Abstract:
OBJECTIVES:The authors investigated if timing of medical treatment is associated with the analgesic effect of pregabalin or placebo in patients with chronic pancreatitis (CP). METHODS:Sixty-four patients received pregabalin (150-300 mg twice a day) or matching placebo for 3 consecutive weeks. Responders to treatment were defined as patients with a reduction in clinical pain scores of 30% or greater. Factors associated with timing of pain treatment (ie, duration of CP and opioid usage) were collected at baseline. In addition, other factors that potentially could influence outcome (eg, clinical pain scores prior to study medication, diabetes, and exocrine pancreatic insufficiency) were also included. Conventional groupwise logistic regression and analysis on the individual patient level with a machine learning technique were used to predict treatment response. RESULTS:In the conventional statistical analysis duration of CP (odds ratio, 0.9; 95% confidence interval, 0.8-1.1; P = 0.3) and opioid treatment (odds ratio, 1.0; 95% confidence interval, 0.9-1.1; P = 0.6) were not associated with pain relief. In addition, none of the supplementary factors were associated with treatment response (all P > 0.1). Likewise, in the individual patient-level analysis, none of the included variables reached classification accuracies greater than chance level (all P > 0.1). CONCLUSIONS:Pregabalin can be added as adjuvant analgesic at any time point during the disease course of CP.
journal_name
Pancreasjournal_title
Pancreasauthors
Olesen SS,Graversen C,Bouwense SA,Wilder-Smith OH,van Goor H,Drewes AMdoi
10.1097/MPA.0000000000000475subject
Has Abstractpub_date
2016-03-01 00:00:00pages
381-7issue
3eissn
0885-3177issn
1536-4828journal_volume
45pub_type
杂志文章,随机对照试验相关文献
PANCREAS文献大全abstract:OBJECTIVES:Inoperable pancreatic ductal adenocarcinoma is known to have an extremely poor prognosis. Although rare, there are some patients who have unexpected long-term survival, but the reason is not yet clear. METHODS:A total of 482 inoperable pancreatic ductal adenocarcinoma of 1602 patients diagnosed at Severance...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000163
更新日期:2014-10-01 00:00:00
abstract::Amyloid was isolated from islets of amyloidotic pancreata of monkey and human beings by solubilization of non-amyloid materials from the pancreas and digestion of contaminating collagen and elastin. The resulting pellet was estimated to be greater than 90% pure islet amyloid. Antibodies specific for monkey islet amylo...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198607000-00001
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to evaluate the efficacy of a pancreatic stent regarding the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis after aspiration of pure pancreatic juice in patients with intraductal papillary mucinous neoplasms. METHODS:A retrospective stud...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181bb8da1
更新日期:2010-04-01 00:00:00
abstract::We demonstrated dynamic aspects of granulocyte activation in rat severe acute pancreatitis, which was induced by cerulein and aggravated following lipopolysaccharide (LPS) injection. Pancreatitis induced by cerulein increased intracellular elastase activity of granulocytes in the blood. However, significant systemic c...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200308000-00004
更新日期:2003-08-01 00:00:00
abstract::It was reported that free fatty acids degraded from triglycerides by lipase may play a major role in acute necrotizing or hyperlipidemia-induced pancreatitis. We hypothesized that this injury may be related to the peroxidation of cell membrane phospholipids and tested this hypothesis using isolated pancreatic acini. P...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199811000-00009
更新日期:1998-11-01 00:00:00
abstract::Increased activity of various proteases is observed in both human and experimental pancreatitis; however, the information on the effects of specific protease inhibitors on the disease is limited. In this study we show that a novel elastase inhibitor, guamerin-derived synthetic peptide (GDSP), improves the parameters o...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199904000-00003
更新日期:1999-04-01 00:00:00
abstract:OBJECTIVE:We sought to identify clinicopathological characteristics of high-grade pancreatic intraepithelial neoplasia (PanIN)/carcinoma in situ to facilitate screening for pancreatic ductal adenocarcinoma. METHODS:We evaluated PanIN lesions in 173 consecutive autopsy cases with no evidence of pancreatic ductal adenoc...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000786
更新日期:2017-05-01 00:00:00
abstract::This study compared diet, type of alcoholism, and smoking in three groups of alcoholic men, with chronic pancreatitis (n = 56), with histological cirrhosis (n = 50), and without pancreatitis or cirrhosis (controls; n = 50) by a multidimensional analysis. Only patients in whom the first symptom of pancreatitis or cirrh...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199504000-00003
更新日期:1995-04-01 00:00:00
abstract::Cultivation and preservation of human pancreatic ductal cells have remained a challenge. With a defined culture medium and refinement of culturing techniques, we have been able to maintain human pancreatic ductal cells without any genetic manipulation in culture for more than 16 months. Freshly isolated ductal fragmen...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200011000-00006
更新日期:2000-11-01 00:00:00
abstract:OBJECTIVES:Acute pancreatitis (AP) is a leading cause of hospitalization for a gastrointestinal illness in the United States. We hypothesized that enhanced recovery approaches may lead to earlier time to refeeding in patients with AP. METHODS:We performed a double-blind, randomized controlled trial of patients admitte...
