Distributional patterns of phospholipase C isozymes in rat pancreas.

abstract：BACKGROUND:Psychological distress is highly prevalent in patients with pancreatic cancer (PC), yet little is known about the pathophysiology underlying the relationship between these 2 diseases. Our aim was to systematically review the evidence examining the pathophysiological mechanisms of the association between PC a...

journal_title：Pancreas

authors： Bettison TM,Nahm CB,Gill AJ,Mittal A,Malhi GS,Samra JS

更新日期：2018-04-01 00:00:00

abstract：:The accuracies of assays of serum CA 19-9 and elastase 1 in the diagnosis of pancreatic carcinoma were investigated by the cutoff method and discriminant analysis of data on 98 patients with pancreatitis, 65 patients with pancreatic carcinoma, 107 patients with benign diseases of other organs, and 108 patients with ca...

journal_title：Pancreas

authors： Yamamura H,Tatsuta M,Ito M,Iishi H,Noguchi S,Okuda S,Yoshida M

更新日期：1989-01-01 00:00:00

abstract：:Cultivation and preservation of human pancreatic ductal cells have remained a challenge. With a defined culture medium and refinement of culturing techniques, we have been able to maintain human pancreatic ductal cells without any genetic manipulation in culture for more than 16 months. Freshly isolated ductal fragmen...

journal_title：Pancreas

authors： Ulrich AB,Schmied BM,Matsuzaki H,El-Metwally T,Moyer MP,Ricordi C,Adrian TE,Batra SK,Pour PM

更新日期：2000-11-01 00:00:00

abstract：:Fetal and neonatal pancreatic islets have lower insulin secretory responses compared with adult islets. In culture conditions and after treatment with mammosomatotropic hormones, neonatal islets undergo maturation of the secretory machinery that might involve regulation of cell-cell contacts within the islet. This stu...

journal_title：Pancreas

authors： Collares-Buzato CB,Leite AR,Boschero AC

更新日期：2001-08-01 00:00:00

abstract：OBJECTIVE:We conducted this study to ascertain whether chronic inflammation secondary to chronic pancreatitis (CP) has any association with myocardial infarction(MI). METHODS:Data were collected from a commercial database (Explorys, Inc, IBM Watson, Ohio). Adults with the diagnosis of "chronic pancreatitis," based on ...

journal_title：Pancreas

authors： Khan D,Abureesh M,Alkhayyat M,Sadiq W,Alshami M,Munir AB,Karam B,Deeb L,Lafferty J

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVES:Autoimmune pancreatitis (AIP) responds well to steroid therapy but frequently relapses after discontinuing the steroid. It is difficult to know which cases are most likely to relapse. The aim of this study was to investigate the relation between the rate of decrease in serum IgG4 level after initial steroid ...

journal_title：Pancreas

authors： Shimizu K,Tahara J,Takayama Y,Akao J,Ajihara T,Nagao K,Shiratori K,Tokushige K

更新日期：2016-10-01 00:00:00

abstract：:Platelet-activating factor (PAF) may play a critical and primary role in the pathogenesis of acute pancreatitis and pancreatitis-associated distant organ injury. The present study evaluated the effect of a PAF antagonist, lexipafant (an (S)-4-methyl-2[methyl-imidazo[4,5-c]pyridin-1-ylmethyl)-benzene sulphonyl]-amino]p...

journal_title：Pancreas

authors： Andersson R,Wang X,Sun Z,Deng X,Soltesz V,Ihse I

更新日期：1998-08-01 00:00:00

abstract：:The influence of pancreatic secretions on growth and brush-border enzyme activity, throughout the entire small intestine, was examined in the rat. Pancreatic secretions were excluded from the gut lumen by stapling the pancreatic ducts, without interruption of bile flow. The entire small intestine was studied as four s...

journal_title：Pancreas

authors： Hauer-Jensen M,Christensen K,Wilson HD,Schedl HP

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVES:Korean red ginseng (KRG) is a representative herbal remedy in Korea. We examined the effects of KRG treatment on superoxide dismutase inhibitor-induced experimental pancreatitis. METHODS:Sprague-Dawley rats and KRG from the roots of a 6-year-old fresh Panax ginseng C. A. Meyer plant were used in this study....

journal_title：Pancreas

authors： Joo KR,Shin HP,Cha JM,Nam S,Huh Y

更新日期：2009-08-01 00:00:00

abstract：:Metastatic pancreatic cancer (PC) is an aggressive malignancy, with most patients deriving benefit only from first-line chemotherapy. Increasingly, the recommended treatment for those with a germline mutation in a gene involved in homologous recombination repair is with a platinum drug followed by a poly (ADP-ribose) ...

