Long-term correction of hyperglycemia in diabetic mice after implantation of cultured human cells derived from fetal pancreas.

abstract：:The human exocrine pancreas consists of 2 main cell types: acinar and ductal cells. These exocrine cells interact closely to contribute to the secretion of pancreatic juice. The most important ion in terms of the pancreatic ductal secretion is HCO3. In fact, duct cells produce an alkaline fluid that may contain up to ...

journal_title：Pancreas

authors： Pallagi P,Hegyi P,Rakonczay Z Jr

更新日期：2015-11-01 00:00:00

abstract：:Clinical, histopathologic, immunohistochemical, and genetic analyses of 2 osteoclastic giant cell tumors of the pancreas are presented. The neoplasms were composed of osteoclastic giant cells and pleomorphic cells (PCs). The tissue-specific markers gave evidence of mesenchymal nature of the osteoclastic giant cells, a...

journal_title：Pancreas

authors： Lukás Z,Dvorák K,Kroupová I,Valásková I,Habanec B

更新日期：2006-04-01 00:00:00

abstract：:This study was undertaken to determine the involvement of endogenous cholecystokinin (CCK) in the regeneration of pancreatic tissue after cerulein-induced acute pancreatitis treated by the CCK receptor antagonist L364,718. Acute pancreatitis was induced in rats by s.c. injections of cerulein in gelatin (12 micrograms/...

journal_title：Pancreas

authors： Jurkowska G,Grondin G,Morisset J

更新日期：1992-01-01 00:00:00

abstract：:Non-Hodgkin pancreatic lymphoma is a rare disease. Its diagnosis is difficult without histological examination. Ultrasonographic, computed tomodensitometric, and endoscopic retrograde cholangio-pancreatographic findings are not pathognomonic. The better prognosis of these tumors, compared to adenocarcinoma, and their ...

journal_title：Pancreas

authors： Joly I,David A,Payan MJ,Sahel J,Sarles H

更新日期：1992-01-01 00:00:00

abstract：:We have studied the degree of pancreatic secretory alterations assessed by secretin-cerulein test (S-C) in relation to various morphological changes detected by real-time ultrasonography (US) in 42 patients affected by chronic pancreatitis. Exocrine insufficiency was found in 41 patients (97.6%), while morphological a...

journal_title：Pancreas

authors： Bolondi L,Priori P,Gullo L,Santi V,Li Bassi S,Barbara L,Labó G

更新日期：1987-01-01 00:00:00

abstract：:Metastatic pancreatic cancer (PC) is an aggressive malignancy, with most patients deriving benefit only from first-line chemotherapy. Increasingly, the recommended treatment for those with a germline mutation in a gene involved in homologous recombination repair is with a platinum drug followed by a poly (ADP-ribose) ...

journal_title：Pancreas

authors： Martino C,Pandya D,Lee R,Levy G,Lo T,Lobo S,Frank RC

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:Homocysteine has been implicated in vascular dysfunction and thrombosis, as well as inflammatory conditions. This study was aimed to find out whether chronic pancreatitis (CP) is associated with hyperhomocysteinemia and derangements of transmethylation and transsulfuration pathways. METHODS:We estimated hom...

journal_title：Pancreas

authors： Girish BN,Vaidyanathan K,Rao NA,Rajesh G,Reshmi S,Balakrishnan V

更新日期：2010-01-01 00:00:00

abstract：:Utilizing scanning electron microscopy and isolated, vascularly perfused rat pancreas, we studied the angioarchitecture and the effect of the insulinotropic hormone, gastric inhibitory polypeptide (GIP), on cholecystokinin (CCK)-stimulated exocrine secretion. We tried to correlate the microcirculation with the physiol...

journal_title：Pancreas

authors： Mueller MK,Scheck T,Dreesmann V,Miodonski A,Goebell H

更新日期：1987-01-01 00:00:00

abstract：:Although surgical procedures that improve pancreatic drainage alleviate abdominal pain in the vast majority of patients with chronic pancreatitis, postoperative absorption and nutritional status are less predictable. The present study was designed to determine the efficacy of pancreatic enzyme supplementation in maint...

journal_title：Pancreas

authors： Van Hoozen CM,Peeke PG,Taubeneck M,Frey CF,Halsted CH

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVE:Opioid therapy for pain in chronic pancreatitis (CP) is associated with tolerance and possibly opioid-induced hyperalgesia. We thus examined opioid use and pain rating in CP patients. METHODS:Medical records of patients with established CP treated at the University of Pittsburgh Medical Center's Digestive Di...

