听力与言语-语言病理学

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医学伦理学

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  • Genetic deletion of dopamine D1 receptors increases the sensitivity to cannabinoid CB1 receptor antagonist-precipitated withdrawal when compared with wild-type littermates: studies in female mice repeatedly exposed to the Spice cannabinoid HU-210.

    abstract:RATIONALE:The emergence of the consumption of highly potent synthetic cannabinoid receptor agonists (spice drugs) that produce important neurological symptoms has prompted the research on the consequences of acute and chronic use of these new psychoactive substances. Most studies on cannabinoid dependence have been per...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05704-8

    authors: Serrano A,Vadas E,Ferrer B,Bilbao A,Granado N,Suárez J,Pavon FJ,Moratalla R,Rodríguez de Fonseca F

    更新日期:2021-02-01 00:00:00

  • Ketamine reduces temporal expectation in the rhesus monkey.

    abstract:RATIONALE:Ketamine, a well-known general dissociative anesthetic agent that is a non-competitive antagonist of the N-methyl-D-aspartate receptor, perturbs the perception of elapsed time and the expectation of upcoming events. OBJECTIVE:The objective of this study was to determine the influence of ketamine on temporal ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05706-6

    authors: Brulé S,Herlin B,Pouget P,Missal M

    更新日期:2021-02-01 00:00:00

  • Sequential reversal learning: a new touchscreen schedule for assessing cognitive flexibility in mice.

    abstract:RATIONALE:The widespread deficits in cognitive flexibility observed across psychiatric disorders call for improved rodent tests to understand the biology of cognitive flexibility and development of better psychotherapeutics. Current reversal learning paradigms have a forced-choice setup that challenges the interpretati...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05687-6

    authors: Odland AU,Sandahl R,Andreasen JT

    更新日期:2021-02-01 00:00:00

  • Serotonin 5-HT1B receptor-mediated behavior and binding in mice with the overactive and dysregulated serotonin transporter Ala56 variant.

    abstract:RATIONALE:Elevated whole-blood serotonin (5-HT) is a robust biomarker in ~ 30% of patients with autism spectrum disorders, in which repetitive behavior is a core symptom. Furthermore, elevated whole-blood 5-HT has also been described in patients with pediatric obsessive-compulsive disorder. The 5-HT1B receptor is assoc...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05758-8

    authors: O'Reilly KC,Connor M,Pierson J,Shuffrey LC,Blakely RD,Ahmari SE,Veenstra-VanderWeele J

    更新日期:2021-01-29 00:00:00

  • A buprenorphine-validated rat model of opioid use disorder optimized to study sex differences in vulnerability to relapse.

    abstract:RATIONALE:Opioid use disorder (OUD) is a major epidemic in the USA. Despite evidence indicating that OUD may be particularly severe for women, preclinical models have yet to establish sex as a major factor in OUD. OBJECTIVES:Here, we examined sex differences in vulnerability to relapse following intermittent access fe...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05750-2

    authors: Bakhti-Suroosh A,Towers EB,Lynch WJ

    更新日期:2021-01-06 00:00:00

  • Morphine and ethanol pretreatment effects on expression and extinction of ethanol-induced conditioned place preference and aversion in mice.

    abstract:RATIONALE:Opioid receptor antagonists reliably alter the expression or extinction of ethanol's conditioned motivational effects as indexed by the place conditioning procedure, suggesting endogenous opioids are normally involved. These studies examined how exogenous stimulation of opioid receptors alters ethanol's condi...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05658-x

    authors: Cunningham CL,Bakner L,Schuette LM,Young EA

    更新日期:2021-01-01 00:00:00

  • Treatment with the calcineurin inhibitor and immunosuppressant cyclosporine A impairs sensorimotor gating in Dark Agouti rats.

