Retrospective analysis to investigate the effect of concomitant use of gastric acid-suppressing drugs on the efficacy and safety of pancrelipase/pancreatin (CREON®) in patients with pancreatic exocrine insufficiency.

abstract：OBJECTIVES:Existing reference ranges for stool fat and energy absorption were developed using subjects in controlled environments on precise diets. This study measured energy and fat absorption in healthy, community-dwelling adults eating a moderate-to-high fat American diet via stool- and serum-based methods. METHODS...

journal_title：Pancreas

authors： Bashaw H,Brownell JN,Schall JI,Stallings VA

更新日期：2020-07-01 00:00:00

abstract：:The Second International Islet Transplantation Symposium was held at UCLA in January, 1993. The symposium, sponsored by the Jerry's Foundation for Diabetes Research was focused on the issues in clinical islet transplantation. The leaders from each of the clinically active programs around the world were invited to disc...

journal_title：Pancreas

authors： Brunicardi FC,Mullen Y

更新日期：1994-05-01 00:00:00

abstract：OBJECTIVES:To investigate the inhibition of PANC-1 pancreatic cancer cell growth by cucurmosin (CUS) and its possible mechanism. METHODS:We observed the inhibition of PANC-1 cell growth by sulforhodamine B and colony-forming experiments in vitro and established nonobese diabetic/severe combined immunodeficiency mouse ...

journal_title：Pancreas

authors： Wang C,Yang A,Zhang B,Yin Q,Huang H,Chen M,Xie J

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVES:The median age of patients with pancreatic ductal adenocarcinoma (PDAC) is approximately 70 years, and PDAC rarely affects individuals younger than 40 years. Here, we investigated clinicopathologic features and genetic background of PDAC occurring in young patients (age ≤ 40 years) to determine whether any d...

journal_title：Pancreas

authors： Ohmoto A,Yachida S,Kubo E,Takai E,Suzuki M,Shimada K,Okusaka T,Morizane C

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:Green tea polyphenols (GTPs) are naturally occurring antioxidants acting through pathways that include reactive oxygen species and nuclear factor kappa B (NF-kappaB). This study investigates the effect of GTPs in a cerulein-induced murine model of acute pancreatitis (AP). METHODS:Male CD mice (median weight,...

journal_title：Pancreas

authors： Babu BI,Malleo G,Genovese T,Mazzon E,Di Paola R,Crisafulli C,Caminiti R,Siriwardena AK,Cuzzocrea S

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVES:This case-control study was performed to evaluate the association between a specific caspase-9 polymorphism as well as the genetic polymorphism -31G/C located in the cycle-dependent elements/cell cycle homology regions repressor element of the human survivin promoter and the risk of pancreatic cancer. METHO...

journal_title：Pancreas

authors： Theodoropoulos GE,Michalopoulos NV,Panoussopoulos SG,Taka S,Gazouli M

更新日期：2010-10-01 00:00:00

abstract：INTRODUCTION:Main pancreatic duct (MPD)-narrowed chronic pancreatitis (CP) may be an autoimmune abnormality. It also has been called autoimmune pancreatitis and sclerosing pancreatitis. It is unclear whether cases with focal pancreatographic changes are part of the same clinical entity as cases with diffuse MPD changes...

journal_title：Pancreas

authors： Wakabayashi T,Kawaura Y,Satomura Y,Fujii T,Motoo Y,Okai T,Sawabu N

更新日期：2002-10-01 00:00:00

abstract：:Pancreatic cystic insulinoma is an uncommon tumor. Perioperative localization remained challenging if the tumor is atypical with cystic feature or in small size. Near-infrared (NIR) imaging is a technique by injecting fluorescent dye intravenously, which accumulates to the target lesion and creating signal by laser so...

journal_title：Pancreas

authors： Kou HW,Yu MC,Chong SW,Hsu HY,Chou HH,Lee CW,Chen TC,Huang SF

更新日期：2020-11-01 00:00:00

abstract：:Cultivation and preservation of human pancreatic ductal cells have remained a challenge. With a defined culture medium and refinement of culturing techniques, we have been able to maintain human pancreatic ductal cells without any genetic manipulation in culture for more than 16 months. Freshly isolated ductal fragmen...

journal_title：Pancreas

authors： Ulrich AB,Schmied BM,Matsuzaki H,El-Metwally T,Moyer MP,Ricordi C,Adrian TE,Batra SK,Pour PM

