Predictive Effect of the Total Number of Examined Lymph Nodes on N Staging and Survival in Pancreatic Neuroendocrine Neoplasms.

abstract：:Sarcophytol A (SaA), a cembrane-type diterpene isolated from the marine soft coral Sarcophyton glaucum showed anticancer and cancer preventive effects in two different experiments. Growth of transplanted human pancreatic cancer cells (MIA paca-2, 1 x 10(7)) in nude mice (BALB/C 4W female) (Experiment 1) and pancreatic...

journal_title：Pancreas

authors： Yokomatsu H,Satake K,Hiura A,Tsutsumi M,Suganuma M

更新日期：1994-07-01 00:00:00

abstract：OBJECTIVE:Pancreatic ductal adenocarcinoma (PDAC) is the third most common cause of cancer death in the United States. Improved characterized models of PDAC are needed for drug screening. METHODS:We grew 4 established pancreatic cancer cell lines in hanging drop cultures to produce spheroids. We also grew organoids fr...

journal_title：Pancreas

authors： Matsushita Y,Smith B,Delannoy M,Trujillo MA,Chianchiano P,McMillan R,Kamiyama H,Liang H,Thompson ED,Hruban RH,Matsui W,Wood LD,Roberts NJ,Eshleman JR

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:Given the lack of consensus on surveillance guidelines after pancreatic neuroendocrine tumor (PanNET) resection, we assessed outcomes in a large cohort of patients with nonmetastatic, surgically resected PanNETs. METHODS:Data of patients with PanNETs resected between 1990 and 2017 were retrospectively collec...

journal_title：Pancreas

authors： Rosenblum RE,Harris CK,Baeg KJ,Starr JA,Brais LK,Stashek KM,Ward SC,Katona BW,Clancy TE,Wisnivesky JP,Kulke MH,Metz DC,Kim MK,Chan JA

更新日期：2020-02-01 00:00:00

abstract：:This prospective study aimed to pinpoint acute pancreatic patients who are at a higher risk of clinical deterioration. Once identified, they can be given more costly intensive-care therapy or transferred promptly to hospitals with specialized equipment. Our study included 217 patients with acute pancreatitis. All of t...

journal_title：Pancreas

authors： Lankisch PG,Pflichthofer D,Lehnick D

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVES:The aim of this prospective study was to evaluate the diagnostic value of the rapid urinary trypsinogen-2 test strip in post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. METHODS:A total of 150 patients were tested with the urinary trypsinogen-2 test strip and serum levels of amylase a...

journal_title：Pancreas

authors： Tseng CW,Chen CC,Lin SZ,Chang FY,Lin HC,Lee SD

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVES:We previously reported the finding that pancreatic stellate cells (PSCs) have a phagocytic function. The aim of the present study was to investigate whether engulfment of gram-positive bacteria by PSCs plays any role in the pathogenesis of pancreatic fibrosis. METHODS:Rat PSCs were cultured with lipoteichoi...

journal_title：Pancreas

authors： Morishita K,Shimizu K,Haruta I,Kawamura S,Kobayashi M,Shiratori K

更新日期：2010-10-01 00:00:00

abstract：:Measurement of pancreatic blood flow (PBF) is technically demanding. Although radiolabeled microspheres are considered the "gold standard" for PBF assessment, they have practical limitations. In the current study, H2 and xenon-133 gas clearance techniques were adapted to PBF measurement and compared to radiolabeled mi...

journal_title：Pancreas

authors： DeMar AR,Graham LS,Lake R,Fink AS

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:We sought to identify clinicopathological characteristics of high-grade pancreatic intraepithelial neoplasia (PanIN)/carcinoma in situ to facilitate screening for pancreatic ductal adenocarcinoma. METHODS:We evaluated PanIN lesions in 173 consecutive autopsy cases with no evidence of pancreatic ductal adenoc...

journal_title：Pancreas

authors： Matsuda Y,Furukawa T,Yachida S,Nishimura M,Seki A,Nonaka K,Aida J,Takubo K,Ishiwata T,Kimura W,Arai T,Mino-Kenudson M

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVES:The postoperative morbidity after pancreatectomy remains high. The role of somatostatin and its analogs in reducing complications after pancreatic resection is controversial. The aim of the study was to evaluate the ability of somatostatin to influence pancreatic cell's function with consequence the decrease...

journal_title：Pancreas

authors： Katsourakis A,Zezos P,Noussios G,Kouklakis G,Chatzitheoklitos E,Simopoulos K,Pitiakoudis M

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:Beacon gene expression is elevated in the hypothalamus of the Israeli sand rat (Psammomys obesus), an animal that is used as a polygenic animal model of obesity and NIDDM. We performed studies aimed at investigating the expression of beacon mRNA and protein in pancreatic islets of the rat and the possible bea...

