Abstract:
:We demonstrated dynamic aspects of granulocyte activation in rat severe acute pancreatitis, which was induced by cerulein and aggravated following lipopolysaccharide (LPS) injection. Pancreatitis induced by cerulein increased intracellular elastase activity of granulocytes in the blood. However, significant systemic cytokinemia was not provoked under such conditions. After induction of severe pancreatitis by LPS, intracellular elastase activity of circulating granulocytes decreased markedly and immediately. This decrease occurred simultaneous to induction of systemic hypercytokinemia and granulocyte migration into the lung. Overall results imply that: (1) circulating granulocytes are activated by induction of mild pancreatitis; (2) activation of granulocytes is mediated by factors other than systemic cytokinemia, such as locally produced cytokines; (3) those priming granulocytes immediately and significantly migrate from the circulation into the extravascular space by induction of endotoxemia; and (4) migration of granulocytes, in turn, may be mediated by systemic cytokinemia.
journal_name
Pancreasjournal_title
Pancreasauthors
Kimura Y,Hirota M,Okabe A,Inoue K,Kuwata K,Ohmuraya M,Ogawa Mdoi
10.1097/00006676-200308000-00004subject
Has Abstractpub_date
2003-08-01 00:00:00pages
127-32issue
2eissn
0885-3177issn
1536-4828pii
00006676-200308000-00004journal_volume
27pub_type
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