Abstract:
OBJECTIVES:To evaluate the systemic effects of moderate hypothermia (MH) and the timing of induction on acute pancreatitis (AP) and endotoxemia in rats. METHODS:The effects of MH were compared in 4 groups, that is, sham group (38 degrees C), control group (38 degrees C), early MH group (32 degrees C on administration of lipopolysaccharide [LPS]), and delayed MH group (32 degrees C 1 hour after LPS). AP and endotoxemia were induced by intramuscular injection of caerulein and intraperitoneal injection of LPS. RESULTS:Serum interleukin 6 (IL-6) in both MH groups was significantly lower than that in the control group at 3 hours. Serum interleukin 10 (IL-10) in the early MH group was significantly higher than those in the other 3 groups at 1 hour. IL-10/IL-6 ratios in both MH groups were significantly higher than that in the control group at 3 hours. Serum soluble intercellular adhesion molecule (sICAM-1) in both MH groups was significantly lower than that in the control group at 3 hours. Serum sICAM-1 in the early MH group was significantly lower than that in the delayed MH group. The tendency of pancreatic ICAM-1 was similar to that of serum sICAM-1. CONCLUSIONS:Early induction of MH might be protective against pancreatic injury and systemic inflammation in AP and endotoxemia.
journal_name
Pancreasjournal_title
Pancreasauthors
Fujimoto K,Fujita M,Tsuruta R,Tanaka R,Shinagawa H,Izumi T,Kasaoka S,Maekawa Tdoi
10.1097/MPA.0b013e318162cb26subject
Has Abstractpub_date
2008-08-01 00:00:00pages
176-81issue
2eissn
0885-3177issn
1536-4828pii
00006676-200808000-00011journal_volume
37pub_type
杂志文章相关文献
PANCREAS文献大全abstract:OBJECTIVES:Existing reference ranges for stool fat and energy absorption were developed using subjects in controlled environments on precise diets. This study measured energy and fat absorption in healthy, community-dwelling adults eating a moderate-to-high fat American diet via stool- and serum-based methods. METHODS...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001587
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to clarify the clinical and pathophysiological characteristics of autoimmune pancreatitis (AIP) and its subtypes (lymphoplasmacytic sclerosing pancreatitis [LPSP] and idiopathic duct-centric pancreatitis [IDCP]) seen around the world. METHODS:An international multicenter surve...
journal_title:Pancreas
pub_type: 杂志文章,多中心研究
doi:10.1097/MPA.0b013e3182258a15
更新日期:2011-08-01 00:00:00
abstract::This study compared diet, type of alcoholism, and smoking in three groups of alcoholic men, with chronic pancreatitis (n = 56), with histological cirrhosis (n = 50), and without pancreatitis or cirrhosis (controls; n = 50) by a multidimensional analysis. Only patients in whom the first symptom of pancreatitis or cirrh...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199504000-00003
更新日期:1995-04-01 00:00:00
abstract::We evaluated the diagnostic significance of the K-ras point mutations at codon 12 in duodenal lavage fluid (DLF) compared with pure pancreatic juice (PPJ). The DLF was easily and safely collected by injecting distilled water into the duodenum and then aspirating through the working channel of the endoscope during endo...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199903000-00004
更新日期:1999-03-01 00:00:00
abstract:OBJECTIVES:Previously, we showed that diazoxide (DZ), an effective ischemic preconditioning agent, protected rodent pancreas against ischemia-reperfusion injury. Here, we further investigate whether DZ supplementation to University of Wisconsin (UW) solution during pancreas procurement and islet isolation has similar c...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001557
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to determine the accuracy of cytology, carcinoembryonic antigen (CEA), and amylase levels in the preoperative diagnosis of intraductal papillary mucinous neoplasms (IPMNs). METHODS:An international registry was started in 2005 and included patients with clinically suspected IPMNs. ...
