Suppression of human pancreatic carcinoma cell growth and invasion by epigallocatechin-3-gallate.

abstract：OBJECTIVE:To evaluate the effects of iodine contrast media and gadoteric acid in acute necrotizing pancreatitis. METHODS:Fifty rabbits were distributed in 5 groups: 10 rabbits were assigned in the control group (group 5) and 40 rabbits were assigned in the pancreatitis group, wherein acute necrotizing pancreatitis was...

journal_title：Pancreas

authors： Apodaca-Torrez FR,Goldenberg A,Lobo EJ,Farah JF,Triviño T,Montero EF,Schraibman V,Benvenuto RB,Artigiani Neto R

更新日期：2007-11-01 00:00:00

abstract：:Pretreatment of rat pancreatic acini with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) for 5 or 10 min reduced cytosolic free calcium and amylase secretion stimulated by submaximal concentration (10(-6) M) of carbachol in a dose-dependent manner. 10(-7) M TPA inhibited initial amylase secretion and had no effect on sus...

journal_title：Pancreas

authors： Arita Y,Kimura T,Ogami Y,Nawata H

更新日期：1991-01-01 00:00:00

abstract：:The hedgehog (Hh) family of genes, sonic hedgehog (Shh), Indian hedgehog (Ihh), and desert hedgehog (Dhh) encode signaling molecules that regulate multiple functions during organ development and in adult tissues. Altered hedgehog signaling has been implicated in disturbed organ development as well as in different dege...

journal_title：Pancreas

authors： Kayed H,Kleeff J,Osman T,Keleg S,Büchler MW,Friess H

更新日期：2006-03-01 00:00:00

abstract：INTRODUCTION:Adenocarcinoma of the pancreas remains one of the most difficult malignancies to treat. Its incidence has steadily increased over the past four decades, and its prognosis is still dismal. AIM To assess tumor control and the palliative benefit of 5-fluorouracil (5-FU), cisplatin (CDDP), and radiotherapy in ...

journal_title：Pancreas

authors： Azria D,Ychou M,Jacot W,Thezenas S,Lemanski C,Senesse P,Prost P,Delard R,Masson B,Dubois JB

更新日期：2002-11-01 00:00:00

abstract：:Over the last 3 decades, there have been substantial improvements in diagnostic imaging and sampling techniques to evaluate pancreatic diseases. The modern technology has helped us to recognize premalignant conditions of pancreas including mucinous cystic neoplasms and intraductal papillary mucinous neoplasms (IPMNs)....

journal_title：Pancreas

authors： Thosani N,Dasari CS,Bhutani MS,Raimondo M,Guha S

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate whether 6 candidate serum miRNAs and their interactions with serum folate level were associated with the risk for pancreatic cancer (PC). METHOD:A hospital-based case-control study including 74 incident PC cases and 74 controls was conducted. Serum folate and miRNAs ...

journal_title：Pancreas

authors： Tian Y,Xue Y,Ruan G,Cheng K,Tian J,Qiu Q,Xiao M,Li H,Yang H,Wang L

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:Hypertriglyceridemia-induced pancreatitis is an important cause of acute pancreatitis (AP) in children, which lacks established guidelines. The aim of this study was to review management approaches at a single pediatric center. METHODS:This retrospective study included all inpatients younger than 21 years w...

journal_title：Pancreas

authors： Ippisch HM,Alfaro-Cruz L,Fei L,Zou Y,Thompson T,Abu-El-Haija M

更新日期：2020-03-01 00:00:00

abstract：:Solid pseudopapillary tumor of the pancreas is a rare neoplasm with low malignant potential, which affects predominantly young females. Only approximately 10% to 15% cases of solid pseudopapillary tumors (SPTs) are malignant. We present the case of a 57-year-old woman who developed malignant SPT of the pancreas. Meanw...

journal_title：Pancreas

authors： Ji S,Xu J,Zhang B,Xu Y,Liu C,Long J,Ni Q,Yu X

更新日期：2012-11-01 00:00:00

abstract：INTRODUCTION:Hypercytokinemia is known to occur in severe acute pancreatitis, suggesting that the production, deposition, and degradation of the extracellular matrix (ECM) occur actively as a result of the actions of the complicated cytokine network. AIMS AND METHODOLOGY:To examine the influence of cytokines and growt...

journal_title：Pancreas

authors： Nakae H,Endo S,Inoue Y,Fujino Y,Wakabayashi G,Inada K,Sato S

更新日期：2003-03-01 00:00:00

abstract：:: Human tumor antigens recognized by T cells have been recently identified in various cancers, including pancreatic cancer. With the identified antigens, new immunotherapies can be developed using more efficient immunologic intervention (due to sufficient amounts of antigens in a more immunogenic form), as well as mor...

