Abstract:
OBJECTIVES:Chronic asymptomatic pancreatic hyperenzymemia (CAPH) was described as a benign disease. However, we already described clinically relevant findings requiring surgery or follow-up in half of the subjects. The aim of this study was to evaluate the long-term outcome of CAPH in terms of symptoms and evolution toward chronic pancreatitis. METHODS:Subjects previously enrolled in the first phase of the study (from 2005 to 2010) were reinvestigated from December 2013 to January 2017 with a phone call ± magnetic resonance cholangiopancreatography with secretin stimulation. RESULTS:A total of 133 subjects were eligible for the follow-up study (75 males, 58 females; age, 48.4 [standard deviation {SD}, 14] years); 24 (18%) of them dropped out. During a mean follow-up of 9.3 (SD, 5.2) years after the first diagnosis of CAPH, no episode of acute pancreatitis or abdominal pain was reported. Sixty-three subjects (58%) of 109 underwent magnetic resonance cholangiopancreatography with secretin stimulation with a mean follow-up of 5.7 [SD, 3.1] years (range, 1-11 years). Secretin stimulation-MRCP resulted unchanged in 54 (90%) of 60 subjects, worsened in 3 (5%) and improved in 3 (5%). Two subjects died from causes unrelated to pancreatic disease. CONCLUSIONS:Excluding subjects with a pancreatic disease at index magnetic resonance imaging, CAPH is a benign condition.
journal_name
Pancreasjournal_title
Pancreasauthors
Amodio A,De Marchi G,Granato A,de Pretis N,Gabbrielli A,Manfredi R,Pozzi Mucelli R,Frulloni Ldoi
10.1097/MPA.0000000000001272subject
Has Abstractpub_date
2019-04-01 00:00:00pages
544-547issue
4eissn
0885-3177issn
1536-4828journal_volume
48pub_type
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