Pancreatic hypersecretion in the jejunal-bypass rat.

abstract：OBJECTIVES:The contribution of overexpressed microRNA-21 and -221 (miR-21 and miR-221) to the malignant phenotype was determined by inhibiting these miRNAs using antisense oligonucleotides. METHODS:The effects of antisense to miR-21 and miR-221 on cell proliferation, cell cycle arrest, induction of apoptosis, combinat...

journal_title：Pancreas

authors： Park JK,Lee EJ,Esau C,Schmittgen TD

更新日期：2009-10-01 00:00:00

abstract：:Despite the new diagnostic and therapeutic advancements, acute pancreatitis has still high rate of morbidity and mortality. We aimed to evaluate the effects of hyperbaric oxygen (HBO) therapy alone or combined with S-methylisothiourea (SMT), and meropenem (MER) therapy in an experimental rat model of acute necrotizing...

journal_title：Pancreas

authors： Isik AT,Mas MR,Comert B,Yasar M,Korkmaz A,Akay C,Deveci S,Tasci I,Mas N,Ates Y,Kocar IH

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:This study aimed to investigate whether the previously described differentiating islet-like aggregates of human pancreatic adenocarcinoma cells (PANC-1) develop glucose response and exhibit intercellular communication. METHODS:Fura 2-loaded PANC-1 cells in serum-free medium were assayed for changes in cytoso...

journal_title：Pancreas

authors： Hiram-Bab S,Shapira Y,Gershengorn MC,Oron Y

更新日期：2012-03-01 00:00:00

abstract：:To confirm the accuracy of guided percutaneous aspiration (GPA) in distinguishing sterile from infected pancreatic necrosis, we have performed Brown-Brenn tissue Gram stains on pancreatic and peripancreatic necrotic tissue removed operatively in 15 patients. In eight patients judged to have sterile necrosis on the bas...

journal_title：Pancreas

authors： Banks PA,Gerzof SG,Chong FK,Worthington MG,Doos WG,Sullivan JG,Johnson WC

更新日期：1990-05-01 00:00:00

abstract：OBJECTIVES:Previously, we showed that diazoxide (DZ), an effective ischemic preconditioning agent, protected rodent pancreas against ischemia-reperfusion injury. Here, we further investigate whether DZ supplementation to University of Wisconsin (UW) solution during pancreas procurement and islet isolation has similar c...

journal_title：Pancreas

authors： Wang Y,Qi M,McGarrigle JJ,Xing Y,Mendoza-Elias JE,Bochenek M,Marchese E,He Y,Oberholzer J

更新日期：2020-05-01 00:00:00

abstract：:It was recently demonstrated in experimental models that, after pancreatic outflow obstruction, serum amylase levels first increase and then progressively decline regardless of whether the obstruction was maintained or relieved. Furthermore, early decompression of the ductal biliary system may prevent the progression ...

journal_title：Pancreas

authors： Pezzilli R,Billi P,Barakat B,Baroncini D,D'Imperio N,Miglio F

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVES:During the past decade, numerous studies in both humans and animals have demonstrated that C-peptide, although not influencing blood sugar control, might play a role in preventing and potentially reversing some of the chronic complications of type 1 diabetes. The aim of this paper is to present an up-to-date...

journal_title：Pancreas

authors： Marques RG,Fontaine MJ,Rogers J

更新日期：2004-10-01 00:00:00

abstract：:Solitary fibrous tumor (SFT) arising in the pancreas is exceedingly rare, with only 11 cases reported in the English literature. All cases described thus far have exhibited benign histology. We report the first case of malignant SFT of the pancreas. The patient was a 52-year-old woman who presented with obstructive ja...

journal_title：Pancreas

authors： Estrella JS,Wang H,Bhosale PR,Evans HL,Abraham SC

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVES:Pancreatic carcinoma etiology and molecular pathogenesis is weakly understood. According to the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, an association of functional polymorphisms in oxidative stress-modifying genes superoxide dismutase...

journal_title：Pancreas

authors： Mohelnikova-Duchonova B,Marsakova L,Vrana D,Holcatova I,Ryska M,Smerhovsky Z,Slamova A,Schejbalova M,Soucek P

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:Angiogenesis plays a major role in tumor progression and metastasis; however, its role in pancreatic cancer (PC) remains unclear. The aim of the study was to explore the cumulative evidence concerning the impact of microvessel density (MVD), an estimator of angiogenesis, on resected PC patients. METHODS:A s...

journal_title：Pancreas

authors： Ntellas P,Dadouli K,Perivoliotis K,Sogka E,Pentheroudakis G,Ioannou M,Hadjichristodoulou C,Tepetes K,Mauri D

