A population-based evaluation of severity and mortality among transferred patients with acute pancreatitis.

abstract：OBJECTIVES:The aims of this study were to compare the safety, efficacy, and patients' quality of life with continuous subcutaneous insulin infusion (CSII) versus multiple daily injections (MDIs) in type 3c diabetes mellitus (T3cDM) following total pancreatectomy (TP) and pancreatic enzyme usage. METHODS:Thirty-nine pa...

journal_title：Pancreas

authors： Struyvenberg MR,Fong ZV,Martin CR,Tseng JF,Clancy TE,Fernández-Del Castillo C,Tillman HJ,Bellin MD,Freedman SD

更新日期：2017-10-01 00:00:00

abstract：INTRODUCTION:Between April 1992 and December 2000, 167 patients with pancreatic carcinoma were evaluated and treated in our department. One hundred eight patients (64.7%) with pancreatic carcinoma underwent pancreatectomy. Of these patients, 94 had histologically proven ductal adenocarcinoma. The overall postoperative ...

journal_title：Pancreas

authors： Takai S,Satoi S,Toyokawa H,Yanagimoto H,Sugimoto N,Tsuji K,Araki H,Matsui Y,Imamura A,Kwon AH,Kamiyama Y

更新日期：2003-04-01 00:00:00

abstract：:The mechanism of tissue alteration in chronic pancreatitis (CP) is still unclear. Different hypotheses have been discussed, including increasing oxidant stress in the acinar cells, often as a result of exposure to xenobiotics. To evaluate the role of oxidative stress in CP, the authors investigated the expression of t...

journal_title：Pancreas

authors： Ulrich AB,Schmied BM,Matsuzaki H,Lawson TA,Friess H,Andrén-Sandberg A,Büchler MW,Pour PM

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to establish a minimally invasive and simple screening test for detection of pancreatic ductal adenocarcinoma (PDAC) using duodenal juice (DJ). METHODS:Duodenal juice was collected prospectively before endoscopic retrograde cholangiopancreatography in 46 patients. A protease inhibi...

journal_title：Pancreas

authors： Mori Y,Ohtsuka T,Kono H,Nagayoshi Y,Ideno N,Aso T,Kozono S,Ohuchida K,Takahata S,Nakamura M,Mizumoto K,Tanaka M

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVES:Endovascular techniques can now access the arterial blood supply of the pancreas in humans to enable therapeutics to reach the gland in high concentrations while concurrently avoiding issues related to non-targeted delivery. However, there is no way to replicate this in small animals. In a rat model, we ther...

journal_title：Pancreas

authors： Choi J,Wang J,Ren G,Thakor AS

更新日期：2018-08-01 00:00:00

abstract：:The glycolytic inhibitor, 2-deoxy-D-glucose (2-DG), inhibits growth of some cancers. alpha-Difluoromethylornithine (DFMO) is an irreversible inhibitor of ornithine decarboxylase, the rate-limiting enzyme in polyamine biosynthesis. We and others have previously shown that DFMO inhibits cancer growth in a number of mode...

journal_title：Pancreas

authors： Saydjari R,Alexander RW,Barranco SC,Townsend CM Jr,Thompson JC

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to evaluate the relevance of defining borderline resectable (BR) pancreatic cancer as a distinct entity in the treatment scheme of pancreatic cancer as proposed by the National Comprehensive Cancer Network. METHODS:Among 375 patients with pancreatic cancer, 137 patients were ...

journal_title：Pancreas

authors： Yamada S,Fujii T,Sugimoto H,Nomoto S,Takeda S,Kodera Y,Nakao A

更新日期：2013-08-01 00:00:00

abstract：:250 syngeneic islets were implanted either beneath the kidney capsule or into the liver of diabetic LEW 1.A rats to investigate the functional response of a limited mass of beta-cells to long-term hyperglycemia. The number of islets, per se, was expected to be insufficient to reverse the hyperglycemia. All animals wer...

journal_title：Pancreas

authors： Dunger A,Kauert C,Brömme HJ,Hildebrandt W,Blech W,Hahn HJ

更新日期：1994-03-01 00:00:00

abstract：OBJECTIVES:This study aimed to investigate the frequency, predictors, and management of relapse of type 1 autoimmune pancreatitis (AIP) after steroid treatment. METHODS:One hundred one patients with type 1 AIP receiving steroid as initial treatment were enrolled. Predictors were identified by multivariate analysis usi...

journal_title：Pancreas

authors： Xin L,Meng QQ,Hu LH,Lin H,Pan J,Hao L,Liu PP,Qian W,Wang LW,Li ZS

更新日期：2018-10-01 00:00:00

abstract：:Serum expression of the cancer-associated antigens CA 19-9 and CA 50 and their relation to Lewis blood cell status were studied in 26 patients with pancreatic duct carcinoma and 26 patients with pancreatitis. The discriminating capacity between benign and malignant disease was high for both tumor markers. The correspo...

