Expression of Transient Receptor Potential Channels in the Purified Human Pancreatic β-Cells.

abstract：OBJECTIVES:Pancreatic carcinoma etiology and molecular pathogenesis is weakly understood. According to the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, an association of functional polymorphisms in oxidative stress-modifying genes superoxide dismutase...

journal_title：Pancreas

authors： Mohelnikova-Duchonova B,Marsakova L,Vrana D,Holcatova I,Ryska M,Smerhovsky Z,Slamova A,Schejbalova M,Soucek P

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Microcirculatory disorders, in particular increased capillary permeability (CapPerm), contribute to the multiple organ dysfunction syndrome in severe acute pancreatitis (AP). Endothelin receptor antagonists (ET-RA) have been shown to stabilize capillary leakage and improve organ function in AP. AIM:To fin...

journal_title：Pancreas

authors： Eibl G,Forgacs B,Hotz HG,Buhr HJ,Foitzik T

更新日期：2002-08-01 00:00:00

abstract：:Peptide YY (PYY) is a recently isolated gut peptide that is found primarily in the mucosal endocrine cells of the terminal ileum, colon, and rectum of several mammalian species, including humans. The purpose of this study was to characterize the effect of PYY on pancreatic exocrine secretion in six conscious dogs prep...

journal_title：Pancreas

authors： Lluis F,Gomez G,Fujimura M,Greeley GH Jr,Thompson JC

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVES:Single-institution studies have shown improved outcomes among patients with a pathologic complete response (pCR) following neoadjuvant therapy. We sought to evaluate the impact of pCR and near-complete response (nCR) on overall survival (OS) using a large national database. METHODS:The National Cancer Datab...

journal_title：Pancreas

authors： Sell NM,Lee GC,Fernández-Del Castillo C,Ferrone CR,Warshaw AL,Hong TS,Blaszkowsky LS,Lillemoe KD,Qadan M

更新日期：2020-08-01 00:00:00

abstract：:Several studies have shown that pituitary adenylate cyclase activating polypeptide (PACAP) stimulates at very low concentration insulin release from pancreatic beta cells. In addition, PACAP has been evidenced in pancreatic nervous fibers surrounding the islets, the core of the islet, and the capillaries. The aim of t...

journal_title：Pancreas

authors： Petruzzo P,Cappai A,Spiga S,Picciau S,Serra G,Fattore L,Onali P,Brotzu G

更新日期：2001-07-01 00:00:00

abstract：:A new technique to obstruct the pancreatic ducts was developed by injecting zein solution into the common bile duct of the rat. Four weeks after the injection, the fate of the endocrine pancreas was investigated by studying (a) pancreatic content of four pancreatic hormones, (b) histology and immunohistochemistry of t...

journal_title：Pancreas

authors： Tomita T,Rhodes J,Falscroft J,Doull V,Kimmel JR,Pollock HG

更新日期：1988-01-01 00:00:00

abstract：:The aim of the study was to establish whether correlations were discernible between calcification, smoking, and other variables--including alcohol intake--in chronic pancreatitis. A total of 637 patients with chronic pancreatitis diagnosed over the period of 1973-1989 were reviewed. Only patients who had had one or mo...

journal_title：Pancreas

authors： Cavallini G,Talamini G,Vaona B,Bovo P,Filippini M,Rigo L,Angelini G,Vantini I,Riela A,Frulloni L

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVES:Intraductal papillary mucinous neoplasms (IPMNs) and pancreatic intraepithelial neoplasia (PanIN) are both precancerous lesions. Papillary mucinous neoplasms have been described in patients with IPMN, but their relationship is still poorly understood. The aims of this study were to look for PanIN lesions in ...

journal_title：Pancreas

authors： Maire F,Couvelard A,Palazzo L,Aubert A,Vullierme MP,Rebours V,Hammel P,Sauvanet A,Levy P,Ruszniewski P

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVES:Association between acute pancreatitis and acute viral hepatitis (AVH) is more frequent than previously thought. Most cases are hepatitis A or B virus related. Only 6 cases of acute pancreatitis with acute hepatitis E virus (HEV)-related hepatitis has been reported so far. METHODS:We analyzed the hospital r...

journal_title：Pancreas

authors： Bhagat S,Wadhawan M,Sud R,Arora A

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVES:To study the association of binge drinking and the outcomes of severe acute pancreatitis (SAP). METHODS:This retrospective study included 347 patients with first-attack SAP from January 2001 to February 2004. On the basis of the history of binge drinking or not, the patients were divided into the alcohol (n...

