Abstract:
OBJECTIVES:Survival improvement for pancreatic cancer has not been observed in the last 4 decades. We report the most up-to-date population-based relative survival (RS) estimates and recent trends in Germany and the United States. METHODS:Data for patients diagnosed in 1997 to 2010 and followed up to 2010 were drawn from 12 population-based German cancer registries and the US SEER (Surveillance, Epidemiology and End Results) 13 registries database. Using period analysis, 5-year RS for 2007 to 2010 was derived. Model-based period analysis was used to assess 5-year RS time trends, 2002-2010. RESULTS:In total 28,977 (Germany) and 34,793 (United States) patients aged 15 to 74 years were analyzed. Five-year RS was 10.7% and 10.3% in Germany and the United States, respectively, and strongly decreased with age and tumor spread. Prognosis slightly improved from the period 2002-2004 to 2008-2010 (overall age-adjusted RS: +2.5% units in Germany and +3.4% units in the United States); improvement was particularly strong for regional stage and head and body subsites in Germany and for localized and regional stages and tail subsite in the United States. CONCLUSIONS:Although pancreatic cancer survival continues to be poor for advanced-stage patients, our study disclosed encouraging indications of first improvements in 5-year RS after decades of stagnation.
journal_name
Pancreasjournal_title
Pancreasauthors
Sirri E,Castro FA,Kieschke J,Jansen L,Emrich K,Gondos A,Holleczek B,Katalinic A,Urbschat I,Vohmann C,Brenner Hdoi
10.1097/MPA.0000000000000588subject
Has Abstractpub_date
2016-07-01 00:00:00pages
908-14issue
6eissn
0885-3177issn
1536-4828journal_volume
45pub_type
杂志文章相关文献
PANCREAS文献大全abstract::Thirty-six patients (21 male, 15 female) with ductal pancreatic cancer were treated with the long-acting synthetic luteinizing hormone releasing hormone (LH-RH) analogue buserelin. All patients had advanced tumor stages (stage II: 7 patients; stage III: 11 patients; stage IV: 18 patients). A monthly follow-up includin...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199209000-00002
更新日期:1992-01-01 00:00:00
abstract::A 66-year-old patient had been admitted four times for recurrent episodes of acute pancreatitis. At each time, elevated serum calcium levels, between 13.5-14.5 mg/dl, were found. Surgical drainage of necrotic pancreatic tissue had to be done on one occasion. Extensive investigations failed to disclose any conventional...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198906000-00017
更新日期:1989-01-01 00:00:00
abstract::Several studies have shown that pituitary adenylate cyclase activating polypeptide (PACAP) stimulates at very low concentration insulin release from pancreatic beta cells. In addition, PACAP has been evidenced in pancreatic nervous fibers surrounding the islets, the core of the islet, and the capillaries. The aim of t...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200107000-00010
更新日期:2001-07-01 00:00:00
abstract::The effect of surgical celiac and superior mesenteric ganglionectomy (GGX) on intrinsic pancreatic innervation was studied in male Wistar rats. Neurons were stained in the pancreas of control and ganglionectomized rats with histochemical methods evidencing the acetylcholinesterase (AChE) activity and the induced fluor...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198709000-00013
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVES:After standardization of the perioperative management of pancreaticoduodenectomy, we retrospectively compared results in nonstented pancreaticojejunostomy with external-stented pancreaticojejunostomy. METHODS:The study population included 129 consecutive patients who underwent pancreaticoduodenectomy betwee...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181bd672c
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVES:Glucagon-like peptide-1 (GLP-1) is known to stimulate glucose-dependent insulin production and secretion by pancreatic beta-cells. Preliminary evidence suggests that GLP-1 may also influence endocrine differentiation from pancreatic progenitor cells. Additionally, TGF-beta signaling can also control endocrin...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000172566.70619.58
更新日期:2005-08-01 00:00:00
abstract:OBJECTIVES:To evaluate the clinical significance of high-volume modified continuous closed and/or open lavage for the treatment of infected necrotizing pancreatitis. METHODS:From August 1997 to December 2006, 53 patients with infected necrotizing pancreatitis who underwent in situ high-volume (>20 L/d) continuous clos...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/mpa.0b013e31812e9688
