Quantitative Proteomic Analysis of Differentially Expressed Protein Profiles Involved in Pancreatic Ductal Adenocarcinoma.

abstract：:Wheat amylase inhibitor (WAI) was given to growing rats to determine whether chronic inhibition of intraluminal amylase activity alters pancreatic growth, pancreatic enzyme composition, and secretory responsiveness to cholecystokinin octapeptide (CCK-OP) and carbachol. For 21 days 13 rats were fed amylase inhibitor (A...

journal_title：Pancreas

authors： Kataoka K,DiMagno EP

更新日期：1998-07-01 00:00:00

abstract：OBJECTIVES:Oxidative stress has been implicated in the pathogenesis of chronic pancreatitis (CP) and pancreatic cancer (PC). The study aim was to assess the oxidative stress markers and antioxidant defense system in patients with CP and those with PC. METHODS:Activities of superoxide dismutase 1 (SOD1), catalase (CAT)...

journal_title：Pancreas

authors： Kodydkova J,Vavrova L,Stankova B,Macasek J,Krechler T,Zak A

更新日期：2013-05-01 00:00:00

abstract：:In recent studies performed on pancreatic stones from patients with alcoholic pancreatitis, a novel secretory protein was identified: the pancreatic stone protein (PSP Mr 14,000). This protein suppresses CaCO3 precipitation, and could therefore stabilize normally supersaturated pancreatic juice. Crystallographic analy...

journal_title：Pancreas

authors： Montalto G,Multigner L,Sarles H,De Caro A

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVES:It is of utmost importance that autoimmune pancreatitis (AIP) be differentiated from pancreatic cancer (PC) because some AIP cases undergo unnecessary laparotomy or pancreatic resection on suspicion of PC. This study aimed to develop an appropriate strategy for differentiating between AIP and PC. METHODS:Cl...

journal_title：Pancreas

authors： Kamisawa T,Imai M,Yui Chen P,Tu Y,Egawa N,Tsuruta K,Okamoto A,Suzuki M,Kamata N

更新日期：2008-10-01 00:00:00

abstract：:Because abnormalities of the autonomic nervous system have been described in several animal models of obesity, and because galanin has been proposed to be a sympathetic neurotransmitter in the endocrine pancreas, we hypothesized that the hyperinsulinemia observed in genetically obese (ob/ob) mice may result either fro...

journal_title：Pancreas

authors： Dunning BE,Ahrén B

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVES:We compared the clinical profiles and organ manifestations of the commonly encountered immunoglobulin G4-related diseases (IgG4-RDs) on either side of the diaphragm: head and neck (HN) versus pancreatobiliary (PB) in IgG4-RD. METHODS:From the Mayo Clinic, Rochester, database, we identified 53 HN and 88 PB I...

journal_title：Pancreas

authors： Mohapatra S,Sharma A,Chari ST

更新日期：2019-07-01 00:00:00

abstract：:This review discusses the current imaging modalities for the diagnosis and staging of solid and cystic pancreatic lesions and for the assessment of acute and chronic pancreatitis, and the future role of emerging technologies in the management of pancreatic diseases. Multidetector row spiral computed tomography is supe...

journal_title：Pancreas

authors： Nichols MT,Russ PD,Chen YK

更新日期：2006-10-01 00:00:00

abstract：:To examine previous work carried out at a single center, i.e., France, on the pathologic features of chronic pancreatitis and to examine geographic differences, 359 cases of chronic pancreatitis from five centers were studied pathologically and the results analyzed according to appropriate statistical methods. It was ...

journal_title：Pancreas

authors： Sahel J,Cros RC,Durbec JP,Sarles H,Bank S,Marks IN,Bettarello A,Duarte I,Guarita D,Machado M

更新日期：1986-01-01 00:00:00

abstract：:In dispersed acini from rat pancreas, verapamil (a phenylalkylamine calcium channel blocker) potentiated amylase secretion stimulated by vasoactive intestinal peptide (VIP), secretin, peptide histidine isoleucine, helodermin, forskolin, and 8-bromocyclic AMP. The action of verapamil on VIP-stimulated amylase secretion...

journal_title：Pancreas

authors： Slimak GG,Stark HA,Egan JJ,Jensen RT,Gardner JD

更新日期：1993-03-01 00:00:00

abstract：:To determine the role of endogenous pancreatic polypeptide (PP) as a physiological inhibitor of pancreatic secretion, normal rabbit serum (control) or rabbit PP-antiserum was administered intravenously to dogs with chronic esophageal, gastric, and pancreatic fistulas. In all dogs tested, sham-feeding and ordinary feed...

