Alcoholic nonprogressive chronic pancreatitis: prospective long-term study of a large cohort with alcoholic acute pancreatitis (1976-1992).

abstract：OBJECTIVE:Postoperative pancreatic fistula (POPF) and readmission remain the significant sources of morbidity after distal pancreatectomy (DP). We describe a technique of drainage and postoperation management to prevent severe POPF and readmission. METHODS:A retrospective analysis of 57 patients who underwent DP from ...

journal_title：Pancreas

authors： Wang H,Xiu D,Jiang B,Ma C,Yuan C

更新日期：2014-05-01 00:00:00

abstract：INTRODUCTION:Adhesion of tumor cells to extracellular matrix (ECM) proteins plays an important role in tumor invasion and metastasis. AIMS:To investigate the expression of integrins in human pancreatic cancer cell lines and its alteration by interleukin (IL)-1alpha to examine the mechanism of adhesion of metastatic hu...

journal_title：Pancreas

authors： Sawai H,Yamamoto M,Okada Y,Sato M,Akamo Y,Takeyama H,Manabe T

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVES:Sex-determining region Y (SRY) box 9 (SOX9) is an important transcription factor required for development and has been implicated in several types of cancer. Sex-determining region Y box 9 has never been linked to pancreatic ductal adenocarcinoma (PDAC) and intraductal papillary mucinous neoplasm (IPMN) of t...

journal_title：Pancreas

authors： Tanaka T,Kuroki T,Adachi T,Ono S,Hirabaru M,Soyama A,Kitasato A,Takatsuki M,Hayashi T,Eguchi S

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVES:During the past decade, numerous studies in both humans and animals have demonstrated that C-peptide, although not influencing blood sugar control, might play a role in preventing and potentially reversing some of the chronic complications of type 1 diabetes. The aim of this paper is to present an up-to-date...

journal_title：Pancreas

authors： Marques RG,Fontaine MJ,Rogers J

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVES:Cyclooxygenase 2 (COX-2) and vascular endothelial growth factor (VEGF), often coexpressed in cancer, are associated with poor prognosis. However, results from pancreatic cancer trials of their inhibitors were disappointing. This study delineated the role of COX-2 and nonsteroidal anti-inflammatory drugs in a...

journal_title：Pancreas

authors： Toomey DP,Manahan E,McKeown C,Rogers A,McMillan H,Geary M,Conlon KC,Murphy JF

更新日期：2010-07-01 00:00:00

abstract：:Human pure pancreatic juice (PPJ) and serum were analyzed for free fatty acids (FFAs) to study whether the damage to pancreatic cell membranes in pancreatitis is reflected as abnormal FFAs concentration and composition. Patients consisted of 13 normal controls, 7 patients with acute pancreatitis (AP) in remission, and...

journal_title：Pancreas

authors： Miyake H,Harada H,Ochi K,Oka H,Ishibashi T,Kimura I

更新日期：1988-01-01 00:00:00

abstract：:A case of relapsing pancreatitis in a young man is presented. Stenosis of the main duct and cystic lesions of the tail of the pancreas were shown by ultrasonography, CT scan, and endoscopic retrograde cholangiopancreatography (ERCP). After a wrong diagnosis of cancer, the pathological examination demonstrated an eosin...

journal_title：Pancreas

authors： Bastid C,Sahel J,Choux R,Payan MJ,Sarles H

更新日期：1990-01-01 00:00:00

abstract：:Over the last 3 decades, there have been substantial improvements in diagnostic imaging and sampling techniques to evaluate pancreatic diseases. The modern technology has helped us to recognize premalignant conditions of pancreas including mucinous cystic neoplasms and intraductal papillary mucinous neoplasms (IPMNs)....

journal_title：Pancreas

authors： Thosani N,Dasari CS,Bhutani MS,Raimondo M,Guha S

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVES:We examined how lipotoxicity contributes to pancreatic beta-cell secretory dysfunction. METHODS:Effects of palmitate (0.2 mmol/L) were assessed on insulin secretion and soluble N-ethylmaleimide-sensitive factor attachment protein receptor exocytotic machinery in isolated pancreatic islets of type 2 diabetic...

journal_title：Pancreas

authors： Ostenson CG,Chen J,Sheu L,Gaisano HY

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVES:Survivin, an antiapoptotic gene inhibited by p53, is overexpressed in human cancers and correlates with chemotherapy resistance. Here, we investigated the mutual regulatory mechanism between MGMT (O-methylguanine DNA methyltransferase) and survivin. METHODS:This study used standard techniques for protein an...

