Abstract:
OBJECTIVES:We evaluated how well phase II trials in locally advanced and metastatic pancreatic cancer (LAMPC) meet current recommendations for trial design. METHODS:We conducted a systematic review of phase II first-line treatment trial for LAMPC. We assessed baseline characteristics, type of comparison, and primary end point to examine adherence to the National Cancer Institute recommendations for trial design. RESULTS:We identified 148 studies (180 treatment arms, 7505 participants). Forty-seven (32%) studies adhered to none of the 5 evaluated National Cancer Institute recommendations, 62 (42%) followed 1, 31 (21%) followed 2, and 8 (5%) followed 3 recommendations. Studies varied with respect to the proportion of patients with good performance status (range, 0%-80%) and locally advanced disease (range, 14%-100%). Eighty-two (55%) studies concluded that investigational agents should progress to phase III testing; of these, 24 (16%) had documented phase III trials. Three (8%) phase III trials demonstrated clinically meaningful improvements for investigational agents. One of 38 phase II trials that investigated biological investigational agents was enriched for a biomarker. CONCLUSIONS:Phase II trials do not conform well to current recommendations for trial design in LAMPC.
journal_name
Pancreasjournal_title
Pancreasauthors
Tang M,Chen J,Goldstein D,Links M,Lord S,Marschner I,Simes RJ,Lee CKdoi
10.1097/MPA.0000000000001429subject
Has Abstractpub_date
2019-11-01 00:00:00pages
1274-1284issue
10eissn
0885-3177issn
1536-4828pii
00006676-201911000-00009journal_volume
48pub_type
杂志文章相关文献
PANCREAS文献大全abstract:OBJECTIVES:Nitric oxide (NO) is a potent nonadrenergic, noncholinergic mediator of gastrointestinal smooth muscle. We aimed to investigate the effects of new NO/cyclic guanosine monophosphate (cGMP) pathway-affecting agents at the sheep sphincter of Oddi (SO) in vitro. METHODS:Sheep SO rings were mounted in organ bath...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181d3645b
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVES:Pancreatic duct disruption (PDD) after acute pancreatitis can cause pancreatic collections in the early phase and biliary stenosis (BS) or gastric outlet obstruction (GOO) in the late phase. We aimed to document those late complications after moderate or severe acute pancreatitis. METHODS:Between September ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001064
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVES:In injury conditions, myofibroblasts are induced to lay down matrix proteins and support the repair process. In this study, we investigated the role of myofibroblasts, particularly stellate cells, in the growth and regeneration of pancreatic β cells. METHODS:We used both in vitro and in vivo approaches to a...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000431
更新日期:2015-10-01 00:00:00
abstract:INTRODUCTION:Adenocarcinoma of the pancreas remains one of the most difficult malignancies to treat. Its incidence has steadily increased over the past four decades, and its prognosis is still dismal. AIM To assess tumor control and the palliative benefit of 5-fluorouracil (5-FU), cisplatin (CDDP), and radiotherapy in ...
