abstract：:Heparin and protamine are fundamental in the management of anticoagulation during cardiac surgery. Excess protamine has been associated with increased bleeding. Interaction between protamine and platelet function has been demonstrated but the mechanism remains unclear. We examined the effect of protamine on platelet f...

journal_title：Platelets

authors： Törnudd M,Ramström S,Kvitting JE,Alfredsson J,Pihl R,Berg S

更新日期：2021-01-02 00:00:00

abstract：:The spleen, in addition to its role in immunity, plays key roles in erythrocyte maintenance and platelet sequestration. Loss of the spleen via splenectomy occurs in approximately 6.4 to 7.1 per 100 000 people per year globally, commonly as a life-saving emergency procedure in trauma and a therapeutic procedure in hema...

journal_title：Platelets

authors： Luu S,Woolley IJ,Andrews RK

更新日期：2021-01-02 00:00:00

abstract：:The assessment of platelet spreading through light microscopy, and the subsequent quantification of parameters such as surface area and circularity, is a key assay for many platelet biologists. Here we present an analysis workflow which robustly segments individual platelets to facilitate the analysis of large numbers...

journal_title：Platelets

authors： Pike JA,Simms VA,Smith CW,Morgan NV,Khan AO,Poulter NS,Styles IB,Thomas SG

更新日期：2021-01-02 00:00:00

abstract：:Current guidelines favor dual anti-platelet therapy with ticagrelor 90 mg BID (T90BID) over clopidogrel 75 mg QD (C75QD) in addition to aspirin for acute coronary syndrome. However, an increased risk of ticagrelor-related adverse events prompted the evaluation of low-dose regimens. This study (NCT03381742) retrospecti...

journal_title：Platelets

authors： Shi J,He M,Wang W,Liu G,Zhang H,Sun D,Li J,Mu H,Xu M,Zhao C,Wang J,Zhang C,Cang H,Zhao S,Zhang Z,Li Y

更新日期：2021-01-02 00:00:00

abstract：:Most agonists stimulate platelet Ca2+ rises via G-protein coupled receptors (GPCRs) or ITAM-linked receptors (ILRs). Well studied are the GPCRs stimulated by the soluble agonists thrombin (PAR1, PAR4), ADP (P2Y1, P2Y12), and thromboxane A2 (TP), signaling via phospholipase (PLC)β isoforms. The platelet ILRs glycoprote...

journal_title：Platelets

authors： Fernández DI,Kuijpers MJE,Heemskerk JWM

更新日期：2020-12-26 00:00:00

abstract：:Cessation of one component of dual antiplatelet therapy (DAPT) following percutaneous coronary intervention (PCI) has been associated with increased risk of ischemic events but it is uncertain whether discontinuation of aspirin is preferable to discontinuation of the oral P2Y12 inhibitor. The GLOBAL LEADERS study comp...

journal_title：Platelets

authors： Hennigan BW,Good R,Adamson C,Parker WAE,Martin L,Anderson L,Campbell M,Serruys PW,Storey RF,Oldroyd KG

更新日期：2020-12-26 00:00:00

abstract：:Information regarding the profile of reticulated platelets (RP) in ischemic cerebrovascular disease (CVD) patients is limited. Data from two prospective, observational, case-control studies were combined to compare the %RP using whole blood flow cytometry in patients ≤ 4 weeks of TIA/stroke onset (baseline, N = 210), ...

journal_title：Platelets

authors： Lim ST,Tobin WO,Murphy S,Kinsella JA,Smith DR,Lim SY,Murphy SM,Coughlan T,Collins DR,O'Neill D,Egan B,Tierney S,McCabe D

更新日期：2020-12-21 00:00:00

abstract：:This phase III, randomized, placebo-controlled study conducted in three stages (6-week, randomized, placebo-controlled stage 1; 24-week, open-label stage 2; and continuous extension stage 3) assessed the long-term efficacy and safety of eltrombopag use in Chinese patients with chronic immune thrombocytopenia (ITP). Th...