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:Pancreatic stellate cells (PSCs) play a crucial role during pancreatic fibrosis development. Hydrogen sulfide (H2S) is a recently discovered gaseous transmitter, whose role in PSCs has not been explored yet. In the present study, we examined the effects of sodium hydrosulfide (NaHS), an H2S donor, on rat PSC...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318223645b
更新日期:2012-01-01 00:00:00
abstract::Pancreatic cancer presenting as acute pancreatitis is relatively uncommon. Pancreatic cancer should be included in the differential diagnosis of "idiopathic" acute pancreatitis, particularly in the elderly. The following case report describes a patient in whom pancreatic cancer presented as acute pancreatitis with pse...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199307000-00016
更新日期:1993-07-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess the relationship between the computed tomography (CT) pancreatic parenchyma attenuation value and clinically relevant postoperative pancreatic fistula (POPF). METHODS:The medical records of 115 patients who underwent pancreaticoduodenectomy and preoperative dynamic CT were...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001229
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVES:The pancreas can metabolize ethanol via oxidative pathway involving the enzymes alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) as well as the nonoxidative pathway. In this study, we compared the activity of ADH isoenzymes and ALDH in the pancreatic cancer with the activity in normal tissue. In...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318053eae2
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the effects of iodine contrast media and gadoteric acid in acute necrotizing pancreatitis. METHODS:Fifty rabbits were distributed in 5 groups: 10 rabbits were assigned in the control group (group 5) and 40 rabbits were assigned in the pancreatitis group, wherein acute necrotizing pancreatitis was...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/mpa.0b013e3180a6f366
更新日期:2007-11-01 00:00:00
abstract::Sarcophytol A (SaA), a cembrane-type diterpene isolated from the marine soft coral Sarcophyton glaucum showed anticancer and cancer preventive effects in two different experiments. Growth of transplanted human pancreatic cancer cells (MIA paca-2, 1 x 10(7)) in nude mice (BALB/C 4W female) (Experiment 1) and pancreatic...
journal_title:Pancreas
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract:OBJECTIVES:In the hamster model, pancreatic ductal adenocarcinoma develops after treatment with N-nitrosobis-(2-oxopropyl)amino (BOP). In this model, Langerhans islets play a central role in carcinogenesis. In contrast, treatment with BOP in rats and mice did not result in cancer development. We investigated whether pa...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3182016a08
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:Systemic complications in alcoholic pancreatitis are supposed to be aggravated by inflammatory liver damage. Resident macrophages including hepatic Kupffer cells play a pivotal role in mediating systemic complications in severe necrotizing pancreatitis (SNP). The aim of this study was to evaluate the effects ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181bd6470
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:Pancreatic ductal carcinoma frequently recurs postoperatively, and we analyzed clinicopathological features of patients treated by surgical resection to find predictors of postoperative recurrence. METHODS:A retrospective cohort study was performed that included 69 patients between 1985 and 2003. Clinicopath...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000166998.04266.88
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVES:Human primary microRNA-155/B-cell integration cluster (BIC) transcript is the precursor of microRNA-155. The overexpression of them has been widely observed in the progression of various types of tumors. Our objective was to investigate the effect of anticancer agents on the expression of BIC and possible si...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181e89f74
更新日期:2011-01-01 00:00:00
abstract::Tumor relapse occurs frequently in patients with ductal pancreatic head cancer despite the absence of residual tumor detectable at primary surgery. Therefore it has to be assumed that current tumor staging procedures fail to detect minimal amounts of disseminated tumor cells present in secondary organs, which might be...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199708000-00007
更新日期:1997-08-01 00:00:00
abstract:OBJECTIVES:This study aimed to compare severity of acute pancreatitis (AP) and mortality rates between transferred and nontransferred patients and to determine the factors that influence the decision to transfer. METHODS:A retrospective analysis coding a statewide administrative database in Maryland was conducted. Sev...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000179
