Endoscopic stent therapy for patients with chronic pancreatitis: results from a prospective follow-up study.

abstract：OBJECTIVES:In patients with acute recurrent pancreatitis (ARP), pancreas divisum, and no other etiologic factors, endoscopic retrograde cholangiopancreatography (ERCP) with minor papilla endoscopic sphincterotomy (miES) is often performed to enlarge the minor papillary orifice, based on limited data. The aims of this s...

journal_title：Pancreas

authors： Coté GA,Durkalski-Mauldin VL,Serrano J,Klintworth E,Williams AW,Cruz-Monserrate Z,Arain M,Buxbaum JL,Conwell DL,Fogel EL,Freeman ML,Gardner TB,van Geenen E,Groce JR,Jonnalagadda SS,Keswani RN,Menon S,Moffatt DC,Papach

更新日期：2019-09-01 00:00:00

abstract：:A 62-year-old man underwent distal pancreatectomy for invasive pancreatic carcinoma. Histopathologically, the main lesion that obstructed the main pancreatic duct and measured 2.0 cm in diameter was a moderately differentiated adenocarcinoma with marked neural invasion. The main pancreatic duct immediately distal to t...

journal_title：Pancreas

authors： Sanada Y,Masumoto T,Nishimura R

更新日期：2005-08-01 00:00:00

abstract：:Platelet-activating factor (PAF) may play a critical and primary role in the pathogenesis of acute pancreatitis and pancreatitis-associated distant organ injury. The present study evaluated the effect of a PAF antagonist, lexipafant (an (S)-4-methyl-2[methyl-imidazo[4,5-c]pyridin-1-ylmethyl)-benzene sulphonyl]-amino]p...

journal_title：Pancreas

authors： Andersson R,Wang X,Sun Z,Deng X,Soltesz V,Ihse I

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVES:Attaining high-quality RNA from the tissues or organs of deceased donors used for research can be challenging due to physiological and logistical considerations. In this investigation, METHODS: RNA Integrity Number (RIN) was determined in pancreatic samples from 236 organ donors and used to define high (≥6.5...

journal_title：Pancreas

authors： Philips T,Kusmartseva I,Gerling IC,Campbell-Thompson M,Wasserfall C,Pugliese A,Longmate JA,Schatz DA,Atkinson MA,Kaddis JS

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:We sought to identify clinicopathological characteristics of high-grade pancreatic intraepithelial neoplasia (PanIN)/carcinoma in situ to facilitate screening for pancreatic ductal adenocarcinoma. METHODS:We evaluated PanIN lesions in 173 consecutive autopsy cases with no evidence of pancreatic ductal adenoc...

journal_title：Pancreas

authors： Matsuda Y,Furukawa T,Yachida S,Nishimura M,Seki A,Nonaka K,Aida J,Takubo K,Ishiwata T,Kimura W,Arai T,Mino-Kenudson M

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:We aimed to investigate preoperative findings that are useful to distinguish intraductal papillary-mucinous neoplasm (IPMN) subtypes. METHODS:One hundred twenty-three patients who underwent pancreatectomy for IPMN were analyzed clinicopathologically and radiologically. Invasive IPM carcinomas (IPMCs) were su...

journal_title：Pancreas

authors： Nara S,Onaya H,Hiraoka N,Shimada K,Sano T,Sakamoto Y,Esaki M,Kosuge T

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVES:We aim to examine the predictive effect of the total number of examined lymph nodes on N stage and survival in pancreatic neuroendocrine neoplasms (pNENs) and to determine the optimal threshold. METHODS:A pNENs data set from 2004 to 2013 was extracted from the Surveillance, Epidemiology, and End Result data...

journal_title：Pancreas

authors： Zhang X,Lu L,Liu P,Cao F,Wei Y,Ma L,Gong P

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:Beacon gene expression is elevated in the hypothalamus of the Israeli sand rat (Psammomys obesus), an animal that is used as a polygenic animal model of obesity and NIDDM. We performed studies aimed at investigating the expression of beacon mRNA and protein in pancreatic islets of the rat and the possible bea...

journal_title：Pancreas

authors： Nowak KW,Ruciński M,Kaczmarek P,Szkudelski T,Malendowicz LK

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVES:Previous research has shown that the retinoid 9-cis retinoic acid (RA) promotes apoptosis in pancreatic cancer cells. The vitamin D analog EB1089 does not. Furthermore, cotreatment of cells with 9-cis RA and EB1089 abrogates apoptosis. To explain this, we studied the regulation of proteins involved in apopto...

journal_title：Pancreas

authors： Mouratidis PX,Dalgleish AG,Colston KW

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVES:This case-control study was performed to evaluate the association between a specific caspase-9 polymorphism as well as the genetic polymorphism -31G/C located in the cycle-dependent elements/cell cycle homology regions repressor element of the human survivin promoter and the risk of pancreatic cancer. METHO...

