Alteration of integrins by interleukin-1alpha in human pancreatic cancer cells.

abstract：OBJECTIVE:Epithelial-mesenchymal transition may interfere with the differentiation of cultured pancreatic acinar cells toward endocrine cells. Therefore, it will be important to investigate into detail the reprogramming of human pancreatic acinar cells toward a mesenchymal phenotype: the association with acinoductal tr...

journal_title：Pancreas

authors： De Waele E,Wauters E,Ling Z,Bouwens L

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess the relationship between the computed tomography (CT) pancreatic parenchyma attenuation value and clinically relevant postoperative pancreatic fistula (POPF). METHODS:The medical records of 115 patients who underwent pancreaticoduodenectomy and preoperative dynamic CT were...

journal_title：Pancreas

authors： Maehira H,Iida H,Mori H,Kitamura N,Miyake T,Shimizu T,Tani M

更新日期：2019-02-01 00:00:00

abstract：:Pancreatic duct bicarbonate secretion is mediated primarily by secretin-induced elevation of intracellular cyclic AMP, although little is known of the effects of other physiological regulators on pancreatic duct cyclic AMP metabolism. We investigated the effects of secretin and several other potential agonists on cycl...

journal_title：Pancreas

authors： de Ondarza J,Hootman SR

更新日期：1995-10-01 00:00:00

abstract：:We performed molecular biological studies as well as immunohistochemical analysis of three cases of giant cell carcinoma of the pancreas. Histologically, one case was a pleomorphic giant cell carcinoma consisting of pleomorphic giant/ small cells and spindle cells, one an osteoclast-like giant cell tumor composed of o...

journal_title：Pancreas

authors： Imai Y,Morishita S,Ikeda Y,Toyoda M,Ashizawa T,Yamamoto K,Inoue T,Ishikawa T

更新日期：1999-04-01 00:00:00

abstract：OBJECTIVES:Most of the acetaldehyde, a recognized animal carcinogen, generated during alcohol metabolism is eliminated by liver mitochondrial aldehyde dehydrogenase 2 (ALDH2). More than 40% of Japanese have the inactive form of ALDH2, and inactive ALDH2 is a risk factor for multiple cancers of the esophagus as well as ...

journal_title：Pancreas

authors： Miyasaka K,Kawanami T,Shimokata H,Ohta S,Funakoshi A

更新日期：2005-03-01 00:00:00

abstract：:In this study, we performed a detailed analysis of the immunoreactive (IR) patterns and tissue distribution of vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY), and gastrin-releasing peptide (GRP) in the feline pancreas by means of immunohistochemical and radioimmunological techniques. Immunoreactivity fo...

journal_title：Pancreas

authors： De Giorgio R,Sternini C,Brecha NC,Widdison AL,Karanjia ND,Reber HA,Go VL

更新日期：1992-01-01 00:00:00

abstract：:Chronic pancreatitis (CP) is one condition in which epidemiologic studies have demonstrated a definite association with pancreatic adenocarcinoma (PAC). The pathophysiologic and molecular events that either predispose to the development of, or potentiate the growth of, PAC are unknown. Mutation of the codon 12 K-ras g...

journal_title：Pancreas

authors： Banerjee SK,Zoubine MN,Mullick M,Weston AP,Cherian R,Campbell DR

更新日期：2000-04-01 00:00:00

abstract：OBJECTIVES:In injury conditions, myofibroblasts are induced to lay down matrix proteins and support the repair process. In this study, we investigated the role of myofibroblasts, particularly stellate cells, in the growth and regeneration of pancreatic β cells. METHODS:We used both in vitro and in vivo approaches to a...

journal_title：Pancreas

authors： Bayan JA,Peng Z,Zeng N,He L,Chen J,Stiles BL

更新日期：2015-10-01 00:00:00

abstract：:Pseudocysts and post-necrotic collections of the pancreas are sometimes treated by percutaneous drainage. In cases of post-necrotic collection, intractable pancreatic juice fistula is often formed by disruption of the main pancreatic duct in the necrotized region. We radically treated intractable pancreatic juice fist...

journal_title：Pancreas

authors： Hirota M,Kamekawa K,Tashima T,Mizumoto M,Ohara C,Beppu T,Shimada S,Yamaguchi Y,Ogawa M

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVES:This study aimed to develop target-specific binding agents for in vitro and in vivo imaging of human pancreatic cancer. METHODS:A monoclonal neutrophil gelatinase-associated lipocalin (NGAL)-specific antibody and a peptide specific for matrix metalloproteinase (MMP) were labeled with a near-infrared dye for...

journal_title：Pancreas

authors： Wang W,Lin J,Guha S,Tong Z,Cameron AG,Zhang F,Qiu X,Zou C,Gao X,Mawad ME,Ke S