journal_title：Pancreas

authors： Bobustuc GC,Patel A,Thompson M,Srivenugopal KS,Frick J,Weese J,Konduri SD

更新日期：2015-05-01 00:00:00

abstract：:The vast majority of patients who present with pancreatic adenocarcinoma have locally advanced or metastatic disease at the time of presentation without possibility of cure. Although in recent years there have been some new promising chemotherapy regimens that improve overall survival by a few months, the prognosis re...

journal_title：Pancreas

authors： Shah R,Ostapoff KT,Kuvshinoff B,Hochwald SN

更新日期：2018-01-01 00:00:00

abstract：:Ornithine decarboxylase (ODC) is the rate-limiting enzyme in polyamine biosynthesis. We examined circadian variations in pancreatic ODC activity and time-course effects of caerulein in fed and fasted rats. Significant circadian variations in amount of ODC activity were observed. The highest values were obtained during...

journal_title：Pancreas

authors： Langlois A,Morisset J

更新日期：1991-09-01 00:00:00

abstract：:The aim of this study was to determine the relationship between pancreatic necrosis and organ failure in acute pancreatitis. Two hundred seventeen patients with acute pancreatitis were prospectively included. All of them had been examined by computed tomography (CT) within 72 hours of admission. Initial organ failure ...

journal_title：Pancreas

authors： Lankisch PG,Pflichthofer D,Lehnick D

更新日期：2000-04-01 00:00:00

abstract：:Adenocarcinoma of the pancreas is one of most catastrophic and least understood of cancers. Evidence from clinical studies indicates that the development of pancreas cancer progresses over many years before symptoms appear. Most people with pancreatic cancer die within six months of diagnosis. The lack of early diseas...

journal_title：Pancreas

authors： Hine RJ,Srivastava S,Milner JA,Ross SA

更新日期：2003-11-01 00:00:00

abstract：:We report a case of severe acute pancreatitis associated with both gastric and abdominal wall infarction. The early skin changes on the anterior abdominal wall could be confused with Grey-Turner's sign. ...

journal_title：Pancreas

authors： Scholefield JH,Goodman AJ,Morgan WP

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVES:Pancreatoduodenectomy is feasible also in patients with locally advanced pancreatic adenocarcinoma (PA) nowadays. Data on risk and survival analysis of palliative pancreatic resections followed by gemcitabine-based chemotherapy (Cx) are limited. METHODS:Between 2000 and 2009, a total of 45 patients had prim...

journal_title：Pancreas

authors： Bahra M,Pratschke J,Klein F,Neuhaus P,Boas-Knoop S,Puhl G,Denecke T,Pullankavumkal JR,Sinn M,Riess H,Pelzer U

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVES:Currently available pancreatic enzyme products are crude porcine products with few data available regarding their efficacy, safety, and manufacture. We conducted a phase 1 study of a novel pancreatic enzyme product, TheraCLEC-Total (TCT), a proprietary formulation of microbial-derived lipase, protease, and a...

journal_title：Pancreas

authors： Borowitz D,Goss CH,Stevens C,Hayes D,Newman L,O'Rourke A,Konstan MW,Wagener J,Moss R,Hendeles L,Orenstein D,Ahrens R,Oermann CM,Aitken ML,Mahl TC,Young KR Jr,Dunitz J,Murray FT

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVES:Tumor necrosis is often found in pancreatic ductal adenocarcinoma (PDAC). Objective histological assessment and adequate radiological detection of necrosis could be used as biomarkers for therapeutic decision. However, standardized clinical utility of necrosis remains unknown. Here, we aimed to determine the...

journal_title：Pancreas

authors： Kudo M,Kobayashi T,Gotohda N,Konishi M,Takahashi S,Kobayashi S,Sugimoto M,Okubo S,Martin J,Cabral H,Ishii G,Kojima M

更新日期：2020-05-01 00:00:00

abstract：:Pancreatic cancer presenting as acute pancreatitis is relatively uncommon. Pancreatic cancer should be included in the differential diagnosis of "idiopathic" acute pancreatitis, particularly in the elderly. The following case report describes a patient in whom pancreatic cancer presented as acute pancreatitis with pse...

journal_title：Pancreas

authors： Nugent CE,Lehman GA,Madura JA,Kopecky K

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVE:To develop a ¹³C-labeled substrate breath test by defining the optimal ¹³C-labeled substrate, substrate dose, test meal, and duration of the test and evaluating its accuracy for the diagnosis of pancreatic exocrine insufficiency (PEI) in chronic pancreatitis (CP). METHODS:Five consecutive prospective compara...

