Pancreatic trauma--12-year experience from a tertiary center.


UNLABELLED:Pancreatic trauma is rare and often missed during initial assessment of patients with abdominal trauma. This study reviews our experience of managing pancreatic trauma at a tertiary referral center and discusses the diagnostic and therapeutic challenges. METHODS:A retrospective study of our prospectively maintained hepato-pancreatico-biliary database for 12 years preceding December 2007. RESULTS:Twenty-eight patients (23 males, 10 children) with a median age of 11.5 years (range, 6-16 years) in children and 27.5 years (range, 17-54 years) in adults were identified. Nineteen of the 28 had pancreatic duct injury of which 15 were missed on initial evaluation and referred after conservative management (n = 9) or laparotomy (n = 6). Twenty-one patients developed complications including abdominal collections (n = 10), pancreatic fistulae (n = 9), and pseudocysts (n = 2). There were 2 deaths (7%), both of which were associated with multiple intra-abdominal injuries. At a median follow-up of 7.5 months (range, 3-44 months), 19 of 23 patients were asymptomatic and had been discharged from follow-up. CONCLUSIONS:Pancreatic trauma in the United Kingdom is mainly the result of blunt trauma and most commonly affects young males. The presence of pancreatic duct disruption accounts for most of the complications, and in the absence of associated injuries, mortality is rare.






Thomas H,Madanur M,Bartlett A,Marangoni G,Heaton N,Rela M




Has Abstract


2009-03-01 00:00:00
















  • Distributional patterns of phospholipase C isozymes in rat pancreas.

    abstract::Phospholipase C (PLC) isozymes are believed to play a role in regulating pancreatic exocrine and endocrine secretion. In an attempt to investigate the role of PLC, we examined the distribution patterns of PLC isozymes in the normal rat pancreas by Western blot analysis and immunohistochemistry. Western blot analysis w...


    pub_type: 杂志文章


    authors: Kim MJ,Lee KH,Min DS,Yoon SH,Hahn SJ,Kim MS,Jo YH

    更新日期:2001-01-01 00:00:00

  • Standard Operating Procedures for Biospecimen Collection, Processing, and Storage: From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer.

    abstract::High-quality and well-annotated biorepositories are needed to better understand the pathophysiology and biologic mechanisms of chronic pancreatitis (CP) and its consequences. We report a methodology for the development of a robust standard operating procedure (SOP) for a biorepository based on the experience of the cl...


    pub_type: 杂志文章


    authors: Fisher WE,Cruz-Monserrate Z,McElhany AL,Lesinski GB,Hart PA,Ghosh R,Van Buren G,Fishman DS,Rinaudo JAS,Serrano J,Srivastava S,Mace T,Topazian M,Feng Z,Yadav D,Pandol SJ,Hughes SJ,Liu RY,Lu E,Orr R,Whitcomb DC,Ab

    更新日期:2018-11-01 00:00:00

  • Treatment of duct carcinoma of the pancreas with the LH-RH analogue buserelin.

    abstract::Thirty-six patients (21 male, 15 female) with ductal pancreatic cancer were treated with the long-acting synthetic luteinizing hormone releasing hormone (LH-RH) analogue buserelin. All patients had advanced tumor stages (stage II: 7 patients; stage III: 11 patients; stage IV: 18 patients). A monthly follow-up includin...


    pub_type: 杂志文章


    authors: Friess H,Büchler M,Krüger M,Beger HG

    更新日期:1992-01-01 00:00:00

  • Combination treatment with comprehensive cryoablation and immunotherapy in metastatic pancreatic cancer.

    abstract:OBJECTIVE:The aim of this study was to retrospectively assess the effect of comprehensive cryosurgery (ablation of intrapancreatic and extrapancreatic tumors) plus immunotherapy in metastatic pancreatic cancer. METHODS:We divided 106 patients (57 men, 49 women; median age, 65 years) into the cryoimmunotherapy (31 pati...


    pub_type: 杂志文章


    authors: Niu L,Chen J,He L,Liao M,Yuan Y,Zeng J,Li J,Zuo J,Xu K

    更新日期:2013-10-01 00:00:00

  • Effects of parathyroid hormone on pancreatic exocrine secretion.