journal_title：Pancreas

authors： Nusrat S,Yadav D,Bielefeldt K

更新日期：2012-03-01 00:00:00

abstract：:It was recently demonstrated in experimental models that, after pancreatic outflow obstruction, serum amylase levels first increase and then progressively decline regardless of whether the obstruction was maintained or relieved. Furthermore, early decompression of the ductal biliary system may prevent the progression ...

journal_title：Pancreas

authors： Pezzilli R,Billi P,Barakat B,Baroncini D,D'Imperio N,Miglio F

更新日期：1998-03-01 00:00:00

abstract：INTRODUCTION:We recently established a method of isolation and primary monolayer culture of porcine pancreatic endocrine cells that involves the use of nicotinamide. AIM:To obtain genetic information on cultured porcine endocrine cells and to examine cell function in relation to insulin secretion during long-term cult...

journal_title：Pancreas

authors： Tsuchiya M,Tsuchiya K,Iwami Y,Ohgawara H

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVES:Clinical and morphological criteria are not precise enough to diagnose early chronic pancreatitis (CP). We investigated if short endoscopic pancreas function testing as a part of routine upper endoscopy could improve clinical diagnostics. METHODS:Patients with suspected CP underwent modified secretin-stimul...

journal_title：Pancreas

authors： Erchinger F,Engjom T,Tjora E,Hoem D,Hausken T,Gilja OH,Dimcevski G

更新日期：2013-10-01 00:00:00

abstract：:The accuracies of assays of serum CA 19-9 and elastase 1 in the diagnosis of pancreatic carcinoma were investigated by the cutoff method and discriminant analysis of data on 98 patients with pancreatitis, 65 patients with pancreatic carcinoma, 107 patients with benign diseases of other organs, and 108 patients with ca...

journal_title：Pancreas

authors： Yamamura H,Tatsuta M,Ito M,Iishi H,Noguchi S,Okuda S,Yoshida M

更新日期：1989-01-01 00:00:00

abstract：:A 62-year-old Chinese woman suffering from pancreatic carcinoma coexisting with chronic calcifying pancreatitis is reported. Ultrasonography and computed tomography disclosed multiple intraductal calcifications in the pancreatic head and body and a tumor at the tail. Laparotomy revealed cancerous peritonitis in additi...

journal_title：Pancreas

authors： Lin JT,Wang TH,Chen DS,How SW,Lai MY,Chen JC,Sung JL

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Psychological distress is highly prevalent in patients with pancreatic cancer (PC), yet little is known about the pathophysiology underlying the relationship between these 2 diseases. Our aim was to systematically review the evidence examining the pathophysiological mechanisms of the association between PC a...

journal_title：Pancreas

authors： Bettison TM,Nahm CB,Gill AJ,Mittal A,Malhi GS,Samra JS

更新日期：2018-04-01 00:00:00

abstract：:Paraoxonase 1 (PON1) is an antioxidant enzyme that inhibits the oxidative modification of LDL. Since PON1 has been shown to express in pancreatic islets and oxidative stress plays a role in beta-cell dysfunction, we investigated the impact of the PON1 polymorphisms on beta-cell function. This study included 84 healthy...

journal_title：Pancreas

authors： Chiu KC,Chuang LM,Chu A,Lu J,Hu J,Fernando S

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to compare the perioperative clinical characteristics between patients with distal cholangiocarcinoma (DCC) and pancreatic head carcinoma (PHC) with biliary obstruction. METHODS:This study included patients who underwent pancreatoduodenectomy and were diagnosed with DCC (n = 85) or...

journal_title：Pancreas

authors： Yokoyama Y,Ebata T,Igami T,Sugawara G,Mizuno T,Yamaguchi J,Nagino M

更新日期：2017-11-01 00:00:00

abstract：:Thirty-six patients (21 male, 15 female) with ductal pancreatic cancer were treated with the long-acting synthetic luteinizing hormone releasing hormone (LH-RH) analogue buserelin. All patients had advanced tumor stages (stage II: 7 patients; stage III: 11 patients; stage IV: 18 patients). A monthly follow-up includin...

journal_title：Pancreas

authors： Friess H,Büchler M,Krüger M,Beger HG

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVES:To investigate the inhibition of PANC-1 pancreatic cancer cell growth by cucurmosin (CUS) and its possible mechanism. METHODS:We observed the inhibition of PANC-1 cell growth by sulforhodamine B and colony-forming experiments in vitro and established nonobese diabetic/severe combined immunodeficiency mouse ...