journal_title：Pancreas

authors： Martino C,Pandya D,Lee R,Levy G,Lo T,Lobo S,Frank RC

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:Pancreatic anastomotic leakage remains a major troublesome complication after pancreaticoduodenectomy. Thus, various technical modifications regarding the pancreatic anastomosis after pancreaticoduodenectomy have been attempted to minimize anastomotic leakage. We have performed duct-to-mucosa pancreaticojeju...

journal_title：Pancreas

authors： Hayashibe A,Kameyama M

更新日期：2007-10-01 00:00:00

abstract：:A comparative study of antibacterial activity of pancreatic juice was conducted on six mammalian species. Pancreatic juice collections were conducted as acute (rabbit, guinea pig, rat) and chronic (pig, sheep, cattle) experiments, in the former before and after stimulation [cholecystokinin (CCK) and secretin] and in t...

journal_title：Pancreas

authors： Pierzynowski SG,Sharma P,Sobczyk J,Garwacki S,Barej W,Weström B

更新日期：1993-09-01 00:00:00

abstract：OBJECTIVES:Understanding the effect of lymph node metastasis (LNM) on prognosis in pancreatic neuroendocrine neoplasm is helpful for surgery and follow-up. In this study, we investigated the significance of LNM in well-differentiated pancreatic neuroendocrine tumors (PanNETs) according to the World Health Organization ...

journal_title：Pancreas

authors： Harimoto N,Hoshino K,Muranushi R,Hagiwara K,Yamanaka T,Ishii N,Tsukagoshi M,Igarashi T,Tanaka H,Watanabe A,Kubo N,Araki K,Hosouchi Y,Suzuki H,Arakawa K,Hirai K,Fukazawa T,Ikota H,Shirabe K

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVES:Pancreatic cancer is a serious disease worldwide for its high mortality. Gemcitabine has become the frontline option for the treatment of this disease since its approval. However, resistance to the drug has been on the rise in recent years. Searching for other chemotherapeutic agents therefore has attracted ...

journal_title：Pancreas

authors： Zhang M,Sun C,Shan X,Yang X,Li-Ling J,Deng Y

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVES:Sex-determining region Y (SRY) box 9 (SOX9) is an important transcription factor required for development and has been implicated in several types of cancer. Sex-determining region Y box 9 has never been linked to pancreatic ductal adenocarcinoma (PDAC) and intraductal papillary mucinous neoplasm (IPMN) of t...

journal_title：Pancreas

authors： Tanaka T,Kuroki T,Adachi T,Ono S,Hirabaru M,Soyama A,Kitasato A,Takatsuki M,Hayashi T,Eguchi S

更新日期：2013-04-01 00:00:00

abstract：:Adenocarcinoma of the pancreas is one of most catastrophic and least understood of cancers. Evidence from clinical studies indicates that the development of pancreas cancer progresses over many years before symptoms appear. Most people with pancreatic cancer die within six months of diagnosis. The lack of early diseas...

journal_title：Pancreas

authors： Hine RJ,Srivastava S,Milner JA,Ross SA

更新日期：2003-11-01 00:00:00

abstract：:Genistein is a plant isoflavonoid bearing potent tumor growth-regulating characteristics. This effect of genistein has been attributed partially to its tyrosine kinase-regulating properties, resulting in cell-cycle arrest and limited angiogenesis. Genistein has been used in chemotherapy-resistant cases of advanced leu...

journal_title：Pancreas

authors： Boros LG,Bassilian S,Lim S,Lee WN

更新日期：2001-01-01 00:00:00

abstract：:To investigate the heterogeneity of hematogenous metastases of pancreatic ductal carcinoma, we investigated carcinomatous spread in 130 autopsy cases. Hepatic metastases occurred most frequently, in 81 cases (62%), which may be explained by the fact that all veins draining the pancreas flow into the portal system. We ...

journal_title：Pancreas

authors： Kamisawa T,Isawa T,Koike M,Tsuruta K,Okamoto A

更新日期：1995-11-01 00:00:00

abstract：:The efficacy of medications to treat pancreatic diseases, even when proven effective by experimental studies, are difficult to prove by controlled clinical trials. In the treatment of acute pancreatitis, prophylactic antibiotics, somatostatin, protease inhibitors, and cholecystokinin (CCK)-receptor antagonists are adv...

journal_title：Pancreas

authors： Kitagawa M,Naruse S,Ishiguro H,Hayakawa T

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVES:Aggressive invasion and early metastases are characteristic features of pancreatic ductal adenocarcinoma (PDAC). More than 90% of patients have surgically nonresectable disease at presentation. Despite increasing knowledge of the genetics of this complex disease, systemic therapies, particularly gemcitabine,...