journal_title：Pancreas

authors： Domínguez-Muñoz JE,Nieto L,Vilariño M,Lourido MV,Iglesias-García J

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVES:Treatment of the pain caused by chronic pancreatitis (CP) is not standardized. Knowledge of the response to placebo in this setting may aid the design of future trials. We aimed at investigating the placebo effect on abdominal pain remission rates in patients with CP. METHODS:MEDLINE, EMBASE, and Scopus wer...

journal_title：Pancreas

authors： Capurso G,Cocomello L,Benedetto U,Cammà C,Delle Fave G

更新日期：2012-10-01 00:00:00

abstract：:Recently, the landscape of the diagnosis and treatment of patients with well-differentiated gastrointestinal/pancreatic neuroendocrine tumors (previously referred to as carcinoid tumors) has changed dramatically. We will need to work with all of the stakeholders including clinicians, patients, regulatory agencies, and...

journal_title：Pancreas

authors： Asmis T

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:Pancreatic ductal carcinoma frequently recurs postoperatively, and we analyzed clinicopathological features of patients treated by surgical resection to find predictors of postoperative recurrence. METHODS:A retrospective cohort study was performed that included 69 patients between 1985 and 2003. Clinicopath...

journal_title：Pancreas

authors： Shibata K,Matsumoto T,Yada K,Sasaki A,Ohta M,Kitano S

更新日期：2005-07-01 00:00:00

abstract：:The accuracies of assays of serum CA 19-9 and elastase 1 in the diagnosis of pancreatic carcinoma were investigated by the cutoff method and discriminant analysis of data on 98 patients with pancreatitis, 65 patients with pancreatic carcinoma, 107 patients with benign diseases of other organs, and 108 patients with ca...

journal_title：Pancreas

authors： Yamamura H,Tatsuta M,Ito M,Iishi H,Noguchi S,Okuda S,Yoshida M

更新日期：1989-01-01 00:00:00

abstract：:Tumor relapse occurs frequently in patients with ductal pancreatic head cancer despite the absence of residual tumor detectable at primary surgery. Therefore it has to be assumed that current tumor staging procedures fail to detect minimal amounts of disseminated tumor cells present in secondary organs, which might be...

journal_title：Pancreas

authors： Hosch SB,Knoefel WT,Metz S,Stoecklein N,Niendorf A,Broelsch CE,Izbicki JR

更新日期：1997-08-01 00:00:00

abstract：:Measurement of pancreatic blood flow (PBF) is technically demanding. Although radiolabeled microspheres are considered the "gold standard" for PBF assessment, they have practical limitations. In the current study, H2 and xenon-133 gas clearance techniques were adapted to PBF measurement and compared to radiolabeled mi...

journal_title：Pancreas

authors： DeMar AR,Graham LS,Lake R,Fink AS

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:There is reluctance to use donation after cardiac death (DCD) organs for fear of worse outcomes due to increased warm ischemia time. Extensive evidence to confirm the quality of DCD pancreas transplants is not manifest. METHODS:A united network for organ sharing database review of pancreas transplants perfor...

journal_title：Pancreas

authors： Siskind E,Akerman M,Maloney C,Huntoon K,Alex A,Siskind T,Bhaskeran M,Ali N,Basu A,Molmenti E,Ortiz J

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVES:Nitric oxide (NO) is a potent nonadrenergic, noncholinergic mediator of gastrointestinal smooth muscle. We aimed to investigate the effects of new NO/cyclic guanosine monophosphate (cGMP) pathway-affecting agents at the sheep sphincter of Oddi (SO) in vitro. METHODS:Sheep SO rings were mounted in organ bath...

journal_title：Pancreas

authors： Sarac B,Durmus N,Bagcivan I,Altun A,Turan M,Sencan M

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to assess the association of hemodynamic factors with 90-day mortality in critically ill patients with severe acute pancreatitis (SAP). METHODS:One hundred fifty-nine consecutive patients with SAP admitted to the intensive care units between January 2005 and December 2008 were incl...

journal_title：Pancreas

authors： Wilkman E,Kaukonen KM,Pettilä V,Kuitunen A,Varpula M

更新日期：2013-03-01 00:00:00

abstract：INTRODUCTION:Invasion and metastasis of pancreatic cancer (PC) require cell motility and adhesion, which depend on the activity of cytoskeleton. A cytoskeletal component indispensable for these processes is myosin II, the cytoplasmic analogue of smooth and skeletal muscle myosin. AIMS AND METHODOLOGY:Because the activ...

journal_title：Pancreas

authors： Kaneko K,Satoh K,Masamune A,Satoh A,Shimosegawa T

更新日期：2002-01-01 00:00:00