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVES:It is of utmost importance that autoimmune pancreatitis (AIP) be differentiated from pancreatic cancer (PC) because some AIP cases undergo unnecessary laparotomy or pancreatic resection on suspicion of PC. This study aimed to develop an appropriate strategy for differentiating between AIP and PC. METHODS:Cl...

journal_title：Pancreas

authors： Kamisawa T,Imai M,Yui Chen P,Tu Y,Egawa N,Tsuruta K,Okamoto A,Suzuki M,Kamata N

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVE:Emphysematous pancreatitis is characterized by the presence of intraparenchymal pancreatic air in the setting of necrotizing pancreatitis. Mortality and morbidity rates approach approximately 40% and 100%, respectively. Traditionally, emphysematous pancreatitis was an indication for surgical intervention. The...

journal_title：Pancreas

authors： Kvinlaug K,Kriegler S,Moser M

更新日期：2009-08-01 00:00:00

abstract：:Pancreatic insufficiency was induced in rats by a single injection of 50 microliter oleic acid into the pancreatic duct over a period of 3 min. Exocrine tissue was destroyed within 3-6 days, and after 6 weeks the remaining pancreas equaled 2.7% of the original organ. The rats showed retardation of body weight in spite...

journal_title：Pancreas

authors： Mundlos S,Adler G,Schaar M,Koop I,Arnold R

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVES:Human primary microRNA-155/B-cell integration cluster (BIC) transcript is the precursor of microRNA-155. The overexpression of them has been widely observed in the progression of various types of tumors. Our objective was to investigate the effect of anticancer agents on the expression of BIC and possible si...

journal_title：Pancreas

authors： Xia QS,Ishigaki Y,Zhao X,Shimasaki T,Nakajima H,Nakagawa H,Takegami T,Chen ZH,Motoo Y

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:There have been various studies of exocrine pancreatic function after acute pancreatitis, but few have examined the relationship between this function and the etiology of the pancreatitis. The aim of this work was to study pancreatic function in patients who had had acute alcoholic or acute biliary pancreati...

journal_title：Pancreas

authors： Migliori M,Pezzilli R,Tomassetti P,Gullo L

更新日期：2004-05-01 00:00:00

abstract：:140 patients with alcoholic acute (recurrent) pancreatitis were enrolled in a prospective long-term study over the last 16 years. Regular control studies regarding progression to advanced chronic pancreatitis were performed. Based on long-term outcome the patients were classified into two groups: group A (n = 109; 77....

journal_title：Pancreas

authors： Ammann RW,Muellhaupt B,Meyenberger C,Heitz PU

更新日期：1994-05-01 00:00:00

abstract：:The human exocrine pancreas consists of 2 main cell types: acinar and ductal cells. These exocrine cells interact closely to contribute to the secretion of pancreatic juice. The most important ion in terms of the pancreatic ductal secretion is HCO3. In fact, duct cells produce an alkaline fluid that may contain up to ...

journal_title：Pancreas

authors： Pallagi P,Hegyi P,Rakonczay Z Jr

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVES:Studies show an increased incidence of adult acute pancreatitis (AP) in recent decades. The aim was to review pediatric AP incidence. METHODS:Retrospective review of computerized databases at the Children's Hospital of Pittsburgh from 1993 to 2004. The International Classification of Diseases, Ninth Revisio...

journal_title：Pancreas

authors： Morinville VD,Barmada MM,Lowe ME

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:In recent years a type of chronic pancreatitis has been described that is clearly distinct from alcoholic chronic pancreatitis. It is characterized by its special pathology, immunologic features, clinical presentation, and steroid responsiveness. Because of its histologic hallmarks, i.e., ductal and peridu...

journal_title：Pancreas

authors： Klöppel G,Lüttges J,Löhr M,Zamboni G,Longnecker D

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVES:Intra-abdominal fungal infections (AFIs) complicating acute pancreatitis arise in the context of pancreatic necrosis. Our goal was to determine which risk factors contribute to AFI in patients with acute pancreatitis. METHODS:Records were reviewed from 479 nontransfer patients admitted to our medical center...

journal_title：Pancreas

authors： Schwender BJ,Gordon SR,Gardner TB

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVES:Interleukin-36 (IL-36) is a recently described proinflammatory cytokine, characterized by the induction of inflammatory mediators. In the present study, we investigated the biological activity and the signal transduction of IL-36α in human pancreatic myofibroblasts. METHODS:The mRNA and protein expression o...