更新日期：2019-02-01 00:00:00

abstract：:Changes in pancreatic growth and in mRNA concentrations in rat pancreas were monitored by dot-blot hybridization with cloned cDNAs of rat amylase, chymotrypsinogen B, proinsulin I, and actin during the pre- and postnatal period in the rat. Wistar rats were killed at the 18th day of gestation and at the 1st, 10th, 20th...

journal_title：Pancreas

authors： Iovanna JL,Dusetti N,Cadenas B,Calvo EL

更新日期：1990-07-01 00:00:00

abstract：INTRODUCTION:Invasion and metastasis of pancreatic cancer (PC) require cell motility and adhesion, which depend on the activity of cytoskeleton. A cytoskeletal component indispensable for these processes is myosin II, the cytoplasmic analogue of smooth and skeletal muscle myosin. AIMS AND METHODOLOGY:Because the activ...

journal_title：Pancreas

authors： Kaneko K,Satoh K,Masamune A,Satoh A,Shimosegawa T

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate microRNAs related to postoperative prognosis of pancreatic cancer by applying microarray analysis to stored surgical specimens. METHODS:We retrospectively analyzed the relationship between microRNA expression and postoperative survival of pancreatic cancer patients i...

journal_title：Pancreas

authors： Lee KH,Lee JK,Choi DW,Do IG,Sohn I,Jang KT,Jung SH,Heo JS,Choi SH,Lee KT

更新日期：2015-07-01 00:00:00

abstract：:Tumor relapse occurs frequently in patients with ductal pancreatic head cancer despite the absence of residual tumor detectable at primary surgery. Therefore it has to be assumed that current tumor staging procedures fail to detect minimal amounts of disseminated tumor cells present in secondary organs, which might be...

journal_title：Pancreas

authors： Hosch SB,Knoefel WT,Metz S,Stoecklein N,Niendorf A,Broelsch CE,Izbicki JR

更新日期：1997-08-01 00:00:00

abstract：:Radical pancreaticoduodenectomy was performed for cancer of the head of the pancreas in a 65-year-old male patient with congenital celiac occlusion. Preoperative angiography revealed that the arterial flow to the liver, spleen, and stomach was supplied via the pancreaticoduodenal arcade and that the dorsal pancreatic ...

journal_title：Pancreas

authors： Manabe T,Baba N,Setoyama H,Ohshio G,Tobe T

更新日期：1991-05-01 00:00:00

abstract：OBJECTIVES:Recent studies have shown that overexpression of S-phase kinase-associated protein 2 (Skp2) occurs in many cancers at an advanced stage. We examined the clinicopathologic significance and prognostic implication of Skp2 expression in pancreatic invasive ductal carcinoma. METHODS:Tissue samples from 46 pancre...

journal_title：Pancreas

authors： Einama T,Kagata Y,Tsuda H,Morita D,Ogata S,Ueda S,Takigawa T,Kawarabayashi N,Fukatsu K,Sugiura Y,Matsubara O,Hatsuse K

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to clarify the clinical and pathophysiological characteristics of autoimmune pancreatitis (AIP) and its subtypes (lymphoplasmacytic sclerosing pancreatitis [LPSP] and idiopathic duct-centric pancreatitis [IDCP]) seen around the world. METHODS:An international multicenter surve...

journal_title：Pancreas

authors： Kamisawa T,Chari ST,Giday SA,Kim MH,Chung JB,Lee KT,Werner J,Bergmann F,Lerch MM,Mayerle J,Pickartz T,Lohr M,Schneider A,Frulloni L,Webster GJ,Reddy DN,Liao WC,Wang HP,Okazaki K,Shimosegawa T,Kloeppel G,Go VL

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVES:Chronic asymptomatic pancreatic hyperenzymemia (CAPH) was described as a benign disease. However, we already described clinically relevant findings requiring surgery or follow-up in half of the subjects. The aim of this study was to evaluate the long-term outcome of CAPH in terms of symptoms and evolution to...

journal_title：Pancreas

authors： Amodio A,De Marchi G,Granato A,de Pretis N,Gabbrielli A,Manfredi R,Pozzi Mucelli R,Frulloni L

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVES:Pancreatic duct disruption (PDD) after acute pancreatitis can cause pancreatic collections in the early phase and biliary stenosis (BS) or gastric outlet obstruction (GOO) in the late phase. We aimed to document those late complications after moderate or severe acute pancreatitis. METHODS:Between September ...

journal_title：Pancreas

authors： Sugimoto M,Sonntag DP,Flint GS,Boyce CJ,Kirkham JC,Harris TJ,Carr SM,Nelson BD,Bell DA,Barton JG,Traverso LW

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVES:In injury conditions, myofibroblasts are induced to lay down matrix proteins and support the repair process. In this study, we investigated the role of myofibroblasts, particularly stellate cells, in the growth and regeneration of pancreatic β cells. METHODS:We used both in vitro and in vivo approaches to a...