journal_title:Pancreas
pub_type: 临床试验,杂志文章
doi:10.1097/00006676-200211000-00007
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVES:Oxidative stress has been implicated in the pathogenesis of chronic pancreatitis (CP) and pancreatic cancer (PC). The study aim was to assess the oxidative stress markers and antioxidant defense system in patients with CP and those with PC. METHODS:Activities of superoxide dismutase 1 (SOD1), catalase (CAT)...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318288360a
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVES:The 2012 international consensus guidelines for the management of intraductal papillary mucinous neoplasm (IPMN) of the pancreas stratified patients into 2 clinical categories, "high-risk stigmata" and "worrisome features," and recommended different therapeutic strategies for these groups. The aim of this st...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000199
更新日期:2014-11-01 00:00:00
abstract::The application of a commercially available enzyme immunoassay method for the determination of lipase concentration in human duodenal fluid is reported. Variations in the test procedure have been investigated. A sample incubation and a conjugate incubation of 1 h at 37 degrees C are necessary. There is substantial agr...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198902000-00014
更新日期:1989-01-01 00:00:00
abstract::Computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) are sophisticated modalities typically used in the second-line diagnosis following routine clinical practice. Among them, CT is regarded as the standard imaging in diagnosing pancreatic cancer at present in Japan due to ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200404000-00011
更新日期:2004-04-01 00:00:00
abstract:OBJECTIVE:The indolent nature and expression of progesterone receptor (PR), a well-known estrogen-induced gene, in a subset of pancreatic neuroendocrine tumors (PanNETs), raise the possibility of hormonal regulation in these tumors. METHODS:Immunohistochemical expression of estrogen receptors (ERs) α and β as well as ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000203
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVES:Protein kinase C (PKC) is involved in cell growth, differentiation, and apoptosis. We investigated the effects of the PKC activator, the tetradecanylphorbol acetate (TPA), in human pancreatic cancer cells. METHODS:Cell proliferation was measured by thymidine incorporation. Expression of cell cycle proteins ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000226896.93945.41
更新日期:2006-08-01 00:00:00
abstract::Chemokines may regulate the process of immune cell infiltration that is often found in pancreatic cancer. In this study, we investigated the secretion of the chemokines [interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, and RANTES (regulated on activation, normal T cell expressed and secreted)] in human pa...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200007000-00049
更新日期:2000-07-01 00:00:00
abstract:OBJECTIVES:This study aims to identify the computed tomography (CT) features that may differentiate nonfunctioning pancreatic neuroendocrine tumors (NF-PanNETs) with lymph node (LN) metastasis from NF-PanNETs without lymph node metastasis. METHODS:We retrospectively analyzed 166 NF-PanNETs in 166 patients who had unde...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000888
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVES:Despite a lack of evidence, gabexate mesylate (GM) is routinely used for the treatment of acute pancreatitis (AP) in some countries. The present study examined the effect and cost of GM for AP treatment using the Japanese Diagnosis Procedure Combination database. METHODS:We performed a propensity score anal...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31826495a0
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVES:Pancreatic cancer is a serious disease worldwide for its high mortality. Gemcitabine has become the frontline option for the treatment of this disease since its approval. However, resistance to the drug has been on the rise in recent years. Searching for other chemotherapeutic agents therefore has attracted ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181ce719e
更新日期:2010-08-01 00:00:00
abstract::The efficacy of medications to treat pancreatic diseases, even when proven effective by experimental studies, are difficult to prove by controlled clinical trials. In the treatment of acute pancreatitis, prophylactic antibiotics, somatostatin, protease inhibitors, and cholecystokinin (CCK)-receptor antagonists are adv...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/00006676-199804000-00035
更新日期:1998-04-01 00:00:00
abstract::In recent studies performed on pancreatic stones from patients with alcoholic pancreatitis, a novel secretory protein was identified: the pancreatic stone protein (PSP Mr 14,000). This protein suppresses CaCO3 precipitation, and could therefore stabilize normally supersaturated pancreatic juice. Crystallographic analy...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198805000-00004
更新日期:1988-01-01 00:00:00
abstract::In a patient with pancreatic cancer, an arterial anomaly was observed that apparently consisted of the congenital absence of the celiac axis and the replacement of the pancreaticoduodenal arcade by an anomalous vessel. The complete or near-complete arterial flow to the liver and spleen depended upon this anomalous pre...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198910000-00013
更新日期:1989-01-01 00:00:00
abstract::A comparative study of antibacterial activity of pancreatic juice was conducted on six mammalian species. Pancreatic juice collections were conducted as acute (rabbit, guinea pig, rat) and chronic (pig, sheep, cattle) experiments, in the former before and after stimulation [cholecystokinin (CCK) and secretin] and in t...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199309000-00003
更新日期:1993-09-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to determine if there had been any change in the number of solid-pseudopapillary neoplasm (SPN) cases detected and their evaluation or management over time. METHODS:A systematic review of SPN was performed of all articles published in English in PubMed and Scopus. RESULTS:A total of...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/MPA.0000000000000061
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVES:IQ motif containing GTPase-activating protein 1 (IQGAP1) acts as a scaffold for aberrant mitogen-activated protein kinase (MAPK) signaling driven by KRAS mutations in pancreatic ductal adenocarcinoma (PDAC). We determined the role of IQGAP1 in clonogenic growth and metastasis in PDAC. METHODS:We inhibited I...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001198
更新日期:2019-01-01 00:00:00
abstract::Solid pseudopapillary tumors (SPTs) are a rare pancreatic neoplastic lesion. Familial aggregation has not been reported in this disease. The objectives of this study were to report the history, clinicopathological features, and gene mutations of 3 familial cases of SPT. Three female cases of SPT presented in 1 family....
