Characterization and control of pulsatile secretion of insulin and glucagon.

abstract：:Twelve patients with acute pancreatitis admitted to our department between January 1993 and December 1994 were studied prospectively and classified into two groups (severe group, five patients; mild group, seven patients), according to the criteria for grading severity of acute pancreatitis proposed by the Research Co...

journal_title：Pancreas

authors： Inagaki T,Hoshino M,Hayakawa T,Ohara H,Yamada T,Yamada H,Iida M,Nakazawa T,Ogasawara T,Uchida A,Hasegawa C,Miyaji M,Takeuchi T

更新日期：1997-01-01 00:00:00

abstract：:Islet amyloid polypeptide (IAPP) is a 37-amino acid residue polypeptide, originally isolated from the pancreatic amyloid deposits of patients with type II diabetes mellitus. Subsequently, IAPP was found to be colocalised with insulin in beta-cell secretory granules of the normal mammalian pancreas. Recently, IAPP has ...

journal_title：Pancreas

authors： Jamal H,Suda K,Bretherton-Watt D,Ghatei MA,Bloom SR

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVES:Currently available pancreatic enzyme products are crude porcine products with few data available regarding their efficacy, safety, and manufacture. We conducted a phase 1 study of a novel pancreatic enzyme product, TheraCLEC-Total (TCT), a proprietary formulation of microbial-derived lipase, protease, and a...

journal_title：Pancreas

authors： Borowitz D,Goss CH,Stevens C,Hayes D,Newman L,O'Rourke A,Konstan MW,Wagener J,Moss R,Hendeles L,Orenstein D,Ahrens R,Oermann CM,Aitken ML,Mahl TC,Young KR Jr,Dunitz J,Murray FT

更新日期：2006-04-01 00:00:00

abstract：:In this study, we performed a detailed analysis of the immunoreactive (IR) patterns and tissue distribution of vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY), and gastrin-releasing peptide (GRP) in the feline pancreas by means of immunohistochemical and radioimmunological techniques. Immunoreactivity fo...

journal_title：Pancreas

authors： De Giorgio R,Sternini C,Brecha NC,Widdison AL,Karanjia ND,Reber HA,Go VL

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:We conducted this study to ascertain whether chronic inflammation secondary to chronic pancreatitis (CP) has any association with myocardial infarction(MI). METHODS:Data were collected from a commercial database (Explorys, Inc, IBM Watson, Ohio). Adults with the diagnosis of "chronic pancreatitis," based on ...

journal_title：Pancreas

authors： Khan D,Abureesh M,Alkhayyat M,Sadiq W,Alshami M,Munir AB,Karam B,Deeb L,Lafferty J

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVES:Based mainly on animal models, 2 lesions have been suggested as possible precursors of pancreatic ductal adenocarcinoma (PDAC): pancreatic intraepithelial neoplasia (PanIN) and tubular complexes (TCs). The aim of the study was to find support for either of the 2 models through the analysis of a large panel o...

journal_title：Pancreas

authors： Esposito I,Seiler C,Bergmann F,Kleeff J,Friess H,Schirmacher P

更新日期：2007-10-01 00:00:00

abstract：:To evaluate the effect of the prostaglandin inhibitor acetylsalicylic acid (ASA) on rat exocrine pancreas secretion, three groups of rats were administered ASA by infusion: Groups 1-3, 50, 100, and 200 mg/kg body wt, respectively; Group 4 received saline. Twenty minutes later these ASA-pretreated groups were given int...

journal_title：Pancreas

authors： Fabris C,Munaretto S,Basso D,Dodi G,Infantino A,Piccoli A,Meggiato T,Fogar P,Panozzo MP,Del Favero G

更新日期：1993-07-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) is a widely expressed growth factor secreted by cells of mesenchymal origin, which has been shown to be involved in growth processes of multiple cell types. The HGF receptor, the product of the c-met protooncogene, is expressed mainly by epithelial cells. Increased expression of the HGF ...

journal_title：Pancreas

authors： Kiehne K,Herzig KH,Fölsch UR

更新日期：1997-07-01 00:00:00

abstract：:Opioid growth factor (OGF, [Met5]-enkephalin) is an endogenous peptide that regulates the growth of human pancreatic cancer. To evaluate whether human subjects with pancreatic cancer have alterations in plasma levels of OGF, fasting blood samples were obtained from 15 patients with histologically confirmed pancreatic ...

journal_title：Pancreas

authors： Smith JP,Conter RL,Demers TM,McLaughlin PJ,Zagon IS

更新日期：2000-08-01 00:00:00

abstract：:Stimulation of the exocrine pancreas with cholecystokinin analogues leads to a variety of intraacinar processes, many coupled to energy consumption. It was hypothesized that extensive ATP depletion could play a role in the pathophysiology of acute pancreatitis, especially in the hyperstimulation (cerulein) model. Mice...