    abstract::The role of parathyroid hormone (PTH) and calcium on pancreatic exocrine secretion were observed using sham-operated and parathyroidectomized dogs. First, exocrine secretion of the pancreas stimulated with secretin and cholecystokinin octapeptide (CCK-8) was examined in vivo 3 weeks after parathyroidectomy. Secondly, ...


    pub_type: 杂志文章


    authors: Kuroda T,Shiohara E,Haba Y,Kaneko G,Hanazaki K,Kajikawa S,Iida F

    更新日期:1993-11-01 00:00:00

  • Green tea consumption and the risk of pancreatic cancer in Japanese adults.

    abstract:OBJECTIVE:Green tea polyphenols have been shown to inhibit tumor growth in animal and in vitro studies. We examined the relationship between green tea consumption and the risk of death from pancreatic cancer in a large Japanese cohort. METHODS:At baseline (1988-1990), study participants reported the frequency and amou...


    pub_type: 杂志文章,多中心研究


    authors: Lin Y,Kikuchi S,Tamakoshi A,Yagyu K,Obata Y,Kurosawa M,Inaba Y,Kawamura T,Motohashi Y,Ishibashi T,JACC Study Group.

    更新日期:2008-07-01 00:00:00

  • Diagnostic Strategy for Differentiating Autoimmune Pancreatitis From Pancreatic Cancer: Is an Endoscopic Retrograde Pancreatography Essential?

    abstract::OBJECTIVES: The purpose of this study was to determine whether the choice for performance of endoscopic retrograde pancreatography (ERP) could be tailored to findings on computed tomography (CT) in patients with suspected autoimmune pancreatitis (AIP). METHODS: Eighty-four AIP patients and 73 pathology-proven pancreat...


    pub_type: 杂志文章


    authors: Kim JH,Kim MH,Byun JH,Lee SS,Lee SJ,Park SH,Lee SK,Park DH,Lee MG,Moon SH

    更新日期:2012-05-01 00:00:00

  • Analysis of gene expression and insulin secretion by monolayer-forming adult porcine pancreatic endocrine cells.

    abstract:INTRODUCTION:We recently established a method of isolation and primary monolayer culture of porcine pancreatic endocrine cells that involves the use of nicotinamide. AIM:To obtain genetic information on cultured porcine endocrine cells and to examine cell function in relation to insulin secretion during long-term cult...


    pub_type: 杂志文章


    authors: Tsuchiya M,Tsuchiya K,Iwami Y,Ohgawara H

    更新日期:2003-01-01 00:00:00

  • Inhibition of pancreatic and liver carcinogenesis in rats by retinoid- and selenium-supplemented diets.

    abstract::Chemoprevention by a synthetic retinoid, selenium, and these agents in combination during the postinitiation stages of carcinogenesis induced in rats by azaserine was evaluated. Male Lewis rats were given three weekly injections of 30 mg/kg azaserine while being fed a purified diet. One week after completion of carcin...


    pub_type: 杂志文章


    authors: Curphey TJ,Kuhlmann ET,Roebuck BD,Longnecker DS

    更新日期:1988-01-01 00:00:00

  • Adrenal insufficiency in severe acute pancreatitis.

    abstract::Relative adrenal insufficiency is common in patients with severe sepsis and septic shock. We describe three patients with severe acute pancreatitis who developed signs suggestive of adrenal insufficiency during the early phase of the disease. Clinical features and possible causes of adrenal insufficiency are discussed...


    pub_type: 杂志文章


    authors: De Waele JJ,Hoste E,Decruyenaere J,Colardyn F

    更新日期:2003-10-01 00:00:00

  • Staplers in palliative bypass surgery for unresectable pancreatic cancer.

    abstract::To assess the role of stapling devices and routine gastroenterostomy in palliative bypass surgery, the hospital records of 150 consecutive patients with unresectable, histologically proven pancreatic adenocarcinoma requiring palliative bypass procedure were reviewed. During recent years staplers have gained increasing...