journal_title：Pancreas

authors： Deng L,Xue P,Huang L,Yang X,Wan M,Xia Q

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVES:Exocrine pancreatic secretion contributes to limit pathogenic bacteria-associated diarrhea. Bovine colostrum, used in the treatment of diarrhea, reduces symptoms originating from gut pathogenic bacteria overgrowth. We hypothesized that bovine colostrum may stimulate the exocrine pancreatic secretion. METHOD...

journal_title：Pancreas

authors： Huguet A,Savary G,Bobillier E,Le Huërou-Luron I

更新日期：2009-04-01 00:00:00

abstract：:In recent studies performed on pancreatic stones from patients with alcoholic pancreatitis, a novel secretory protein was identified: the pancreatic stone protein (PSP Mr 14,000). This protein suppresses CaCO3 precipitation, and could therefore stabilize normally supersaturated pancreatic juice. Crystallographic analy...

journal_title：Pancreas

authors： Montalto G,Multigner L,Sarles H,De Caro A

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVES:To evaluate the systemic effects of moderate hypothermia (MH) and the timing of induction on acute pancreatitis (AP) and endotoxemia in rats. METHODS:The effects of MH were compared in 4 groups, that is, sham group (38 degrees C), control group (38 degrees C), early MH group (32 degrees C on administration ...

journal_title：Pancreas

authors： Fujimoto K,Fujita M,Tsuruta R,Tanaka R,Shinagawa H,Izumi T,Kasaoka S,Maekawa T

更新日期：2008-08-01 00:00:00

abstract：:We evaluated the diagnostic significance of the K-ras point mutations at codon 12 in duodenal lavage fluid (DLF) compared with pure pancreatic juice (PPJ). The DLF was easily and safely collected by injecting distilled water into the duodenum and then aspirating through the working channel of the endoscope during endo...

journal_title：Pancreas

authors： Nakamura Y,Onda M,Uchida E

更新日期：1999-03-01 00:00:00

abstract：:To clarify the role of nitric oxide (NO) in the development and progression of acute pancreatitis, we investigated the effect of different NO synthase inhibitors and NO donors on experimental pancreatitis in rats. Closed duodenal loop (CDL)-induced pancreatitis was produced in male Wistar rats, and the animals were tr...

journal_title：Pancreas

authors： Nishino T,Watanabe S,Oyama H,Fukuya Y,Hayashi N,Kobayashi M

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to clarify the clinical and pathophysiological characteristics of autoimmune pancreatitis (AIP) and its subtypes (lymphoplasmacytic sclerosing pancreatitis [LPSP] and idiopathic duct-centric pancreatitis [IDCP]) seen around the world. METHODS:An international multicenter surve...

journal_title：Pancreas

authors： Kamisawa T,Chari ST,Giday SA,Kim MH,Chung JB,Lee KT,Werner J,Bergmann F,Lerch MM,Mayerle J,Pickartz T,Lohr M,Schneider A,Frulloni L,Webster GJ,Reddy DN,Liao WC,Wang HP,Okazaki K,Shimosegawa T,Kloeppel G,Go VL

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVES:Endoscopic ultrasound (EUS) may offer a diagnostic tool through the combination of imaging and guided fine-needle aspiration of pancreatic cysts. The purpose of this investigation was to determine the most accurate test for differentiating mucinous from nonmucinous cysts. METHODS:The results of EUS imaging,...

journal_title：Pancreas

authors： Cizginer S,Turner BG,Bilge AR,Karaca C,Pitman MB,Brugge WR

更新日期：2011-10-01 00:00:00

abstract：INTRODUCTION:In autoimmune diseases, malignancies, and inflammatory conditions, a correlation of serum levels of CD44, interleukin-2 receptor (IL-2r), and neopterin with disease activity could be shown. AIMS:To assess the immune parameters in chronic pancreatitis in correlation to clinical data to evaluate the potenti...

journal_title：Pancreas

authors： Schlosser W,Gansauge F,Schlosser S,Gansauge S,Beger HG

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVES:Pancreatic cancer is a serious disease worldwide for its high mortality. Gemcitabine has become the frontline option for the treatment of this disease since its approval. However, resistance to the drug has been on the rise in recent years. Searching for other chemotherapeutic agents therefore has attracted ...

journal_title：Pancreas

authors： Zhang M,Sun C,Shan X,Yang X,Li-Ling J,Deng Y

更新日期：2010-08-01 00:00:00

abstract：:We diverted bile and pancreatic juice from jejunal blind loops of different lengths in conscious rats to see if the pancreatic secretory response was dependent on the length of the jejunal blind loop. Short-term bile and pancreatic juice diversion from a short jejunal blind loop, representing only 8-10% of the total l...

