Bacteriologic status of necrotic tissue in necrotizing pancreatitis.

abstract：:Adenosine-5'-O-(2-thiodiphosphate) (ADP beta S), a P2y purinergic agonist, has been shown to be a potent insulin secretagogue on the isolated rat pancreas. In the present work the effects of ADP beta S on insulin somatostatin, and glucagon secretions were investigated in dogs. In vivo, in anesthetized fasted dogs, i.v...

journal_title：Pancreas

authors： Hillaire-Buys D,Gross R,Parés-Herbuté N,Ribes G,Loubatières-Mariani MM

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVES:Clinical and morphological criteria are not precise enough to diagnose early chronic pancreatitis (CP). We investigated if short endoscopic pancreas function testing as a part of routine upper endoscopy could improve clinical diagnostics. METHODS:Patients with suspected CP underwent modified secretin-stimul...

journal_title：Pancreas

authors： Erchinger F,Engjom T,Tjora E,Hoem D,Hausken T,Gilja OH,Dimcevski G

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVES:To analyze the expression modulation of pancreatic protein tyrosine phosphatase (PTP)1B during the development of cerulein (Cer)-induced acute pancreatitis (AP) and the effect of inhibition of type 4 phosphodiesterase and c-Jun N-terminal kinase and extracellular signal-regulated kinase 1/2 on its expression...

journal_title：Pancreas

authors： Sarmiento N,Sánchez-Bernal C,Pérez N,Sardina JL,Mangas A,Calvo JJ,Sánchez-Yagüe J

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVES:The 2012 international consensus guidelines for the management of intraductal papillary mucinous neoplasm (IPMN) of the pancreas stratified patients into 2 clinical categories, "high-risk stigmata" and "worrisome features," and recommended different therapeutic strategies for these groups. The aim of this st...

journal_title：Pancreas

authors： Aso T,Ohtsuka T,Matsunaga T,Kimura H,Watanabe Y,Tamura K,Ideno N,Osoegawa T,Takahata S,Shindo K,Ushijima Y,Aishima S,Oda Y,Ito T,Mizumoto K,Tanaka M

更新日期：2014-11-01 00:00:00

abstract：:The human exocrine pancreas consists of 2 main cell types: acinar and ductal cells. These exocrine cells interact closely to contribute to the secretion of pancreatic juice. The most important ion in terms of the pancreatic ductal secretion is HCO3. In fact, duct cells produce an alkaline fluid that may contain up to ...

journal_title：Pancreas

authors： Pallagi P,Hegyi P,Rakonczay Z Jr

更新日期：2015-11-01 00:00:00

abstract：:The effect of a potent and long-acting bradykinin B2-receptor antagonist (HOE140) on acute pancreatitis induced by retrograde infusion of trypsin and taurocholate into the pancreatic duct was studied in rats. HOE140 was administered subcutaneously immediately before and 3 h after the induction of pancreatitis and the ...

journal_title：Pancreas

authors： Kanbe T,Naruse S,Kitagawa M,Nakae Y,Hayakawa T

更新日期：1996-10-01 00:00:00

abstract：:This review discusses the current imaging modalities for the diagnosis and staging of solid and cystic pancreatic lesions and for the assessment of acute and chronic pancreatitis, and the future role of emerging technologies in the management of pancreatic diseases. Multidetector row spiral computed tomography is supe...

journal_title：Pancreas

authors： Nichols MT,Russ PD,Chen YK

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVES:This study aimed to develop target-specific binding agents for in vitro and in vivo imaging of human pancreatic cancer. METHODS:A monoclonal neutrophil gelatinase-associated lipocalin (NGAL)-specific antibody and a peptide specific for matrix metalloproteinase (MMP) were labeled with a near-infrared dye for...

journal_title：Pancreas

authors： Wang W,Lin J,Guha S,Tong Z,Cameron AG,Zhang F,Qiu X,Zou C,Gao X,Mawad ME,Ke S

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVES:This analysis investigated nomogram use to evaluate metastatic pancreatic cancer prognosis. METHODS:Thirty-four baseline factors were examined in the Metastatic Pancreatic Adenocarcinoma Clinical Trial (MPACT) (nab-paclitaxel plus gemcitabine vs gemcitabine) data set. Factors significantly (P < 0.1) associa...

journal_title：Pancreas

authors： Goldstein D,Von Hoff DD,Chiorean EG,Reni M,Tabernero J,Ramanathan RK,Botteman M,Aly A,Margunato-Debay S,Lu B,Louis CU,McGovern D,Lee CK