    abstract:RATIONALE:Calcineurin is a protein regulating cytokine expression in T lymphocytes and calcineurin inhibitors such as cyclosporine A (CsA) are widely used for immunosuppressive therapy. It also plays a functional role in distinct neuronal processes in the central nervous system. Disturbed information processing as seen...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05751-1

    authors: Brosda J,Becker T,Richter M,Jakobs M,Hörbelt T,Bendix I,Lückemann L,Schedlowski M,Hadamitzky M

    更新日期:2020-12-21 00:00:00

  • Context, acute tolerance, and subjective response affect alcohol-impaired driving decisions.

    abstract:RATIONALE:Alcohol intoxication produces effects that can impair judgment and increase engagement in risky behaviors, including alcohol-impaired driving (AID). Real-world AID decisions are informed by contextual circumstances and judgments of associated risk. How individuals vary in their AID decision-making across cont...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05639-0

    authors: Motschman CA,Warner OM,Wycoff AM,Davis-Stober CP,McCarthy DM

    更新日期:2020-12-01 00:00:00

  • Behavioral effects of benzylideneoxymorphone (BOM), a low efficacy µ opioid receptor agonist and a δ opioid receptor antagonist.

    abstract:RATIONALE:Opioids remain the drugs of choice for treating moderate to severe pain, although adverse effects often limit use. Drugs acting concomitantly as agonists at μ opioid receptors and antagonists at δ opioid receptors produce antinociceptive effects with a reduced profile of adverse effects; one such drug, benzyl...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05638-1

    authors: Mada S,Gerak LR,Soyer A,Maguire DR,Hu Z,Minervini V,Cunningham CW,France CP

    更新日期:2020-12-01 00:00:00

  • Prevalence of obesity and clinical and metabolic correlates in first-episode schizophrenia relative to healthy controls.

    abstract:OBJECTIVE:People with schizophrenia exhibit a high obesity rate. However, little is known about the prevalence of obesity and its relationship with clinical symptoms and metabolic indicators in first-episode drug-naïve (FEDN) schizophrenia. METHODS:Demographic and lipid parameters were gathered from 297 FEDN schizophr...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05727-1

    authors: Tian Y,Wang D,Wei G,Wang J,Zhou H,Xu H,Dai Q,Xiu M,Chen D,Wang L,Zhang XY

    更新日期:2020-11-25 00:00:00

  • MDPV self-administration in female rats: influence of reinforcement history.

    abstract:RATIONALE:A subset of male rats that self-administer 3,4-methylenedioxypyrovalerone (MDPV) have unusually high levels of drug intake; however, factor(s) that influence this behavior (e.g., reinforcement history and sex) are unknown. OBJECTIVES:Characterize the reinforcing potency and effectiveness of MDPV in female ra...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05726-2

    authors: Doyle MR,Sulima A,Rice KC,Collins GT

    更新日期:2020-11-24 00:00:00

  • Correction to: Effect of a dual orexin receptor antagonist (DORA-12) on sleep and event-related oscillations in rats exposed to ethanol vapor during adolescence.

    abstract::The title of this article is "Effect of a dual orexin receptor antagonist (DORA-12) on sleep and event-related oscillations in rats exposed to ethanol vapor during adolescence". ...

    journal_title:Psychopharmacology

    pub_type: 已发布勘误

    doi:10.1007/s00213-020-05673-y

    authors: Ehlers CL,Benedict J,Wills D,Sanchez-Alavez M

    更新日期:2020-11-01 00:00:00

  • Acute effects of alcohol on error-elicited negative affect during a cognitive control task.

    abstract:RATIONALE:Alcohol intoxication can dampen negative affective reactions to stressors. Recently, it has been proposed that these acute anxiolytic effects of alcohol may extend to dampening of negative affective reactions to error commission during cognitive control tasks. Nonetheless, empirical verification of this claim...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05619-4

    authors: Cofresí RU,Bartholow BD

    更新日期:2020-11-01 00:00:00

  • The rate of dasotraline brain entry is slow following intravenous administration.