journal_title：Pancreas

authors： Nowak KW,Ruciński M,Kaczmarek P,Szkudelski T,Malendowicz LK

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVES:There is strong evidence for an important role of cyclooxygenase (COX) 2 and COX-2-generated PGE2 during pancreatic tumorigenesis. Cyclooxygenase 2 has therefore become a potential chemotherapeutic target for pancreatic cancer. However, recent studies raised concerns regarding the safety of selective COX-2 i...

journal_title：Pancreas

authors： Hasan S,Satake M,Dawson DW,Funahashi H,Angst E,Go VL,Reber HA,Hines OJ,Eibl G

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVES:Mammalian targets of rapamycin inhibitors (mTORi) are considered second-line immunosuppression agents because of associated increases in rejection and impaired wound healing. Recent reports indicate mTORi have been linked to improved survival, decreased inflammatory response in pancreatitis, and antiprolifer...

journal_title：Pancreas

authors： Siskind EJ,Liu C,Collins DT,Emery E,Steen E,Tran E,Stodghill J,Piper J,Jonsson J,Ortiz J

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:This paper aimed to assess the physiological effects of p53 on glucose homeostasis in vivo. METHODS:A recombinant adenoviral p53 (rAd-p53) vector was administered to insulin-resistant diabetic mice. Intraperitoneal glucose tolerance test was performed in all groups of mice. Changes in fasting blood glucose, ...

journal_title：Pancreas

authors： Zhang X,Duan W,Lee WN,Zhang Y,Xiang F,Liu Q,Go VL,Xiao GG

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to perform an external validation of 2 Asian prognostic indices for patients with advanced pancreatic cancer. METHODS:A score was calculated in patients treated with frontline therapy derived from the factors Eastern Cooperative Oncology Group Performance Status, localization...

journal_title：Pancreas

authors： Haas M,Laubender RP,Klose C,Schulz C,Mansmann U,Boeck S,Heinemann V

更新日期：2012-07-01 00:00:00

abstract：:To clarify the role of nitric oxide (NO) in the development and progression of acute pancreatitis, we investigated the effect of different NO synthase inhibitors and NO donors on experimental pancreatitis in rats. Closed duodenal loop (CDL)-induced pancreatitis was produced in male Wistar rats, and the animals were tr...

journal_title：Pancreas

authors： Nishino T,Watanabe S,Oyama H,Fukuya Y,Hayashi N,Kobayashi M

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVES:We evaluated carcinoid syndrome (CS) symptoms and the real-world effectiveness of telotristat ethyl (TE) among patients with ≤3 bowel movements (BM) per day. METHODS:Patients with CS initiating TE between March and November 2017 could participate in a nurse support program collecting demographic and CS symp...

journal_title：Pancreas

authors： Benson AB 3rd,Strosberg J,Joish VN,Dharba S,Sapre D,Lapuerta P

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate microRNAs related to postoperative prognosis of pancreatic cancer by applying microarray analysis to stored surgical specimens. METHODS:We retrospectively analyzed the relationship between microRNA expression and postoperative survival of pancreatic cancer patients i...

journal_title：Pancreas

authors： Lee KH,Lee JK,Choi DW,Do IG,Sohn I,Jang KT,Jung SH,Heo JS,Choi SH,Lee KT

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:Chronic pancreatitis is the consequence of multiple episodes of recurrent acute pancreatitis (RAP). We hypothesized that apigenin can minimize the sequelae of RAP by limiting acinar cells' proinflammatory signaling pathways. METHODS:AR42J acinar cells were treated in vitro with transforming growth factor β (...

journal_title：Pancreas

authors： Mrazek AA,Bhatia V,Falzon M,Spratt H,Chao C,Hellmich MR

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVES:Pancreatic ductal adenocarcinoma remains as a chemoresistant disease with the poorest prognosis. Gemcitabine has been the standard treatment during the last decade. Erlotinib, a tyrosine kinase inhibitor, in combination with gemcitabine produces a small increase in survival. However, these results remain ins...

journal_title：Pancreas

authors： Torres C,Linares A,Alejandre MJ,Palomino-Morales RJ,Delgado JR,Perales S

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVES:This case-control study was performed to evaluate the association between a specific caspase-9 polymorphism as well as the genetic polymorphism -31G/C located in the cycle-dependent elements/cell cycle homology regions repressor element of the human survivin promoter and the risk of pancreatic cancer. METHO...

