Abstract:
OBJECTIVES:Acute pancreatitis (AP) guidelines for adult patients do not recommend routine prophylactic use of antibiotics because of no clinical merit on mortality, infectious complications, or length of stay. Although the mortality of pediatric AP is low, no studies have explored the rationale for antibiotic use in pediatric patients. The aim of this study was to evaluate the effects of early prophylactic antibiotics on length of stay and total costs in pediatric patients. METHODS:Using the Japanese Diagnosis Procedure Combination database from 2010 to 2017, we used the stabilized inverse probability of treatment weighting method using propensity scores to balance the background characteristics in the antibiotics group and the control group, and compared length of stay and total costs between the groups. RESULTS:We found significant differences between the antibiotics group (n = 652) and the control group (n = 467) in length of stay (11 days vs 9 days; percent difference, 15.4%; 95% confidence interval, 5.0%-26.8%) and total costs (US $4085 vs US $3648; percent difference, 19.8%; 95% confidence interval, 8.0%-32.9%). CONCLUSIONS:Prophylactic antibiotics were associated with longer length of stay and higher total costs. Our results do not support routine use of prophylactic antibiotics in pediatric AP populations.
journal_name
Pancreasjournal_title
Pancreasauthors
Ikeda Kurakawa K,Okada A,Jo T,Ono S,Bessho K,Michihata N,Matsui H,Yamaguchi S,Fushimi K,Kadowaki T,Yasunaga Hdoi
10.1097/MPA.0000000000001682subject
Has Abstractpub_date
2020-11-01 00:00:00pages
1321-1326issue
10eissn
0885-3177issn
1536-4828pii
00006676-202011000-00009journal_volume
49pub_type
杂志文章相关文献
PANCREAS文献大全abstract::We evaluated the diagnostic significance of the K-ras point mutations at codon 12 in duodenal lavage fluid (DLF) compared with pure pancreatic juice (PPJ). The DLF was easily and safely collected by injecting distilled water into the duodenum and then aspirating through the working channel of the endoscope during endo...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199903000-00004
更新日期:1999-03-01 00:00:00
abstract::Examining the actions of L-364,718 on rat pancreatic acini, we found that L-364,718 causes persistent inhibition of cholecystokinin (CCK)-8-stimulated enzyme secretion in acini that were first incubated with L-364,718, washed repeatedly, and then reincubated with CCK-8. This inhibition is maximal after as little as 5 ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199401000-00015
更新日期:1994-01-01 00:00:00
abstract::A case of papillary cystic tumor (PCT) of the pancreas in a 55-year-old woman is described. She presented with a gradually enlarging and painless abdominal mass for > 26 years. The tumor was encapsulated and measured 16 x 12 x 10 cm. The gross features and conventional light microscopic appearance of this tumor were c...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199301000-00023
更新日期:1993-01-01 00:00:00
abstract::Pretreatment of rat pancreatic acini with phorbol 12-myristate, 13-acetate (PMA), a protein kinase C (PK-C) activator, caused the desensitization of carbamylcholine (CBC)-induced amylase release in a concentration- and time-dependent fashion. The less potent phorbol-12, 13-dibutyrate (PDBu) also provoked a desensitiza...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199001000-00007
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:To develop a ¹³C-labeled substrate breath test by defining the optimal ¹³C-labeled substrate, substrate dose, test meal, and duration of the test and evaluating its accuracy for the diagnosis of pancreatic exocrine insufficiency (PEI) in chronic pancreatitis (CP). METHODS:Five consecutive prospective compara...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000434
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVES:To evaluate the systemic effects of moderate hypothermia (MH) and the timing of induction on acute pancreatitis (AP) and endotoxemia in rats. METHODS:The effects of MH were compared in 4 groups, that is, sham group (38 degrees C), control group (38 degrees C), early MH group (32 degrees C on administration ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e318162cb26