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVES:Intra-abdominal fungal infections (AFIs) complicating acute pancreatitis arise in the context of pancreatic necrosis. Our goal was to determine which risk factors contribute to AFI in patients with acute pancreatitis. METHODS:Records were reviewed from 479 nontransfer patients admitted to our medical center...

journal_title：Pancreas

authors： Schwender BJ,Gordon SR,Gardner TB

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:Ethnic disparities in pancreatic cancer (PanCan) incidence exist, but little is known about incidence trends in heterogeneous Asian Americans. We examined PanCan incidence and temporal patterns among detailed ethnic populations, including Asian American subgroups. METHODS:A total of 71,099 invasive exocrine ...

journal_title：Pancreas

authors： Liu L,Zhang J,Deapen D,Stern MC,Sipin A,Pandol SJ,Setiawan VW

更新日期：2019-08-01 00:00:00

abstract：INTRODUCTION:Although somatostatin inhibits pancreatic exocrine secretion, the inhibitory mechanism of endogenous somatostatin is not clearly understood. AIM:To investigate the effect of endogenous somatostatin on the interaction between endogenous insulin and exogenous cholecystokinin (CCK) in exocrine secretion of t...

journal_title：Pancreas

authors： Park HS,Yoon HS,Park YD,Cui ZY,Lee YL,Park HJ

更新日期：2002-05-01 00:00:00

abstract：:The effects of coffee on exocrine pancreatic secretion are unknown but may be important, because a link between chronic stimulation of pancreatic secretion and experimental chemical carcinogenesis and an association between coffee drinking and human pancreatic adenocarcinoma have been reported. We measured exocrine pa...

journal_title：Pancreas

authors： Coffey RJ,Go VL,Zinsmeister AR,DiMagno EP

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVES:Homocysteine has been implicated in vascular dysfunction and thrombosis, as well as inflammatory conditions. This study was aimed to find out whether chronic pancreatitis (CP) is associated with hyperhomocysteinemia and derangements of transmethylation and transsulfuration pathways. METHODS:We estimated hom...

journal_title：Pancreas

authors： Girish BN,Vaidyanathan K,Rao NA,Rajesh G,Reshmi S,Balakrishnan V

更新日期：2010-01-01 00:00:00

abstract：:Experimental studies have demonstrated an association between low birth weight and the later development of type 2 diabetes. This association could be a result of the programming process that affects pancreatic beta-cell development due to poor fetal nutrition. This mechanism may not be limited to the first generation...

journal_title：Pancreas

authors： Frantz ED,Peixoto-Silva N,Pinheiro-Mulder A

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:Emphysematous pancreatitis is characterized by the presence of intraparenchymal pancreatic air in the setting of necrotizing pancreatitis. Mortality and morbidity rates approach approximately 40% and 100%, respectively. Traditionally, emphysematous pancreatitis was an indication for surgical intervention. The...

journal_title：Pancreas

authors： Kvinlaug K,Kriegler S,Moser M

更新日期：2009-08-01 00:00:00

abstract：:Despite the new diagnostic and therapeutic advancements, acute pancreatitis has still high rate of morbidity and mortality. We aimed to evaluate the effects of hyperbaric oxygen (HBO) therapy alone or combined with S-methylisothiourea (SMT), and meropenem (MER) therapy in an experimental rat model of acute necrotizing...

journal_title：Pancreas

authors： Isik AT,Mas MR,Comert B,Yasar M,Korkmaz A,Akay C,Deveci S,Tasci I,Mas N,Ates Y,Kocar IH

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVES:Human primary microRNA-155/B-cell integration cluster (BIC) transcript is the precursor of microRNA-155. The overexpression of them has been widely observed in the progression of various types of tumors. Our objective was to investigate the effect of anticancer agents on the expression of BIC and possible si...

journal_title：Pancreas

authors： Xia QS,Ishigaki Y,Zhao X,Shimasaki T,Nakajima H,Nakagawa H,Takegami T,Chen ZH,Motoo Y

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:The postoperative morbidity after pancreatectomy remains high. The role of somatostatin and its analogs in reducing complications after pancreatic resection is controversial. The aim of the study was to evaluate the ability of somatostatin to influence pancreatic cell's function with consequence the decrease...

journal_title：Pancreas

authors： Katsourakis A,Zezos P,Noussios G,Kouklakis G,Chatzitheoklitos E,Simopoulos K,Pitiakoudis M

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:Pancreatic stellate cells (PSCs) are important players in pancreatic fibrosis and are major contributors to the extracellular matrix proteins observed with the stromal response characteristic of pancreatic ductal adenocarcinoma (PDAC). Pancreatic stellate cells are also believed to secrete soluble factors tha...