journal_title：Pancreas

authors： Theodoropoulos GE,Michalopoulos NV,Panoussopoulos SG,Taka S,Gazouli M

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to evaluate racial differences in cancer treatment and survival in gastroenteropancreatic neuroendocrine tumor (GEP-NET) patients. METHODS:Using the Surveillance, Epidemiology, and End Results Registry, we identified patients with GEP-NETs of the stomach, small intestine (SI)...

journal_title：Pancreas

authors： Kessel E,Naparst M,Alpert N,Diaz K,Ahn E,Wolin E,Taioli E,Kim MK

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVES:The present study describes a simple and cost-effective islet isolation procedure. Using this method, allogeneic islets reverse diabetes in cynomolgus monkeys. METHODS:Pancreatic tissue from 11 cynomolgus monkeys were digested, collected, and purified using a simplified method. Islet quantification, purity,...

journal_title：Pancreas

authors： Qi M,Wang Y,Formo K,Marchese E,Wang S,McGarrigle JJ,Bochenek MA,Kinzer K,Vaca P,Davis M,Ahn SJ,Chang K,Bartholomew A,Benedetti E,Oberholzer J

更新日期：2014-03-01 00:00:00

abstract：:Serum expression of the cancer-associated antigens CA 19-9 and CA 50 and their relation to Lewis blood cell status were studied in 26 patients with pancreatic duct carcinoma and 26 patients with pancreatitis. The discriminating capacity between benign and malignant disease was high for both tumor markers. The correspo...

journal_title：Pancreas

authors： von Rosen A,Linder S,Harmenberg U,Pegert S

更新日期：1993-03-01 00:00:00

abstract：:In 134 consecutive patients with acute abdominal pain, we evaluated the clinical role of a new rapid test for serum lipase based on latex agglutination. The results were compared with those obtained with a widely used lipase immunoassay as well as with serum amylase and pancreatic isoamylase measurements. Fifty-five h...

journal_title：Pancreas

authors： Ventrucci M,Pezzilli R,Naldoni P,Montone L,Gullo L

更新日期：1986-01-01 00:00:00

abstract：:Solid pseudopapillary tumors (SPTs) are a rare pancreatic neoplastic lesion. Familial aggregation has not been reported in this disease. The objectives of this study were to report the history, clinicopathological features, and gene mutations of 3 familial cases of SPT. Three female cases of SPT presented in 1 family....

journal_title：Pancreas

authors： Gou S,Yu J,Wang C,Liu T,Cui P,Li X

更新日期：2013-01-01 00:00:00

abstract：:The surgical treatment of pancreatic cancer (PDAC) has seen sweeping changes during the past 5 decades. Up to the middle of the 20th century resection rates were below 5%, but the numbers of curative resections for PDAC are now continuously increasing due to improved neoadjuvant treatment concepts as well as progress ...

journal_title：Pancreas

authors： Hackert T,Klaiber U,Pausch T,Mihaljevic AL,Büchler MW

更新日期：2020-09-01 00:00:00

abstract：:In this article, we introduce our rapid-production model for pancreatic duct adenocarcinomas and describe the mechanisms of pancreatic duct carcinogenesis so far elucidated in Syrian golden hamsters. It is evident that a series of histogenetic steps are involved, leading from hyperplasia through atypical hyperplasia t...

journal_title：Pancreas

authors： Konishi Y,Tsutsumi M,Tsujiuchi T

更新日期：1998-04-01 00:00:00

abstract：:Protein phosphatases have recently been recognized to represent an important, independently regulated portion of cellular signaling cascades. Although reversible phosphorylation of multiple pancreatic proteins has been described, suggesting a role for these enzymes, little is known about the characteristics of protein...

journal_title：Pancreas

authors： Lutz MP,Pinon DI,Miller LJ

更新日期：1994-07-01 00:00:00

abstract：OBJECTIVES:Angiogenesis plays a major role in tumor progression and metastasis; however, its role in pancreatic cancer (PC) remains unclear. The aim of the study was to explore the cumulative evidence concerning the impact of microvessel density (MVD), an estimator of angiogenesis, on resected PC patients. METHODS:A s...

journal_title：Pancreas

authors： Ntellas P,Dadouli K,Perivoliotis K,Sogka E,Pentheroudakis G,Ioannou M,Hadjichristodoulou C,Tepetes K,Mauri D

更新日期：2019-02-01 00:00:00

abstract：:Pancreatic acinar cells within the islets of Langerhans in human pancreas were investigated both histopathologically and electron microscopically. Acinar cells inside the islets of Langerhans were observed in all 50 adult cases investigated. Between such acinar cells and endocrine tissues, no reticular fiber was obser...

journal_title：Pancreas

authors： Suda K,Hosokawa Y,Kuroda J,Yuminamochi T,Ishii Y,Nakazawa K

更新日期：1994-09-01 00:00:00