Regulation of cyclic AMP levels in guinea pig pancreatic ducts and cultured duct epithelial monolayers.

abstract：OBJECTIVES:To study the association of binge drinking and the outcomes of severe acute pancreatitis (SAP). METHODS:This retrospective study included 347 patients with first-attack SAP from January 2001 to February 2004. On the basis of the history of binge drinking or not, the patients were divided into the alcohol (n...

journal_title：Pancreas

authors： Deng L,Xue P,Huang L,Yang X,Wan M,Xia Q

更新日期：2010-03-01 00:00:00

abstract：:Stimulation of the exocrine pancreas is one of the biological effects attributed to the tridecapeptide neurotensin (NT). Only the C-terminal 8-13 fragment with its extremely short plasma half-life in the peripheral circulation was considered to be necessary for biological activity. The N-terminal fragments that are de...

journal_title：Pancreas

authors： Nustede R,Köhler H,Pfannkuche A,Fölsch UR,Schafmayer A

更新日期：1989-01-01 00:00:00

abstract：INTRODUCTION:Islet cell transplantation offers a new approach for the treatment of diabetes. Before transplantation, immunomodulation procedures are conducted to reduce the immunogenicity of the pancreatic islets. AIM:To study the effect of cyclophosphamide pretreatment and culture on the xenograft survival of monkey ...

journal_title：Pancreas

authors： Mythili MD,Ramakrishna B,Gunasekaran S

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVES:Previous research has shown that the retinoid 9-cis retinoic acid (RA) promotes apoptosis in pancreatic cancer cells. The vitamin D analog EB1089 does not. Furthermore, cotreatment of cells with 9-cis RA and EB1089 abrogates apoptosis. To explain this, we studied the regulation of proteins involved in apopto...

journal_title：Pancreas

authors： Mouratidis PX,Dalgleish AG,Colston KW

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVES:To evaluate the clinical significance of high-volume modified continuous closed and/or open lavage for the treatment of infected necrotizing pancreatitis. METHODS:From August 1997 to December 2006, 53 patients with infected necrotizing pancreatitis who underwent in situ high-volume (>20 L/d) continuous clos...

journal_title：Pancreas

authors： Dong X,Gao SL,Xie QP,Xu L,Xu YL,Wu YL

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:Autoimmune pancreatitis (AIP) responds well to steroid therapy but frequently relapses after discontinuing the steroid. It is difficult to know which cases are most likely to relapse. The aim of this study was to investigate the relation between the rate of decrease in serum IgG4 level after initial steroid ...

journal_title：Pancreas

authors： Shimizu K,Tahara J,Takayama Y,Akao J,Ajihara T,Nagao K,Shiratori K,Tokushige K

更新日期：2016-10-01 00:00:00

abstract：INTRODUCTION:Hypercytokinemia is known to occur in severe acute pancreatitis, suggesting that the production, deposition, and degradation of the extracellular matrix (ECM) occur actively as a result of the actions of the complicated cytokine network. AIMS AND METHODOLOGY:To examine the influence of cytokines and growt...

journal_title：Pancreas

authors： Nakae H,Endo S,Inoue Y,Fujino Y,Wakabayashi G,Inada K,Sato S

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVE:This paper aimed to assess the physiological effects of p53 on glucose homeostasis in vivo. METHODS:A recombinant adenoviral p53 (rAd-p53) vector was administered to insulin-resistant diabetic mice. Intraperitoneal glucose tolerance test was performed in all groups of mice. Changes in fasting blood glucose, ...

journal_title：Pancreas

authors： Zhang X,Duan W,Lee WN,Zhang Y,Xiang F,Liu Q,Go VL,Xiao GG

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:To develop a ¹³C-labeled substrate breath test by defining the optimal ¹³C-labeled substrate, substrate dose, test meal, and duration of the test and evaluating its accuracy for the diagnosis of pancreatic exocrine insufficiency (PEI) in chronic pancreatitis (CP). METHODS:Five consecutive prospective compara...

journal_title：Pancreas

authors： Domínguez-Muñoz JE,Nieto L,Vilariño M,Lourido MV,Iglesias-García J

更新日期：2016-02-01 00:00:00

abstract：INTRODUCTION:Peroxisome proliferator-activated receptors (PPARs) are a family of ligand-activated nuclear transcription factors belonging to the nuclear hormone receptors. Troglitazone, a specific ligand for PPAR-gamma is shown to regulate not only lipids and glucose metabolism, but also cell cycle, differentiation, an...