journal_title：Platelets

authors： Liu X,Hou M,Li J,Jin J,Huang M,Yu Z,Xu X,Zhang X,Yang R

更新日期：2020-11-29 00:00:00

abstract：:Binding of podoplanin to the C-type lectin-like receptor 2 (CLEC-2) promotes platelet activation and soluble CLEC-2 (sCLEC-2) is shed from activated platelets. The role of sCLEC-2 in the plasma is unknown. The expression level and plasma concentration of sCLEC-2 could be affected by variants of the corresponding gene,...

journal_title：Platelets

authors： Etemad M,Christodoulou F,Weiss C,Klüter H,Bugert P

更新日期：2020-11-29 00:00:00

abstract：:A pathogen-free and standardized xeno-free supplement of growth media is required for the ex vivo propagation of human cells used as advanced therapeutic medicinal products and for clinical translation in regenerative medicine and cell therapies. Human platelet lysate (HPL) made from therapeutic-grade platelet concent...

journal_title：Platelets

authors： Barro L,Burnouf PA,Chou ML,Nebie O,Wu YW,Chen MS,Radosevic M,Knutson F,Burnouf T

更新日期：2020-11-29 00:00:00

abstract：:Cytochrome P450 (CYP) 2C19 genotype is closely associated with the metabolism and efficacy of clopidogrel, thereby having an important impact on clinical outcomes of patients with acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI). This study aimed to evaluate the efficacy and safety ...

journal_title：Platelets

authors： Lyu SQ,Yang YM,Zhu J,Wang J,Wu S,Zhang H,Shao XH,Ren JM

更新日期：2020-11-16 00:00:00

abstract：:The aim of the study was to evaluate diurnal changes of tissue factor (TF) and tissue factor pathway inhibitor (TFPI) concentrations in relation to on-treatment platelet reactivity. The study group included 51 patients with acute myocardial infarction (AMI) treated with primary percutaneous coronary intervention and d...

journal_title：Platelets

authors： Boinska J,Koziński M,Kasprzak M,Ziołkowska K,Dziembowska I,Ziołkowski M,Kubica J,Rość D

更新日期：2020-10-02 00:00:00

abstract：:The pathogenesis of thrombocytopenia can be divided into increased destruction (ID) of platelets in the peripheral blood and decreased production (DP) of platelets in the bone marrow. This study aimed to analyze the efficacy of immature platelet fraction (IPF) related parameters, including the IPF count (IPF#), IPF pe...

journal_title：Platelets

authors： Li J,Li Y,Ouyang J,Zhang F,Liang C,Ye Z,Chen S,Cheng J

更新日期：2020-08-17 00:00:00

abstract：:Catastrophic antiphospholipid syndrome (CAPS) involves sudden multiorgan dysfunction from thrombosis due to antibodies that cause platelet activation and endothelial dysfunction. Treatment variably combines anticoagulation, corticosteroid use, therapeutic plasma exchange (TPE), and high-dose intravenous immunoglobulin...

journal_title：Platelets

authors： James TE,Martin LJ,Warkentin TE,Crowther MA

更新日期：2020-08-07 00:00:00

abstract：:The ADP receptor P2Y12, the thromboxane A2 receptor (TXA2R) and the C-type lectin-like receptor 2 (CLEC-2) mediate platelet activation by different mechanisms. Only little is known about the expression of the receptors in human megakaryopoiesis. Our study aimed to establish a flow cytometry (FC) method for the measure...

journal_title：Platelets

authors： Gerhards C,Uhlig S,Etemad M,Christodoulou F,Bieback K,Klüter H,Bugert P

更新日期：2020-07-03 00:00:00

abstract：:Intracranial hemorrhage (ICH) is a devastating complication of immune thrombocytopenia (ITP). However, information on ICH in ITP patients under the age of 60 years is limited, and no predictive tools are available in clinical practice. A total of 93 adult patients with ITP who developed ICH before 60 years of age were...