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVES:During the past decade, numerous studies in both humans and animals have demonstrated that C-peptide, although not influencing blood sugar control, might play a role in preventing and potentially reversing some of the chronic complications of type 1 diabetes. The aim of this paper is to present an up-to-date...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/00006676-200410000-00009
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVES:Endovascular techniques can now access the arterial blood supply of the pancreas in humans to enable therapeutics to reach the gland in high concentrations while concurrently avoiding issues related to non-targeted delivery. However, there is no way to replicate this in small animals. In a rat model, we ther...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001100
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVES:Our aim was to establish and characterize a novel pancreatic ductal adenocarcinoma cell line from a patient in whom the origin of the invasive carcinoma could be traced back to the intraductal papillary mucinous neoplasm (IPMN) precursor lesion. METHODS:The primary patient-derived tumor was propagated in im...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000673
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVES:The immune environment and the potential for neuroendocrine tumors (NETs) to respond to immune checkpoint inhibitors remain largely unexplored. We assessed immune checkpoint marker expression, lymphocytic infiltrate, and associated mutational profiles in a cohort of small intestine and pancreatic NETs. METH...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001150
更新日期:2018-10-01 00:00:00
abstract::Pancreatic duct bicarbonate secretion is mediated primarily by secretin-induced elevation of intracellular cyclic AMP, although little is known of the effects of other physiological regulators on pancreatic duct cyclic AMP metabolism. We investigated the effects of secretin and several other potential agonists on cycl...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199510000-00008
更新日期:1995-10-01 00:00:00
abstract:OBJECTIVES:We aim to examine the predictive effect of the total number of examined lymph nodes on N stage and survival in pancreatic neuroendocrine neoplasms (pNENs) and to determine the optimal threshold. METHODS:A pNENs data set from 2004 to 2013 was extracted from the Surveillance, Epidemiology, and End Result data...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000987
更新日期:2018-02-01 00:00:00
abstract::Chemokines may regulate the process of immune cell infiltration that is often found in pancreatic cancer. In this study, we investigated the secretion of the chemokines [interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, and RANTES (regulated on activation, normal T cell expressed and secreted)] in human pa...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200007000-00049
更新日期:2000-07-01 00:00:00
abstract::250 syngeneic islets were implanted either beneath the kidney capsule or into the liver of diabetic LEW 1.A rats to investigate the functional response of a limited mass of beta-cells to long-term hyperglycemia. The number of islets, per se, was expected to be insufficient to reverse the hyperglycemia. All animals wer...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199403000-00008
更新日期:1994-03-01 00:00:00
abstract:OBJECTIVES:To study the association of binge drinking and the outcomes of severe acute pancreatitis (SAP). METHODS:This retrospective study included 347 patients with first-attack SAP from January 2001 to February 2004. On the basis of the history of binge drinking or not, the patients were divided into the alcohol (n...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181baeae6
更新日期:2010-03-01 00:00:00
abstract::This prospective study aimed to pinpoint acute pancreatic patients who are at a higher risk of clinical deterioration. Once identified, they can be given more costly intensive-care therapy or transferred promptly to hospitals with specialized equipment. Our study included 217 patients with acute pancreatitis. All of t...
journal_title:Pancreas
pub_type: 杂志文章
doi:
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVE:To investigate whether human heme oxygenase-1 (HO-1) gene has protective action on islets cultured in vitro, and to explore whether transduction of HO-1 gene to donor islets could enhance engrafted islets survival and suppress local lymphocytic infiltration in islet grafts. METHODS:Newly isolated rat islets ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000236735.39241.d0
更新日期:2006-10-01 00:00:00