journal_title：Pancreas

authors： Lüthen RE,Niederau C,Ferrell LD,Grendell JH

更新日期：1995-08-01 00:00:00

abstract：OBJECTIVES:The postoperative morbidity after pancreatectomy remains high. The role of somatostatin and its analogs in reducing complications after pancreatic resection is controversial. The aim of the study was to evaluate the ability of somatostatin to influence pancreatic cell's function with consequence the decrease...

journal_title：Pancreas

authors： Katsourakis A,Zezos P,Noussios G,Kouklakis G,Chatzitheoklitos E,Simopoulos K,Pitiakoudis M

更新日期：2013-01-01 00:00:00

abstract：:Solid pseudopapillary tumors (SPTs) are a rare pancreatic neoplastic lesion. Familial aggregation has not been reported in this disease. The objectives of this study were to report the history, clinicopathological features, and gene mutations of 3 familial cases of SPT. Three female cases of SPT presented in 1 family....

journal_title：Pancreas

authors： Gou S,Yu J,Wang C,Liu T,Cui P,Li X

更新日期：2013-01-01 00:00:00

abstract：:The insulin-like growth factor-II (IGF-II) receptor (IGF-IIR) is a single-chain transmembrane protein identical to the mannose-6-phosphate receptor. In the present study we examined IGF-IIR expression in normal and cancerous human pancreatic tissues. In the normal pancreas, moderately strong IGF-IIR immunoreactivity w...

journal_title：Pancreas

authors： Ishiwata T,Bergmann U,Kornmann M,Lopez M,Beger HG,Korc M

更新日期：1997-11-01 00:00:00

abstract：OBJECTIVES:This study aimed to compare severity of acute pancreatitis (AP) and mortality rates between transferred and nontransferred patients and to determine the factors that influence the decision to transfer. METHODS:A retrospective analysis coding a statewide administrative database in Maryland was conducted. Sev...

journal_title：Pancreas

authors： Anand G,Hutfless SM,Akshintala VS,Khashab MA,Lennon AM,Makary MA,Hirose K,Andersen DK,Kalloo AN,Singh VK

更新日期：2014-10-01 00:00:00

abstract：:The surgical treatment of pancreatic cancer (PDAC) has seen sweeping changes during the past 5 decades. Up to the middle of the 20th century resection rates were below 5%, but the numbers of curative resections for PDAC are now continuously increasing due to improved neoadjuvant treatment concepts as well as progress ...

journal_title：Pancreas

authors： Hackert T,Klaiber U,Pausch T,Mihaljevic AL,Büchler MW

更新日期：2020-09-01 00:00:00

abstract：:In recent studies performed on pancreatic stones from patients with alcoholic pancreatitis, a novel secretory protein was identified: the pancreatic stone protein (PSP Mr 14,000). This protein suppresses CaCO3 precipitation, and could therefore stabilize normally supersaturated pancreatic juice. Crystallographic analy...

journal_title：Pancreas

authors： Montalto G,Multigner L,Sarles H,De Caro A

更新日期：1988-01-01 00:00:00

abstract：:Abdominal and/or back pain is one of the most common symptoms in patients with pancreatic cancer. However, the cause of the pain and the clinicopathologic features of patients with pain have not been fully elucidated. We retrospectively determined the factors related to preoperative abdominal and/or back pain in 95 pa...

journal_title：Pancreas

authors： Okusaka T,Okada S,Ueno H,Ikeda M,Shimada K,Yamamoto J,Kosuge T,Yamasaki S,Fukushima N,Sakamoto M

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:We aimed to investigate preoperative findings that are useful to distinguish intraductal papillary-mucinous neoplasm (IPMN) subtypes. METHODS:One hundred twenty-three patients who underwent pancreatectomy for IPMN were analyzed clinicopathologically and radiologically. Invasive IPM carcinomas (IPMCs) were su...

journal_title：Pancreas

authors： Nara S,Onaya H,Hiraoka N,Shimada K,Sano T,Sakamoto Y,Esaki M,Kosuge T

更新日期：2009-01-01 00:00:00

abstract：:To determine the role of endogenous pancreatic polypeptide (PP) as a physiological inhibitor of pancreatic secretion, normal rabbit serum (control) or rabbit PP-antiserum was administered intravenously to dogs with chronic esophageal, gastric, and pancreatic fistulas. In all dogs tested, sham-feeding and ordinary feed...

journal_title：Pancreas

authors： Konturek SJ,Bielański W,Kwiecień N,Konturek J,Czarnobilski K

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:The transcription factor Stat1 is a member of the family of signal transducers and transcription activators and responds to interferon-γ stimulation. p21 is a p53-responsive gene for cell cycle regulation and mediates Stat1 antitumor activity. The aim of this study was to analyze their expression for predicti...