journal_title：Pancreas

authors： Nishida A,Inatomi O,Fujimoto T,Imaeda H,Tani M,Andoh A

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVES:Pancreatic cancer (PC), a common cause of cancer death, is rarely diagnosed at an early stage. Early detection of PC may improve outcomes in affected patients. This study evaluated the utility of screening of high-risk individuals (HRIs) using an endoscopic ultrasound (EUS)-only approach to detect early mali...

journal_title：Pancreas

authors： Gangi A,Malafa M,Klapman J

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:We aim to examine the predictive effect of the total number of examined lymph nodes on N stage and survival in pancreatic neuroendocrine neoplasms (pNENs) and to determine the optimal threshold. METHODS:A pNENs data set from 2004 to 2013 was extracted from the Surveillance, Epidemiology, and End Result data...

journal_title：Pancreas

authors： Zhang X,Lu L,Liu P,Cao F,Wei Y,Ma L,Gong P

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:Pancreatic ductal adenocarcinoma (PDAC) is the third most common cause of cancer death in the United States. Improved characterized models of PDAC are needed for drug screening. METHODS:We grew 4 established pancreatic cancer cell lines in hanging drop cultures to produce spheroids. We also grew organoids fr...

journal_title：Pancreas

authors： Matsushita Y,Smith B,Delannoy M,Trujillo MA,Chianchiano P,McMillan R,Kamiyama H,Liang H,Thompson ED,Hruban RH,Matsui W,Wood LD,Roberts NJ,Eshleman JR

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:Bax-interacting factor 1 (Bif-1) protein plays a critical role in apoptosis, mitochondrial morphogenesis, and autophagy, and its loss promotes tumorigenesis. The role of Bif-1 in pancreatic cancer has not been studied. METHODS:We determined Bif-1 expression in 82 human pancreatic ductal adenocarcinomas (PDCs...

journal_title：Pancreas

authors： Coppola D,Helm J,Ghayouri M,Malafa MP,Wang HG

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to evaluate the relevance of defining borderline resectable (BR) pancreatic cancer as a distinct entity in the treatment scheme of pancreatic cancer as proposed by the National Comprehensive Cancer Network. METHODS:Among 375 patients with pancreatic cancer, 137 patients were ...

journal_title：Pancreas

authors： Yamada S,Fujii T,Sugimoto H,Nomoto S,Takeda S,Kodera Y,Nakao A

更新日期：2013-08-01 00:00:00

abstract：:Clinical and translational research is critical for the development of improvement in care of pancreatic diseases. Major concerns are the lack of dedicated trainees in pancreatic research and the difficulty for the remaining trainees to develop independent research careers to be included into the pancreas research com...

journal_title：Pancreas

authors： Gelrud A,Whitcomb DC

更新日期：2010-04-01 00:00:00

abstract：:The effects of a specific cholecystokinin (CCK) receptor antagonist (L364,718) and a gastrin receptor antagonist (L365,260) on gastrin-releasing peptide-10 (GRP-10)-stimulated pancreatic secretion were investigated in the anesthetized rat. GRP-10 stimulated pancreatic exocrine secretion in a dose-dependent manner. A d...

journal_title：Pancreas

authors： Terashima H,Debas HT,Bunnett NW

更新日期：1992-01-01 00:00:00

abstract：:Adenosine-5'-O-(2-thiodiphosphate) (ADP beta S), a P2y purinergic agonist, has been shown to be a potent insulin secretagogue on the isolated rat pancreas. In the present work the effects of ADP beta S on insulin somatostatin, and glucagon secretions were investigated in dogs. In vivo, in anesthetized fasted dogs, i.v...

journal_title：Pancreas

authors： Hillaire-Buys D,Gross R,Parés-Herbuté N,Ribes G,Loubatières-Mariani MM

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVE:To investigate whether human heme oxygenase-1 (HO-1) gene has protective action on islets cultured in vitro, and to explore whether transduction of HO-1 gene to donor islets could enhance engrafted islets survival and suppress local lymphocytic infiltration in islet grafts. METHODS:Newly isolated rat islets ...

journal_title：Pancreas

authors： Li Y,Li G,Dong W,Chen J,Lu D,Tan J

更新日期：2006-10-01 00:00:00

abstract：:This study compared diet, type of alcoholism, and smoking in three groups of alcoholic men, with chronic pancreatitis (n = 56), with histological cirrhosis (n = 50), and without pancreatitis or cirrhosis (controls; n = 50) by a multidimensional analysis. Only patients in whom the first symptom of pancreatitis or cirrh...

journal_title：Pancreas

authors： Lévy P,Mathurin P,Roqueplo A,Rueff B,Bernades P

更新日期：1995-04-01 00:00:00