journal_title：Pancreas

authors： Theodoropoulos GE,Michalopoulos NV,Panoussopoulos SG,Taka S,Gazouli M

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVES:Korean red ginseng (KRG) is a representative herbal remedy in Korea. We examined the effects of KRG treatment on superoxide dismutase inhibitor-induced experimental pancreatitis. METHODS:Sprague-Dawley rats and KRG from the roots of a 6-year-old fresh Panax ginseng C. A. Meyer plant were used in this study....

journal_title：Pancreas

authors： Joo KR,Shin HP,Cha JM,Nam S,Huh Y

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVES:We evaluated whether neoadjuvant therapy followed by surgical resection improves the clinical outcome for patients with borderline resectable pancreatic cancer with radiologic artery involvement (BRPC-A). METHODS:We reviewed 143 BRPC-A patients from among 330 pancreatic cancer patients, including 111 potent...

journal_title：Pancreas

authors： Hirono S,Kawai M,Okada KI,Miyazawa M,Shimizu A,Kitahata Y,Ueno M,Yamaue H

更新日期：2016-11-01 00:00:00

abstract：:A 62-year-old Chinese woman suffering from pancreatic carcinoma coexisting with chronic calcifying pancreatitis is reported. Ultrasonography and computed tomography disclosed multiple intraductal calcifications in the pancreatic head and body and a tumor at the tail. Laparotomy revealed cancerous peritonitis in additi...

journal_title：Pancreas

authors： Lin JT,Wang TH,Chen DS,How SW,Lai MY,Chen JC,Sung JL

更新日期：1988-01-01 00:00:00

abstract：:OBJECTIVES: The purpose of this study was to determine whether the choice for performance of endoscopic retrograde pancreatography (ERP) could be tailored to findings on computed tomography (CT) in patients with suspected autoimmune pancreatitis (AIP). METHODS: Eighty-four AIP patients and 73 pathology-proven pancreat...

journal_title：Pancreas

authors： Kim JH,Kim MH,Byun JH,Lee SS,Lee SJ,Park SH,Lee SK,Park DH,Lee MG,Moon SH

更新日期：2012-05-01 00:00:00

abstract：:The present investigation provides follow-up data (up to 36 months) of exocrine and endocrine pancreatic function, inflammatory activity, pain, and body weight in 23 chronic pancreatitis patients submitted to Whipple's procedure plus intraoperative Ethibloc occlusion of the remaining pancreatic duct system between Jan...

journal_title：Pancreas

authors： Schneider MU,Meister R,Domschke S,Zirngibl H,Strebl H,Heptner G,Gebhardt C,Gall FP,Domschke W

更新日期：1987-01-01 00:00:00

abstract：:Pseudocysts and post-necrotic collections of the pancreas are sometimes treated by percutaneous drainage. In cases of post-necrotic collection, intractable pancreatic juice fistula is often formed by disruption of the main pancreatic duct in the necrotized region. We radically treated intractable pancreatic juice fist...

journal_title：Pancreas

authors： Hirota M,Kamekawa K,Tashima T,Mizumoto M,Ohara C,Beppu T,Shimada S,Yamaguchi Y,Ogawa M

更新日期：2001-03-01 00:00:00

abstract：:Pancreatic acinar cells within the islets of Langerhans in human pancreas were investigated both histopathologically and electron microscopically. Acinar cells inside the islets of Langerhans were observed in all 50 adult cases investigated. Between such acinar cells and endocrine tissues, no reticular fiber was obser...

journal_title：Pancreas

authors： Suda K,Hosokawa Y,Kuroda J,Yuminamochi T,Ishii Y,Nakazawa K

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVE:In 2003, the American Diabetes Association recommended that the lower limit for the diagnosis of impaired fasting glucose (IFG) should be reduced from 110 to 100 mg/dL in the analysis of the associated risk factors of IFG. It has been proposed that liver dysfunction may contribute to the development of type 2...

journal_title：Pancreas

authors： Hsiao JY,Wang CL,Hsia PJ,Hsieh MC,Hsin SC,Lin KD,Shin SJ

更新日期：2007-11-01 00:00:00

abstract：INTRODUCTION:Massive bleeding may complicate the course of either acute or chronic pancreatitis. Although the latter is more frequently involved when bleeding occurs in the acute form, a poorer prognosis is to be expected. Abscess, severe inflammation, regional necrosis, and pseudocysts may cause major vessel erosion, ...

journal_title：Pancreas

authors： Flati G,Andrén-Sandberg A,La Pinta M,Porowska B,Carboni M

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVES:Recent studies have demonstrated that synthetic protease inhibitors could ameliorate the progression of pancreatic fibrosis in some animal models. Since oral administration of protease inhibitors increases the plasma cholecystokinin (CCK) levels and causes hypertrophy of the pancreas in rats, there is a poss...

