Prognostic significance of DNA ploidy in pancreatic carcinoma.

abstract：INTRODUCTION:Peroxisome proliferator-activated receptors (PPARs) are a family of ligand-activated nuclear transcription factors belonging to the nuclear hormone receptors. Troglitazone, a specific ligand for PPAR-gamma is shown to regulate not only lipids and glucose metabolism, but also cell cycle, differentiation, an...

journal_title：Pancreas

authors： Jia DM,Otsuki M

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVES:We aimed to determine the difference in endoscopic ultrasonography (EUS) images between portal vein (PV) and arterial invasion of pancreatic cancer and to develop criteria for arterial involvement. METHODS:We reviewed EUS data of consecutive patients who underwent distal pancreatectomy from December 2010 to...

journal_title：Pancreas

authors： Yamato M,Mikata R,Yasui S,Iino Y,Shingyoji A,Kusakabe Y,Ohyama H,Sugiyama H,Sakai Y,Tsuyuguchi T,Yoshitomi H,Ohtsuka M,Kishimoto T,Kato N

更新日期：2020-04-01 00:00:00

abstract：:The influence of pancreatic secretions on growth and brush-border enzyme activity, throughout the entire small intestine, was examined in the rat. Pancreatic secretions were excluded from the gut lumen by stapling the pancreatic ducts, without interruption of bile flow. The entire small intestine was studied as four s...

journal_title：Pancreas

authors： Hauer-Jensen M,Christensen K,Wilson HD,Schedl HP

更新日期：1987-01-01 00:00:00

abstract：:Serum expression of the cancer-associated antigens CA 19-9 and CA 50 and their relation to Lewis blood cell status were studied in 26 patients with pancreatic duct carcinoma and 26 patients with pancreatitis. The discriminating capacity between benign and malignant disease was high for both tumor markers. The correspo...

journal_title：Pancreas

authors： von Rosen A,Linder S,Harmenberg U,Pegert S

更新日期：1993-03-01 00:00:00

abstract：:Amylase inhibition has gastrointestinal and metabolic effects that may aid in the treatment of diabetes and obesity. We tested whether 4 g of a commercially available wheat amylase inhibitor (WAI) affected postprandial carbohydrate (CHO) absorption and plasma glucose or hormones. Twelve persons (four lean and four obe...

journal_title：Pancreas

authors： Lankisch M,Layer P,Rizza RA,DiMagno EP

更新日期：1998-08-01 00:00:00

abstract：:In a patient with pancreatic cancer, an arterial anomaly was observed that apparently consisted of the congenital absence of the celiac axis and the replacement of the pancreaticoduodenal arcade by an anomalous vessel. The complete or near-complete arterial flow to the liver and spleen depended upon this anomalous pre...

journal_title：Pancreas

authors： Howard JM,Woldenberg LS,Conover SV

更新日期：1989-01-01 00:00:00

abstract：:beta-1,4-Galactosyltransferase (GalTase) is the glycosyltransferase in the Golgi apparatus that transfers galactose from UDP-galactose to terminal N-acetylglucosamine residues in glycoconjugates with formation of a beta-1,4 linkage. Neoplasms undergo various changes in the carbohydrate moieties of their glycoconjugate...

journal_title：Pancreas

authors： Yamamoto K,Kawakami H,Sugiyama M,Atomi Y,Hirano H

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVES:The aim of this prospective study was to evaluate the diagnostic value of the rapid urinary trypsinogen-2 test strip in post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. METHODS:A total of 150 patients were tested with the urinary trypsinogen-2 test strip and serum levels of amylase a...

journal_title：Pancreas

authors： Tseng CW,Chen CC,Lin SZ,Chang FY,Lin HC,Lee SD

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:To establish new biomarkers for accurate diagnosis of pancreatic cancer (PC) using a standardized serum peptidome profiling and compare the results with those from the tumor marker, CA 19-9. METHODS:Serum samples from 102 patients (55 with chronic pancreatitis and 47 with PC) and 56 healthy controls were col...

journal_title：Pancreas

authors： Zapico-Muñiz E,Farré-Viladrich A,Rico-Santana N,González-Sastre F,Mora-Brugués J

更新日期：2010-11-01 00:00:00

abstract：:The insulin-like growth factor-II (IGF-II) receptor (IGF-IIR) is a single-chain transmembrane protein identical to the mannose-6-phosphate receptor. In the present study we examined IGF-IIR expression in normal and cancerous human pancreatic tissues. In the normal pancreas, moderately strong IGF-IIR immunoreactivity w...