journal_title：Pancreas

authors： Wang C,Yang A,Zhang B,Yin Q,Huang H,Chen M,Xie J

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVES:To evaluate the clinical significance of high-volume modified continuous closed and/or open lavage for the treatment of infected necrotizing pancreatitis. METHODS:From August 1997 to December 2006, 53 patients with infected necrotizing pancreatitis who underwent in situ high-volume (>20 L/d) continuous clos...

journal_title：Pancreas

authors： Dong X,Gao SL,Xie QP,Xu L,Xu YL,Wu YL

更新日期：2008-01-01 00:00:00

abstract：:It has been suggested that the severity of an attack of acute pancreatitis is related to the presence of intraglandular trypsinogen activation and that disease severity is also reflected by the degree of the acute-phase protein response. In this study we examine the relationships among amylase release, the degree of t...

journal_title：Pancreas

authors： Heath DI,Cruickshank A,Gudgeon AM,Jehanli A,Shenkin A,Imrie CW

更新日期：1995-05-01 00:00:00

abstract：:Islet amyloid polypeptide (IAPP) is a 37-amino acid residue polypeptide, originally isolated from the pancreatic amyloid deposits of patients with type II diabetes mellitus. Subsequently, IAPP was found to be colocalised with insulin in beta-cell secretory granules of the normal mammalian pancreas. Recently, IAPP has ...

journal_title：Pancreas

authors： Jamal H,Suda K,Bretherton-Watt D,Ghatei MA,Bloom SR

更新日期：1993-03-01 00:00:00

abstract：:This review article has 4 major objectives to follow pancreatic physiology development more than close to 70 years of intensive and productive basic research. At first, the review will focus on secretion of the pancreatic enzymes with (1) the controls involved, (2) the interrelations existing between secretion and syn...

journal_title：Pancreas

authors： Morisset J

更新日期：2014-11-01 00:00:00

abstract：:ATM protein anticipates in the initiation of the DNA repair signal pathway and also mediates cell cycle arrest and repair. ATM deficiency predictably results in radiosensitivity, germ cell degeneration, chromosomal instability, immunodeficiency, and an extreme predisposition to tumors. Moreover, studies found that ATM...

journal_title：Pancreas

authors： Yu G,Zhu MH,Zhu Z,Ni CR,Zheng JM,Li FM

更新日期：2004-05-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma is characterized by a high rate of activating mutations involving codon 12 of the K-ras protooncogene. As a means of ras-targeted intervention, the effects of enhanced Krev-1 gene expression on the growth and tumorigenicity of the hamster pancreatic adenocarcinoma cell line PC-1 were e...

journal_title：Pancreas

authors： Leach SD,Berger DH,Davidson BS,Curley SA,Tainsky MA

更新日期：1998-05-01 00:00:00

abstract：OBJECTIVE:Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis involves persistent serum amylase levels of 3 times or more the standard upper limit. However, these criteria were mostly based on retrospective studies and not necessarily supported by diagnostic imaging. Our prospective study aimed to i...

journal_title：Pancreas

authors： Inatomi O,Bamba S,Nakai Y,Kusumoto K,Kawakami T,Suzuki T,Suzuki A,Endoh B,Ota S,Inoue A,Itokawa Y,Chikugo K,Andoh A,Mizumoto Y,Tanaka K

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVES:Endoscopic ultrasound (EUS) quality benchmarks for pancreatic disease previously focused on maintaining thresholds of diagnostic accuracy for fine-needle aspiration and measuring complications. We aimed to evaluate quality indicators when performing EUS specifically for the diagnosis of chronic pancreatitis ...

journal_title：Pancreas

authors： Gardner TB,Taylor DJ,Gordon SR

更新日期：2014-01-01 00:00:00

abstract：:Conscious rats were infused with optimal doses of secretin (16 clinical units [CU]/kg/h), cerulein (0.25 microgram/kg/h), and both for varying periods of time over 24 h. The presence of zymogen granules in acinar cells and the tissue content of enzymes showed progressive decreases over 3 and 12 h for cerulein and secr...

journal_title：Pancreas

authors： Rausch U,Rüdiger K,Vasiloudes P,Kern H,Scheele G

更新日期：1986-01-01 00:00:00

abstract：:Tumor relapse occurs frequently in patients with ductal pancreatic head cancer despite the absence of residual tumor detectable at primary surgery. Therefore it has to be assumed that current tumor staging procedures fail to detect minimal amounts of disseminated tumor cells present in secondary organs, which might be...

journal_title：Pancreas

authors： Hosch SB,Knoefel WT,Metz S,Stoecklein N,Niendorf A,Broelsch CE,Izbicki JR

更新日期：1997-08-01 00:00:00