journal_title：Platelets

authors： Zhao P,Hou M,Liu Y,Liu HX,Huang RB,Yao HX,Niu T,Peng J,Jiang M,Han YQ,Hu JD,Zhou H,Zhou ZP,Qiu L,Zhang LS,Wang X,Wang HQ,Feng R,Yang LH,Ma LM,Wang SQ,Kong PY,Wang WS,Sun HP,Sun J,Zhou HB,Zhu TN,Wang

更新日期：2020-07-02 00:00:00

abstract：:Extracellular vesicles (EV) act as a cellular communication tool by carrying lipids, proteins and micro RNA (miR) between cells, thereby playing a pivotal role in thromboembolic processes. The effect of P2Y12 inhibitors on pro-coagulatory, phosphatidylserine (PS)-expressing EV has been investigated previously, but onl...

journal_title：Platelets

authors： Haller PM,Stojkovic S,Piackova E,Andric T,Wisgrill L,Spittler A,Wojta J,Huber K,Jäger B

更新日期：2020-05-18 00:00:00

abstract：BACKGROUND:Thrombocytopenia has been implicated in patients infected with severe acute respiratory syndrome coronavirus 2, while the association of platelet count and changes with subsequent mortality remains unclear. METHODS:The clinical and laboratory data of 383 patients with the definite outcome by March 1, 2020 i...

journal_title：Platelets

authors： Liu Y,Sun W,Guo Y,Chen L,Zhang L,Zhao S,Long D,Yu L

更新日期：2020-05-18 00:00:00

abstract：:Hermansky-Pudlak syndrome (HPS) is a rare form of syndromic oculocutaneous albinism caused by disorders in lysosome-related organelles. Ten genes are associated with different forms of HPS. HPS type 9 (HPS-9) is caused by biallelic variants of BLOC1S6. To date, only three patients with HPS-9 have been reported. We des...

journal_title：Platelets

authors： Michaud V,Fiore M,Coste V,Huguenin Y,Bordet JC,Plaisant C,Lasseaux E,Morice-Picard F,Arveiler B

更新日期：2020-04-03 00:00:00

abstract：:The isolation of mitochondria is gaining importance in experimental and clinical laboratory settings. The mitochondrion is known as the powerhouse of the cell as it produces the energy to power most cellular functions but is also involved in many cellular processes. Of interest, mitochondria and mitochondrial componen...

journal_title：Platelets

authors： Léger JL,Jougleux JL,Savadogo F,Pichaud N,Boudreau LH

更新日期：2020-01-01 00:00:00

abstract：:Platelet-rich plasma (PRP) is increasingly used in the treatment of musculoskeletal diseases. Its preservation by freezing it for the realization of multiple injections in clinical use has never been discussed. Calcaneal tendons of rats were surgically sectioned. Platelet concentration of the PRP was 2.5 x 106/µl with...

journal_title：Platelets

authors： Kaux JF,Libertiaux V,Dupont L,Colige A,Denoël V,Lecut C,Hego A,Gustin M,Duwez L,Oury C,Gothot A,Greimers L,Drion P

更新日期：2020-01-01 00:00:00

abstract：:Avian influenza A (H7N9) is a serve zoonosis with a high mortality rate. Timely and effective diagnosis and early warning is crucial for the clinical treatment of H7N9 patients. The previous studies indicated that thrombocytopenia was associated with the prognosis of influenza cases, but the related evidence of platel...

journal_title：Platelets

authors： Chen Y,Yang Y,Cheng J,Lu J,Hu W

更新日期：2020-01-01 00:00:00

abstract：:Despite the transient hyporeactivity of neonatal platelets, full-term neonates do not display a bleeding tendency, suggesting potential compensatory mechanisms which allow for balanced and efficient neonatal hemostasis. This study aimed to utilize small-volume, whole blood platelet functional assays to assess the neon...

journal_title：Platelets

authors： Ngo ATP,Sheriff J,Rocheleau AD,Bucher M,Jones KR,Sepp AI,Malone LE,Zigomalas A,Maloyan A,Bahou WF,Bluestein D,McCarty OJT,Haley KM

