Nutritional links to plausible mechanisms underlying pancreatic cancer: a conference report.

abstract：OBJECTIVES:To measure the usefulness of Ki-67 proliferative index (Ki-67 index) as a prognostic variable for grading pancreatic neuroendocrine tumors. METHODS:A multi-institutional prospective database comprising 350 patients. Grading based on mitotic activity (<2 mitoses/10 high-power fields, 2-20 and >20) and Ki-67 ...

journal_title：Pancreas

authors： Philips P,Kooby DA,Maithel S,Merchant NB,Weber SM,Winslow ER,Ahmad S,Kim HJ,Scoggins CR,McMasters KM,Martin RCG 2nd

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVES:Many patients with small bowel neuroendocrine tumors (SBNETs) have multifocal tumors (MFTs), but the frequency of MFTs has varied widely across SBNET studies. It is also unclear whether patients with MFTs have more advanced disease or worse clinical course than do those with unifocal SBNETs. We set out to de...

journal_title：Pancreas

authors： Choi AB,Maxwell JE,Keck KJ,Bellizzi AJ,Dillon JS,OʼDorisio TM,Howe JR

更新日期：2017-10-01 00:00:00

abstract：:The mechanism of tissue alteration in chronic pancreatitis (CP) is still unclear. Different hypotheses have been discussed, including increasing oxidant stress in the acinar cells, often as a result of exposure to xenobiotics. To evaluate the role of oxidative stress in CP, the authors investigated the expression of t...

journal_title：Pancreas

authors： Ulrich AB,Schmied BM,Matsuzaki H,Lawson TA,Friess H,Andrén-Sandberg A,Büchler MW,Pour PM

更新日期：2001-05-01 00:00:00

abstract：:Periodic oscillation of insulin and glucagon by isolated mice islets has been studied. Pulsatile secretion of insulin and glucagon was observed at all glucose concentrations tested. The frequency of oscillation per 20 min for glucagon was 5.0 +/- 0.26 and for insulin 4.0 +/- 0.26 (n = 6), approximating to periodicitie...

journal_title：Pancreas

authors： Opara EC,Atwater I,Go VL

更新日期：1988-01-01 00:00:00

abstract：:To investigate the heterogeneity of hematogenous metastases of pancreatic ductal carcinoma, we investigated carcinomatous spread in 130 autopsy cases. Hepatic metastases occurred most frequently, in 81 cases (62%), which may be explained by the fact that all veins draining the pancreas flow into the portal system. We ...

journal_title：Pancreas

authors： Kamisawa T,Isawa T,Koike M,Tsuruta K,Okamoto A

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVES:Existing reference ranges for stool fat and energy absorption were developed using subjects in controlled environments on precise diets. This study measured energy and fat absorption in healthy, community-dwelling adults eating a moderate-to-high fat American diet via stool- and serum-based methods. METHODS...

journal_title：Pancreas

authors： Bashaw H,Brownell JN,Schall JI,Stallings VA

更新日期：2020-07-01 00:00:00

abstract：:Cultivation and preservation of human pancreatic ductal cells have remained a challenge. With a defined culture medium and refinement of culturing techniques, we have been able to maintain human pancreatic ductal cells without any genetic manipulation in culture for more than 16 months. Freshly isolated ductal fragmen...

journal_title：Pancreas

authors： Ulrich AB,Schmied BM,Matsuzaki H,El-Metwally T,Moyer MP,Ricordi C,Adrian TE,Batra SK,Pour PM

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Psychological distress is highly prevalent in patients with pancreatic cancer (PC), yet little is known about the pathophysiology underlying the relationship between these 2 diseases. Our aim was to systematically review the evidence examining the pathophysiological mechanisms of the association between PC a...

journal_title：Pancreas

authors： Bettison TM,Nahm CB,Gill AJ,Mittal A,Malhi GS,Samra JS

更新日期：2018-04-01 00:00:00

abstract：:This study was undertaken to determine the involvement of endogenous cholecystokinin (CCK) in the regeneration of pancreatic tissue after cerulein-induced acute pancreatitis treated by the CCK receptor antagonist L364,718. Acute pancreatitis was induced in rats by s.c. injections of cerulein in gelatin (12 micrograms/...

journal_title：Pancreas

authors： Jurkowska G,Grondin G,Morisset J

更新日期：1992-01-01 00:00:00

abstract：INTRODUCTION:Although cell kinetics of the gastrointestinal mucosa has been extensively examined, that of the pancreas has not been fully analyzed. AIM:To determine the renewal rate of pancreatic cells directly. METHODOLOGY:Postnatal proliferative activity and cellular renewal of the parenchymal cells in ICR mouse pa...

