Abstract:
OBJECTIVES:An impaired host immunity might concur in determining the dismal prognosis of patients with pancreatic cancer (PC). Our aim was to ascertain whether the immunophenotype pattern of blood lymphocytes in PC correlates with tumor stage, grade, or survival. METHODS:We studied 115 patients with PC, 44 with chronic pancreatitis (CP), 23 with tumors of the pancreatico-biliary tract, and 34 healthy controls (CS). Survival data were available for 77 patients with PC. Lymphocyte subsets were determined by fluorescent activated cell sorter (FACS) analysis. RESULTS:In patients with PC, total lymphocyte counts were lower than in CP or CS, and CD8 lymphocyte subset levels were higher with respect to CS. Lower circulating lymphocytes were found in advanced PC stages (IIB-IV; chi2 = 11.55, P < 0.05) compared with stages 0 to IIA. Cox regression analysis, made considering total lymphocyte counts and tumor stage as covariates, was found to be significant for both tumor stage (P < 0.001) and total lymphocyte counts (P < 0.05). CONCLUSIONS:The reduction of total lymphocytes in blood is the main immunologic change in advanced PC. The survival of these patients depends mainly on tumor stage, but it is also affected by the number of circulating lymphocytes, suggesting that the immune system plays an important role in pancreatic adenocarcinoma immunosurveillance and immunoediting.
journal_name
Pancreasjournal_title
Pancreasauthors
Fogar P,Sperti C,Basso D,Sanzari MC,Greco E,Davoli C,Navaglia F,Zambon CF,Pasquali C,Venza E,Pedrazzoli S,Plebani Mdoi
10.1097/01.mpa.0000188305.90290.50subject
Has Abstractpub_date
2006-01-01 00:00:00pages
22-8issue
1eissn
0885-3177issn
1536-4828pii
00006676-200601000-00004journal_volume
32pub_type
杂志文章相关文献
PANCREAS文献大全abstract:OBJECTIVES:Autoimmune pancreatitis (AIP) responds well to steroid therapy but frequently relapses after discontinuing the steroid. It is difficult to know which cases are most likely to relapse. The aim of this study was to investigate the relation between the rate of decrease in serum IgG4 level after initial steroid ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000633
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVES:Cyclooxygenase 2 (COX-2) and vascular endothelial growth factor (VEGF), often coexpressed in cancer, are associated with poor prognosis. However, results from pancreatic cancer trials of their inhibitors were disappointing. This study delineated the role of COX-2 and nonsteroidal anti-inflammatory drugs in a...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181c6575d
更新日期:2010-07-01 00:00:00
abstract::The effects of a specific cholecystokinin (CCK) receptor antagonist (L364,718) and a gastrin receptor antagonist (L365,260) on gastrin-releasing peptide-10 (GRP-10)-stimulated pancreatic secretion were investigated in the anesthetized rat. GRP-10 stimulated pancreatic exocrine secretion in a dose-dependent manner. A d...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199203000-00013
更新日期:1992-01-01 00:00:00
abstract:INTRODUCTION:Adenocarcinoma of the pancreas remains one of the most difficult malignancies to treat. Its incidence has steadily increased over the past four decades, and its prognosis is still dismal. AIM To assess tumor control and the palliative benefit of 5-fluorouracil (5-FU), cisplatin (CDDP), and radiotherapy in ...