    abstract:RATIONALE:Drugs that rapidly increase dopamine levels have an increased risk of abuse. Dasotraline (DAS) is a dopamine and norepinephrine reuptake inhibitor characterized by slow oral absorption with low potential for abuse. However, it remains unclear whether intravenous (i.v.) administration would facilitate the rapi...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05623-8

    authors: Lew R,Constantinescu CC,Holden D,Carson RE,Carroll V,Galluppi G,Koblan KS,Hopkins SC

    更新日期:2020-11-01 00:00:00

  • Chronic exposure to cocaine is associated with persistent behavioral disturbances. A cross-sectional dimensional study in outpatients with multiple substance use disorders.

    abstract:RATIONALE:Behavioral disturbances (BD) are prevalent in patients with substance use disorders (SUD). OBJECTIVES:To test the hypothesis that chronic exposure to cocaine could favor the acquisition of BD that were not present in childhood. METHODS:We used child and adult ADHD self-report screening scales (WURS-25 and A...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05620-x

    authors: Vorspan F,de Witt P,Zerdazi EH,Karsinti E,Ksouda K,Icick R,Bellivier F,Marie N,Brousse G,Bloch V

    更新日期:2020-11-01 00:00:00

  • Kolaviron protects against nigrostriatal degeneration and gut oxidative damage in a stereotaxic rotenone model of Parkinson's disease.

    abstract::The asymptomatic and clinical stages of Parkinson's disease (PD) are associated with comorbid non-motor symptoms including gastrointestinal (GI) dysfunction. Although the neuroprotective and gastroprotective roles of kolaviron (KV) have been reported independently, whether KV-mediated GI-protective capacity could be b...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05605-w

    authors: Farombi EO,Awogbindin IO,Olorunkalu PD,Ogbuewu E,Oyetunde BF,Agedah AE,Adeniyi PA

    更新日期:2020-11-01 00:00:00

  • Caffeine intake and cognitive functions in children.

    abstract:RATIONALE:There is a growing concern over excessive caffeine use and development of caffeine use disorder in children. OBJECTIVES:This study aimed to identify the association between caffeine intake and cognitive functioning in children. METHODS:This study included 11,718 youths aged 9-10 years with cognitive and caf...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05596-8

    authors: Zhang H,Lee ZX,Qiu A

    更新日期:2020-10-01 00:00:00

  • 17β-Estradiol augments the neuroprotective effect of agomelatine in depressive- and anxiety-like behaviors in ovariectomized rats.

    abstract:RATIONALE AND OBJECTIVE:Estradiol decline has been associated with depression and anxiety in post-menopausal women. Agomelatine (Ago) is an agonist of the melatonergic MT1/MT2 receptors and an antagonist of the serotonergic 5-HT2c receptors. The present study aimed to evaluate the effects of combining Ago with 17β-estr...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05580-2

    authors: El-Khatib YA,Sayed RH,Sallam NA,Zaki HF,Khattab MM

    更新日期:2020-09-01 00:00:00

  • Active vaccination reduces reinforcing effects of MDPV in male Sprague-Dawley rats trained to self-administer cocaine.

    abstract:RATIONALE:3,4-Methylenedioxypyrovalerone (MDPV) is a synthetic cathinone abused for its cocaine-like psychostimulant effects in "bath salts" products. While there are currently no pharmacotherapies for MDPV abuse, rodent studies suggest immunotherapy may offer a feasible treatment option. OBJECTIVES:These studies test...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05558-0

    authors: McClenahan SJ,Gunnell MG,Owens SM,Fantegrossi WE

    更新日期:2020-09-01 00:00:00

  • Caveolin-1 regulates medium spiny neuron structural and functional plasticity.

    abstract:RATIONALE:Caveolin-1 (CAV1) is a structural protein critical for spatial organization of neuronal signaling molecules. Whether CAV1 is required for long-lasting neuronal plasticity remains unknown. OBJECTIVE AND METHODS:We sought to examine the effects of CAV1 knockout (KO) on functional plasticity and hypothesized th...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05564-2

    authors: Eisinger KRT,Chapp AD,Swanson SP,Tam D,Lopresti NM,Larson EB,Thomas MJ,Lanier LM,Mermelstein PG