journal_title：Pancreas

authors： Magami Y,Azuma T,Inokuchi H,Moriyasu F,Kawai K,Hattori T

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVES:Nuclear factor κB (NF-κB) plays an intrinsic role in promoting growth, angiogenesis, and metastasis in pancreatic cancer (PC) and serves as a mechanism underlying therapeutic resistance. Accordingly, we investigated the efficacy of bioactive phytochemicals in inhibiting radiotherapy (RT)-induced NF-κB activi...

journal_title：Pancreas

authors： Veeraraghavan J,Natarajan M,Lagisetty P,Awasthi V,Herman TS,Aravindan N

更新日期：2011-10-01 00:00:00

abstract：:Clinical, histopathologic, immunohistochemical, and genetic analyses of 2 osteoclastic giant cell tumors of the pancreas are presented. The neoplasms were composed of osteoclastic giant cells and pleomorphic cells (PCs). The tissue-specific markers gave evidence of mesenchymal nature of the osteoclastic giant cells, a...

journal_title：Pancreas

authors： Lukás Z,Dvorák K,Kroupová I,Valásková I,Habanec B

更新日期：2006-04-01 00:00:00

abstract：:Although ethanol abuse is the major etiologic factor in the development of acute and chronic pancreatitis, the mechanisms of ethanol effects to cause pancreatitis are poorly understood. The major reason for the lack of progress is the relative lack of animal models that reproduce the deleterious effects of ethanol on ...

journal_title：Pancreas

authors： Pandol SJ,Gukovsky I,Satoh A,Lugea A,Gukovskaya AS

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVES:To correlate magnetic resonance cholangiopancreatography (MRCP) and magnetic resonance imaging (MRI) findings of the pancreas with the pancreatic exocrine function determined by fecal elastase 1 concentration. METHODS:Magnetic resonance imaging and MRCP findings of 81 consecutive patients with clinically su...

journal_title：Pancreas

authors： Bilgin M,Bilgin S,Balci NC,Momtahen AJ,Bilgin Y,Klör HU,Rau WS

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:Survival improvement for pancreatic cancer has not been observed in the last 4 decades. We report the most up-to-date population-based relative survival (RS) estimates and recent trends in Germany and the United States. METHODS:Data for patients diagnosed in 1997 to 2010 and followed up to 2010 were drawn f...

journal_title：Pancreas

authors： Sirri E,Castro FA,Kieschke J,Jansen L,Emrich K,Gondos A,Holleczek B,Katalinic A,Urbschat I,Vohmann C,Brenner H

更新日期：2016-07-01 00:00:00

abstract：INTRODUCTION:Although somatostatin inhibits pancreatic exocrine secretion, the inhibitory mechanism of endogenous somatostatin is not clearly understood. AIM:To investigate the effect of endogenous somatostatin on the interaction between endogenous insulin and exogenous cholecystokinin (CCK) in exocrine secretion of t...

journal_title：Pancreas

authors： Park HS,Yoon HS,Park YD,Cui ZY,Lee YL,Park HJ

更新日期：2002-05-01 00:00:00

abstract：:Changes in pancreatic growth and in mRNA concentrations in rat pancreas were monitored by dot-blot hybridization with cloned cDNAs of rat amylase, chymotrypsinogen B, proinsulin I, and actin during the pre- and postnatal period in the rat. Wistar rats were killed at the 18th day of gestation and at the 1st, 10th, 20th...

journal_title：Pancreas

authors： Iovanna JL,Dusetti N,Cadenas B,Calvo EL

更新日期：1990-07-01 00:00:00

abstract：OBJECTIVE:We sought to identify clinicopathological characteristics of high-grade pancreatic intraepithelial neoplasia (PanIN)/carcinoma in situ to facilitate screening for pancreatic ductal adenocarcinoma. METHODS:We evaluated PanIN lesions in 173 consecutive autopsy cases with no evidence of pancreatic ductal adenoc...

journal_title：Pancreas

authors： Matsuda Y,Furukawa T,Yachida S,Nishimura M,Seki A,Nonaka K,Aida J,Takubo K,Ishiwata T,Kimura W,Arai T,Mino-Kenudson M

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVES:We evaluated whether neoadjuvant therapy followed by surgical resection improves the clinical outcome for patients with borderline resectable pancreatic cancer with radiologic artery involvement (BRPC-A). METHODS:We reviewed 143 BRPC-A patients from among 330 pancreatic cancer patients, including 111 potent...

journal_title：Pancreas

authors： Hirono S,Kawai M,Okada KI,Miyazawa M,Shimizu A,Kitahata Y,Ueno M,Yamaue H

更新日期：2016-11-01 00:00:00

abstract：:Because abnormalities of the autonomic nervous system have been described in several animal models of obesity, and because galanin has been proposed to be a sympathetic neurotransmitter in the endocrine pancreas, we hypothesized that the hyperinsulinemia observed in genetically obese (ob/ob) mice may result either fro...