journal_title：Pancreas

authors： von Rosen A,Linder S,Harmenberg U,Pegert S

更新日期：1993-03-01 00:00:00

abstract：:Adenocarcinoma of the pancreas is one of most catastrophic and least understood of cancers. Evidence from clinical studies indicates that the development of pancreas cancer progresses over many years before symptoms appear. Most people with pancreatic cancer die within six months of diagnosis. The lack of early diseas...

journal_title：Pancreas

authors： Hine RJ,Srivastava S,Milner JA,Ross SA

更新日期：2003-11-01 00:00:00

abstract：:We performed molecular biological studies as well as immunohistochemical analysis of three cases of giant cell carcinoma of the pancreas. Histologically, one case was a pleomorphic giant cell carcinoma consisting of pleomorphic giant/ small cells and spindle cells, one an osteoclast-like giant cell tumor composed of o...

journal_title：Pancreas

authors： Imai Y,Morishita S,Ikeda Y,Toyoda M,Ashizawa T,Yamamoto K,Inoue T,Ishikawa T

更新日期：1999-04-01 00:00:00

abstract：OBJECTIVES:Attaining high-quality RNA from the tissues or organs of deceased donors used for research can be challenging due to physiological and logistical considerations. In this investigation, METHODS: RNA Integrity Number (RIN) was determined in pancreatic samples from 236 organ donors and used to define high (≥6.5...

journal_title：Pancreas

authors： Philips T,Kusmartseva I,Gerling IC,Campbell-Thompson M,Wasserfall C,Pugliese A,Longmate JA,Schatz DA,Atkinson MA,Kaddis JS

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVES:Activation of "nicotinic anti-inflammatory pathway" could reduce severity of inflammation and injury induced by acute pancreatitis. However, the role of regulatory T (Treg) cells in this pathway is unclear. METHODS:Severe acute pancreatitis (SAP) was induced in mice through retrograde injection of 50-μL 2% ...

journal_title：Pancreas

authors： Zheng YS,Wu ZS,Zhang LY,Ke L,Li WQ,Li N,Li JS

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION AND AIMS:It has been proposed that distinct tertiary structures of the C-terminus of CCK-8 and CCK-58 result in differences in stimulation of pancreatic amylase secretion. Binding of CCK-8 and CCK-58 to CCK-A and CCK-B receptors and stability to enzymatic digestion were used as independent probes for terti...

journal_title：Pancreas

authors： Reeve JR Jr,McVey DC,Bunnett NW,Solomon TE,Keire DA,Ho FJ,Davis MT,Lee TD,Shively JE,Vigna SR

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVES:We examined pancreatic cancer risk in association with hormonal and reproductive factors in a prospective cohort study of 89,835 Canadian women, aged 40-59 at recruitment, who were enrolled in the National Breast Screening Study (NBSS). METHODS:Linkages to national cancer and mortality databases yielded dat...

journal_title：Pancreas

authors： Navarro Silvera SA,Miller AB,Rohan TE

更新日期：2005-05-01 00:00:00

abstract：:Chemokines may regulate the process of immune cell infiltration that is often found in pancreatic cancer. In this study, we investigated the secretion of the chemokines [interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, and RANTES (regulated on activation, normal T cell expressed and secreted)] in human pa...

journal_title：Pancreas

authors： Takaya H,Andoh A,Shimada M,Hata K,Fujiyama Y,Bamba T

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVES:C-terminal tensin-like gene (CTEN, also known as TNS4) localizes to focal adhesions and is reported to function as an oncogene in colonic, breast, lung, and gastric cancers. Its role in pancreatic cancer is unknown and was thus investigated in this study. METHODS:C-terminal tensinlike gene expression was ev...

journal_title：Pancreas

authors： Al-Ghamdi S,Cachat J,Albasri A,Ahmed M,Jackson D,Zaitoun A,Guppy N,Otto WR,Alison MR,Kindle KB,Ilyas M

更新日期：2013-01-01 00:00:00

abstract：:Although fat accumulation in acinar cells is the earliest histopathological change in the pancreas of patients and experimental animals, there are few long-term studies regarding lipid composition of the pancreas in alcoholism. In the present study, female Sprague-Dawley rats were divided into three groups each fed Wa...

journal_title：Pancreas

authors： Simsek H,Singh M

更新日期：1990-07-01 00:00:00

abstract：:This prospective study aimed to pinpoint acute pancreatic patients who are at a higher risk of clinical deterioration. Once identified, they can be given more costly intensive-care therapy or transferred promptly to hospitals with specialized equipment. Our study included 217 patients with acute pancreatitis. All of t...