    pub_type: 杂志文章


    authors: Kairaluoma MI,Kiviniemi H,Laitinen S,Ståhlberg M

    更新日期:1987-01-01 00:00:00

  • The role of insulin in the interaction of secretin and cholecystokinin in exocrine secretion of the isolated perfused rat pancreas.

    abstract::To investigate the role of insulin in the potentiation effect of secretin and cholecystokinin (CCK) on pancreatic exocrine secretion, the pancreas was isolated from rats and perfused with modified Krebs-Henseleit solution containing glucose at three concentrations. Intraarterial glucose at concentrations of 2.5, 10, a...


    pub_type: 杂志文章


    authors: Lee YL,Kwon HY,Park HS,Lee TH,Park HJ

    更新日期:1996-01-01 00:00:00

  • Multicenter pathological study of chronic pancreatitis. Morphological regional variations and differences between chronic calcifying pancreatitis and obstructive pancreatitis.

    abstract::To examine previous work carried out at a single center, i.e., France, on the pathologic features of chronic pancreatitis and to examine geographic differences, 359 cases of chronic pancreatitis from five centers were studied pathologically and the results analyzed according to appropriate statistical methods. It was ...


    pub_type: 杂志文章


    authors: Sahel J,Cros RC,Durbec JP,Sarles H,Bank S,Marks IN,Bettarello A,Duarte I,Guarita D,Machado M

    更新日期:1986-01-01 00:00:00

  • Evaluation of Pathologic Response on Overall Survival After Neoadjuvant Therapy in Pancreatic Ductal Adenocarcinoma.

    abstract:OBJECTIVES:Single-institution studies have shown improved outcomes among patients with a pathologic complete response (pCR) following neoadjuvant therapy. We sought to evaluate the impact of pCR and near-complete response (nCR) on overall survival (OS) using a large national database. METHODS:The National Cancer Datab...


    pub_type: 杂志文章


    authors: Sell NM,Lee GC,Fernández-Del Castillo C,Ferrone CR,Warshaw AL,Hong TS,Blaszkowsky LS,Lillemoe KD,Qadan M

    更新日期:2020-08-01 00:00:00

  • Reported findings on endoscopic ultrasound examinations for chronic pancreatitis: toward establishing an endoscopic ultrasound quality benchmark.

    abstract:OBJECTIVES:Endoscopic ultrasound (EUS) quality benchmarks for pancreatic disease previously focused on maintaining thresholds of diagnostic accuracy for fine-needle aspiration and measuring complications. We aimed to evaluate quality indicators when performing EUS specifically for the diagnosis of chronic pancreatitis ...


    pub_type: 杂志文章


    authors: Gardner TB,Taylor DJ,Gordon SR

    更新日期:2014-01-01 00:00:00

  • Pharmaceutical development for treating pancreatic diseases.

    abstract::The efficacy of medications to treat pancreatic diseases, even when proven effective by experimental studies, are difficult to prove by controlled clinical trials. In the treatment of acute pancreatitis, prophylactic antibiotics, somatostatin, protease inhibitors, and cholecystokinin (CCK)-receptor antagonists are adv...


    pub_type: 杂志文章,评审


    authors: Kitagawa M,Naruse S,Ishiguro H,Hayakawa T

    更新日期:1998-04-01 00:00:00

  • The Research of Acellular Pancreatic Bioscaffold as a Natural 3-Dimensional Platform In Vitro.

    abstract:OBJECTIVE:The aim of the study was to investigate the biochemical and functional properties of a rat acellular pancreatic bioscaffolds (APBs). METHODS:Fresh pancreata from 10 rats were soaked and perfused through portal veins using Easy-Load Digital Drive peristaltic pumps. The histological structure, extracellular ma...


    pub_type: 杂志文章


    authors: Wang X,Li YG,Du Y,Zhu JY,Li Z

    更新日期:2018-09-01 00:00:00

  • Redistribution of clathrin heavy and light chains in anoxic pancreatic acinar cells.

    abstract::In the present study, antibodies directed against clathrin light (33 kDa-36 kDa) and heavy (180 kDa) chains were used to confirm, by immunocytochemistry, that coated vesicles increase in number in the exocrine cells of pancreatic lobules incubated under anoxic (N2) conditions. The same antibodies were used to check wh...