journal_title：Pancreas

authors： Ishiwata T,Bergmann U,Kornmann M,Lopez M,Beger HG,Korc M

更新日期：1997-11-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to observe the role of nucleotide-binding and oligomerization domain (NOD)-like receptors (NLR) in intestinal injury of severe acute pancreatitis (SAP) in rats. METHODS:Severe acute pancreatitis was induced by retrograde infusion of sodium taurocholate into the biliopancreatic duct....

journal_title：Pancreas

authors： Xu S,Wei S,Guo Y,Cui D,Yao J

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVES:Infected necrotizing pancreatitis represents a serious and therapeutically challenging complication. Percutaneous drainage of infected pancreatic necrosis is often unsuccessful. Alternatively, open necrosectomies are associated with high morbidity. Recently, minimally invasive necrosectomy techniques have be...

journal_title：Pancreas

authors： Bucher P,Pugin F,Morel P

更新日期：2008-03-01 00:00:00

abstract：:Diabetes mellitus secondary to chronic pancreatitis is characterized by a progressive destruction of the pancreas, including loss of the islet cells, leading to a form of diabetes that can mimic both type 1 and type 2 diabetes. Glucagon-like peptide 1(7-36)amide (GLP-1), an intestinally derived insulinotropic hormone,...

journal_title：Pancreas

authors： Hedetoft C,Sheikh SP,Larsen S,Holst JJ

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVES:Literature addressing the significance of lymph node positivity in the management of nonfunctional pancreatic neuroendocrine tumors (PNETs) is conflicting. METHODS:The National Cancer Data Base was queried for patients who underwent surgical resection of nonfunctional PNETs between 1998 and 2011. Clinical d...

journal_title：Pancreas

authors： Jutric Z,Grendar J,Hoen HM,Cho SW,Cassera MA,Newell PH,Hammill CW,Hansen PD,Wolf RF

更新日期：2017-08-01 00:00:00

abstract：:Opioid growth factor (OGF, [Met5]-enkephalin) is an endogenous peptide that regulates the growth of human pancreatic cancer. To evaluate whether human subjects with pancreatic cancer have alterations in plasma levels of OGF, fasting blood samples were obtained from 15 patients with histologically confirmed pancreatic ...

journal_title：Pancreas

authors： Smith JP,Conter RL,Demers TM,McLaughlin PJ,Zagon IS

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to evaluate the relevance of defining borderline resectable (BR) pancreatic cancer as a distinct entity in the treatment scheme of pancreatic cancer as proposed by the National Comprehensive Cancer Network. METHODS:Among 375 patients with pancreatic cancer, 137 patients were ...

journal_title：Pancreas

authors： Yamada S,Fujii T,Sugimoto H,Nomoto S,Takeda S,Kodera Y,Nakao A

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVES:To measure the usefulness of Ki-67 proliferative index (Ki-67 index) as a prognostic variable for grading pancreatic neuroendocrine tumors. METHODS:A multi-institutional prospective database comprising 350 patients. Grading based on mitotic activity (<2 mitoses/10 high-power fields, 2-20 and >20) and Ki-67 ...

journal_title：Pancreas

authors： Philips P,Kooby DA,Maithel S,Merchant NB,Weber SM,Winslow ER,Ahmad S,Kim HJ,Scoggins CR,McMasters KM,Martin RCG 2nd

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVES:Previously, we showed that diazoxide (DZ), an effective ischemic preconditioning agent, protected rodent pancreas against ischemia-reperfusion injury. Here, we further investigate whether DZ supplementation to University of Wisconsin (UW) solution during pancreas procurement and islet isolation has similar c...

journal_title：Pancreas

authors： Wang Y,Qi M,McGarrigle JJ,Xing Y,Mendoza-Elias JE,Bochenek M,Marchese E,He Y,Oberholzer J

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVES:Association between acute pancreatitis and acute viral hepatitis (AVH) is more frequent than previously thought. Most cases are hepatitis A or B virus related. Only 6 cases of acute pancreatitis with acute hepatitis E virus (HEV)-related hepatitis has been reported so far. METHODS:We analyzed the hospital r...

journal_title：Pancreas

authors： Bhagat S,Wadhawan M,Sud R,Arora A

更新日期：2008-05-01 00:00:00

abstract：:Chronic pancreatitis (CP) is one condition in which epidemiologic studies have demonstrated a definite association with pancreatic adenocarcinoma (PAC). The pathophysiologic and molecular events that either predispose to the development of, or potentiate the growth of, PAC are unknown. Mutation of the codon 12 K-ras g...

journal_title：Pancreas

authors： Banerjee SK,Zoubine MN,Mullick M,Weston AP,Cherian R,Campbell DR

更新日期：2000-04-01 00:00:00

abstract：:The hedgehog (Hh) family of genes, sonic hedgehog (Shh), Indian hedgehog (Ihh), and desert hedgehog (Dhh) encode signaling molecules that regulate multiple functions during organ development and in adult tissues. Altered hedgehog signaling has been implicated in disturbed organ development as well as in different dege...