journal_title：Pancreas

authors： Lankisch PG,Pflichthofer D,Lehnick D

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:Opioid therapy for pain in chronic pancreatitis (CP) is associated with tolerance and possibly opioid-induced hyperalgesia. We thus examined opioid use and pain rating in CP patients. METHODS:Medical records of patients with established CP treated at the University of Pittsburgh Medical Center's Digestive Di...

journal_title：Pancreas

authors： Nusrat S,Yadav D,Bielefeldt K

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVES:Intra-abdominal fungal infections (AFIs) complicating acute pancreatitis arise in the context of pancreatic necrosis. Our goal was to determine which risk factors contribute to AFI in patients with acute pancreatitis. METHODS:Records were reviewed from 479 nontransfer patients admitted to our medical center...

journal_title：Pancreas

authors： Schwender BJ,Gordon SR,Gardner TB

更新日期：2015-07-01 00:00:00

abstract：:Periodic oscillation of insulin and glucagon by isolated mice islets has been studied. Pulsatile secretion of insulin and glucagon was observed at all glucose concentrations tested. The frequency of oscillation per 20 min for glucagon was 5.0 +/- 0.26 and for insulin 4.0 +/- 0.26 (n = 6), approximating to periodicitie...

journal_title：Pancreas

authors： Opara EC,Atwater I,Go VL

更新日期：1988-01-01 00:00:00

abstract：:The in vitro incorporation of [35S]cysteine into lipase, colipase, amylase, procarboxypeptidase A and B, and the serine proteases and total proteins was studied in pancreatic lobules isolated from normal and diabetic rats with or without insulin treatment. The incorporation of [35S]cysteine into total proteins was 65%...

journal_title：Pancreas

authors： Duan RD,Erlanson-Albertsson C

更新日期：1990-03-01 00:00:00

abstract：OBJECTIVES:Homocysteine has been implicated in vascular dysfunction and thrombosis, as well as inflammatory conditions. This study was aimed to find out whether chronic pancreatitis (CP) is associated with hyperhomocysteinemia and derangements of transmethylation and transsulfuration pathways. METHODS:We estimated hom...

journal_title：Pancreas

authors： Girish BN,Vaidyanathan K,Rao NA,Rajesh G,Reshmi S,Balakrishnan V

更新日期：2010-01-01 00:00:00

abstract：:Several studies have shown that pituitary adenylate cyclase activating polypeptide (PACAP) stimulates at very low concentration insulin release from pancreatic beta cells. In addition, PACAP has been evidenced in pancreatic nervous fibers surrounding the islets, the core of the islet, and the capillaries. The aim of t...

journal_title：Pancreas

authors： Petruzzo P,Cappai A,Spiga S,Picciau S,Serra G,Fattore L,Onali P,Brotzu G

更新日期：2001-07-01 00:00:00

abstract：OBJECTIVES:Many patients with small bowel neuroendocrine tumors (SBNETs) have multifocal tumors (MFTs), but the frequency of MFTs has varied widely across SBNET studies. It is also unclear whether patients with MFTs have more advanced disease or worse clinical course than do those with unifocal SBNETs. We set out to de...

journal_title：Pancreas

authors： Choi AB,Maxwell JE,Keck KJ,Bellizzi AJ,Dillon JS,OʼDorisio TM,Howe JR

更新日期：2017-10-01 00:00:00

abstract：INTRODUCTION:Although somatostatin inhibits pancreatic exocrine secretion, the inhibitory mechanism of endogenous somatostatin is not clearly understood. AIM:To investigate the effect of endogenous somatostatin on the interaction between endogenous insulin and exogenous cholecystokinin (CCK) in exocrine secretion of t...

journal_title：Pancreas

authors： Park HS,Yoon HS,Park YD,Cui ZY,Lee YL,Park HJ

更新日期：2002-05-01 00:00:00

abstract：:The effect of a potent and long-acting bradykinin B2-receptor antagonist (HOE140) on acute pancreatitis induced by retrograde infusion of trypsin and taurocholate into the pancreatic duct was studied in rats. HOE140 was administered subcutaneously immediately before and 3 h after the induction of pancreatitis and the ...

journal_title：Pancreas

authors： Kanbe T,Naruse S,Kitagawa M,Nakae Y,Hayakawa T

更新日期：1996-10-01 00:00:00

abstract：:Thirty-six patients (21 male, 15 female) with ductal pancreatic cancer were treated with the long-acting synthetic luteinizing hormone releasing hormone (LH-RH) analogue buserelin. All patients had advanced tumor stages (stage II: 7 patients; stage III: 11 patients; stage IV: 18 patients). A monthly follow-up includin...

journal_title：Pancreas

authors： Friess H,Büchler M,Krüger M,Beger HG

更新日期：1992-01-01 00:00:00