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVES:Main duct intraductal papillary mucinous neoplasms (IPMNs) of the pancreas include neoplasms with varying likelihood of progression to malignancy. The aim of this study was to investigate a natural course of main duct IPMNs with a lower likelihood of malignancy. METHODS:Twenty main duct IPMNs with a lower l...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181c81b52
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVES:Previously, we showed that diazoxide (DZ), an effective ischemic preconditioning agent, protected rodent pancreas against ischemia-reperfusion injury. Here, we further investigate whether DZ supplementation to University of Wisconsin (UW) solution during pancreas procurement and islet isolation has similar c...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000001557
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVES:The aims of this study were to evaluate diagnostic value of endoscopic ultrasound strain ratio elastography in patients with focal pancreatic masses and to determine the cutoff value between the pancreatic malignancies and inflammatory pancreatic masses using reference areas different than those used by othe...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000758
更新日期:2017-03-01 00:00:00
abstract:INTRODUCTION:Main pancreatic duct (MPD)-narrowed chronic pancreatitis (CP) may be an autoimmune abnormality. It also has been called autoimmune pancreatitis and sclerosing pancreatitis. It is unclear whether cases with focal pancreatographic changes are part of the same clinical entity as cases with diffuse MPD changes...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200210000-00011
更新日期:2002-10-01 00:00:00
abstract:OBJECTIVES:Cigarette smoking is an independent risk factor for chronic pancreatitis. We conducted a systematic review of the literature assessing whether cigarette smoking is a risk factor for acute pancreatitis (AP) and recurrent AP (RAP). METHODS:MEDLINE, PubMed, Embase, and Cochrane Database of Systematic Reviews w...
journal_title:Pancreas
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MPA.0000000000000301
更新日期:2015-05-01 00:00:00
abstract::In pancreas, the activities of several sex steroid-transforming enzymes have been reported. Data have been obtained in perfused organs, total tissue homogenates, and subcellular organelles. These data, concurrent with the description of the presence of ligand-regulated steroid receptors, as well as the sexually dimorp...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199907000-00006
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVES:Interleukin-36 (IL-36) is a recently described proinflammatory cytokine, characterized by the induction of inflammatory mediators. In the present study, we investigated the biological activity and the signal transduction of IL-36α in human pancreatic myofibroblasts. METHODS:The mRNA and protein expression o...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000765
更新日期:2017-04-01 00:00:00
abstract::In a patient with pancreatic cancer, an arterial anomaly was observed that apparently consisted of the congenital absence of the celiac axis and the replacement of the pancreaticoduodenal arcade by an anomalous vessel. The complete or near-complete arterial flow to the liver and spleen depended upon this anomalous pre...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198910000-00013
更新日期:1989-01-01 00:00:00
abstract::This study was performed to assess the effects of misoprostol, a synthetic prostaglandin E1 analog, on cerulein-induced pancreatitis. Per group of 10 each, male Wistar rats received either cerulein (2.5 micrograms/kg/h subcutaneously), cerulein and misoprostol (500 micrograms/kg intraperitoneally at 0 and 4 h), or sal...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199003000-00008
更新日期:1990-03-01 00:00:00
abstract:OBJECTIVE:Octreotide is used to treat patients with neuroendocrine tumors. Previous reports show that octreotide long-acting repeatable (LAR) dose and patient body weight affect nadir plasma octreotide levels (approximately 1250, 2500, 5000, and 11,000 pg/mL for LAR doses of 10, 20, 30 and 60 mg/mo). However, plasma oc...