journal_title:Pancreas
pub_type: 临床试验,杂志文章
doi:10.1097/00006676-200211000-00007
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVE:Bax-interacting factor 1 (Bif-1) protein plays a critical role in apoptosis, mitochondrial morphogenesis, and autophagy, and its loss promotes tumorigenesis. The role of Bif-1 in pancreatic cancer has not been studied. METHODS:We determined Bif-1 expression in 82 human pancreatic ductal adenocarcinomas (PDCs...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318205eb03
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVES:Endovascular techniques can now access the arterial blood supply of the pancreas in humans to enable therapeutics to reach the gland in high concentrations while concurrently avoiding issues related to non-targeted delivery. However, there is no way to replicate this in small animals. In a rat model, we ther...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001100
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVES:This case-control study was performed to evaluate the association between a specific caspase-9 polymorphism as well as the genetic polymorphism -31G/C located in the cycle-dependent elements/cell cycle homology regions repressor element of the human survivin promoter and the risk of pancreatic cancer. METHO...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181d705d4
更新日期:2010-10-01 00:00:00
abstract::Several reports have described a loss of endogenous antioxidants and molecular oxidative damage during acute pancreatitis. Since hyaluronic acid and chondroitin-4-sulfate possess antioxidant properties, the effect of the administration of these glycosaminoglycans in a cerulein-induced acute pancreatitis in rats was in...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200403000-00019
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVES:Exocrine pancreatic secretion contributes to limit pathogenic bacteria-associated diarrhea. Bovine colostrum, used in the treatment of diarrhea, reduces symptoms originating from gut pathogenic bacteria overgrowth. We hypothesized that bovine colostrum may stimulate the exocrine pancreatic secretion. METHOD...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318192eb83
更新日期:2009-04-01 00:00:00
abstract::The accuracies of assays of serum CA 19-9 and elastase 1 in the diagnosis of pancreatic carcinoma were investigated by the cutoff method and discriminant analysis of data on 98 patients with pancreatitis, 65 patients with pancreatic carcinoma, 107 patients with benign diseases of other organs, and 108 patients with ca...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198908000-00002
更新日期:1989-01-01 00:00:00
abstract::Lipid peroxidation, which may be involved in the pathogenesis of acute pancreatitis, is usually assessed in vitro or indirectly using antioxidants or free radical scavengers. We assessed lipid peroxidation in an in vivo model by measuring ethane exhalation in two models of acute pancreatitis. Edematous acute pancreati...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199705000-00004
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:Pancreatic ductal adenocarcinoma (PDAC) is the third most common cause of cancer death in the United States. Improved characterized models of PDAC are needed for drug screening. METHODS:We grew 4 established pancreatic cancer cell lines in hanging drop cultures to produce spheroids. We also grew organoids fr...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001390
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVES:Pregnane X receptor (PXR) has been involved in human malignancy, either by directly affecting carcinogenesis or by inducing drug-drug interactions and chemotherapy resistance. The present study aimed to assess the clinical significance of PXR in pancreatic adenocarcinoma. METHODS:Pregnane X receptor and its...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000405
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVES:Pancreatic ductal adenocarcinoma remains as a chemoresistant disease with the poorest prognosis. Gemcitabine has been the standard treatment during the last decade. Erlotinib, a tyrosine kinase inhibitor, in combination with gemcitabine produces a small increase in survival. However, these results remain ins...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000452
更新日期:2016-02-01 00:00:00
abstract::Monoclonal antibodies (McAbs) to pancreatic cancer were developed by fusing SP2/0 cells and splenocytes from Balb/c mice immunized with CH-2 cells. The specific binding rates of McAb P1 and P2 were 40.1 and 43.8%, respectively, shown by binding radioreactivity assay in vitro, which were in sharp contrast with those of...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199305000-00002
更新日期:1993-05-01 00:00:00
abstract::Pancreatic insufficiency was induced in rats by a single injection of 50 microliter oleic acid into the pancreatic duct over a period of 3 min. Exocrine tissue was destroyed within 3-6 days, and after 6 weeks the remaining pancreas equaled 2.7% of the original organ. The rats showed retardation of body weight in spite...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198601000-00007
更新日期:1986-01-01 00:00:00
abstract:INTRODUCTION:Severe acute pancreatitis (SAP) remains a serious disease state difficult to manage. Laparoscopic surgery represents a relatively new solution to this problem. This study was aimed to investigate the feasibility of laparoscopic treatment of SAP and the selection of laparoscopic procedures in various stages...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200310000-00019
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVES:This study aimed to evaluate the usefulness of the 48-hour fasting test and insulin surrogates followed by a glucagon stimulatory test (GST) for the diagnosis of insulinoma. METHODS:Thirty-five patients with suspected insulinoma who underwent 48-hour fasting test and GST were retrospectively included in our...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000772
更新日期:2017-04-01 00:00:00
abstract:INTRODUCTION:Microcirculatory disorders, in particular increased capillary permeability (CapPerm), contribute to the multiple organ dysfunction syndrome in severe acute pancreatitis (AP). Endothelin receptor antagonists (ET-RA) have been shown to stabilize capillary leakage and improve organ function in AP. AIM:To fin...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200208000-00019
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to assess prevailing treatment of pancreatolithiasis in Japan. METHODS:We surveyed clinical data from 1834 patients (1479 men and 355 women) at 125 hospitals. RESULTS:Extracorporeal shock-wave lithotripsy (ESWL) was performed alone in 103 patients (5.6%), ESWL plus an endoscopic p...