journal_title：Pancreas

authors： Dunning BE,Ahrén B

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVES:Scutellaria baicalensis has been a subject of research interest due to its potential multiple therapeutic benefits. This study was to examine the distribution of baicalein, wogonin, oroxylin A and their glucuronide/sulfate-conjugated metabolites in plasma, colon, small intestine, lung, liver, pancreas, kidne...

journal_title：Pancreas

authors： Lu QY,Zhang L,Moro A,Chen MC,Harris DM,Eibl G,Go VL

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to evaluate the relevance of defining borderline resectable (BR) pancreatic cancer as a distinct entity in the treatment scheme of pancreatic cancer as proposed by the National Comprehensive Cancer Network. METHODS:Among 375 patients with pancreatic cancer, 137 patients were ...

journal_title：Pancreas

authors： Yamada S,Fujii T,Sugimoto H,Nomoto S,Takeda S,Kodera Y,Nakao A

更新日期：2013-08-01 00:00:00

abstract：:Pancreatic insufficiency was induced in rats by a single injection of 50 microliter oleic acid into the pancreatic duct over a period of 3 min. Exocrine tissue was destroyed within 3-6 days, and after 6 weeks the remaining pancreas equaled 2.7% of the original organ. The rats showed retardation of body weight in spite...

journal_title：Pancreas

authors： Mundlos S,Adler G,Schaar M,Koop I,Arnold R

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVE:The purpose of this study is to assess the prognostic significance of late parenchymal pancreas necrosis as observed on serial contrast-enhanced computed tomographic (CT) scan. METHODS:Eighty-four patients with acute necrotizing pancreatitis were included. All initial CT scans were examined on complete contr...

journal_title：Pancreas

authors： Wijffels NA,van Walraven LA,Ophof PJ,Hop WC,van der Harst E,Lange JF

更新日期：2007-03-01 00:00:00

abstract：:Type I diabetes is characterized by destruction of insulin-producing beta-islet cells in the pancreas resulting in hyperglycemia and associated morbidity. The successful treatment of diabetes by transplanted islets has resulted in renewed efforts to identify methods to augment islet availability. One approach is to id...

journal_title：Pancreas

authors： Wu F,Jagir M,Powell JS

更新日期：2004-07-01 00:00:00

abstract：:Non-Hodgkin pancreatic lymphoma is a rare disease. Its diagnosis is difficult without histological examination. Ultrasonographic, computed tomodensitometric, and endoscopic retrograde cholangio-pancreatographic findings are not pathognomonic. The better prognosis of these tumors, compared to adenocarcinoma, and their ...

journal_title：Pancreas

authors： Joly I,David A,Payan MJ,Sahel J,Sarles H

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVES:The circulating neutrophil-lymphocyte ratio (NLR) has been shown to be a prognostic factor for a variety of tumors. In this study, we evaluated the prognostic significance of NLR in a large cohort of Chinese patients with pancreatic ductal adenocarcinomas (PDACs). METHODS:A total of 381 patients with PDAC w...

journal_title：Pancreas

authors： Ben Q,An W,Wang L,Wang W,Yu L,Yuan Y

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVES:Rare cases of pancreatic neuroendocrine tumors (PNETs) that produce only proinsulin (PI) and manifest with hypoglycemia have been reported. Proinsulin expression in PNET has not been systematically studied, and the clinicopathologic features of such tumors remain unknown. METHODS:We studied expression of PI...

journal_title：Pancreas

authors： Celli R,Tang LH,Cai G,Freedman-Weiss M,Colunga M,Salem RR,Majumdar S,Jain D

更新日期：2019-01-01 00:00:00

abstract：UNLABELLED:Serum adiponectin (ADP) levels are reported inversely related to the risk in breast, endometrial cancer, and gastric cancer. Serum ADP as a potential marker compared with CA-19-9 in pancreatic carcinoma (PC) and chronic pancreatitis (CP) was studied. Adiponectin and CA-19-9 levels were examined at the time o...

journal_title：Pancreas

authors： Chang MC,Chang YT,Su TC,Yang WS,Chen CL,Tien YW,Liang PC,Wei SC,Wong JM

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVES:In patients with pancreaticobiliary maljunction (PBM), reflux of pancreatic juice to the bile duct may contribute to carcinogenesis of the biliary tract. This study aimed to investigate the pancreatographic findings in patients with PBM and the relationship to their clinical findings in view of pancreatic ju...

journal_title：Pancreas

authors： Kamisawa T,Egawa N,Nakajima H,Matsukawa M

更新日期：2005-04-01 00:00:00