journal_title：Pancreas

authors： Spannagel AW,Green GM

更新日期：1999-01-01 00:00:00

abstract：:Five human pancreatic carcinoma cell lines were screened for the presence of muscarinic cholinergic receptors (mAChRs), using [3H]N-methylscopolamine ([3H]NMS). T3M4 and COLO-357 cells exhibited specific, high-affinity binding to mAChRs. A small amount of [3H]NMS also bound in PANCI and ASPC-I cells, but not in MIA Pa...

journal_title：Pancreas

authors： Ackerman MS,Roeske WR,Heck RJ,Korc M

更新日期：1989-01-01 00:00:00

abstract：:Periodic oscillation of insulin and glucagon by isolated mice islets has been studied. Pulsatile secretion of insulin and glucagon was observed at all glucose concentrations tested. The frequency of oscillation per 20 min for glucagon was 5.0 +/- 0.26 and for insulin 4.0 +/- 0.26 (n = 6), approximating to periodicitie...

journal_title：Pancreas

authors： Opara EC,Atwater I,Go VL

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:The goals of this study were to characterize bacterial communities within fecal samples, pancreatic fluid, bile, and jejunal contents from patients undergoing pancreaticoduodenectomy (PD) and to identify associations between microbiome profiles and clinical variables. METHODS:Fluid was collected from the pan...

journal_title：Pancreas

authors： Rogers MB,Aveson V,Firek B,Yeh A,Brooks B,Brower-Sinning R,Steve J,Banfield JF,Zureikat A,Hogg M,Boone BA,Zeh HJ,Morowitz MJ

更新日期：2017-02-01 00:00:00

abstract：:The 3 International Conference for Cancer Metabolism and Therapy was successfully held at the South Hospital Conference Center of Shanghai First People's Hospital, nearly 200 international experts from the field of cancer metabolism and therapy and about two thousand local scientists attended the conference. The confe...

journal_title：Pancreas

authors： Xiao GG,Zhang Z,Lu B,Wang H,Fan TW,Boros LG,Gao P,Pan Y,Go VLW

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVES:Rare cases of pancreatic neuroendocrine tumors (PNETs) that produce only proinsulin (PI) and manifest with hypoglycemia have been reported. Proinsulin expression in PNET has not been systematically studied, and the clinicopathologic features of such tumors remain unknown. METHODS:We studied expression of PI...

journal_title：Pancreas

authors： Celli R,Tang LH,Cai G,Freedman-Weiss M,Colunga M,Salem RR,Majumdar S,Jain D

更新日期：2019-01-01 00:00:00

abstract：:The vast majority of patients who present with pancreatic adenocarcinoma have locally advanced or metastatic disease at the time of presentation without possibility of cure. Although in recent years there have been some new promising chemotherapy regimens that improve overall survival by a few months, the prognosis re...

journal_title：Pancreas

authors： Shah R,Ostapoff KT,Kuvshinoff B,Hochwald SN

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:We sought to identify clinicopathological characteristics of high-grade pancreatic intraepithelial neoplasia (PanIN)/carcinoma in situ to facilitate screening for pancreatic ductal adenocarcinoma. METHODS:We evaluated PanIN lesions in 173 consecutive autopsy cases with no evidence of pancreatic ductal adenoc...

journal_title：Pancreas

authors： Matsuda Y,Furukawa T,Yachida S,Nishimura M,Seki A,Nonaka K,Aida J,Takubo K,Ishiwata T,Kimura W,Arai T,Mino-Kenudson M

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVES:To analyze the expression modulation of pancreatic protein tyrosine phosphatase (PTP)1B during the development of cerulein (Cer)-induced acute pancreatitis (AP) and the effect of inhibition of type 4 phosphodiesterase and c-Jun N-terminal kinase and extracellular signal-regulated kinase 1/2 on its expression...

journal_title：Pancreas

authors： Sarmiento N,Sánchez-Bernal C,Pérez N,Sardina JL,Mangas A,Calvo JJ,Sánchez-Yagüe J

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVES:There have been various studies of exocrine pancreatic function after acute pancreatitis, but few have examined the relationship between this function and the etiology of the pancreatitis. The aim of this work was to study pancreatic function in patients who had had acute alcoholic or acute biliary pancreati...

journal_title：Pancreas

authors： Migliori M,Pezzilli R,Tomassetti P,Gullo L

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVES:Previous research has shown that the retinoid 9-cis retinoic acid (RA) promotes apoptosis in pancreatic cancer cells. The vitamin D analog EB1089 does not. Furthermore, cotreatment of cells with 9-cis RA and EB1089 abrogates apoptosis. To explain this, we studied the regulation of proteins involved in apopto...

journal_title：Pancreas

authors： Mouratidis PX,Dalgleish AG,Colston KW

更新日期：2006-01-01 00:00:00