Abstract:
OBJECTIVES:In reference to our earlier publication, laboratory tests that reflect severe intravascular volume depletion can be used for predicting the severity of acute pancreatitis (AP). The aim of the study was to assess whether urinary level of neutrophil gelatinase-associated lipocalin (NGAL) could represent a useful marker of AP severity. METHODS:We observed a cohort of 104 prospectively enrolled patients. The patients were classified into 3 groups: mild AP, moderately severe AP, and severe AP. Urine samples were collected on admission (NGAL-as) and during the first 24 hours (NGAL-first day) for examination of urinary level of NGAL concentrations from the first day. RESULTS:Acute pancreatitis was considered severe in 16 (15%) patients, moderately severe in 25 (24%) patients, and mild in 63 (61%) patients.There were statistically significant trends for an increase in severity (P = 0.04, P = 0.003) and mortality (P < 0.031, P = 0.01) with raising NGAL-as and NGAL-first day concentrations, respectively. The areas under the curve for severity predicted by NGAL-as and NGAL-first day were 0.75 and 0.93, respectively. The areas under the curve for mortality prediction by NGAL-as and NGAL-first day were 0.980 and 0.92, respectively. CONCLUSIONS:The urinary level of NGAL is a promising new diagnostic and prognostic factor for severe AP in an early stage of the disease.
journal_name
Pancreasjournal_title
Pancreasauthors
Lipinski M,Rydzewska-Rosolowska A,Rydzewski A,Rydzewska Gdoi
10.1097/MPA.0000000000000282subject
Has Abstractpub_date
2015-04-01 00:00:00pages
448-52issue
3eissn
0885-3177issn
1536-4828journal_volume
44pub_type
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