journal_title:Pancreas
pub_type: 杂志文章,多中心研究
doi:10.1097/MPA.0000000000001071
更新日期:2018-07-01 00:00:00
abstract::To assess the role of stapling devices and routine gastroenterostomy in palliative bypass surgery, the hospital records of 150 consecutive patients with unresectable, histologically proven pancreatic adenocarcinoma requiring palliative bypass procedure were reviewed. During recent years staplers have gained increasing...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198703000-00004
更新日期:1987-01-01 00:00:00
abstract::A 66-year-old patient had been admitted four times for recurrent episodes of acute pancreatitis. At each time, elevated serum calcium levels, between 13.5-14.5 mg/dl, were found. Surgical drainage of necrotic pancreatic tissue had to be done on one occasion. Extensive investigations failed to disclose any conventional...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198906000-00017
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVES:Secretin stimulation testing (SST) is used to evaluate patients with hypergastrinemia in the diagnosis of Zollinger-Ellison syndrome. Case series have documented false-positive SST in patients with achlorhydria. This study reviews our experience with SST in hypochlorhydric and achlorhydric patients. METHODS...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3182847b2e
更新日期:2013-08-01 00:00:00
abstract:METHODOLOGY:The authors performed the reverse transcription-polymerase chain reaction (RT-PCR) in 17 cases of pancreatic ductal cell carcinoma (PDC) and five cases of normal pancreatic tissues to determine the expression of tumor necrosis factor -related apoptosis-inducing factor (TRAIL) and its five receptors in PDC. ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200110000-00005
更新日期:2001-10-01 00:00:00
abstract:INTRODUCTION:Invasion and metastasis of pancreatic cancer (PC) require cell motility and adhesion, which depend on the activity of cytoskeleton. A cytoskeletal component indispensable for these processes is myosin II, the cytoplasmic analogue of smooth and skeletal muscle myosin. AIMS AND METHODOLOGY:Because the activ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200201000-00005
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVES:We aimed to determine the difference in endoscopic ultrasonography (EUS) images between portal vein (PV) and arterial invasion of pancreatic cancer and to develop criteria for arterial involvement. METHODS:We reviewed EUS data of consecutive patients who underwent distal pancreatectomy from December 2010 to...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001523
更新日期:2020-04-01 00:00:00
abstract:INTRODUCTION AND AIMS:It has been proposed that distinct tertiary structures of the C-terminus of CCK-8 and CCK-58 result in differences in stimulation of pancreatic amylase secretion. Binding of CCK-8 and CCK-58 to CCK-A and CCK-B receptors and stability to enzymatic digestion were used as independent probes for terti...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200210000-00021
更新日期:2002-10-01 00:00:00
abstract::The association between acute pancreatitis and severe hypertriglyceridemia has long been recognized. We report two cases of severe primary hypertriglyceridemia (types 1 and V) with recurrent acute pancreatitis. In both patients, observance of appropriate diet and drug therapy was insufficient. Recurrent episodes of pa...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199607000-00013
更新日期:1996-07-01 00:00:00
abstract::Pancreatic acinar cells within the islets of Langerhans in human pancreas were investigated both histopathologically and electron microscopically. Acinar cells inside the islets of Langerhans were observed in all 50 adult cases investigated. Between such acinar cells and endocrine tissues, no reticular fiber was obser...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199409000-00004
更新日期:1994-09-01 00:00:00
abstract::In this study, we performed a detailed analysis of the immunoreactive (IR) patterns and tissue distribution of vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY), and gastrin-releasing peptide (GRP) in the feline pancreas by means of immunohistochemical and radioimmunological techniques. Immunoreactivity fo...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199205000-00016
更新日期:1992-01-01 00:00:00