更新日期：2020-01-01 00:00:00

abstract：:In patients with acute coronary syndrome (ACS), treatment using ticagrelor demonstrated significant ischemic benefits over clopidogrel; however, it was associated with increased bleeding complications leading to frequent de-escalation to clopidogrel. The objective of the present study was to investigate the efficacy a...

journal_title：Platelets

authors： Wang C,Zheng W,Shaqdan A,Wang C,Qin X,Zhao X,Wang X,Yuan L,Nie S,Liu R

更新日期：2020-01-01 00:00:00

abstract：:Platelet-rich plasma (PRP) has a potential effect on tissue repair through proliferation and differentiation of tissue progenitor cells. The aim of this study was to evaluate the effect of PRP on the testis structure and function in infertile rat model by stereological method. Thirty-two male rats were divided into fo...

journal_title：Platelets

authors： Dehghani F,Sotoude N,Bordbar H,Panjeshahin MR,Karbalay-Doust S

更新日期：2019-01-01 00:00:00

abstract：:The Total Thrombus-formation Analyser System (T-TAS) is a whole blood flow chamber system for the measurement of in vitro thrombus formation under variable shear stress conditions. Our current study sought to evaluate the potential utility of the T-TAS for the measurement of thrombus formation within human and mouse w...

journal_title：Platelets

authors： Al Ghaithi R,Mori J,Nagy Z,Maclachlan A,Hardy L,Philippou H,Hethershaw E,Morgan NV,Senis YA,Harrison P

更新日期：2019-01-01 00:00:00

abstract：:Platelets are needed to prevent or arrest bleeding and aggregate at the site of injury upon vascular damage. Platelets express receptors for estrogens which might affect the function of the platelets and their hemostatic ability. The aim was to identify possible differences in platelet function related to age, gender,...

journal_title：Platelets

authors： Berlin G,Hammar M,Tapper L,Tynngård N

更新日期：2019-01-01 00:00:00

abstract：:Recent studies have indicated that medical options without splenectomy, such as rituximab (RTX) or thrombopoietin receptor agonists (TPO-RAs), can be effective to treat persistent or chronic primary immune thrombocytopenia (ITP). However, it remains to be determined which of these strategies should be the first choice...

journal_title：Platelets

authors： Arai Y,Matsui H,Jo T,Kondo T,Takaori-Kondo A

更新日期：2019-01-01 00:00:00

abstract：:The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone. Platelets express several members of the MAPK signalling cascade including MEK1 and MEK2 and ERK1 and ERK2 but their role in platel...

journal_title：Platelets

authors： Unsworth AJ,Bye AP,Kriek N,Sage T,Osborne AA,Donaghy D,Gibbins JM

更新日期：2019-01-01 00:00:00

abstract：:This manuscript reviews pathogenic variants in RASGRP2, which are the cause of a relatively new autosomal recessive and nonsyndromic inherited platelet function disorder, referred to as platelet-type bleeding disorder-18 (BDPLT18)(OMIM:615888). To date, 18 unrelated BDPLT18 pedigrees have been reported, harboring 19 d...

journal_title：Platelets

authors： Palma-Barqueros V,Ruiz-Pividal J,Bohdan N,Vicente V,Bastida JM,Lozano M,Rivera J

更新日期：2019-01-01 00:00:00

abstract：:Platelet-rich fibrin (PRF) is generated from the patients' own venous blood by a single centrifugation step without the additional use of anticoagulants. Based on the previously described LSCC (low-speed centrifugation concept), our group showed that modification of the centrifugation setting, that is, reducing the re...

journal_title：Platelets

authors： Kubesch A,Barbeck M,Al-Maawi S,Orlowska A,Booms PF,Sader RA,Miron RJ,Kirkpatrick CJ,Choukroun J,Ghanaati S

更新日期：2019-01-01 00:00:00

abstract：:Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor is a mainstay of the prevention of stent thrombosis following percutaneous coronary intervention (PCI). In the 2015 European guidelines for the management of acute coronary syndrome (ACS), prasugrel (PRA) and ticagrelor (TICA) combined with aspirin ar...

