A population-based study of severity in patients with acute on chronic pancreatitis.

abstract：OBJECTIVES:This study aimed to study magnetic resonance imaging (MRI) findings of pancreatic ductal adenocarcinomas (PDAs) induced by N-nitrosobis (2-oxopropyl) amine (BOP) in Syrian hamsters. METHODS:A total of 101 female hamsters, 8 weeks old, were randomized into 3 groups. They were randomized into a BOP-treated gr...

journal_title：Pancreas

authors： Ma QS,Zhang XM,Shen CY,Zeng NL,Wu ZS,Pu Y,Wu CY,Zhou LS,Yang ZW,Zhang M,Shao Y

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVES:We aim to examine the predictive effect of the total number of examined lymph nodes on N stage and survival in pancreatic neuroendocrine neoplasms (pNENs) and to determine the optimal threshold. METHODS:A pNENs data set from 2004 to 2013 was extracted from the Surveillance, Epidemiology, and End Result data...

journal_title：Pancreas

authors： Zhang X,Lu L,Liu P,Cao F,Wei Y,Ma L,Gong P

更新日期：2018-02-01 00:00:00

abstract：:Stimulation of the exocrine pancreas with cholecystokinin analogues leads to a variety of intraacinar processes, many coupled to energy consumption. It was hypothesized that extensive ATP depletion could play a role in the pathophysiology of acute pancreatitis, especially in the hyperstimulation (cerulein) model. Mice...

journal_title：Pancreas

authors： Lüthen RE,Niederau C,Ferrell LD,Grendell JH

更新日期：1995-08-01 00:00:00

abstract：OBJECTIVES:Endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) is the main diagnostic modality for pancreatic mass lesions. However, cytology is often indeterminate, leading to repeat FNAs and delay in care. Here, we evaluate whether combining routine cytology with fluorescence in situ hybridization (FISH) ...

journal_title：Pancreas

authors： Reicher S,Boyar FZ,Albitar M,Sulcova V,Agersborg S,Nga V,Zhou Y,Li G,Venegas R,French SW,Chung DS,Stabile BE,Eysselein VE,Anguiano A

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVES:This analysis investigated nomogram use to evaluate metastatic pancreatic cancer prognosis. METHODS:Thirty-four baseline factors were examined in the Metastatic Pancreatic Adenocarcinoma Clinical Trial (MPACT) (nab-paclitaxel plus gemcitabine vs gemcitabine) data set. Factors significantly (P < 0.1) associa...

journal_title：Pancreas

authors： Goldstein D,Von Hoff DD,Chiorean EG,Reni M,Tabernero J,Ramanathan RK,Botteman M,Aly A,Margunato-Debay S,Lu B,Louis CU,McGovern D,Lee CK

更新日期：2020-07-01 00:00:00

abstract：:In recent studies performed on pancreatic stones from patients with alcoholic pancreatitis, a novel secretory protein was identified: the pancreatic stone protein (PSP Mr 14,000). This protein suppresses CaCO3 precipitation, and could therefore stabilize normally supersaturated pancreatic juice. Crystallographic analy...

journal_title：Pancreas

authors： Montalto G,Multigner L,Sarles H,De Caro A

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVES:This case-control study was performed to evaluate the association between a specific caspase-9 polymorphism as well as the genetic polymorphism -31G/C located in the cycle-dependent elements/cell cycle homology regions repressor element of the human survivin promoter and the risk of pancreatic cancer. METHO...

journal_title：Pancreas

authors： Theodoropoulos GE,Michalopoulos NV,Panoussopoulos SG,Taka S,Gazouli M

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:Pancreatic ischemia-reperfusion (IR) has a key role in pancreas surgery and transplantation. Most experimental models evaluate the normothermic phase of the IR. We proposed a hypothermic model of pancreas IR to evaluate the benefic effects of the cold ischemic phase. METHODS:We performed a reproducible model...

journal_title：Pancreas

authors： Rocha-Santos V,Ferro OC,Pantanali CA,Seixas MP,Pecora RA,Pinheiro RS,Claro LC,Abdo EE,Chaib E,D'Albuquerque LA

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVES:Thymidylate synthase (TS) inhibitors activate human equilibrative nucleoside transporter 1. We evaluated the contribution of TS expression to determine a treatment method providing an effect from gemcitabine (GEM). METHODS:The expression of 5-fluorouracil (5-FU) and GEM metabolic factors (5-FU: TS, dihydrop...

journal_title：Pancreas

authors： Komori S,Osada S,Mori R,Matsui S,Sanada Y,Tomita H,Tokuyama Y,Takahashi T,Yamaguchi K,Yoshida K