journal_title:Pancreas
pub_type: 杂志文章,多中心研究
doi:10.1097/MPA.0000000000000559
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVES:Pancreatic anastomotic leakage remains a major troublesome complication after pancreaticoduodenectomy. Thus, various technical modifications regarding the pancreatic anastomosis after pancreaticoduodenectomy have been attempted to minimize anastomotic leakage. We have performed duct-to-mucosa pancreaticojeju...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3180676dc2
更新日期:2007-10-01 00:00:00
abstract::Increased activity of various proteases is observed in both human and experimental pancreatitis; however, the information on the effects of specific protease inhibitors on the disease is limited. In this study we show that a novel elastase inhibitor, guamerin-derived synthetic peptide (GDSP), improves the parameters o...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199904000-00003
更新日期:1999-04-01 00:00:00
abstract::In this article, we introduce our rapid-production model for pancreatic duct adenocarcinomas and describe the mechanisms of pancreatic duct carcinogenesis so far elucidated in Syrian golden hamsters. It is evident that a series of histogenetic steps are involved, leading from hyperplasia through atypical hyperplasia t...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/00006676-199804000-00015
更新日期:1998-04-01 00:00:00
abstract:OBJECTIVE:Secreted apoptosis-related protein (SARP) families are considered to counteract the oncogenic Wnt signaling pathway, and inactivation of this gene may aid cancer development and progression. Recently, the aberrant methylation of SARP2 was detected frequently in pancreatic carcinoma (PCa) tissue, but not in no...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000221617.89376.38
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVES:Autoimmune pancreatitis (AIP) responds well to steroid therapy but frequently relapses after discontinuing the steroid. It is difficult to know which cases are most likely to relapse. The aim of this study was to investigate the relation between the rate of decrease in serum IgG4 level after initial steroid ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000633
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVES:Recent studies have demonstrated that synthetic protease inhibitors could ameliorate the progression of pancreatic fibrosis in some animal models. Since oral administration of protease inhibitors increases the plasma cholecystokinin (CCK) levels and causes hypertrophy of the pancreas in rats, there is a poss...
journal_title:Pancreas
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVES:The authors investigated if timing of medical treatment is associated with the analgesic effect of pregabalin or placebo in patients with chronic pancreatitis (CP). METHODS:Sixty-four patients received pregabalin (150-300 mg twice a day) or matching placebo for 3 consecutive weeks. Responders to treatment w...
journal_title:Pancreas
pub_type: 杂志文章,随机对照试验
doi:10.1097/MPA.0000000000000475
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:We conducted this study to ascertain whether chronic inflammation secondary to chronic pancreatitis (CP) has any association with myocardial infarction(MI). METHODS:Data were collected from a commercial database (Explorys, Inc, IBM Watson, Ohio). Adults with the diagnosis of "chronic pancreatitis," based on ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001721
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVES:The circulating neutrophil-lymphocyte ratio (NLR) has been shown to be a prognostic factor for a variety of tumors. In this study, we evaluated the prognostic significance of NLR in a large cohort of Chinese patients with pancreatic ductal adenocarcinomas (PDACs). METHODS:A total of 381 patients with PDAC w...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000271
更新日期:2015-04-01 00:00:00
abstract::The influence of pancreatic secretions on growth and brush-border enzyme activity, throughout the entire small intestine, was examined in the rat. Pancreatic secretions were excluded from the gut lumen by stapling the pancreatic ducts, without interruption of bile flow. The entire small intestine was studied as four s...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198705000-00008
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVES:Acute pancreatitis is associated with compromised pancreatic microcirculation. Galanin is a vasoactive neuropeptide, but its role in the regulation of pancreatic vascular perfusion (PVP) is unclear. METHODS:Localization of galanin immunoreactivity was investigated by immunohistochemistry, and the effects of...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31815ac561
更新日期:2008-04-01 00:00:00
abstract::To determine the role of endogenous pancreatic polypeptide (PP) as a physiological inhibitor of pancreatic secretion, normal rabbit serum (control) or rabbit PP-antiserum was administered intravenously to dogs with chronic esophageal, gastric, and pancreatic fistulas. In all dogs tested, sham-feeding and ordinary feed...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198709000-00008