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to investigate the biochemical and functional properties of a rat acellular pancreatic bioscaffolds (APBs). METHODS:Fresh pancreata from 10 rats were soaked and perfused through portal veins using Easy-Load Digital Drive peristaltic pumps. The histological structure, extracellular ma...

journal_title：Pancreas

authors： Wang X,Li YG,Du Y,Zhu JY,Li Z

更新日期：2018-09-01 00:00:00

abstract：:The vast majority of patients who present with pancreatic adenocarcinoma have locally advanced or metastatic disease at the time of presentation without possibility of cure. Although in recent years there have been some new promising chemotherapy regimens that improve overall survival by a few months, the prognosis re...

journal_title：Pancreas

authors： Shah R,Ostapoff KT,Kuvshinoff B,Hochwald SN

更新日期：2018-01-01 00:00:00

abstract：:The role of parathyroid hormone (PTH) and calcium on pancreatic exocrine secretion were observed using sham-operated and parathyroidectomized dogs. First, exocrine secretion of the pancreas stimulated with secretin and cholecystokinin octapeptide (CCK-8) was examined in vivo 3 weeks after parathyroidectomy. Secondly, ...

journal_title：Pancreas

authors： Kuroda T,Shiohara E,Haba Y,Kaneko G,Hanazaki K,Kajikawa S,Iida F

更新日期：1993-11-01 00:00:00

abstract：:This study was undertaken to determine the involvement of endogenous cholecystokinin (CCK) in the regeneration of pancreatic tissue after cerulein-induced acute pancreatitis treated by the CCK receptor antagonist L364,718. Acute pancreatitis was induced in rats by s.c. injections of cerulein in gelatin (12 micrograms/...

journal_title：Pancreas

authors： Jurkowska G,Grondin G,Morisset J

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVES:Inoperable pancreatic ductal adenocarcinoma is known to have an extremely poor prognosis. Although rare, there are some patients who have unexpected long-term survival, but the reason is not yet clear. METHODS:A total of 482 inoperable pancreatic ductal adenocarcinoma of 1602 patients diagnosed at Severance...

journal_title：Pancreas

authors： Jo JH,Chung MJ,Park JY,Bang S,Park SW,Chung JB,Song SY

更新日期：2014-10-01 00:00:00

abstract：UNLABELLED:Serum adiponectin (ADP) levels are reported inversely related to the risk in breast, endometrial cancer, and gastric cancer. Serum ADP as a potential marker compared with CA-19-9 in pancreatic carcinoma (PC) and chronic pancreatitis (CP) was studied. Adiponectin and CA-19-9 levels were examined at the time o...

journal_title：Pancreas

authors： Chang MC,Chang YT,Su TC,Yang WS,Chen CL,Tien YW,Liang PC,Wei SC,Wong JM

更新日期：2007-07-01 00:00:00

abstract：:Paraoxonase 1 (PON1) is an antioxidant enzyme that inhibits the oxidative modification of LDL. Since PON1 has been shown to express in pancreatic islets and oxidative stress plays a role in beta-cell dysfunction, we investigated the impact of the PON1 polymorphisms on beta-cell function. This study included 84 healthy...

journal_title：Pancreas

authors： Chiu KC,Chuang LM,Chu A,Lu J,Hu J,Fernando S

更新日期：2004-05-01 00:00:00

abstract：:The nuclear DNA content was assessed by image cytometry on cytologic specimens obtained with fine-needle aspiration biopsy in 96 patients with pancreatic duct carcinoma. Twenty-two of these patients had pancreaticoduodenal resection. According to DNA analysis there were 27 (28%) diploid, 17 (18%) tetraploid, and 52 (5...

journal_title：Pancreas

authors： Linder S,Falkmer U,Hagmar T,Blåsjö M,Sundelin P,von Rosen A

更新日期：1994-11-01 00:00:00

abstract：OBJECTIVES:We compared the clinical profiles and organ manifestations of the commonly encountered immunoglobulin G4-related diseases (IgG4-RDs) on either side of the diaphragm: head and neck (HN) versus pancreatobiliary (PB) in IgG4-RD. METHODS:From the Mayo Clinic, Rochester, database, we identified 53 HN and 88 PB I...

journal_title：Pancreas

authors： Mohapatra S,Sharma A,Chari ST

更新日期：2019-07-01 00:00:00

abstract：INTRODUCTION:Massive bleeding may complicate the course of either acute or chronic pancreatitis. Although the latter is more frequently involved when bleeding occurs in the acute form, a poorer prognosis is to be expected. Abscess, severe inflammation, regional necrosis, and pseudocysts may cause major vessel erosion, ...