更新日期：2010-11-01 00:00:00

abstract：:A 62-year-old Chinese woman suffering from pancreatic carcinoma coexisting with chronic calcifying pancreatitis is reported. Ultrasonography and computed tomography disclosed multiple intraductal calcifications in the pancreatic head and body and a tumor at the tail. Laparotomy revealed cancerous peritonitis in additi...

journal_title：Pancreas

authors： Lin JT,Wang TH,Chen DS,How SW,Lai MY,Chen JC,Sung JL

更新日期：1988-01-01 00:00:00

abstract：:In this article, we introduce our rapid-production model for pancreatic duct adenocarcinomas and describe the mechanisms of pancreatic duct carcinogenesis so far elucidated in Syrian golden hamsters. It is evident that a series of histogenetic steps are involved, leading from hyperplasia through atypical hyperplasia t...

journal_title：Pancreas

authors： Konishi Y,Tsutsumi M,Tsujiuchi T

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate microRNAs related to postoperative prognosis of pancreatic cancer by applying microarray analysis to stored surgical specimens. METHODS:We retrospectively analyzed the relationship between microRNA expression and postoperative survival of pancreatic cancer patients i...

journal_title：Pancreas

authors： Lee KH,Lee JK,Choi DW,Do IG,Sohn I,Jang KT,Jung SH,Heo JS,Choi SH,Lee KT

更新日期：2015-07-01 00:00:00

abstract：:Pseudocysts and post-necrotic collections of the pancreas are sometimes treated by percutaneous drainage. In cases of post-necrotic collection, intractable pancreatic juice fistula is often formed by disruption of the main pancreatic duct in the necrotized region. We radically treated intractable pancreatic juice fist...

journal_title：Pancreas

authors： Hirota M,Kamekawa K,Tashima T,Mizumoto M,Ohara C,Beppu T,Shimada S,Yamaguchi Y,Ogawa M

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVES:To assess the degree of interobserver agreement of MRI in the diagnostic assessment of pancreatic cysts (PCs). METHODS:Magnetic resonance imaging sets of images of 62 patients with PCs (32 with histological confirmation and 30 with clinical diagnosis) were reviewed by 4 experienced radiologists. Features sc...

journal_title：Pancreas

authors： de Jong K,Nio CY,Mearadji B,Phoa SS,Engelbrecht MR,Dijkgraaf MG,Bruno MJ,Fockens P

更新日期：2012-03-01 00:00:00

abstract：:Recently, the landscape of the diagnosis and treatment of patients with well-differentiated gastrointestinal/pancreatic neuroendocrine tumors (previously referred to as carcinoid tumors) has changed dramatically. We will need to work with all of the stakeholders including clinicians, patients, regulatory agencies, and...

journal_title：Pancreas

authors： Asmis T

更新日期：2016-07-01 00:00:00

abstract：:Chemoprevention by a synthetic retinoid, selenium, and these agents in combination during the postinitiation stages of carcinogenesis induced in rats by azaserine was evaluated. Male Lewis rats were given three weekly injections of 30 mg/kg azaserine while being fed a purified diet. One week after completion of carcin...

journal_title：Pancreas

authors： Curphey TJ,Kuhlmann ET,Roebuck BD,Longnecker DS

更新日期：1988-01-01 00:00:00

abstract：:The human exocrine pancreas consists of 2 main cell types: acinar and ductal cells. These exocrine cells interact closely to contribute to the secretion of pancreatic juice. The most important ion in terms of the pancreatic ductal secretion is HCO3. In fact, duct cells produce an alkaline fluid that may contain up to ...

journal_title：Pancreas

authors： Pallagi P,Hegyi P,Rakonczay Z Jr

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to evaluate racial differences in cancer treatment and survival in gastroenteropancreatic neuroendocrine tumor (GEP-NET) patients. METHODS:Using the Surveillance, Epidemiology, and End Results Registry, we identified patients with GEP-NETs of the stomach, small intestine (SI)...

journal_title：Pancreas

authors： Kessel E,Naparst M,Alpert N,Diaz K,Ahn E,Wolin E,Taioli E,Kim MK

更新日期：2021-01-01 00:00:00

abstract：:In the present study, antibodies directed against clathrin light (33 kDa-36 kDa) and heavy (180 kDa) chains were used to confirm, by immunocytochemistry, that coated vesicles increase in number in the exocrine cells of pancreatic lobules incubated under anoxic (N2) conditions. The same antibodies were used to check wh...

journal_title：Pancreas

authors： Merisko EM,Farquhar MG,Palade GE

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVES:Glucagon-like peptide-1 (GLP-1) is known to stimulate glucose-dependent insulin production and secretion by pancreatic beta-cells. Preliminary evidence suggests that GLP-1 may also influence endocrine differentiation from pancreatic progenitor cells. Additionally, TGF-beta signaling can also control endocrin...