journal_title:Pancreas
pub_type: 杂志文章,随机对照试验
doi:10.1097/MPA.0000000000001225
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:All forms of commonly practiced enteral feeding techniques stimulate pancreatic secretion, and only intravenous feeding avoids it. In this study, we explored the possibility of more distal enteral infusions of tube feeds to see whether activation of the ileal brake mechanism can result in enteral feeding with...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000183374.11919.e5
更新日期:2005-11-01 00:00:00
abstract::Diabetes mellitus secondary to chronic pancreatitis is characterized by a progressive destruction of the pancreas, including loss of the islet cells, leading to a form of diabetes that can mimic both type 1 and type 2 diabetes. Glucagon-like peptide 1(7-36)amide (GLP-1), an intestinally derived insulinotropic hormone,...
journal_title:Pancreas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006676-200001000-00004
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVES:Glucagon-like peptide-1 (GLP-1) is known to stimulate glucose-dependent insulin production and secretion by pancreatic beta-cells. Preliminary evidence suggests that GLP-1 may also influence endocrine differentiation from pancreatic progenitor cells. Additionally, TGF-beta signaling can also control endocrin...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000172566.70619.58
更新日期:2005-08-01 00:00:00
abstract:OBJECTIVE:To investigate whether human heme oxygenase-1 (HO-1) gene has protective action on islets cultured in vitro, and to explore whether transduction of HO-1 gene to donor islets could enhance engrafted islets survival and suppress local lymphocytic infiltration in islet grafts. METHODS:Newly isolated rat islets ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000236735.39241.d0
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVES:Clinical trials are a prerequisite for evidence-based medicine. Trial representativity by internal and external validities is an assumption for a transfer into the real world. METHODS:A questionnaire addressing several forms of bias was established. Randomized controlled trials for adjuvant treatment of pan...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31819d7370
更新日期:2009-07-01 00:00:00
abstract::Computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) are sophisticated modalities typically used in the second-line diagnosis following routine clinical practice. Among them, CT is regarded as the standard imaging in diagnosing pancreatic cancer at present in Japan due to ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200404000-00011
更新日期:2004-04-01 00:00:00
abstract::We performed molecular biological studies as well as immunohistochemical analysis of three cases of giant cell carcinoma of the pancreas. Histologically, one case was a pleomorphic giant cell carcinoma consisting of pleomorphic giant/ small cells and spindle cells, one an osteoclast-like giant cell tumor composed of o...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199904000-00013
更新日期:1999-04-01 00:00:00
abstract::The glycolytic inhibitor, 2-deoxy-D-glucose (2-DG), inhibits growth of some cancers. alpha-Difluoromethylornithine (DFMO) is an irreversible inhibitor of ornithine decarboxylase, the rate-limiting enzyme in polyamine biosynthesis. We and others have previously shown that DFMO inhibits cancer growth in a number of mode...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198902000-00006
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVES:Despite decades of effort, the 5-year overall survival rate of pancreatic cancer (PC) remains at only approximately 5%. Until now, no detailed knowledge regarding the worldwide research architecture of PC has yet been established. METHODS:Hence, we conducted this scientometric analysis to quantify the globa...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000693
更新日期:2016-11-01 00:00:00
abstract::The effect on endogenous beta-endorphins of a new synthetic protease inhibitor was studied in acute pancreatitis. Pancreatitis was induced by the injection of autologous bile mixed with trypsin into the main pancreatic duct after ligation of the accessory duct. Plasma beta-endorphin concentrations and cardiovascular f...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199107000-00011