    更新日期:2020-09-01 00:00:00

  • Hold-down as an alternative to unit dose in cocaine self-administration experiments: Characterization using a progressive ratio schedule.

    abstract:RATIONALE:Virtually all cocaine self-administration studies have used a "unit dose" as a reinforcing stimulus; the subject is a passive recipient of an experimenter-selected dose. OBJECTIVES:The present experiments examined the consequence of requiring the subject to actively determine the dose and speed of each injec...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05565-1

    authors: Roberts DCS,Zimmer BA

    更新日期:2020-09-01 00:00:00

  • Metformin attenuates antipsychotic-induced metabolic dysfunctions in MK801-induced schizophrenia-like rats.

    abstract:RATIONALE:Second-generation antipsychotics are the first-line medications prescribed for schizophrenic patients; however, some of them, such as olanzapine and risperidone, may induce metabolic dysfunctions during short-term treatment. Metformin is an effective adjuvant that attenuates antipsychotic-induced metabolic dy...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05524-w

    authors: Luo C,Wang X,Mao X,Huang H,Liu Y,Zhao J,Zhou H,Liu Z,Li X

    更新日期:2020-08-01 00:00:00

  • Perinatal fluoxetine exposure disrupts the circadian response to a phase-shifting challenge in female rats.

    abstract:RATIONALE:Selective serotonin reuptake inhibitor (SSRI) antidepressants are increasingly prescribed during pregnancy. Changes in serotonergic signaling during human fetal development have been associated with changes in brain development and with changes in affective behavior in adulthood. The suprachiasmatic nucleus (...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05556-2

    authors: Houwing DJ,de Waard J,Ramsteijn AS,Woelders T,de Boer SF,Wams EJ,Olivier JDA

    更新日期:2020-08-01 00:00:00

  • Higher anhedonia during withdrawal from initial opioid exposure is protective against subsequent opioid self-administration in rats.

    abstract:RATIONALE:Understanding factors contributing to individual differences in vulnerability to opioid addiction is essential for developing more effective preventions and treatments, yet few reliable behavioral predictors of subsequent opioid self-administration have been identified in rodents. Sensitivity to the acute eff...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05532-w

    authors: Swain Y,Muelken P,Skansberg A,Lanzdorf D,Haave Z,LeSage MG,Gewirtz JC,Harris AC

    更新日期:2020-08-01 00:00:00

  • Gelsemine, a natural alkaloid extracted from Gelsemium elegans Benth. alleviates neuroinflammation and cognitive impairments in Aβ oligomer-treated mice.

    abstract:INTRODUCTION:Gelsemine is a natural alkaloid extracted from Gelsemium elegans Benth., a traditional Chinese medicinal herb. Gelsemine has been shown to penetrate the brain, and could produce neurological activities, such as anxiolytic and neuralgia-alleviating effects, suggesting that this natural compound might be use...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05522-y

    authors: Chen L,Pan H,Bai Y,Li H,Yang W,Lin ZX,Cui W,Xian YF

    更新日期:2020-07-01 00:00:00

  • Dopaminergic and noradrenergic manipulation of anticipatory reward and probability event-related potentials.

    abstract::Predicting what will happen in the future in terms of potential reward is essential in daily life. The aim of the current study was to investigate the neurotransmitter systems involved in the anticipation of reward value and probability. We hypothesized that dopaminergic and noradrenergic antagonism would affect antic...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05515-x

    authors: Schutte I,Deschamps PKH,van Harten PN,Kenemans JL

    更新日期:2020-07-01 00:00:00

  • Intrinsic connections between thalamic sub-regions and the lateral prefrontal cortex are differentially impacted by acute methylphenidate.

    abstract:BACKGROUND:The thalamus is a major target of dopaminergic projections and is densely connected with the prefrontal cortex. A better understanding of how dopamine changes thalamo-cortical communication may shed light on how dopamine supports cognitive function. Methylphenidate has been shown to facilitate cognitive proc...