journal_title：Pancreas

authors： Flati G,Andrén-Sandberg A,La Pinta M,Porowska B,Carboni M

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVES:Amylase level in drains (ALD) has been proposed as a predictor for the development of a clinically significant pancreatic fistula (CS-PF) in patients undergoing a major pancreatic surgery. This study aimed to determine if the ALD in patients who developed a CS-PF after pancreatoduodenectomy is higher than th...

journal_title：Pancreas

authors： Ceroni M,Galindo J,Guerra JF,Salinas J,Martínez J,Jarufe N

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to identify differentially expressed proteins among various stages of pancreatic ductal adenocarcinoma (PDAC) by shotgun proteomics using nano-liquid chromatography coupled tandem mass spectrometry and stable isotope dimethyl labeling. METHODS:Differentially expressed proteins were...

journal_title：Pancreas

authors： Kuo KK,Kuo CJ,Chiu CY,Liang SS,Huang CH,Chi SW,Tsai KB,Chen CY,Hsi E,Cheng KH,Chiou SH

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:Presentation of pancreatic adenocarcinoma (PC) as acute pancreatitis (AP), association of chronic pancreatitis (CP) with PC, and role of inflammation in PC carcinogenesis are well recognized. We hypothesized that inflammatory changes associated with remote history of AP (≥2 years before PC diagnosis) would r...

journal_title：Pancreas

authors： Phillips AE,Shah N,Borhani AA,Yadav D,Brand RE

更新日期：2018-11-01 00:00:00

abstract：:Measurement of pancreatic blood flow (PBF) is technically demanding. Although radiolabeled microspheres are considered the "gold standard" for PBF assessment, they have practical limitations. In the current study, H2 and xenon-133 gas clearance techniques were adapted to PBF measurement and compared to radiolabeled mi...

journal_title：Pancreas

authors： DeMar AR,Graham LS,Lake R,Fink AS

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVES:This study aimed to determine whether the efficacy of pancrelipase/pancreatin (CREON®) may be affected by the concomitant use of proton pump inhibitors (PPIs)/histamine-2 receptor antagonists (H2RAs). METHODS:An analysis of integrated data from all clinical trials of pancrelipase/pancreatin supported by Abb...

journal_title：Pancreas

authors： Sander-Struckmeier S,Beckmann K,Janssen-van Solingen G,Pollack P

更新日期：2013-08-01 00:00:00

abstract：:The glycolytic inhibitor, 2-deoxy-D-glucose (2-DG), inhibits growth of some cancers. alpha-Difluoromethylornithine (DFMO) is an irreversible inhibitor of ornithine decarboxylase, the rate-limiting enzyme in polyamine biosynthesis. We and others have previously shown that DFMO inhibits cancer growth in a number of mode...

journal_title：Pancreas

authors： Saydjari R,Alexander RW,Barranco SC,Townsend CM Jr,Thompson JC

更新日期：1989-01-01 00:00:00

abstract：INTRODUCTION:The consumption of green tea is associated with a lower risk of several types of human carcinomas. A number of studies have focused on the possible mechanisms of cancer prevention by tea extracts, especially polyphenols such as epigallocatechin-3-gallate (EGCG). AIMS AND METHODOLOGY:Green tea-derived EGCG...

journal_title：Pancreas

authors： Takada M,Nakamura Y,Koizumi T,Toyama H,Kamigaki T,Suzuki Y,Takeyama Y,Kuroda Y

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVES:Oxidative stress has been implicated in the pathogenesis of chronic pancreatitis (CP) and pancreatic cancer (PC). The study aim was to assess the oxidative stress markers and antioxidant defense system in patients with CP and those with PC. METHODS:Activities of superoxide dismutase 1 (SOD1), catalase (CAT)...

journal_title：Pancreas

authors： Kodydkova J,Vavrova L,Stankova B,Macasek J,Krechler T,Zak A

更新日期：2013-05-01 00:00:00

abstract：:: Human tumor antigens recognized by T cells have been recently identified in various cancers, including pancreatic cancer. With the identified antigens, new immunotherapies can be developed using more efficient immunologic intervention (due to sufficient amounts of antigens in a more immunogenic form), as well as mor...

journal_title：Pancreas

authors： Kawakami Y,Okada T,Akada M

更新日期：2004-04-01 00:00:00

abstract：:We evaluated the diagnostic significance of the K-ras point mutations at codon 12 in duodenal lavage fluid (DLF) compared with pure pancreatic juice (PPJ). The DLF was easily and safely collected by injecting distilled water into the duodenum and then aspirating through the working channel of the endoscope during endo...

journal_title：Pancreas

authors： Nakamura Y,Onda M,Uchida E

更新日期：1999-03-01 00:00:00