更新日期:1991-07-01 00:00:00
abstract::We diverted bile and pancreatic juice from jejunal blind loops of different lengths in conscious rats to see if the pancreatic secretory response was dependent on the length of the jejunal blind loop. Short-term bile and pancreatic juice diversion from a short jejunal blind loop, representing only 8-10% of the total l...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199901000-00007
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVES:Aggressive invasion and early metastases are characteristic features of pancreatic ductal adenocarcinoma (PDAC). More than 90% of patients have surgically nonresectable disease at presentation. Despite increasing knowledge of the genetics of this complex disease, systemic therapies, particularly gemcitabine,...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/MPA.0b013e3182218ffb
更新日期:2011-11-01 00:00:00
abstract::Solitary fibrous tumor (SFT) arising in the pancreas is exceedingly rare, with only 11 cases reported in the English literature. All cases described thus far have exhibited benign histology. We report the first case of malignant SFT of the pancreas. The patient was a 52-year-old woman who presented with obstructive ja...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000350
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVES:In patients with chronic pancreatitis (cP) with an inflammatory mass in the pancreatic head, the degree of fibrosis in the pancreatic head compared with the tail should be determined and differences in the expression pattern of collagen types I, III, and IV; laminin; vitronectin; and fibronectin should be ev...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200403000-00009
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVE:Pancreatic ischemia-reperfusion (IR) has a key role in pancreas surgery and transplantation. Most experimental models evaluate the normothermic phase of the IR. We proposed a hypothermic model of pancreas IR to evaluate the benefic effects of the cold ischemic phase. METHODS:We performed a reproducible model...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000150
更新日期:2014-08-01 00:00:00
abstract::A case of papillary cystic tumor (PCT) of the pancreas in a 55-year-old woman is described. She presented with a gradually enlarging and painless abdominal mass for > 26 years. The tumor was encapsulated and measured 16 x 12 x 10 cm. The gross features and conventional light microscopic appearance of this tumor were c...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199301000-00023
更新日期:1993-01-01 00:00:00
abstract::Although fat accumulation in acinar cells is the earliest histopathological change in the pancreas of patients and experimental animals, there are few long-term studies regarding lipid composition of the pancreas in alcoholism. In the present study, female Sprague-Dawley rats were divided into three groups each fed Wa...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199007000-00005
更新日期:1990-07-01 00:00:00
abstract:OBJECTIVE:The goals of this study were to characterize bacterial communities within fecal samples, pancreatic fluid, bile, and jejunal contents from patients undergoing pancreaticoduodenectomy (PD) and to identify associations between microbiome profiles and clinical variables. METHODS:Fluid was collected from the pan...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000726
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVES:This study aims to identify the computed tomography (CT) features that may differentiate nonfunctioning pancreatic neuroendocrine tumors (NF-PanNETs) with lymph node (LN) metastasis from NF-PanNETs without lymph node metastasis. METHODS:We retrospectively analyzed 166 NF-PanNETs in 166 patients who had unde...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000888
更新日期:2017-09-01 00:00:00
abstract::Solid pseudopapillary tumor of the pancreas is a rare neoplasm with low malignant potential, which affects predominantly young females. Only approximately 10% to 15% cases of solid pseudopapillary tumors (SPTs) are malignant. We present the case of a 57-year-old woman who developed malignant SPT of the pancreas. Meanw...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/MPA.0b013e31824d52c7
更新日期:2012-11-01 00:00:00