journal_title：Pancreas

authors： Kawakami Y,Okada T,Akada M

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVES:This analysis investigated nomogram use to evaluate metastatic pancreatic cancer prognosis. METHODS:Thirty-four baseline factors were examined in the Metastatic Pancreatic Adenocarcinoma Clinical Trial (MPACT) (nab-paclitaxel plus gemcitabine vs gemcitabine) data set. Factors significantly (P < 0.1) associa...

journal_title：Pancreas

authors： Goldstein D,Von Hoff DD,Chiorean EG,Reni M,Tabernero J,Ramanathan RK,Botteman M,Aly A,Margunato-Debay S,Lu B,Louis CU,McGovern D,Lee CK

更新日期：2020-07-01 00:00:00

abstract：:Five human pancreatic carcinoma cell lines were screened for the presence of muscarinic cholinergic receptors (mAChRs), using [3H]N-methylscopolamine ([3H]NMS). T3M4 and COLO-357 cells exhibited specific, high-affinity binding to mAChRs. A small amount of [3H]NMS also bound in PANCI and ASPC-I cells, but not in MIA Pa...

journal_title：Pancreas

authors： Ackerman MS,Roeske WR,Heck RJ,Korc M

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVES:Despite decades of effort, the 5-year overall survival rate of pancreatic cancer (PC) remains at only approximately 5%. Until now, no detailed knowledge regarding the worldwide research architecture of PC has yet been established. METHODS:Hence, we conducted this scientometric analysis to quantify the globa...

journal_title：Pancreas

authors： Schöffel N,Krempel M,Bundschuh M,Bendels MH,Brüggmann D,Groneberg DA

更新日期：2016-11-01 00:00:00

abstract：:Although ethanol abuse is the major etiologic factor in the development of acute and chronic pancreatitis, the mechanisms of ethanol effects to cause pancreatitis are poorly understood. The major reason for the lack of progress is the relative lack of animal models that reproduce the deleterious effects of ethanol on ...

journal_title：Pancreas

authors： Pandol SJ,Gukovsky I,Satoh A,Lugea A,Gukovskaya AS

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVE:There is reluctance to use donation after cardiac death (DCD) organs for fear of worse outcomes due to increased warm ischemia time. Extensive evidence to confirm the quality of DCD pancreas transplants is not manifest. METHODS:A united network for organ sharing database review of pancreas transplants perfor...

journal_title：Pancreas

authors： Siskind E,Akerman M,Maloney C,Huntoon K,Alex A,Siskind T,Bhaskeran M,Ali N,Basu A,Molmenti E,Ortiz J

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVES:Understanding the effect of lymph node metastasis (LNM) on prognosis in pancreatic neuroendocrine neoplasm is helpful for surgery and follow-up. In this study, we investigated the significance of LNM in well-differentiated pancreatic neuroendocrine tumors (PanNETs) according to the World Health Organization ...

journal_title：Pancreas

authors： Harimoto N,Hoshino K,Muranushi R,Hagiwara K,Yamanaka T,Ishii N,Tsukagoshi M,Igarashi T,Tanaka H,Watanabe A,Kubo N,Araki K,Hosouchi Y,Suzuki H,Arakawa K,Hirai K,Fukazawa T,Ikota H,Shirabe K

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVES:Acute pancreatitis (AP) is a leading cause of hospitalization for a gastrointestinal illness in the United States. We hypothesized that enhanced recovery approaches may lead to earlier time to refeeding in patients with AP. METHODS:We performed a double-blind, randomized controlled trial of patients admitte...

journal_title：Pancreas

authors： Dong E,Chang JI,Verma D,Butler RK,Villarin CK,Kwok KK,Chen W,Wu BU

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:Pancreatic ductal carcinoma frequently recurs postoperatively, and we analyzed clinicopathological features of patients treated by surgical resection to find predictors of postoperative recurrence. METHODS:A retrospective cohort study was performed that included 69 patients between 1985 and 2003. Clinicopath...

journal_title：Pancreas

authors： Shibata K,Matsumoto T,Yada K,Sasaki A,Ohta M,Kitano S

更新日期：2005-07-01 00:00:00

abstract：:Thirty-six patients with pancreatic head carcinoma entered a protocol, but only 20 were suitable for resection and evaluation of long-term survival. They were nine males and 11 females, with a mean age of 64.3 years. Following surgical resection, 10 Gy was delivered to the tumor bed intraoperatively. Postoperative rad...

journal_title：Pancreas

authors： Crucitti F,Doglietto GB,Frontera D,Viola G,Morganti AG,Valentini V,Alfonsi G,Trodella L,Cellini N

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVES:Homocysteine has been implicated in vascular dysfunction and thrombosis, as well as inflammatory conditions. This study was aimed to find out whether chronic pancreatitis (CP) is associated with hyperhomocysteinemia and derangements of transmethylation and transsulfuration pathways. METHODS:We estimated hom...