journal_title：Pancreas

authors： Kayed H,Kleeff J,Osman T,Keleg S,Büchler MW,Friess H

更新日期：2006-03-01 00:00:00

abstract：:Solitary fibrous tumor (SFT) arising in the pancreas is exceedingly rare, with only 11 cases reported in the English literature. All cases described thus far have exhibited benign histology. We report the first case of malignant SFT of the pancreas. The patient was a 52-year-old woman who presented with obstructive ja...

journal_title：Pancreas

authors： Estrella JS,Wang H,Bhosale PR,Evans HL,Abraham SC

更新日期：2015-08-01 00:00:00

abstract：:In 134 consecutive patients with acute abdominal pain, we evaluated the clinical role of a new rapid test for serum lipase based on latex agglutination. The results were compared with those obtained with a widely used lipase immunoassay as well as with serum amylase and pancreatic isoamylase measurements. Fifty-five h...

journal_title：Pancreas

authors： Ventrucci M,Pezzilli R,Naldoni P,Montone L,Gullo L

更新日期：1986-01-01 00:00:00

abstract：:Although fat accumulation in acinar cells is the earliest histopathological change in the pancreas of patients and experimental animals, there are few long-term studies regarding lipid composition of the pancreas in alcoholism. In the present study, female Sprague-Dawley rats were divided into three groups each fed Wa...

journal_title：Pancreas

authors： Simsek H,Singh M

更新日期：1990-07-01 00:00:00

abstract：OBJECTIVES:Mammalian targets of rapamycin inhibitors (mTORi) are considered second-line immunosuppression agents because of associated increases in rejection and impaired wound healing. Recent reports indicate mTORi have been linked to improved survival, decreased inflammatory response in pancreatitis, and antiprolifer...

journal_title：Pancreas

authors： Siskind EJ,Liu C,Collins DT,Emery E,Steen E,Tran E,Stodghill J,Piper J,Jonsson J,Ortiz J

更新日期：2019-05-01 00:00:00

abstract：:Paraoxonase 1 (PON1) is an antioxidant enzyme that inhibits the oxidative modification of LDL. Since PON1 has been shown to express in pancreatic islets and oxidative stress plays a role in beta-cell dysfunction, we investigated the impact of the PON1 polymorphisms on beta-cell function. This study included 84 healthy...

journal_title：Pancreas

authors： Chiu KC,Chuang LM,Chu A,Lu J,Hu J,Fernando S

更新日期：2004-05-01 00:00:00

abstract：:To examine previous work carried out at a single center, i.e., France, on the pathologic features of chronic pancreatitis and to examine geographic differences, 359 cases of chronic pancreatitis from five centers were studied pathologically and the results analyzed according to appropriate statistical methods. It was ...

journal_title：Pancreas

authors： Sahel J,Cros RC,Durbec JP,Sarles H,Bank S,Marks IN,Bettarello A,Duarte I,Guarita D,Machado M

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVES:Acute pancreatitis (AP) is a leading cause of hospitalization for a gastrointestinal illness in the United States. We hypothesized that enhanced recovery approaches may lead to earlier time to refeeding in patients with AP. METHODS:We performed a double-blind, randomized controlled trial of patients admitte...

journal_title：Pancreas

authors： Dong E,Chang JI,Verma D,Butler RK,Villarin CK,Kwok KK,Chen W,Wu BU

更新日期：2019-02-01 00:00:00

abstract：INTRODUCTION:Hypercytokinemia is known to occur in severe acute pancreatitis, suggesting that the production, deposition, and degradation of the extracellular matrix (ECM) occur actively as a result of the actions of the complicated cytokine network. AIMS AND METHODOLOGY:To examine the influence of cytokines and growt...

journal_title：Pancreas

authors： Nakae H,Endo S,Inoue Y,Fujino Y,Wakabayashi G,Inada K,Sato S

更新日期：2003-03-01 00:00:00

abstract：:OBJECTIVES: The purpose of this study was to determine whether the choice for performance of endoscopic retrograde pancreatography (ERP) could be tailored to findings on computed tomography (CT) in patients with suspected autoimmune pancreatitis (AIP). METHODS: Eighty-four AIP patients and 73 pathology-proven pancreat...

journal_title：Pancreas

authors： Kim JH,Kim MH,Byun JH,Lee SS,Lee SJ,Park SH,Lee SK,Park DH,Lee MG,Moon SH

更新日期：2012-05-01 00:00:00