain D

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:Systemic complications in alcoholic pancreatitis are supposed to be aggravated by inflammatory liver damage. Resident macrophages including hepatic Kupffer cells play a pivotal role in mediating systemic complications in severe necrotizing pancreatitis (SNP). The aim of this study was to evaluate the effects ...

journal_title：Pancreas

authors： Schneider L,Hackert T,Longerich T,Hartwig W,Fritz S,Krych R,Fortunato F,Gebhard MM,Werner J

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVES:Targeting anticancer agents to receptors for peptide hormones such as bombesin/gastrin-releasing peptide (GRP) on tumor cells increases the efficacy and lowers the toxicity of cancer therapy. We studied the expression of bombesin/GRP receptors in 6 experimental pancreatic cancers and evaluated tumor inhibiti...

journal_title：Pancreas

authors： Szepeshazi K,Schally AV,Nagy A,Halmos G

更新日期：2005-10-01 00:00:00

abstract：:Recently, the landscape of the diagnosis and treatment of patients with well-differentiated gastrointestinal/pancreatic neuroendocrine tumors (previously referred to as carcinoid tumors) has changed dramatically. We will need to work with all of the stakeholders including clinicians, patients, regulatory agencies, and...

journal_title：Pancreas

authors： Asmis T

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVES:Scutellaria baicalensis has been a subject of research interest due to its potential multiple therapeutic benefits. This study was to examine the distribution of baicalein, wogonin, oroxylin A and their glucuronide/sulfate-conjugated metabolites in plasma, colon, small intestine, lung, liver, pancreas, kidne...

journal_title：Pancreas

authors： Lu QY,Zhang L,Moro A,Chen MC,Harris DM,Eibl G,Go VL

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVES:This study aims to identify the computed tomography (CT) features that may differentiate nonfunctioning pancreatic neuroendocrine tumors (NF-PanNETs) with lymph node (LN) metastasis from NF-PanNETs without lymph node metastasis. METHODS:We retrospectively analyzed 166 NF-PanNETs in 166 patients who had unde...

journal_title：Pancreas

authors： Choi SH,Kim HJ,Kim SY,Byun JH,Kim KW,Song KB,Kim SC,Kim MH

更新日期：2017-09-01 00:00:00

abstract：:Amyloid was isolated from islets of amyloidotic pancreata of monkey and human beings by solubilization of non-amyloid materials from the pancreas and digestion of contaminating collagen and elastin. The resulting pellet was estimated to be greater than 90% pure islet amyloid. Antibodies specific for monkey islet amylo...

journal_title：Pancreas

authors： Fang TY,Howard CF Jr

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVES:Pancreatic carcinoma etiology and molecular pathogenesis is weakly understood. According to the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, an association of functional polymorphisms in oxidative stress-modifying genes superoxide dismutase...

journal_title：Pancreas

authors： Mohelnikova-Duchonova B,Marsakova L,Vrana D,Holcatova I,Ryska M,Smerhovsky Z,Slamova A,Schejbalova M,Soucek P

更新日期：2011-01-01 00:00:00

abstract：:The effect of a potent and long-acting bradykinin B2-receptor antagonist (HOE140) on acute pancreatitis induced by retrograde infusion of trypsin and taurocholate into the pancreatic duct was studied in rats. HOE140 was administered subcutaneously immediately before and 3 h after the induction of pancreatitis and the ...

journal_title：Pancreas

authors： Kanbe T,Naruse S,Kitagawa M,Nakae Y,Hayakawa T

更新日期：1996-10-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to clarify the clinical and pathophysiological characteristics of autoimmune pancreatitis (AIP) and its subtypes (lymphoplasmacytic sclerosing pancreatitis [LPSP] and idiopathic duct-centric pancreatitis [IDCP]) seen around the world. METHODS:An international multicenter surve...

journal_title：Pancreas

authors： Kamisawa T,Chari ST,Giday SA,Kim MH,Chung JB,Lee KT,Werner J,Bergmann F,Lerch MM,Mayerle J,Pickartz T,Lohr M,Schneider A,Frulloni L,Webster GJ,Reddy DN,Liao WC,Wang HP,Okazaki K,Shimosegawa T,Kloeppel G,Go VL

更新日期：2011-08-01 00:00:00