Abstract:
:Acute pancreatitis generates a complex cascade of immunological events that affect the pathogenesis and the progression of this disease. Several inflammatory mediators seem to play a critical role in the pathogenesis of pancreatitis and the subsequent inflammatory response. In turn, these mediators can influence hemostasis. Coagulation abnormalities occur in acute pancreatitis and are related to its severity. The contribution of blood platelets in the disturbed hemostasis in acute pancreatitis, although extensively studied, remains obscure. This article reviews the local and systemic implications of hemostatic abnormalities during acute pancreatitis. Furthermore, we discuss the prognostic value and the potential therapeutic implications of platelet activation and other hemostatic variables.
journal_name
Pancreasjournal_title
Pancreasauthors
Kakafika A,Papadopoulos V,Mimidis K,Mikhailidis DPdoi
10.1097/01.mpa.0000240617.66215.d2subject
Has Abstractpub_date
2007-01-01 00:00:00pages
15-20issue
1eissn
0885-3177issn
1536-4828pii
00006676-200701000-00002journal_volume
34pub_type
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