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3182554276
更新日期:2013-01-01 00:00:00
abstract::The accuracies of assays of serum CA 19-9 and elastase 1 in the diagnosis of pancreatic carcinoma were investigated by the cutoff method and discriminant analysis of data on 98 patients with pancreatitis, 65 patients with pancreatic carcinoma, 107 patients with benign diseases of other organs, and 108 patients with ca...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198908000-00002
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVES:This analysis investigated nomogram use to evaluate metastatic pancreatic cancer prognosis. METHODS:Thirty-four baseline factors were examined in the Metastatic Pancreatic Adenocarcinoma Clinical Trial (MPACT) (nab-paclitaxel plus gemcitabine vs gemcitabine) data set. Factors significantly (P < 0.1) associa...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001563
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVES:Based mainly on animal models, 2 lesions have been suggested as possible precursors of pancreatic ductal adenocarcinoma (PDAC): pancreatic intraepithelial neoplasia (PanIN) and tubular complexes (TCs). The aim of the study was to find support for either of the 2 models through the analysis of a large panel o...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/mpa.0b013e31805d0190
更新日期:2007-10-01 00:00:00
abstract::Islet amyloid polypeptide (IAPP) has been recently identified as the principal constituent of amyloid deposits in pancreatic islets of patients with type 2 (non-insulin-dependent) diabetes mellitus and causes insulin resistance in some target cells. In addition, glucose-induced insulin secretion is inhibited by IAPP. ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199207000-00009
更新日期:1992-01-01 00:00:00
abstract::Pancreatic carcinoma is one of the most devastating neoplasms with regard to its resistance to conventional therapy. In a previous report, we found that endogenous tumor necrosis factor (enTNF) exerts an intracellular protective effect against exogenous TNF- and Adriamycin (ADM)-induced cytotoxicity by scavenging oxyg...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199611000-00009
更新日期:1996-11-01 00:00:00
abstract::We studied the prevalence of mitochondrial gene mutations in subjects with insulin-dependent diabetes mellitus (IDDM) in a Chinese population living in Taiwan. Eighty-four subjects with insulin-dependent diabetes mellitus and 105 unrelated normal controls were recruited in the present study. Both an A-to-G mutation at...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199604000-00006
更新日期:1996-04-01 00:00:00
abstract::The glycolytic inhibitor, 2-deoxy-D-glucose (2-DG), inhibits growth of some cancers. alpha-Difluoromethylornithine (DFMO) is an irreversible inhibitor of ornithine decarboxylase, the rate-limiting enzyme in polyamine biosynthesis. We and others have previously shown that DFMO inhibits cancer growth in a number of mode...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198902000-00006
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to identify differentially expressed proteins among various stages of pancreatic ductal adenocarcinoma (PDAC) by shotgun proteomics using nano-liquid chromatography coupled tandem mass spectrometry and stable isotope dimethyl labeling. METHODS:Differentially expressed proteins were...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000388
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:Given the lack of consensus on surveillance guidelines after pancreatic neuroendocrine tumor (PanNET) resection, we assessed outcomes in a large cohort of patients with nonmetastatic, surgically resected PanNETs. METHODS:Data of patients with PanNETs resected between 1990 and 2017 were retrospectively collec...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001477
更新日期:2020-02-01 00:00:00