    pub_type: 杂志文章


    authors: Merisko EM,Farquhar MG,Palade GE

    更新日期:1986-01-01 00:00:00

  • Aberrant methylation of secreted apoptosis-related protein 2 (SARP2) in pure pancreatic juice in diagnosis of pancreatic neoplasms.

    abstract:OBJECTIVE:Secreted apoptosis-related protein (SARP) families are considered to counteract the oncogenic Wnt signaling pathway, and inactivation of this gene may aid cancer development and progression. Recently, the aberrant methylation of SARP2 was detected frequently in pancreatic carcinoma (PCa) tissue, but not in no...


    pub_type: 杂志文章


    authors: Watanabe H,Okada G,Ohtsubo K,Yao F,Jiang PH,Mouri H,Wakabayashi T,Sawabu N

    更新日期:2006-05-01 00:00:00

  • Patterns of innervation of vasoactive intestinal polypeptide, neuropeptide Y, and gastrin-releasing peptide immunoreactive nerves in the feline pancreas.

    abstract::In this study, we performed a detailed analysis of the immunoreactive (IR) patterns and tissue distribution of vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY), and gastrin-releasing peptide (GRP) in the feline pancreas by means of immunohistochemical and radioimmunological techniques. Immunoreactivity fo...


    pub_type: 杂志文章


    authors: De Giorgio R,Sternini C,Brecha NC,Widdison AL,Karanjia ND,Reber HA,Go VL

    更新日期:1992-01-01 00:00:00

  • GIP potentiates CCK stimulated pancreatic enzyme secretion: correlation of anatomical structures with the effects of GIP and CCK on amylase secretion.

    abstract::Utilizing scanning electron microscopy and isolated, vascularly perfused rat pancreas, we studied the angioarchitecture and the effect of the insulinotropic hormone, gastric inhibitory polypeptide (GIP), on cholecystokinin (CCK)-stimulated exocrine secretion. We tried to correlate the microcirculation with the physiol...


    pub_type: 杂志文章


    authors: Mueller MK,Scheck T,Dreesmann V,Miodonski A,Goebell H

    更新日期:1987-01-01 00:00:00

  • Engulfment of gram-positive bacteria by pancreatic stellate cells in pancreatic fibrosis.

    abstract:OBJECTIVES:We previously reported the finding that pancreatic stellate cells (PSCs) have a phagocytic function. The aim of the present study was to investigate whether engulfment of gram-positive bacteria by PSCs plays any role in the pathogenesis of pancreatic fibrosis. METHODS:Rat PSCs were cultured with lipoteichoi...


    pub_type: 杂志文章


    authors: Morishita K,Shimizu K,Haruta I,Kawamura S,Kobayashi M,Shiratori K

    更新日期:2010-10-01 00:00:00

  • Diazoxide Preconditioning of Nonhuman Primate Pancreas Improves Islet Isolation Outcomes by Mitochondrial Protection.

    abstract:OBJECTIVES:Previously, we showed that diazoxide (DZ), an effective ischemic preconditioning agent, protected rodent pancreas against ischemia-reperfusion injury. Here, we further investigate whether DZ supplementation to University of Wisconsin (UW) solution during pancreas procurement and islet isolation has similar c...


    pub_type: 杂志文章


    authors: Wang Y,Qi M,McGarrigle JJ,Xing Y,Mendoza-Elias JE,Bochenek M,Marchese E,He Y,Oberholzer J

    更新日期:2020-05-01 00:00:00

  • Serological pancreatic tumor markers and the MUC1 apomucin.

    abstract::Over 80% of adenocarcinomas of the pancreas originate from duct cells, which are the major source of mucins in the pancreas. Pathological conditions produce changes in the composition and structure of the oligosaccharides of colonic and pancreatic mucins, and it has been suggested that mucins may have a role in the de...


    pub_type: 杂志文章,评审


    authors: Ho JJ,Kim YS

    更新日期:1994-11-01 00:00:00

  • Diagnostic Performance of 48-Hour Fasting Test and Insulin Surrogates in Patients With Suspected Insulinoma.