journal_title：Pancreas

authors： Konturek SJ,Bielański W,Kwiecień N,Konturek J,Czarnobilski K

更新日期：1987-01-01 00:00:00

abstract：:This study was undertaken to determine the involvement of endogenous cholecystokinin (CCK) in the regeneration of pancreatic tissue after cerulein-induced acute pancreatitis treated by the CCK receptor antagonist L364,718. Acute pancreatitis was induced in rats by s.c. injections of cerulein in gelatin (12 micrograms/...

journal_title：Pancreas

authors： Jurkowska G,Grondin G,Morisset J

更新日期：1992-01-01 00:00:00

abstract：:The aim of this study was to document the natural history of chronic hereditary pancreatitis and to compare its evolution to that of chronic alcoholic pancreatitis. Twelve subjects with chronic hereditary pancreatitis were followed up for a mean duration of 15.8 years (range, 1-23) and compared to subjects with chroni...

journal_title：Pancreas

authors： Paolini O,Hastier P,Buckley M,Maes B,Demarquay JF,Staccini P,Bellon S,Caroli-Bosc FX,Dumas R,Delmont J

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVES:The aim of this prospective study was to evaluate the diagnostic value of the rapid urinary trypsinogen-2 test strip in post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. METHODS:A total of 150 patients were tested with the urinary trypsinogen-2 test strip and serum levels of amylase a...

journal_title：Pancreas

authors： Tseng CW,Chen CC,Lin SZ,Chang FY,Lin HC,Lee SD

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVES:The aims of this study were to determine the prevalence of exocrine pancreatic insufficiency (EPI) and chronic pancreatitis (CP) in patients with chronic alcoholic liver disease and to analyze the possible associated factors. METHODS:This is an analytical observational study of cases and controls for a samp...

journal_title：Pancreas

authors： Aoufi Rabih S,García Agudo R,Legaz Huidobro ML,Ynfante Ferrús M,González Carro P,Pérez Roldán F,Ruiz Carrillo F,Tenías Burillo JM

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVES:Intra-abdominal fungal infections (AFIs) complicating acute pancreatitis arise in the context of pancreatic necrosis. Our goal was to determine which risk factors contribute to AFI in patients with acute pancreatitis. METHODS:Records were reviewed from 479 nontransfer patients admitted to our medical center...

journal_title：Pancreas

authors： Schwender BJ,Gordon SR,Gardner TB

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVES:To correlate magnetic resonance cholangiopancreatography (MRCP) and magnetic resonance imaging (MRI) findings of the pancreas with the pancreatic exocrine function determined by fecal elastase 1 concentration. METHODS:Magnetic resonance imaging and MRCP findings of 81 consecutive patients with clinically su...

journal_title：Pancreas

authors： Bilgin M,Bilgin S,Balci NC,Momtahen AJ,Bilgin Y,Klör HU,Rau WS

更新日期：2008-01-01 00:00:00

abstract：:Over the last 3 decades, there have been substantial improvements in diagnostic imaging and sampling techniques to evaluate pancreatic diseases. The modern technology has helped us to recognize premalignant conditions of pancreas including mucinous cystic neoplasms and intraductal papillary mucinous neoplasms (IPMNs)....

journal_title：Pancreas

authors： Thosani N,Dasari CS,Bhutani MS,Raimondo M,Guha S

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVES:In reference to our earlier publication, laboratory tests that reflect severe intravascular volume depletion can be used for predicting the severity of acute pancreatitis (AP). The aim of the study was to assess whether urinary level of neutrophil gelatinase-associated lipocalin (NGAL) could represent a usef...

journal_title：Pancreas

authors： Lipinski M,Rydzewska-Rosolowska A,Rydzewski A,Rydzewska G

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVES:The median age of patients with pancreatic ductal adenocarcinoma (PDAC) is approximately 70 years, and PDAC rarely affects individuals younger than 40 years. Here, we investigated clinicopathologic features and genetic background of PDAC occurring in young patients (age ≤ 40 years) to determine whether any d...

journal_title：Pancreas

authors： Ohmoto A,Yachida S,Kubo E,Takai E,Suzuki M,Shimada K,Okusaka T,Morizane C

更新日期：2016-08-01 00:00:00

abstract：:Dogs with chronic pancreatic fistulae were given 0.5 ml of nonimmune rabbit serum or antibody S5, an antibody raised against the C-terminal pancreatic polypeptide (PP) hexapeptide. A 3-h infusion of secretin (125 ng/kg/h) and CCK8 (50 ng/kg/h) was started 30 min after injecting serum. Exogenous BPP (400 pmol/kg/h) was...