journal_title：Pancreas

authors： Sun Y,Yang S,Sun N,Chen J

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVES:Many patients with recurrent acute and chronic pancreatitis who are candidates for total pancreatectomy and islet cell autotransplantation (TPIAT) undergo endoscopic retrograde cholangiopancreatography (ERCP). However, little is known on the impact of ERCP on TPIAT outcomes. We aimed to explore the effect of...

journal_title：Pancreas

authors： LaBarre NT,Morgan KA,Adams DB,Waljee AK,Coté GA,Elmunzer BJ

更新日期：2019-01-01 00:00:00

abstract：:Chemoprevention by a synthetic retinoid, selenium, and these agents in combination during the postinitiation stages of carcinogenesis induced in rats by azaserine was evaluated. Male Lewis rats were given three weekly injections of 30 mg/kg azaserine while being fed a purified diet. One week after completion of carcin...

journal_title：Pancreas

authors： Curphey TJ,Kuhlmann ET,Roebuck BD,Longnecker DS

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVES:Tumor necrosis is often found in pancreatic ductal adenocarcinoma (PDAC). Objective histological assessment and adequate radiological detection of necrosis could be used as biomarkers for therapeutic decision. However, standardized clinical utility of necrosis remains unknown. Here, we aimed to determine the...

journal_title：Pancreas

authors： Kudo M,Kobayashi T,Gotohda N,Konishi M,Takahashi S,Kobayashi S,Sugimoto M,Okubo S,Martin J,Cabral H,Ishii G,Kojima M

更新日期：2020-05-01 00:00:00

abstract：:Amylase inhibition has gastrointestinal and metabolic effects that may aid in the treatment of diabetes and obesity. We tested whether 4 g of a commercially available wheat amylase inhibitor (WAI) affected postprandial carbohydrate (CHO) absorption and plasma glucose or hormones. Twelve persons (four lean and four obe...

journal_title：Pancreas

authors： Lankisch M,Layer P,Rizza RA,DiMagno EP

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVES:Pregnane X receptor (PXR) has been involved in human malignancy, either by directly affecting carcinogenesis or by inducing drug-drug interactions and chemotherapy resistance. The present study aimed to assess the clinical significance of PXR in pancreatic adenocarcinoma. METHODS:Pregnane X receptor and its...

journal_title：Pancreas

authors： Koutsounas I,Giaginis C,Alexandrou P,Zizi-Serbetzoglou A,Patsouris E,Kouraklis G,Theocharis S

更新日期：2015-10-01 00:00:00

abstract：:The aim of the study was to establish whether correlations were discernible between calcification, smoking, and other variables--including alcohol intake--in chronic pancreatitis. A total of 637 patients with chronic pancreatitis diagnosed over the period of 1973-1989 were reviewed. Only patients who had had one or mo...

journal_title：Pancreas

authors： Cavallini G,Talamini G,Vaona B,Bovo P,Filippini M,Rigo L,Angelini G,Vantini I,Riela A,Frulloni L

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVES:The aim of this prospective study was to evaluate the diagnostic value of the rapid urinary trypsinogen-2 test strip in post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. METHODS:A total of 150 patients were tested with the urinary trypsinogen-2 test strip and serum levels of amylase a...

journal_title：Pancreas

authors： Tseng CW,Chen CC,Lin SZ,Chang FY,Lin HC,Lee SD

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVES:We evaluated how well phase II trials in locally advanced and metastatic pancreatic cancer (LAMPC) meet current recommendations for trial design. METHODS:We conducted a systematic review of phase II first-line treatment trial for LAMPC. We assessed baseline characteristics, type of comparison, and primary e...

journal_title：Pancreas

authors： Tang M,Chen J,Goldstein D,Links M,Lord S,Marschner I,Simes RJ,Lee CK

更新日期：2019-11-01 00:00:00

abstract：:Examining the actions of L-364,718 on rat pancreatic acini, we found that L-364,718 causes persistent inhibition of cholecystokinin (CCK)-8-stimulated enzyme secretion in acini that were first incubated with L-364,718, washed repeatedly, and then reincubated with CCK-8. This inhibition is maximal after as little as 5 ...

journal_title：Pancreas

authors： Bhat ST,Talkad VD,Pollo DA,Gardner JD

更新日期：1994-01-01 00:00:00

abstract：:Although fat accumulation in acinar cells is the earliest histopathological change in the pancreas of patients and experimental animals, there are few long-term studies regarding lipid composition of the pancreas in alcoholism. In the present study, female Sprague-Dawley rats were divided into three groups each fed Wa...

journal_title：Pancreas

authors： Simsek H,Singh M

更新日期：1990-07-01 00:00:00