journal_title：Pancreas

authors： Jia DM,Otsuki M

更新日期：2002-04-01 00:00:00

abstract：:The human exocrine pancreas consists of 2 main cell types: acinar and ductal cells. These exocrine cells interact closely to contribute to the secretion of pancreatic juice. The most important ion in terms of the pancreatic ductal secretion is HCO3. In fact, duct cells produce an alkaline fluid that may contain up to ...

journal_title：Pancreas

authors： Pallagi P,Hegyi P,Rakonczay Z Jr

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVES:Patients with chronic pancreatitis are managed by extracorporeal shock wave lithotripsy (ESWL) for pancreatic stones. Stone density on noncontrast computed tomography (NCCT) is used to predict stone composition and fragility, but no report investigating the pancreatic stone density has been documented. We ai...

journal_title：Pancreas

authors： Ohyama H,Mikata R,Ishihara T,Tsuyuguchi T,Sakai Y,Sugiyama H,Yasui S,Ishii K,Itoh S,Nishikawa T,Watanabe Y,Yokosuka O

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVES:We evaluated whether neoadjuvant therapy followed by surgical resection improves the clinical outcome for patients with borderline resectable pancreatic cancer with radiologic artery involvement (BRPC-A). METHODS:We reviewed 143 BRPC-A patients from among 330 pancreatic cancer patients, including 111 potent...

journal_title：Pancreas

authors： Hirono S,Kawai M,Okada KI,Miyazawa M,Shimizu A,Kitahata Y,Ueno M,Yamaue H

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:Laparoscopic techniques have been slow to establish a role in pancreatic surgery. Worldwide, laparoscopic left pancreatectomy (LLP) is gaining in popularity; however, there remains little published data from the United Kingdom.We aimed to evaluate the results of LLP performed in a single UK pancreatic unit. ...

journal_title：Pancreas

authors： Mowbray NG,Al-Sarira A,Al-Sarireh B

更新日期：2016-09-01 00:00:00

abstract：:beta-1,4-Galactosyltransferase (GalTase) is the glycosyltransferase in the Golgi apparatus that transfers galactose from UDP-galactose to terminal N-acetylglucosamine residues in glycoconjugates with formation of a beta-1,4 linkage. Neoplasms undergo various changes in the carbohydrate moieties of their glycoconjugate...

journal_title：Pancreas

authors： Yamamoto K,Kawakami H,Sugiyama M,Atomi Y,Hirano H

更新日期：1999-08-01 00:00:00

abstract：:Computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) are sophisticated modalities typically used in the second-line diagnosis following routine clinical practice. Among them, CT is regarded as the standard imaging in diagnosing pancreatic cancer at present in Japan due to ...

journal_title：Pancreas

authors： Saisho H,Yamaguchi T

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVES:There have been various studies of exocrine pancreatic function after acute pancreatitis, but few have examined the relationship between this function and the etiology of the pancreatitis. The aim of this work was to study pancreatic function in patients who had had acute alcoholic or acute biliary pancreati...

journal_title：Pancreas

authors： Migliori M,Pezzilli R,Tomassetti P,Gullo L

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:Emphysematous pancreatitis is characterized by the presence of intraparenchymal pancreatic air in the setting of necrotizing pancreatitis. Mortality and morbidity rates approach approximately 40% and 100%, respectively. Traditionally, emphysematous pancreatitis was an indication for surgical intervention. The...

journal_title：Pancreas

authors： Kvinlaug K,Kriegler S,Moser M

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVES:Survival improvement for pancreatic cancer has not been observed in the last 4 decades. We report the most up-to-date population-based relative survival (RS) estimates and recent trends in Germany and the United States. METHODS:Data for patients diagnosed in 1997 to 2010 and followed up to 2010 were drawn f...

journal_title：Pancreas

authors： Sirri E,Castro FA,Kieschke J,Jansen L,Emrich K,Gondos A,Holleczek B,Katalinic A,Urbschat I,Vohmann C,Brenner H

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:Image-guided radiation therapy allows precise tumor targeting using real-time tracking of radiopaque fiducial markers. To enable appropriate tracking, it is recommended to place fiducials with "ideal fiducial geometry" (IFG). Our objectives were to determine the proportion of patients in whom IFG can be achie...

journal_title：Pancreas

authors： Majumder S,Berzin TM,Mahadevan A,Pawa R,Ellsmere J,Sepe PS,Larosa SA,Pleskow DK,Chuttani R,Sawhney MS

更新日期：2013-05-01 00:00:00

abstract：:Abdominal and/or back pain is one of the most common symptoms in patients with pancreatic cancer. However, the cause of the pain and the clinicopathologic features of patients with pain have not been fully elucidated. We retrospectively determined the factors related to preoperative abdominal and/or back pain in 95 pa...

