Abstract:
:Although ethanol abuse is the major etiologic factor in the development of acute and chronic pancreatitis, the mechanisms of ethanol effects to cause pancreatitis are poorly understood. The major reason for the lack of progress is the relative lack of animal models that reproduce the deleterious effects of ethanol on the pancreas that are observed in human disease. We propose that the effect of ethanol on the pancreas is due to its ability to sensitize animals and humans to the potentially injurious effects of other stimuli. We have developed models of ethanol-induced acute and chronic pancreatitis in rats as well as pancreatic acinar cells in primary culture demonstrating that ethanol sensitizes the pancreas to the inflammatory, cell death, and fibrosing responses caused by cholecystokinin (CCK). Our results indicate that the ethanol-sensitized inflammatory response is the key or trigger event for the development of the other pathologic responses in both acute and chronic pancreatitis, such as cell death, intracellular digestive enzyme activation, and fibrosis. These findings suggest that experimental strategies designed to reveal the modulating effects of ethanol on the mechanisms underlying the inflammatory, cell death, and fibrosing responses stimulated by CCK will provide the key information needed to understand how ethanol abuse causes pancreatitis.
journal_name
Pancreasjournal_title
Pancreasauthors
Pandol SJ,Gukovsky I,Satoh A,Lugea A,Gukovskaya ASdoi
10.1097/00006676-200311000-00004subject
Has Abstractpub_date
2003-11-01 00:00:00pages
297-300issue
4eissn
0885-3177issn
1536-4828pii
00006676-200311000-00004journal_volume
27pub_type
杂志文章相关文献
PANCREAS文献大全abstract::The surgical treatment of pancreatic cancer (PDAC) has seen sweeping changes during the past 5 decades. Up to the middle of the 20th century resection rates were below 5%, but the numbers of curative resections for PDAC are now continuously increasing due to improved neoadjuvant treatment concepts as well as progress ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001634
更新日期:2020-09-01 00:00:00
abstract::We evaluated the diagnostic significance of the K-ras point mutations at codon 12 in duodenal lavage fluid (DLF) compared with pure pancreatic juice (PPJ). The DLF was easily and safely collected by injecting distilled water into the duodenum and then aspirating through the working channel of the endoscope during endo...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199903000-00004
更新日期:1999-03-01 00:00:00
abstract::Sarcophytol A (SaA), a cembrane-type diterpene isolated from the marine soft coral Sarcophyton glaucum showed anticancer and cancer preventive effects in two different experiments. Growth of transplanted human pancreatic cancer cells (MIA paca-2, 1 x 10(7)) in nude mice (BALB/C 4W female) (Experiment 1) and pancreatic...
journal_title:Pancreas
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract:OBJECTIVES:To investigate embryology of complete and incomplete pancreas divisum (PD). METHODS:We analyzed anatomy of the pancreatic duct system in 44 cases of complete PD and 41 cases of incomplete PD. Under the concept of branch fusion between the ventral and dorsal pancreatic ducts, incomplete PD was divided into 3...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000240607.49183.7e
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:In recent years a type of chronic pancreatitis has been described that is clearly distinct from alcoholic chronic pancreatitis. It is characterized by its special pathology, immunologic features, clinical presentation, and steroid responsiveness. Because of its histologic hallmarks, i.e., ductal and peridu...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/00006676-200307000-00002
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVES:This study aimed to evaluate magnetic resonance imaging findings of autoimmune pancreatitis (AIP) and to find radiological patterns that could differentiate type 1 and type 2 AIP. METHODS:Eighty-four patients with diagnosis of AIP were enrolled. Image analysis included pancreatic signal intensity abnormalit...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001142
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVES:In patients with pancreaticobiliary maljunction (PBM), reflux of pancreatic juice to the bile duct may contribute to carcinogenesis of the biliary tract. This study aimed to investigate the pancreatographic findings in patients with PBM and the relationship to their clinical findings in view of pancreatic ju...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000153336.50482.59
更新日期:2005-04-01 00:00:00
abstract::Utilizing scanning electron microscopy and isolated, vascularly perfused rat pancreas, we studied the angioarchitecture and the effect of the insulinotropic hormone, gastric inhibitory polypeptide (GIP), on cholecystokinin (CCK)-stimulated exocrine secretion. We tried to correlate the microcirculation with the physiol...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198701000-00016