    journal_title:Psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00213-020-05505-z

    authors: Gorka AX,Lago TR,Balderston N,Torrisi S,Fuchs B,Grillon C,Ernst M

    更新日期:2020-06-01 00:00:00

  • Decreased sensitivity in adolescent versus adult rats to the antidepressant-like effects of cannabidiol.

    abstract:RATIONALE:Cannabidiol is a non-psychoactive phytocannabinoid with great therapeutic potential in diverse psychiatric disorders; however, its antidepressant potential has been mainly ascertained in adult rats. OBJECTIVES:To compare the antidepressant-like response induced by cannabidiol in adolescent and adult rats and...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05481-4

    authors: Bis-Humbert C,García-Cabrerizo R,García-Fuster MJ

    更新日期:2020-06-01 00:00:00

  • Event-related and readiness potentials when preparing to approach and avoid alcohol cues following cue avoidance training in heavy drinkers.

    abstract:RATIONALE:Cue avoidance training (CAT) reduces alcohol consumption in the laboratory. However, the neural mechanisms that underlie the effects of this intervention are poorly understood. OBJECTIVES:The present study investigated the effects of a single session of CAT on event-related and readiness potentials during pr...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05462-7

    authors: Di Lemma LCG,Stancak A,Soto V,Fallon N,Field M

    更新日期:2020-05-01 00:00:00

  • Differential effects of nicotine delivery rate on subjective drug effects, urges to smoke, heart rate and blood pressure in tobacco smokers.

    abstract:RATIONALE:The nicotine delivery rate is a key feature of tobacco product design, yet there have been limited human studies examining the effects of nicotine as a function of delivery rate. OBJECTIVE:We developed an intravenous nicotine infusion protocol to evaluate differential effects of nicotine delivery rate on sub...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-020-05463-6

    authors: Jensen KP,Valentine G,Gueorguieva R,Sofuoglu M

    更新日期:2020-05-01 00:00:00

  • Reduced response inhibition after exposure to drug-related cues in male heroin abstainers.

    abstract:RATIONALE:Deficits in response inhibition associated with heroin use could last several months after abstinence in heroin users, and their response inhibition can also be interfered with task-irrelevant drug-related cues. However, it is unclear whether exposure to drug-related cues affects subsequent response inhibitio...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-019-05434-6

    authors: Su B,Li S,Yang L,Zheng M

    更新日期:2020-04-01 00:00:00

  • Unequal interactions between alcohol and nicotine co-consumption: suppression and enhancement of concurrent drug intake.

    abstract:RATIONALE:Alcohol and nicotine addiction are prevalent conditions that co-occur. Despite the prevalence of co-use, factors that influence the suppression and enhancement of concurrent alcohol and nicotine intake are largely unknown. OBJECTIVES:Our goals were to assess how nicotine abstinence and availability influence...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-019-05426-6

    authors: DeBaker MC,Moen JK,Robinson JM,Wickman K,Lee AM

    更新日期:2020-04-01 00:00:00

  • Contribution of the prefrontal cortex and basolateral amygdala to behavioral decision-making under reward/punishment conflict.

    abstract:RATIONALE:Control of reward-seeking behavior under conditions of punishment is an important function for survival. OBJECTIVES AND METHODS:We designed a task in which rats could choose to either press a lever and obtain a food pellet accompanied by a footshock or refrain from pressing the lever to avoid footshock, in r...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-019-05398-7

    authors: Ishikawa J,Sakurai Y,Ishikawa A,Mitsushima D

    更新日期:2020-03-01 00:00:00

  • Assessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats.

    abstract:RATIONALE:Kratom is proposed to exhibit therapeutic potential as an opium substitute, but little is known about its dependence-producing profile, particularly of its main psychoactive compound, mitragynine (MG). OBJECTIVES:This study examined the dependence-producing effects of MG using operant-scheduled behaviour in ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-019-05418-6

    authors: Harun N,Johari IS,Mansor SM,Shoaib M

    更新日期:2020-03-01 00:00:00

  • A role for leptin and ghrelin in the augmentation of heroin seeking induced by chronic food restriction.