journal_title：Pancreas

authors： Tei E,Mehta S,Tulachan SS,Yew H,Hembree M,Preuett B,Snyder CL,Yamataka A,Miyano T,Gittes GK

更新日期：2005-08-01 00:00:00

abstract：:Computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) are sophisticated modalities typically used in the second-line diagnosis following routine clinical practice. Among them, CT is regarded as the standard imaging in diagnosing pancreatic cancer at present in Japan due to ...

journal_title：Pancreas

authors： Saisho H,Yamaguchi T

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVES:Pancreatic stellate cells (PSCs) play a crucial role during pancreatic fibrosis development. Hydrogen sulfide (H2S) is a recently discovered gaseous transmitter, whose role in PSCs has not been explored yet. In the present study, we examined the effects of sodium hydrosulfide (NaHS), an H2S donor, on rat PSC...

journal_title：Pancreas

authors： Schwer CI,Stoll P,Goebel U,Buerkle H,Hoetzel A,Schmidt R

更新日期：2012-01-01 00:00:00

abstract：:We reviewed the trends and death rates of pancreatic cancer and pancreatitis in Japan over the past four decades. It is a disturbing fact that the death rate due to pancreatic cancer is rising, parallel to that of lung cancer and colon cancer and that it is affecting primarily the elderly 65 years and older in both se...

journal_title：Pancreas

authors： Oomi K,Amano M

更新日期：1998-04-01 00:00:00

abstract：:In a patient with pancreatic cancer, an arterial anomaly was observed that apparently consisted of the congenital absence of the celiac axis and the replacement of the pancreaticoduodenal arcade by an anomalous vessel. The complete or near-complete arterial flow to the liver and spleen depended upon this anomalous pre...

journal_title：Pancreas

authors： Howard JM,Woldenberg LS,Conover SV

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVES:The purpose of the present study was to compare the development of murine embryonic pancreas in vitro and in vivo. METHODS:Murine embryonic pancreas at 12.5 days of gestation was dissected and cultured at the air-medium interface. At 1, 3, and 7 days of culture, the characteristics of cultured murine pancre...

journal_title：Pancreas

authors： Ma F,Haumaitre C,Chen F,Han Z

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to report the prevalence and predictors of abdominal pain and disability 1 year after an acute pancreatitis (AP) attack. METHODS:Patients were prospectively enrolled between December 2012 and April 2016. Enrolled subjects were contacted at a median of 13 months after enrollment. Mult...

journal_title：Pancreas

authors： Gougol A,Machicado JD,Matta B,Paragomi P,Pothoulakis I,Slivka A,Whitcomb DC,Yadav D,Papachristou GI

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVES:In patients with chronic pancreatitis (cP) with an inflammatory mass in the pancreatic head, the degree of fibrosis in the pancreatic head compared with the tail should be determined and differences in the expression pattern of collagen types I, III, and IV; laminin; vitronectin; and fibronectin should be ev...

journal_title：Pancreas

authors： Muehling B,Kolb A,Ramadani M,Schmidt E,Gansauge F,Beger HG

更新日期：2004-03-01 00:00:00

abstract：OBJECTIVES:Homocysteine has been implicated in vascular dysfunction and thrombosis, as well as inflammatory conditions. This study was aimed to find out whether chronic pancreatitis (CP) is associated with hyperhomocysteinemia and derangements of transmethylation and transsulfuration pathways. METHODS:We estimated hom...

journal_title：Pancreas

authors： Girish BN,Vaidyanathan K,Rao NA,Rajesh G,Reshmi S,Balakrishnan V

更新日期：2010-01-01 00:00:00

abstract：:ATM protein anticipates in the initiation of the DNA repair signal pathway and also mediates cell cycle arrest and repair. ATM deficiency predictably results in radiosensitivity, germ cell degeneration, chromosomal instability, immunodeficiency, and an extreme predisposition to tumors. Moreover, studies found that ATM...

journal_title：Pancreas

authors： Yu G,Zhu MH,Zhu Z,Ni CR,Zheng JM,Li FM

更新日期：2004-05-01 00:00:00

abstract：INTRODUCTION:Hypercytokinemia is known to occur in severe acute pancreatitis, suggesting that the production, deposition, and degradation of the extracellular matrix (ECM) occur actively as a result of the actions of the complicated cytokine network. AIMS AND METHODOLOGY:To examine the influence of cytokines and growt...

journal_title：Pancreas

authors： Nakae H,Endo S,Inoue Y,Fujino Y,Wakabayashi G,Inada K,Sato S

更新日期：2003-03-01 00:00:00