    abstract:OBJECTIVES:This study aimed to evaluate the usefulness of the 48-hour fasting test and insulin surrogates followed by a glucagon stimulatory test (GST) for the diagnosis of insulinoma. METHODS:Thirty-five patients with suspected insulinoma who underwent 48-hour fasting test and GST were retrospectively included in our...


    pub_type: 杂志文章


    authors: Ueda K,Kawabe K,Lee L,Tachibana Y,Fujimori N,Igarashi H,Oda Y,Jensen RT,Takayanagi R,Ito T

    更新日期:2017-04-01 00:00:00

  • Establishment and Characterization of a Novel Cell Line, ASAN-PaCa, Derived From Human Adenocarcinoma Arising in Intraductal Papillary Mucinous Neoplasm of the Pancreas.

    abstract:OBJECTIVES:Our aim was to establish and characterize a novel pancreatic ductal adenocarcinoma cell line from a patient in whom the origin of the invasive carcinoma could be traced back to the intraductal papillary mucinous neoplasm (IPMN) precursor lesion. METHODS:The primary patient-derived tumor was propagated in im...


    pub_type: 杂志文章


    authors: Heller A,Angelova AL,Bauer S,Grekova SP,Aprahamian M,Rommelaere J,Volkmar M,Janssen JW,Bauer N,Herr I,Giese T,Gaida MM,Bergmann F,Hackert T,Fritz S,Giese NA

    更新日期:2016-11-01 00:00:00

  • Expression of the beacon gene in the rat pancreatic islets: opposite effects of beacon (47-73) protein (ubiquitin-like protein 5) on insulin secretion in vivo and insulin release by isolated islets.

    abstract:OBJECTIVE:Beacon gene expression is elevated in the hypothalamus of the Israeli sand rat (Psammomys obesus), an animal that is used as a polygenic animal model of obesity and NIDDM. We performed studies aimed at investigating the expression of beacon mRNA and protein in pancreatic islets of the rat and the possible bea...


    pub_type: 杂志文章


    authors: Nowak KW,Ruciński M,Kaczmarek P,Szkudelski T,Malendowicz LK

    更新日期:2004-08-01 00:00:00

  • Does prophylactic administration of somatostatin decrease the rates of complications after pancreatic resection?: A clinical and electron microscopy study.

    abstract:OBJECTIVES:The postoperative morbidity after pancreatectomy remains high. The role of somatostatin and its analogs in reducing complications after pancreatic resection is controversial. The aim of the study was to evaluate the ability of somatostatin to influence pancreatic cell's function with consequence the decrease...


    pub_type: 杂志文章,随机对照试验


    authors: Katsourakis A,Zezos P,Noussios G,Kouklakis G,Chatzitheoklitos E,Simopoulos K,Pitiakoudis M

    更新日期:2013-01-01 00:00:00

  • The effects of dipeptidyl-peptidase-IV inhibitor, vildagliptin, on the exocrine pancreas in spontaneously diabetic Goto-Kakizaki rats.

    abstract:OBJECTIVES:The risk of adverse effects of dipeptidyl peptidase-4 inhibitors on the exocrine pancreas, particularly the high risk of pancreatitis, is controversial. In this study, we examined the exocrine pancreatic function and structure in spontaneously diabetic Goto-Kakizaki (GK) rats treated with a dipeptidyl peptid...


    pub_type: 杂志文章


    authors: Mizukami H,Inaba W,Takahashi K,Kamata K,Tsuboi K,Yagihashi S

    更新日期:2013-07-01 00:00:00

  • Reduced pancreatic content of the inhibitory neurotransmitter galanin in genetically obese, hyperinsulinemic mice.

    abstract::Because abnormalities of the autonomic nervous system have been described in several animal models of obesity, and because galanin has been proposed to be a sympathetic neurotransmitter in the endocrine pancreas, we hypothesized that the hyperinsulinemia observed in genetically obese (ob/ob) mice may result either fro...


    pub_type: 杂志文章


    authors: Dunning BE,Ahrén B

    更新日期:1992-01-01 00:00:00