更新日期:1987-01-01 00:00:00
abstract::The in vitro incorporation of [35S]cysteine into lipase, colipase, amylase, procarboxypeptidase A and B, and the serine proteases and total proteins was studied in pancreatic lobules isolated from normal and diabetic rats with or without insulin treatment. The incorporation of [35S]cysteine into total proteins was 65%...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199003000-00003
更新日期:1990-03-01 00:00:00
abstract:OBJECTIVES:Endovascular techniques can now access the arterial blood supply of the pancreas in humans to enable therapeutics to reach the gland in high concentrations while concurrently avoiding issues related to non-targeted delivery. However, there is no way to replicate this in small animals. In a rat model, we ther...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001100
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVES:Clinical and morphological criteria are not precise enough to diagnose early chronic pancreatitis (CP). We investigated if short endoscopic pancreas function testing as a part of routine upper endoscopy could improve clinical diagnostics. METHODS:Patients with suspected CP underwent modified secretin-stimul...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3182847a86
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVES:Cigarette smoking is an independent risk factor for chronic pancreatitis. We conducted a systematic review of the literature assessing whether cigarette smoking is a risk factor for acute pancreatitis (AP) and recurrent AP (RAP). METHODS:MEDLINE, PubMed, Embase, and Cochrane Database of Systematic Reviews w...
journal_title:Pancreas
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MPA.0000000000000301
更新日期:2015-05-01 00:00:00
abstract::The aim of this study was to document the natural history of chronic hereditary pancreatitis and to compare its evolution to that of chronic alcoholic pancreatitis. Twelve subjects with chronic hereditary pancreatitis were followed up for a mean duration of 15.8 years (range, 1-23) and compared to subjects with chroni...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199810000-00007
更新日期:1998-10-01 00:00:00
abstract::We performed molecular biological studies as well as immunohistochemical analysis of three cases of giant cell carcinoma of the pancreas. Histologically, one case was a pleomorphic giant cell carcinoma consisting of pleomorphic giant/ small cells and spindle cells, one an osteoclast-like giant cell tumor composed of o...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199904000-00013
更新日期:1999-04-01 00:00:00
abstract::Dithizone (DTZ) is a selective stain for pancreatic islets which facilitates their identification, being of special interest in human islet isolation assessment. Nevertheless, there are few studies concerning its potential toxic effects on islet function. In our study, we have evaluated the effects of DTZ (dissolved i...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199403000-00003
更新日期:1994-03-01 00:00:00
abstract::Neuroendocrine tumors (NETs) arise in most organs of the body and share many common pathologic features. However, a variety of different organ-specific systems have been developed for nomenclature, grading, and staging of NETs, causing much confusion. This review examines issues in the pathologic assessment of NETs th...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/MPA.0b013e3181ec124e
更新日期:2010-08-01 00:00:00
abstract::Relative adrenal insufficiency is common in patients with severe sepsis and septic shock. We describe three patients with severe acute pancreatitis who developed signs suggestive of adrenal insufficiency during the early phase of the disease. Clinical features and possible causes of adrenal insufficiency are discussed...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200310000-00009
更新日期:2003-10-01 00:00:00
abstract::250 syngeneic islets were implanted either beneath the kidney capsule or into the liver of diabetic LEW 1.A rats to investigate the functional response of a limited mass of beta-cells to long-term hyperglycemia. The number of islets, per se, was expected to be insufficient to reverse the hyperglycemia. All animals wer...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199403000-00008
更新日期:1994-03-01 00:00:00
abstract:OBJECTIVES:C-terminal tensin-like gene (CTEN, also known as TNS4) localizes to focal adhesions and is reported to function as an oncogene in colonic, breast, lung, and gastric cancers. Its role in pancreatic cancer is unknown and was thus investigated in this study. METHODS:C-terminal tensinlike gene expression was ev...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3182557ceb
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:The postoperative morbidity after pancreatectomy remains high. The role of somatostatin and its analogs in reducing complications after pancreatic resection is controversial. The aim of the study was to evaluate the ability of somatostatin to influence pancreatic cell's function with consequence the decrease...