更新日期:1987-01-01 00:00:00
abstract:INTRODUCTION:We recently established a method of isolation and primary monolayer culture of porcine pancreatic endocrine cells that involves the use of nicotinamide. AIM:To obtain genetic information on cultured porcine endocrine cells and to examine cell function in relation to insulin secretion during long-term cult...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200301000-00012
更新日期:2003-01-01 00:00:00
abstract::We performed molecular biological studies as well as immunohistochemical analysis of three cases of giant cell carcinoma of the pancreas. Histologically, one case was a pleomorphic giant cell carcinoma consisting of pleomorphic giant/ small cells and spindle cells, one an osteoclast-like giant cell tumor composed of o...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199904000-00013
更新日期:1999-04-01 00:00:00
abstract:OBJECTIVES:There have been various studies of exocrine pancreatic function after acute pancreatitis, but few have examined the relationship between this function and the etiology of the pancreatitis. The aim of this work was to study pancreatic function in patients who had had acute alcoholic or acute biliary pancreati...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200405000-00001
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVES:The pancreas can metabolize ethanol via oxidative pathway involving the enzymes alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) as well as the nonoxidative pathway. In this study, we compared the activity of ADH isoenzymes and ALDH in the pancreatic cancer with the activity in normal tissue. In...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318053eae2
更新日期:2007-08-01 00:00:00
abstract::The 3 International Conference for Cancer Metabolism and Therapy was successfully held at the South Hospital Conference Center of Shanghai First People's Hospital, nearly 200 international experts from the field of cancer metabolism and therapy and about two thousand local scientists attended the conference. The confe...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001482
更新日期:2020-02-01 00:00:00
abstract::Hepatocyte growth factor (HGF) is a widely expressed growth factor secreted by cells of mesenchymal origin, which has been shown to be involved in growth processes of multiple cell types. The HGF receptor, the product of the c-met protooncogene, is expressed mainly by epithelial cells. Increased expression of the HGF ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199707000-00005
更新日期:1997-07-01 00:00:00
abstract::Human islets from an adult subject with nesidioblastosis were isolated and used to perform in vitro studies. Isolated nesidioblastotic islets showed an increased basal rate of insulin secretion (nesidioblastotic islets, 81.3 +/- 6.4 vs. control islets, from cadaveric organ normal donors, 10.2 +/- 0.9 microU/islet/90 m...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199701000-00011
更新日期:1997-01-01 00:00:00
abstract::The effects of a specific cholecystokinin (CCK) receptor antagonist (L364,718) and a gastrin receptor antagonist (L365,260) on gastrin-releasing peptide-10 (GRP-10)-stimulated pancreatic secretion were investigated in the anesthetized rat. GRP-10 stimulated pancreatic exocrine secretion in a dose-dependent manner. A d...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199203000-00013
更新日期:1992-01-01 00:00:00
abstract::Pancreatic duct bicarbonate secretion is mediated primarily by secretin-induced elevation of intracellular cyclic AMP, although little is known of the effects of other physiological regulators on pancreatic duct cyclic AMP metabolism. We investigated the effects of secretin and several other potential agonists on cycl...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199510000-00008
更新日期:1995-10-01 00:00:00
abstract::Peptide YY (PYY) is a recently isolated gut peptide that is found primarily in the mucosal endocrine cells of the terminal ileum, colon, and rectum of several mammalian species, including humans. The purpose of this study was to characterize the effect of PYY on pancreatic exocrine secretion in six conscious dogs prep...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198707000-00013
更新日期:1987-01-01 00:00:00
abstract:INTRODUCTION:Proinflammatory cytokines play an important role in the development of type 1 diabetes. Lisofylline (LSF) is a novel anti-inflammatory compound that specifically inhibits proinflammatory cytokine production and action. AIM:To investigate the effect of LSF on diabetes prevention. METHODOLOGY:A mouse with ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200305000-00021
更新日期:2003-05-01 00:00:00
abstract:OBJECTIVE:Green tea polyphenols have been shown to inhibit tumor growth in animal and in vitro studies. We examined the relationship between green tea consumption and the risk of death from pancreatic cancer in a large Japanese cohort. METHODS:At baseline (1988-1990), study participants reported the frequency and amou...
journal_title:Pancreas
pub_type: 杂志文章,多中心研究
doi:10.1097/MPA.0b013e318160a5e2
更新日期:2008-07-01 00:00:00