journal_title：Pancreas

authors： Wehr AY,Furth EE,Sangar V,Blair IA,Yu KH

更新日期：2011-05-01 00:00:00

abstract：INTRODUCTION:Adenocarcinoma of the pancreas remains one of the most difficult malignancies to treat. Its incidence has steadily increased over the past four decades, and its prognosis is still dismal. AIM To assess tumor control and the palliative benefit of 5-fluorouracil (5-FU), cisplatin (CDDP), and radiotherapy in ...

journal_title：Pancreas

authors： Azria D,Ychou M,Jacot W,Thezenas S,Lemanski C,Senesse P,Prost P,Delard R,Masson B,Dubois JB

更新日期：2002-11-01 00:00:00

abstract：:In pancreas, the activities of several sex steroid-transforming enzymes have been reported. Data have been obtained in perfused organs, total tissue homogenates, and subcellular organelles. These data, concurrent with the description of the presence of ligand-regulated steroid receptors, as well as the sexually dimorp...

journal_title：Pancreas

authors： Morales A,Cuéllar A,Ramírez J,Vilchis F,Díaz-Sánchez V

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVES:Endoscopic ultrasound (EUS) may offer a diagnostic tool through the combination of imaging and guided fine-needle aspiration of pancreatic cysts. The purpose of this investigation was to determine the most accurate test for differentiating mucinous from nonmucinous cysts. METHODS:The results of EUS imaging,...

journal_title：Pancreas

authors： Cizginer S,Turner BG,Bilge AR,Karaca C,Pitman MB,Brugge WR

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVES:Pancreatic stellate cells (PSCs) play a crucial role during pancreatic fibrosis development. Hydrogen sulfide (H2S) is a recently discovered gaseous transmitter, whose role in PSCs has not been explored yet. In the present study, we examined the effects of sodium hydrosulfide (NaHS), an H2S donor, on rat PSC...

journal_title：Pancreas

authors： Schwer CI,Stoll P,Goebel U,Buerkle H,Hoetzel A,Schmidt R

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:Obstruction of the pancreatic duct is a common feature of chronic pancreatitis and often requires interventional therapy. The current prospective study investigated clinical success in 19 patients after initial endoscopic retrograde pancreaticography and relapse rates during a 2-year follow-up period. METHO...

journal_title：Pancreas

authors： Weber A,Schneider J,Neu B,Meining A,Born P,Schmid RM,Prinz C

更新日期：2007-04-01 00:00:00

abstract：:Acute pancreatitis generates a complex cascade of immunological events that affect the pathogenesis and the progression of this disease. Several inflammatory mediators seem to play a critical role in the pathogenesis of pancreatitis and the subsequent inflammatory response. In turn, these mediators can influence hemos...

journal_title：Pancreas

authors： Kakafika A,Papadopoulos V,Mimidis K,Mikhailidis DP

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVES:We evaluated carcinoid syndrome (CS) symptoms and the real-world effectiveness of telotristat ethyl (TE) among patients with ≤3 bowel movements (BM) per day. METHODS:Patients with CS initiating TE between March and November 2017 could participate in a nurse support program collecting demographic and CS symp...

journal_title：Pancreas

authors： Benson AB 3rd,Strosberg J,Joish VN,Dharba S,Sapre D,Lapuerta P

更新日期：2020-03-01 00:00:00

abstract：:Over the last 3 decades, there have been substantial improvements in diagnostic imaging and sampling techniques to evaluate pancreatic diseases. The modern technology has helped us to recognize premalignant conditions of pancreas including mucinous cystic neoplasms and intraductal papillary mucinous neoplasms (IPMNs)....

journal_title：Pancreas

authors： Thosani N,Dasari CS,Bhutani MS,Raimondo M,Guha S

更新日期：2010-11-01 00:00:00

abstract：INTRODUCTION AND AIMS:Extracellular matrix (ECM) components participate in the process of tissue repair and development of fibrosis in the pancreas. We studied the production kinetics of ECM components and transforming growth factor (TGF)-beta1 and identified their production sites in the pancreas following pancreatiti...

journal_title：Pancreas

authors： Tashiro M,Nakamura H,Taguchi M,Yamaguchi T,Yoshikawa H,Fukumitsu K,Kihara Y,Otsuki M

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVES:Pancreatic ductal adenocarcinoma remains as a chemoresistant disease with the poorest prognosis. Gemcitabine has been the standard treatment during the last decade. Erlotinib, a tyrosine kinase inhibitor, in combination with gemcitabine produces a small increase in survival. However, these results remain ins...

journal_title：Pancreas

authors： Torres C,Linares A,Alejandre MJ,Palomino-Morales RJ,Delgado JR,Perales S

更新日期：2016-02-01 00:00:00