journal_title:Pancreas
pub_type: 杂志文章,随机对照试验
doi:10.1097/MPA.0b013e3182557c24
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:We previously reported the finding that pancreatic stellate cells (PSCs) have a phagocytic function. The aim of the present study was to investigate whether engulfment of gram-positive bacteria by PSCs plays any role in the pathogenesis of pancreatic fibrosis. METHODS:Rat PSCs were cultured with lipoteichoi...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181d7ace1
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVES:Inducible nitric oxide synthase (iNOS) activity is increased in experimental acute pancreatitis. The aim of this study was to evaluate treatment with the selective iNOS inhibitors AR-C (AR-C102222AA) and L-NIL (L-N6-(1-iminoethyl)-lysine) in experimental acute pancreatitis. METHODS:Acute pancreatitis was in...
journal_title:Pancreas
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::The last 5 years have seen a dramatic increased interest in the field of exosome biology. Although much is unknown about the role of exosomes in human health and disease, disparate scientific disciplines are recognizing the highly conserved role that exosomes play in fundamental biological processes. Recently, there h...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/MPA.0000000000001203
更新日期:2019-01-01 00:00:00
abstract::The 3 International Conference for Cancer Metabolism and Therapy was successfully held at the South Hospital Conference Center of Shanghai First People's Hospital, nearly 200 international experts from the field of cancer metabolism and therapy and about two thousand local scientists attended the conference. The confe...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001482
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:Given the lack of consensus on surveillance guidelines after pancreatic neuroendocrine tumor (PanNET) resection, we assessed outcomes in a large cohort of patients with nonmetastatic, surgically resected PanNETs. METHODS:Data of patients with PanNETs resected between 1990 and 2017 were retrospectively collec...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001477
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to evaluate the efficacy of a pancreatic stent regarding the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis after aspiration of pure pancreatic juice in patients with intraductal papillary mucinous neoplasms. METHODS:A retrospective stud...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181bb8da1
更新日期:2010-04-01 00:00:00
abstract:INTRODUCTION:Between April 1992 and December 2000, 167 patients with pancreatic carcinoma were evaluated and treated in our department. One hundred eight patients (64.7%) with pancreatic carcinoma underwent pancreatectomy. Of these patients, 94 had histologically proven ductal adenocarcinoma. The overall postoperative ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200304000-00007
更新日期:2003-04-01 00:00:00
abstract::Type I diabetes is characterized by destruction of insulin-producing beta-islet cells in the pancreas resulting in hyperglycemia and associated morbidity. The successful treatment of diabetes by transplanted islets has resulted in renewed efforts to identify methods to augment islet availability. One approach is to id...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200407000-00064
更新日期:2004-07-01 00:00:00
abstract::The Second International Islet Transplantation Symposium was held at UCLA in January, 1993. The symposium, sponsored by the Jerry's Foundation for Diabetes Research was focused on the issues in clinical islet transplantation. The leaders from each of the clinically active programs around the world were invited to disc...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/00006676-199405000-00001
更新日期:1994-05-01 00:00:00
abstract:OBJECTIVES:The authors investigated if timing of medical treatment is associated with the analgesic effect of pregabalin or placebo in patients with chronic pancreatitis (CP). METHODS:Sixty-four patients received pregabalin (150-300 mg twice a day) or matching placebo for 3 consecutive weeks. Responders to treatment w...
journal_title:Pancreas
pub_type: 杂志文章,随机对照试验
doi:10.1097/MPA.0000000000000475
更新日期:2016-03-01 00:00:00