journal_title：Pancreas

authors： Jia D,Taguchi M,Otsuki M

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:The present study was conducted to monitor the expression of pancreas and duodenal homeobox gene (PDX-1) for assessing beta-cell function in islets from patients with chronic pancreatitis (CP). METHODS:Islets isolated from the pancreata of 40 surgical patients categorized as control group, patients with mil...

journal_title：Pancreas

authors： Mitnala S,Pondugala PK,Guduru VR,Rabella P,Thiyyari J,Chivukula S,Boddupalli S,Hardikar AA,Reddy DN

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVES:The immune environment and the potential for neuroendocrine tumors (NETs) to respond to immune checkpoint inhibitors remain largely unexplored. We assessed immune checkpoint marker expression, lymphocytic infiltrate, and associated mutational profiles in a cohort of small intestine and pancreatic NETs. METH...

journal_title：Pancreas

authors： da Silva A,Bowden M,Zhang S,Masugi Y,Thorner AR,Herbert ZT,Zhou CW,Brais L,Chan JA,Hodi FS,Rodig S,Ogino S,Kulke MH

更新日期：2018-10-01 00:00:00

abstract：UNLABELLED:Pancreatic trauma is rare and often missed during initial assessment of patients with abdominal trauma. This study reviews our experience of managing pancreatic trauma at a tertiary referral center and discusses the diagnostic and therapeutic challenges. METHODS:A retrospective study of our prospectively ma...

journal_title：Pancreas

authors： Thomas H,Madanur M,Bartlett A,Marangoni G,Heaton N,Rela M

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVES:In the hamster model, pancreatic ductal adenocarcinoma develops after treatment with N-nitrosobis-(2-oxopropyl)amino (BOP). In this model, Langerhans islets play a central role in carcinogenesis. In contrast, treatment with BOP in rats and mice did not result in cancer development. We investigated whether pa...

journal_title：Pancreas

authors： El-Ghamari M,Bergmann F,Schmied BM,Weitz J,Ulrich A

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVES:Treatment of the pain caused by chronic pancreatitis (CP) is not standardized. Knowledge of the response to placebo in this setting may aid the design of future trials. We aimed at investigating the placebo effect on abdominal pain remission rates in patients with CP. METHODS:MEDLINE, EMBASE, and Scopus wer...

journal_title：Pancreas

authors： Capurso G,Cocomello L,Benedetto U,Cammà C,Delle Fave G

更新日期：2012-10-01 00:00:00

abstract：:This study was undertaken to determine the involvement of endogenous cholecystokinin (CCK) in the regeneration of pancreatic tissue after cerulein-induced acute pancreatitis treated by the CCK receptor antagonist L364,718. Acute pancreatitis was induced in rats by s.c. injections of cerulein in gelatin (12 micrograms/...

journal_title：Pancreas

authors： Jurkowska G,Grondin G,Morisset J

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVES:Autoimmune pancreatitis (AIP) responds well to steroid therapy but frequently relapses after discontinuing the steroid. It is difficult to know which cases are most likely to relapse. The aim of this study was to investigate the relation between the rate of decrease in serum IgG4 level after initial steroid ...

journal_title：Pancreas

authors： Shimizu K,Tahara J,Takayama Y,Akao J,Ajihara T,Nagao K,Shiratori K,Tokushige K

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVES:Clinical and morphological criteria are not precise enough to diagnose early chronic pancreatitis (CP). We investigated if short endoscopic pancreas function testing as a part of routine upper endoscopy could improve clinical diagnostics. METHODS:Patients with suspected CP underwent modified secretin-stimul...

journal_title：Pancreas

authors： Erchinger F,Engjom T,Tjora E,Hoem D,Hausken T,Gilja OH,Dimcevski G

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate whether 6 candidate serum miRNAs and their interactions with serum folate level were associated with the risk for pancreatic cancer (PC). METHOD:A hospital-based case-control study including 74 incident PC cases and 74 controls was conducted. Serum folate and miRNAs ...

journal_title：Pancreas

authors： Tian Y,Xue Y,Ruan G,Cheng K,Tian J,Qiu Q,Xiao M,Li H,Yang H,Wang L

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:The endogenous immune response is influenced by the stimulation of the vagal nerve. Stimulation or ablation has a direct impact on the release of pro- and anti-inflammatory mediators. In the progression of acute pancreatitis from local to systemic disease, these mediators play a pivotal role. This study eval...

journal_title：Pancreas

authors： Schneider L,Jabrailova B,Soliman H,Hofer S,Strobel O,Hackert T,Büchler MW,Werner J

更新日期：2014-01-01 00:00:00