journal_title：Pancreas

authors： Bayan JA,Peng Z,Zeng N,He L,Chen J,Stiles BL

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:The indolent nature and expression of progesterone receptor (PR), a well-known estrogen-induced gene, in a subset of pancreatic neuroendocrine tumors (PanNETs), raise the possibility of hormonal regulation in these tumors. METHODS:Immunohistochemical expression of estrogen receptors (ERs) α and β as well as ...

journal_title：Pancreas

authors： Estrella JS,Ma LT,Milton DR,Yao JC,Wang H,Rashid A,Broaddus RR

更新日期：2014-10-01 00:00:00

abstract：INTRODUCTION AND AIM:Recent studies have suggested that CCK is not essential for normal pancreatic growth in mice. We examined whether the treatment of hyperglycemia participates in a non-CCK-1-receptor-mediated mechanism of pancreatic regeneration after partial (30%) pancreatectomy (Px) with use of Otsuka Long-Evans T...

journal_title：Pancreas

authors： Yamamoto M,Jia DM,Fukumitsu K,Otsuki M

更新日期：2003-05-01 00:00:00

abstract：OBJECTIVES:The median age of patients with pancreatic ductal adenocarcinoma (PDAC) is approximately 70 years, and PDAC rarely affects individuals younger than 40 years. Here, we investigated clinicopathologic features and genetic background of PDAC occurring in young patients (age ≤ 40 years) to determine whether any d...

journal_title：Pancreas

authors： Ohmoto A,Yachida S,Kubo E,Takai E,Suzuki M,Shimada K,Okusaka T,Morizane C

更新日期：2016-08-01 00:00:00

abstract：:In this study, we performed a detailed analysis of the immunoreactive (IR) patterns and tissue distribution of vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY), and gastrin-releasing peptide (GRP) in the feline pancreas by means of immunohistochemical and radioimmunological techniques. Immunoreactivity fo...

journal_title：Pancreas

authors： De Giorgio R,Sternini C,Brecha NC,Widdison AL,Karanjia ND,Reber HA,Go VL

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVES:Main duct intraductal papillary mucinous neoplasms (IPMNs) of the pancreas include neoplasms with varying likelihood of progression to malignancy. The aim of this study was to investigate a natural course of main duct IPMNs with a lower likelihood of malignancy. METHODS:Twenty main duct IPMNs with a lower l...

journal_title：Pancreas

authors： Uehara H,Ishikawa O,Ikezawa K,Kawada N,Inoue T,Takakura R,Takano Y,Tanaka S,Takenaka A

更新日期：2010-07-01 00:00:00

abstract：:The peptide hormones neurotensin (NT) and cholecystokinin (CCK) are commonly attributed with a physiological role in the stimulation of exocrine pancreatic secretion. However, on the other hand, little is known about the effect of diminished exocrine pancreatic function and of the resulting maldigestion on postprandia...

journal_title：Pancreas

authors： Nustede R,Köhler H,Fölsch UR,Schafmayer A

更新日期：1991-05-01 00:00:00

abstract：OBJECTIVES:Cigarette smoking is an independent risk factor for chronic pancreatitis. We conducted a systematic review of the literature assessing whether cigarette smoking is a risk factor for acute pancreatitis (AP) and recurrent AP (RAP). METHODS:MEDLINE, PubMed, Embase, and Cochrane Database of Systematic Reviews w...

journal_title：Pancreas

authors： Majumder S,Gierisch JM,Bastian LA

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVES:Many patients with small bowel neuroendocrine tumors (SBNETs) have multifocal tumors (MFTs), but the frequency of MFTs has varied widely across SBNET studies. It is also unclear whether patients with MFTs have more advanced disease or worse clinical course than do those with unifocal SBNETs. We set out to de...

journal_title：Pancreas

authors： Choi AB,Maxwell JE,Keck KJ,Bellizzi AJ,Dillon JS,OʼDorisio TM,Howe JR

更新日期：2017-10-01 00:00:00

abstract：:To investigate the heterogeneity of hematogenous metastases of pancreatic ductal carcinoma, we investigated carcinomatous spread in 130 autopsy cases. Hepatic metastases occurred most frequently, in 81 cases (62%), which may be explained by the fact that all veins draining the pancreas flow into the portal system. We ...

journal_title：Pancreas

authors： Kamisawa T,Isawa T,Koike M,Tsuruta K,Okamoto A

更新日期：1995-11-01 00:00:00

abstract：:This review discusses the current imaging modalities for the diagnosis and staging of solid and cystic pancreatic lesions and for the assessment of acute and chronic pancreatitis, and the future role of emerging technologies in the management of pancreatic diseases. Multidetector row spiral computed tomography is supe...

journal_title：Pancreas

authors： Nichols MT,Russ PD,Chen YK

更新日期：2006-10-01 00:00:00