journal_title：Platelets

authors： Selhorst G,Schmidtler F,Ott A,Hitzke E,Tomelden J,Antoni D,Hoffmann E,Rieber J

更新日期：2019-01-01 00:00:00

abstract：:Aspirin is traditionally taken once daily in the morning and considered to be effective throughout the 24h interval. Cardiovascular events occur most frequently in the early morning, suggesting that these hours are critical in terms of adequate platelet inhibition. This study therefore assed platelet function in the e...

journal_title：Platelets

authors： Racca C,van Diemen JJK,Fuijkschot WW,Spit K,Bonten TN,Numans ME,van der Bom JG,Smulders YM,Thijs A

更新日期：2019-01-01 00:00:00

abstract：:Previous studies have reported that various factors affect ADP-induced platelet reactivity during clopidogrel therapy. The aim of this study was to determine whether clinical and laboratory variables for platelet reactivity during dual antiplatelet therapy (DAPT) are dependent on the assay used. We enrolled 904 patien...

journal_title：Platelets

authors： Choi SY,Kim MH

更新日期：2019-01-01 00:00:00

abstract：:Thrombosis and bleeding are devastating adverse events in patients supported with blood-contacting medical devices (BCMDs). In this study, we delineated that high non-physiological shear stress (NPSS) caused platelet dysfunction that may contribute to both thrombosis and bleeding. Human blood was subjected to NPSS wit...

journal_title：Platelets

authors： Chen Z,Mondal NK,Zheng S,Koenig SC,Slaughter MS,Griffith BP,Wu ZJ

更新日期：2019-01-01 00:00:00

abstract：:Several lines of evidence are consistent with the hypothesis that activated platelets contribute to colorectal tumorigenesis and metastatization through direct cell-cell interactions and the release of different lipid and protein mediators, and microvesicles. This review examines the clinical pharmacology of low-dose ...

journal_title：Platelets

authors： Patrignani P,Patrono C

更新日期：2018-12-01 00:00:00

abstract：:Platelets, besides their specialised role in haemostasis and atherothrombosis, actively modulate innate and adaptive immune responses with crucial roles in immune surveillance, inflammation and host defence during infection. An important prerequisite for platelet-mediated changes of immune functions involves direct en...

journal_title：Platelets

authors： Finsterbusch M,Schrottmaier WC,Kral-Pointner JB,Salzmann M,Assinger A

更新日期：2018-11-01 00:00:00

abstract：:Ticagrelor is an antiplatelet agent that inhibits platelet activation via P2Y12 antagonism. There are several studies showing that P2Y12 needs lipid rafts to be activated, but there are few data about how ticagrelor impacts lipid raft organization. Therefore, we aimed to investigate how ticagrelor could impact the dis...

journal_title：Platelets

authors： Rabani V,Montange D,Meneveau N,Davani S

更新日期：2018-11-01 00:00:00

abstract：:R-lipoic acid (ALA), a powerful antioxidant valuable for the treatment of diabetes and its complications, has been reported to exhibit an antiplatelet activity in vitro. The aim of this study was to investigate the effect and mechanism of ALA on platelets in vivo. Sprague-Dawley (SD) male rats were intravenously admin...

journal_title：Platelets

authors： Liu J,Song Q,Huang Y,Sun W,Lu D,Zhou B

更新日期：2018-11-01 00:00:00

abstract：:Dopamine (DA), a catecholamine neurotransmitter, is known to for its diverse roles on hematopoiesis, yet its function in thrombopoiesis remains poorly understood. This study shows that DA stimulation can directly induce platelet production from megakaryocytes (MKs) in the final stages of thrombopoiesis via a reactive ...

journal_title：Platelets

authors： Chen S,Hu M,Shen M,Xu Y,Wang C,Wang X,Li F,Zeng D,Chen F,Zhao G,Chen M,Wang F,Cheng T,Su Y,Zhao J,Wang S,Wang J

更新日期：2018-11-01 00:00:00