journal_title：Pancreas

authors： Girish BN,Vaidyanathan K,Rao NA,Rajesh G,Reshmi S,Balakrishnan V

更新日期：2010-01-01 00:00:00

abstract：:To evaluate the effect of the prostaglandin inhibitor acetylsalicylic acid (ASA) on rat exocrine pancreas secretion, three groups of rats were administered ASA by infusion: Groups 1-3, 50, 100, and 200 mg/kg body wt, respectively; Group 4 received saline. Twenty minutes later these ASA-pretreated groups were given int...

journal_title：Pancreas

authors： Fabris C,Munaretto S,Basso D,Dodi G,Infantino A,Piccoli A,Meggiato T,Fogar P,Panozzo MP,Del Favero G

更新日期：1993-07-01 00:00:00

abstract：:Increased activity of various proteases is observed in both human and experimental pancreatitis; however, the information on the effects of specific protease inhibitors on the disease is limited. In this study we show that a novel elastase inhibitor, guamerin-derived synthetic peptide (GDSP), improves the parameters o...

journal_title：Pancreas

authors： Song M,Zaninovic V,Kim D,Gukovsky I,Gukovskaya A,Kang K,Pandol S

更新日期：1999-04-01 00:00:00

abstract：OBJECTIVE:Secreted apoptosis-related protein (SARP) families are considered to counteract the oncogenic Wnt signaling pathway, and inactivation of this gene may aid cancer development and progression. Recently, the aberrant methylation of SARP2 was detected frequently in pancreatic carcinoma (PCa) tissue, but not in no...

journal_title：Pancreas

authors： Watanabe H,Okada G,Ohtsubo K,Yao F,Jiang PH,Mouri H,Wakabayashi T,Sawabu N

更新日期：2006-05-01 00:00:00

abstract：:Cutaneous metastasis of an occult malignancy to the umbilicus has come to be known as a Sister Mary Joseph's nodule (SMJN). More than 400 cases of this well-described clinical presentation of advanced gastrointestinal and gynecologic cancers have been reported. Pancreatic cancer presenting as a SMJN is a rare phenomen...

journal_title：Pancreas

authors： Yendluri V,Centeno B,Springett GM

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVES:Laparoscopic techniques have been slow to establish a role in pancreatic surgery. Worldwide, laparoscopic left pancreatectomy (LLP) is gaining in popularity; however, there remains little published data from the United Kingdom.We aimed to evaluate the results of LLP performed in a single UK pancreatic unit. ...

journal_title：Pancreas

authors： Mowbray NG,Al-Sarira A,Al-Sarireh B

更新日期：2016-09-01 00:00:00

abstract：:Chemokines may regulate the process of immune cell infiltration that is often found in pancreatic cancer. In this study, we investigated the secretion of the chemokines [interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, and RANTES (regulated on activation, normal T cell expressed and secreted)] in human pa...

journal_title：Pancreas

authors： Takaya H,Andoh A,Shimada M,Hata K,Fujiyama Y,Bamba T

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVES:The endogenous immune response is influenced by the stimulation of the vagal nerve. Stimulation or ablation has a direct impact on the release of pro- and anti-inflammatory mediators. In the progression of acute pancreatitis from local to systemic disease, these mediators play a pivotal role. This study eval...

journal_title：Pancreas

authors： Schneider L,Jabrailova B,Soliman H,Hofer S,Strobel O,Hackert T,Büchler MW,Werner J

更新日期：2014-01-01 00:00:00

abstract：:A new model is proposed for pancreatic enzyme secretion in response to food protein intake in rats. We have found a novel peptide in rat bile-pancreatic juice, which exhibits a trypsin-sensitive, cholecystokinin (CCK)-releasing activity. The amino acid sequence of the peptide purified from rat bile-pancreatic juice is...

journal_title：Pancreas

authors： Iwai K,Fushiki T,Fukuoka S

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVES:Recent studies have demonstrated that synthetic protease inhibitors could ameliorate the progression of pancreatic fibrosis in some animal models. Since oral administration of protease inhibitors increases the plasma cholecystokinin (CCK) levels and causes hypertrophy of the pancreas in rats, there is a poss...

journal_title：Pancreas

authors： Jia D,Taguchi M,Otsuki M

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate microRNAs related to postoperative prognosis of pancreatic cancer by applying microarray analysis to stored surgical specimens. METHODS:We retrospectively analyzed the relationship between microRNA expression and postoperative survival of pancreatic cancer patients i...

journal_title：Pancreas

authors： Lee KH,Lee JK,Choi DW,Do IG,Sohn I,Jang KT,Jung SH,Heo JS,Choi SH,Lee KT

更新日期：2015-07-01 00:00:00