journal_title：Pancreas

authors： Okusaka T,Okada S,Ueno H,Ikeda M,Shimada K,Yamamoto J,Kosuge T,Yamasaki S,Fukushima N,Sakamoto M

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVES:A selective therapy for pancreatitis is total pancreatectomy and islet autotransplantation. Outcomes and geographical variability of patients who had total pancreatectomy (TP) alone or total pancreatectomy with islet autotransplantation (TPIAT) were assessed. METHODS:Data were obtained from the Healthcare C...

journal_title：Pancreas

authors： Lara LF,Bellin MD,Ugbarugba E,Nathan JD,Witkowski P,Wijkstrom M,Steel JL,Smith KD,Singh VK,Schwarzenberg SJ,Pruett TL,Naziruddin B,Long-Simpson L,Kirchner VA,Gardner TB,Freeman ML,Dunn TB,Chinnakotla S,Beilman GJ,Ad

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to compare the perioperative clinical characteristics between patients with distal cholangiocarcinoma (DCC) and pancreatic head carcinoma (PHC) with biliary obstruction. METHODS:This study included patients who underwent pancreatoduodenectomy and were diagnosed with DCC (n = 85) or...

journal_title：Pancreas

authors： Yokoyama Y,Ebata T,Igami T,Sugawara G,Mizuno T,Yamaguchi J,Nagino M

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVES:Regeneration of the pancreas is initiated by the tubular complexes that consist of a cluster of epithelia surrounded by the mesenchymal cells. They have the potential to become pancreatic lobes, but their growth stops before the complete regeneration of the organ. To elucidate the possibility that we could p...

journal_title：Pancreas

authors： Kitamura T,Asanuma N,Inaba M,Otsuki M,Kasayama S,Kouhara H,Kawase I

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVES:Hypertriglyceridemia-induced pancreatitis is an important cause of acute pancreatitis (AP) in children, which lacks established guidelines. The aim of this study was to review management approaches at a single pediatric center. METHODS:This retrospective study included all inpatients younger than 21 years w...

journal_title：Pancreas

authors： Ippisch HM,Alfaro-Cruz L,Fei L,Zou Y,Thompson T,Abu-El-Haija M

更新日期：2020-03-01 00:00:00

abstract：:The effect on endogenous beta-endorphins of a new synthetic protease inhibitor was studied in acute pancreatitis. Pancreatitis was induced by the injection of autologous bile mixed with trypsin into the main pancreatic duct after ligation of the accessory duct. Plasma beta-endorphin concentrations and cardiovascular f...

journal_title：Pancreas

authors： Satake K,Hiura A,Ha SS,Nishiwaki H,Umeyama K

更新日期：1991-07-01 00:00:00

abstract：:This study was performed to assess the effects of misoprostol, a synthetic prostaglandin E1 analog, on cerulein-induced pancreatitis. Per group of 10 each, male Wistar rats received either cerulein (2.5 micrograms/kg/h subcutaneously), cerulein and misoprostol (500 micrograms/kg intraperitoneally at 0 and 4 h), or sal...

journal_title：Pancreas

authors： Buscail L,Bussenot I,Bouisson M,Sénégas-Balas F,Bertrand C,Balas D,Vaysse N,Ribet A

更新日期：1990-03-01 00:00:00

abstract：:Radical pancreaticoduodenectomy was performed for cancer of the head of the pancreas in a 65-year-old male patient with congenital celiac occlusion. Preoperative angiography revealed that the arterial flow to the liver, spleen, and stomach was supplied via the pancreaticoduodenal arcade and that the dorsal pancreatic ...

journal_title：Pancreas

authors： Manabe T,Baba N,Setoyama H,Ohshio G,Tobe T

更新日期：1991-05-01 00:00:00

abstract：OBJECTIVES:Pancreatic carcinoma etiology and molecular pathogenesis is weakly understood. According to the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, an association of functional polymorphisms in oxidative stress-modifying genes superoxide dismutase...

journal_title：Pancreas

authors： Mohelnikova-Duchonova B,Marsakova L,Vrana D,Holcatova I,Ryska M,Smerhovsky Z,Slamova A,Schejbalova M,Soucek P

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to determine if there had been any change in the number of solid-pseudopapillary neoplasm (SPN) cases detected and their evaluation or management over time. METHODS:A systematic review of SPN was performed of all articles published in English in PubMed and Scopus. RESULTS:A total of...

journal_title：Pancreas

authors： Law JK,Ahmed A,Singh VK,Akshintala VS,Olson MT,Raman SP,Ali SZ,Fishman EK,Kamel I,Canto MI,Dal Molin M,Moran RA,Khashab MA,Ahuja N,Goggins M,Hruban RH,Wolfgang CL,Lennon AM

更新日期：2014-04-01 00:00:00