journal_title：Pancreas

authors： Steele CW,Oien KA,McKay CJ,Jamieson NB

更新日期：2011-11-01 00:00:00

abstract：:The prognosis of patients with alpha-fetoprotein (AFP)-producing pancreatic cancer is generally very poor. We, however, present a case of a 33-year-old man who survived AFP-producing pancreatic cancer and its metachronous liver metastasis. The patient had undergone a curative total pancreatectomy for AFP-producing pan...

journal_title：Pancreas

authors： Natsume T,Watanabe Y,Maruyama T,Tanaka H,Sunouchi K,Tohma T,Noju M,Muto Y,Tohnosu N,Uehara T,Shimizu S,Ochiai T,Nabeya Y

更新日期：2005-11-01 00:00:00

abstract：:Pancreatic duct bicarbonate secretion is mediated primarily by secretin-induced elevation of intracellular cyclic AMP, although little is known of the effects of other physiological regulators on pancreatic duct cyclic AMP metabolism. We investigated the effects of secretin and several other potential agonists on cycl...

journal_title：Pancreas

authors： de Ondarza J,Hootman SR

更新日期：1995-10-01 00:00:00

abstract：:ATM protein anticipates in the initiation of the DNA repair signal pathway and also mediates cell cycle arrest and repair. ATM deficiency predictably results in radiosensitivity, germ cell degeneration, chromosomal instability, immunodeficiency, and an extreme predisposition to tumors. Moreover, studies found that ATM...

journal_title：Pancreas

authors： Yu G,Zhu MH,Zhu Z,Ni CR,Zheng JM,Li FM

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVES:The aims of this study were to determine the prevalence of exocrine pancreatic insufficiency (EPI) and chronic pancreatitis (CP) in patients with chronic alcoholic liver disease and to analyze the possible associated factors. METHODS:This is an analytical observational study of cases and controls for a samp...

journal_title：Pancreas

authors： Aoufi Rabih S,García Agudo R,Legaz Huidobro ML,Ynfante Ferrús M,González Carro P,Pérez Roldán F,Ruiz Carrillo F,Tenías Burillo JM

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVES:During the past decade, numerous studies in both humans and animals have demonstrated that C-peptide, although not influencing blood sugar control, might play a role in preventing and potentially reversing some of the chronic complications of type 1 diabetes. The aim of this paper is to present an up-to-date...

journal_title：Pancreas

authors： Marques RG,Fontaine MJ,Rogers J

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVE:Beacon gene expression is elevated in the hypothalamus of the Israeli sand rat (Psammomys obesus), an animal that is used as a polygenic animal model of obesity and NIDDM. We performed studies aimed at investigating the expression of beacon mRNA and protein in pancreatic islets of the rat and the possible bea...

journal_title：Pancreas

authors： Nowak KW,Ruciński M,Kaczmarek P,Szkudelski T,Malendowicz LK

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVES:Secretin stimulation testing (SST) is used to evaluate patients with hypergastrinemia in the diagnosis of Zollinger-Ellison syndrome. Case series have documented false-positive SST in patients with achlorhydria. This study reviews our experience with SST in hypochlorhydric and achlorhydric patients. METHODS...

journal_title：Pancreas

authors： Shah P,Singh MH,Yang YX,Metz DC

更新日期：2013-08-01 00:00:00

abstract：:Pretreatment of rat pancreatic acini with phorbol 12-myristate, 13-acetate (PMA), a protein kinase C (PK-C) activator, caused the desensitization of carbamylcholine (CBC)-induced amylase release in a concentration- and time-dependent fashion. The less potent phorbol-12, 13-dibutyrate (PDBu) also provoked a desensitiza...

journal_title：Pancreas

authors： Blanchard LM,Paquette B,Larose L,Morisset J

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVES:This study aimed to develop target-specific binding agents for in vitro and in vivo imaging of human pancreatic cancer. METHODS:A monoclonal neutrophil gelatinase-associated lipocalin (NGAL)-specific antibody and a peptide specific for matrix metalloproteinase (MMP) were labeled with a near-infrared dye for...

journal_title：Pancreas

authors： Wang W,Lin J,Guha S,Tong Z,Cameron AG,Zhang F,Qiu X,Zou C,Gao X,Mawad ME,Ke S

更新日期：2011-07-01 00:00:00

abstract：:Human islets from an adult subject with nesidioblastosis were isolated and used to perform in vitro studies. Isolated nesidioblastotic islets showed an increased basal rate of insulin secretion (nesidioblastotic islets, 81.3 +/- 6.4 vs. control islets, from cadaveric organ normal donors, 10.2 +/- 0.9 microU/islet/90 m...

journal_title：Pancreas

authors： Conget I,Sarri Y,Somoza N,Vives M,Novials A,Ariza A,Fernández-Alvarez J,Pujol-Borrell R,Gomis R

更新日期：1997-01-01 00:00:00