journal_title:Pancreas
pub_type: 杂志文章,多中心研究
doi:10.1097/MPA.0b013e31816907ab
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVES:Prognostic value of histological subtypes of pancreatic intraductal papillary mucinous neoplasm (IPMN) has been reported to have conflicting results. The authors investigated the clinicopathological characteristics and prognostic significance of the histological subtypes of IPMNs with various degrees of dysp...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e31827cddbc
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVES:Attaining high-quality RNA from the tissues or organs of deceased donors used for research can be challenging due to physiological and logistical considerations. In this investigation, METHODS: RNA Integrity Number (RIN) was determined in pancreatic samples from 236 organ donors and used to define high (≥6.5...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000717
更新日期:2017-02-01 00:00:00
abstract::To determine the role of endogenous pancreatic polypeptide (PP) as a physiological inhibitor of pancreatic secretion, normal rabbit serum (control) or rabbit PP-antiserum was administered intravenously to dogs with chronic esophageal, gastric, and pancreatic fistulas. In all dogs tested, sham-feeding and ordinary feed...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198709000-00008
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVES:Intra-abdominal fungal infections (AFIs) complicating acute pancreatitis arise in the context of pancreatic necrosis. Our goal was to determine which risk factors contribute to AFI in patients with acute pancreatitis. METHODS:Records were reviewed from 479 nontransfer patients admitted to our medical center...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000334
更新日期:2015-07-01 00:00:00
abstract::Cystic lesions of the pancreas include inflammatory pseudocysts, serous cystadenomas, and mucinous tumors, some of which are malignant. Preoperative clinical and radiological parameters are unreliable and may result in incorrect diagnosis and inappropriate treatment. Cyst fluid analysis for cytology, viscosity, carcin...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199505000-00004
更新日期:1995-05-01 00:00:00
abstract:OBJECTIVES:Amylase level in drains (ALD) has been proposed as a predictor for the development of a clinically significant pancreatic fistula (CS-PF) in patients undergoing a major pancreatic surgery. This study aimed to determine if the ALD in patients who developed a CS-PF after pancreatoduodenectomy is higher than th...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000060
更新日期:2014-04-01 00:00:00
abstract::The application of a commercially available enzyme immunoassay method for the determination of lipase concentration in human duodenal fluid is reported. Variations in the test procedure have been investigated. A sample incubation and a conjugate incubation of 1 h at 37 degrees C are necessary. There is substantial agr...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-198902000-00014
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE:The transcription factor Stat1 is a member of the family of signal transducers and transcription activators and responds to interferon-γ stimulation. p21 is a p53-responsive gene for cell cycle regulation and mediates Stat1 antitumor activity. The aim of this study was to analyze their expression for predicti...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0000000000000074
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVES:Nitric oxide (NO) is a potent nonadrenergic, noncholinergic mediator of gastrointestinal smooth muscle. We aimed to investigate the effects of new NO/cyclic guanosine monophosphate (cGMP) pathway-affecting agents at the sheep sphincter of Oddi (SO) in vitro. METHODS:Sheep SO rings were mounted in organ bath...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3181d3645b
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVES:In the hamster model, pancreatic ductal adenocarcinoma develops after treatment with N-nitrosobis-(2-oxopropyl)amino (BOP). In this model, Langerhans islets play a central role in carcinogenesis. In contrast, treatment with BOP in rats and mice did not result in cancer development. We investigated whether pa...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3182016a08
更新日期:2011-03-01 00:00:00
abstract:UNLABELLED:Serum adiponectin (ADP) levels are reported inversely related to the risk in breast, endometrial cancer, and gastric cancer. Serum ADP as a potential marker compared with CA-19-9 in pancreatic carcinoma (PC) and chronic pancreatitis (CP) was studied. Adiponectin and CA-19-9 levels were examined at the time o...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/MPA.0b013e3180547709
更新日期:2007-07-01 00:00:00
abstract::The hedgehog (Hh) family of genes, sonic hedgehog (Shh), Indian hedgehog (Ihh), and desert hedgehog (Dhh) encode signaling molecules that regulate multiple functions during organ development and in adult tissues. Altered hedgehog signaling has been implicated in disturbed organ development as well as in different dege...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/01.mpa.0000202937.55460.0c
更新日期:2006-03-01 00:00:00
abstract::Genistein is a plant isoflavonoid bearing potent tumor growth-regulating characteristics. This effect of genistein has been attributed partially to its tyrosine kinase-regulating properties, resulting in cell-cycle arrest and limited angiogenesis. Genistein has been used in chemotherapy-resistant cases of advanced leu...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-200101000-00001
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVES:Intraductal papillary mucinous neoplasms (IPMNs) and pancreatic intraepithelial neoplasia (PanIN) are both precancerous lesions. Papillary mucinous neoplasms have been described in patients with IPMN, but their relationship is still poorly understood. The aims of this study were to look for PanIN lesions in ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/01.mpa.0000437639.38383.41
更新日期:2013-11-01 00:00:00