    abstract:RATIONAL:Caloric restriction increases the risk of relapse in abstinent drug users. Hormones involved in the regulation of energy balance and food intake, such as leptin and ghrelin, are implicated in drug-related behaviors. OBJECTIVES:We investigated the role of leptin and ghrelin in the augmentation of heroin seekin...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-019-05415-9

    authors: D'Cunha TM,Chisholm A,Hryhorczuk C,Fulton S,Shalev U

    更新日期:2020-03-01 00:00:00

  • Environmental enrichment decreases chronic psychosocial stress-impaired extinction and reinstatement of ethanol conditioned place preference in C57BL/6 male mice.

    abstract:RATIONALE:During the last few decades, alcohol use disorders (AUD) have reached an epidemic prevalence, yet social influences on alcoholism have not been fully addressed. Several factors can modulate alcohol intake. On one hand, stress can reinforce ethanol-induced behaviors and be an important component in AUD and alc...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-019-05408-8

    authors: Bahi A,Dreyer JL

    更新日期:2020-03-01 00:00:00

  • Nicotine e-cigarette vapor inhalation effects on nicotine & cotinine plasma levels and somatic withdrawal signs in adult male Wistar rats.

    abstract:RATIONALE:Non-contingent chronic nicotine exposure procedures have evolved rapidly in recent years, culminating in electronic nicotine delivery systems (ENDS or e-cigarettes) to deliver vaporized drugs to rodents in standard housing chambers. OBJECTIVES:The aim of the current work was to use ENDS to test concentration...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-019-05400-2

    authors: Montanari C,Kelley LK,Kerr TM,Cole M,Gilpin NW

    更新日期:2020-03-01 00:00:00

  • Binding of the D3-preferring antipsychotic candidate F17464 to dopamine D3 and D2 receptors: a PET study in healthy subjects with [11C]-(+)-PHNO.

    abstract:RATIONALE:F17464, a dopamine D3 receptor antagonist with relatively high D3 selectivity (70 fold vs D2 in vitro), exhibits an antipsychotic profile in preclinical studies, and therapeutic efficacy was demonstrated in a randomized placebo-controlled clinical trial in patients with schizophrenia (Bitter et al. Neuropsych...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-019-05387-w

    authors: Slifstein M,Abi-Dargham A,Girgis RR,Suckow RF,Cooper TB,Divgi CR,Sokoloff P,Leriche L,Carberry P,Oya S,Joseph SK,Guiraud M,Montagne A,Brunner V,Gaudoux F,Tonner F

    更新日期:2020-02-01 00:00:00

  • Effects of voluntary exercise and sex on multiply-triggered heroin reinstatement in male and female rats.

    abstract:BACKGROUND:The rise in heroin addiction has heightened the need for novel and effective treatments. Physical exercise has been shown as an effective treatment for stimulant abuse in clinical and pre-clinical research. However, this treatment has not yet been tested on opioid addiction. This study examined the effects o...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-019-05381-2

    authors: Smethells JR,Greer A,Dougen B,Carroll ME

    更新日期:2020-02-01 00:00:00

  • Reciprocal cross-sensitization of D1 and D3 receptors following pharmacological stimulation in the hemiparkinsonian rat.

    abstract::In the majority of Parkinson's disease (PD) patients, long-term dopamine (DA) replacement therapy leads to dyskinesia characterized by abnormal involuntary movements (AIMs). There are various mechanisms of dyskinesia, such as the sensitization of striatal DA D1 receptors (D1R) and upregulation of DA D3 receptors (D3R)...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-019-05353-6

    authors: Lanza K,Chemakin K,Lefkowitz S,Saito C,Chambers N,Bishop C

    更新日期:2020-01-01 00:00:00

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