journal_title：Pancreas

authors： Fink AS,Gilbert S,Green H,Taylor IL

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVES:Acute pancreatitis is associated with compromised pancreatic microcirculation. Galanin is a vasoactive neuropeptide, but its role in the regulation of pancreatic vascular perfusion (PVP) is unclear. METHODS:Localization of galanin immunoreactivity was investigated by immunohistochemistry, and the effects of...

journal_title：Pancreas

authors： Brooke-Smith ME,Carati CJ,Bhandari M,Toouli J,Saccone GT

更新日期：2008-04-01 00:00:00

abstract：:We collected pure pancreatic juice during an entire day and examined pancreatic secretory changes induced by ordinary meals in a male patient having an external drainage of the main pancreatic duct. The ingestion of breakfast, lunch, and dinner each caused a marked increase in pancreatic secretion above basal levels. ...

journal_title：Pancreas

authors： Gullo L,Pezzilli R,Priori P,Baldoni F,Paparo F,Mattioli G

更新日期：1987-01-01 00:00:00

abstract：:250 syngeneic islets were implanted either beneath the kidney capsule or into the liver of diabetic LEW 1.A rats to investigate the functional response of a limited mass of beta-cells to long-term hyperglycemia. The number of islets, per se, was expected to be insufficient to reverse the hyperglycemia. All animals wer...

journal_title：Pancreas

authors： Dunger A,Kauert C,Brömme HJ,Hildebrandt W,Blech W,Hahn HJ

更新日期：1994-03-01 00:00:00

abstract：OBJECTIVES:Targeting anticancer agents to receptors for peptide hormones such as bombesin/gastrin-releasing peptide (GRP) on tumor cells increases the efficacy and lowers the toxicity of cancer therapy. We studied the expression of bombesin/GRP receptors in 6 experimental pancreatic cancers and evaluated tumor inhibiti...

journal_title：Pancreas

authors： Szepeshazi K,Schally AV,Nagy A,Halmos G

更新日期：2005-10-01 00:00:00

abstract：:In an attempt to establish the relationship between the protein encoded by the recently cloned type A cholecystokinin (CCK) receptor cDNA and the two distinct plasmalemmal proteins on the rat pancreatic acinar cell that were previously described as candidates to represent this receptor, we have established a Chinese h...

journal_title：Pancreas

authors： Hadac EM,Ghanekar DV,Holicky EL,Pinon DI,Dougherty RW,Miller LJ

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVES:The circulating neutrophil-lymphocyte ratio (NLR) has been shown to be a prognostic factor for a variety of tumors. In this study, we evaluated the prognostic significance of NLR in a large cohort of Chinese patients with pancreatic ductal adenocarcinomas (PDACs). METHODS:A total of 381 patients with PDAC w...

journal_title：Pancreas

authors： Ben Q,An W,Wang L,Wang W,Yu L,Yuan Y

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to establish a minimally invasive and simple screening test for detection of pancreatic ductal adenocarcinoma (PDAC) using duodenal juice (DJ). METHODS:Duodenal juice was collected prospectively before endoscopic retrograde cholangiopancreatography in 46 patients. A protease inhibi...

journal_title：Pancreas

authors： Mori Y,Ohtsuka T,Kono H,Nagayoshi Y,Ideno N,Aso T,Kozono S,Ohuchida K,Takahata S,Nakamura M,Mizumoto K,Tanaka M

更新日期：2013-03-01 00:00:00

abstract：:In the present study, antibodies directed against clathrin light (33 kDa-36 kDa) and heavy (180 kDa) chains were used to confirm, by immunocytochemistry, that coated vesicles increase in number in the exocrine cells of pancreatic lobules incubated under anoxic (N2) conditions. The same antibodies were used to check wh...

journal_title：Pancreas

authors： Merisko EM,Farquhar MG,Palade GE

更新日期：1986-01-01 00:00:00

abstract：:The association between acute pancreatitis and severe hypertriglyceridemia has long been recognized. We report two cases of severe primary hypertriglyceridemia (types 1 and V) with recurrent acute pancreatitis. In both patients, observance of appropriate diet and drug therapy was insufficient. Recurrent episodes of pa...

journal_title：Pancreas

authors： Piolot A,Nadler F,Cavallero E,Coquard JL,Jacotot B

更新日期：1996-07-01 00:00:00

abstract：OBJECTIVES:In patients with pancreaticobiliary maljunction (PBM), reflux of pancreatic juice to the bile duct may contribute to carcinogenesis of the biliary tract. This study aimed to investigate the pancreatographic findings in patients with PBM and the relationship to their clinical findings in view of pancreatic ju...

journal_title：Pancreas

authors： Kamisawa T,Egawa N,Nakajima H,Matsukawa M

更新日期：2005-04-01 00:00:00