abstract：:This study aimed to evaluate the efficacy of Chinese herbal medicine (CHM) in patients with severe/critical coronavirus disease 2019 (COVID-19). In this retrospective study, data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVI...

journal_title：Frontiers of medicine

authors： Chen G,Su W,Yang J,Luo D,Xia P,Jia W,Li X,Wang C,Lang S,Meng Q,Zhang Y,Ke Y,Fan A,Yang S,Zheng Y,Fan X,Qiao J,Lian F,Wei L,Tong X

更新日期：2020-12-01 00:00:00

abstract：:The ongoing pandemic of Coronavirus disease 19 (COVID-19) is caused by a newly discovered β Coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). How long the adaptive immunity triggered by SARS-CoV-2 can last is of critical clinical relevance in assessing the probability of second infection ...

journal_title：Frontiers of medicine

authors： Tan Y,Liu F,Xu X,Ling Y,Huang W,Zhu Z,Guo M,Lin Y,Fu Z,Liang D,Zhang T,Fan J,Xu M,Lu H,Chen S

更新日期：2020-12-01 00:00:00

abstract：:The ability of tumor cells to sustain continuous proliferation is one of the major characteristics of cancer. The activation of oncogenes and the mutation or inactivation of tumor suppressor genes ensure the rapid proliferation of tumor cells. The PI3K-Akt-mTOR axis is one of the most frequently modified signaling pat...

journal_title：Frontiers of medicine

authors： Zhang J,Yin Y,Wang J,Zhang J,Liu H,Feng W,Yang W,Zetter B,Xu Y

更新日期：2020-12-01 00:00:00

abstract：:Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer (NSCLC) risk, biological mechanisms of these variants remain largely unknown. By integrating a large-scale genotype data of 15 581 lung adenocarcinoma (AD) cases, 8350 squamous cell car...

journal_title：Frontiers of medicine

authors： Qin N,Li Y,Wang C,Zhu M,Dai J,Hong T,Albanes D,Lam S,Tardon A,Chen C,Goodman G,Bojesen SE,Landi MT,Johansson M,Risch A,Wichmann HE,Bickeboller H,Rennert G,Arnold S,Brennan P,Field JK,Shete S,Le Marchand L,Me

更新日期：2020-09-05 00:00:00

abstract：:Congenital heart disease (CHD) is the most common birth defect worldwide. Long non-coding RNAs (lncRNAs) have been implicated in many diseases. However, their involvement in CHD is not well understood. This study aimed to investigate the role of dysregulated lncRNAs in CHD. We used Gene Expression Omnibus data mining,...

journal_title：Frontiers of medicine

authors： Ma J,Chen S,Hao L,Sheng W,Chen W,Ma X,Zhang B,Ma D,Huang G

更新日期：2020-08-19 00:00:00

abstract：:As a promising method in artificial intelligence, deep learning has been proven successful in several domains ranging from acoustics and images to natural language processing. With medical imaging becoming an important part of disease screening and diagnosis, deep learning-based approaches have emerged as powerful tec...

journal_title：Frontiers of medicine

authors： Ma J,Song Y,Tian X,Hua Y,Zhang R,Wu J

更新日期：2020-08-01 00:00:00

abstract：:Disorders of sex development (DSD) are a group of rare complex clinical syndromes with multiple etiologies. Distinguishing the various causes of DSD is quite difficult in clinical practice, even for senior general physicians because of the similar and atypical clinical manifestations of these conditions. In addition, ...

journal_title：Frontiers of medicine

authors： Ning D,Zhang Z,Qiu K,Lu L,Zhang Q,Zhu Y,Wang R

更新日期：2020-08-01 00:00:00

abstract：:The rationale for the antibiotic treatment of viral community-acquired pneumonia (CAP) in adults was analyzed to develop a clinical reference standard for this condition. Clinical data from 166 patients diagnosed with viral pneumonia across 14 hospitals in Beijing from November 2010 to December 2017 were collected. Th...

journal_title：Frontiers of medicine

authors： Jiang R,Han B,Dou C,Zhou F,Cao B,Li X

更新日期：2020-06-13 00:00:00

abstract：:This study aimed to define the most consistent white matter microarchitecture pattern in Parkinson's disease (PD) reflected by fractional anisotropy (FA), addressing clinical profiles and methodology-related heterogeneity. Web-based publication databases were searched to conduct a meta-analysis of whole-brain diffusio...

journal_title：Frontiers of medicine

authors： Suo X,Lei D,Li W,Li L,Dai J,Wang S,Li N,Cheng L,Peng R,Kemp GJ,Gong Q

更新日期：2020-05-26 00:00:00

abstract：:The COVID-19 caused by a novel strain of coronavirus has been spreading rapidly since its occurrence in December 2019. It is highly communicable through human-to-human transmission. China has been making unprecedented efforts in treating the confirmed cases, identifying and isolating their close contacts and suspected...

journal_title：Frontiers of medicine

authors： Gong F,Xiong Y,Xiao J,Lin L,Liu X,Wang D,Li X

更新日期：2020-04-01 00:00:00

abstract：:It has been known that, the novel coronavirus, 2019-nCoV, which is considered similar to SARS-CoV, invades human cells via the receptor angiotensin converting enzyme II (ACE2). Moreover, lung cells that have ACE2 expression may be the main target cells during 2019-nCoV infection. However, some patients also exhibit no...

journal_title：Frontiers of medicine

authors： Zou X,Chen K,Zou J,Han P,Hao J,Han Z

更新日期：2020-04-01 00:00:00

abstract：:The aim of this study was to investigate the clinical characteristics of neonates born to SARS-CoV-2 infected mothers and increase the current knowledge on the perinatal consequences of COVID-19. Nineteen neonates were admitted to Tongji Hospital from January 31 to February 29, 2020. Their mothers were clinically diag...

journal_title：Frontiers of medicine

authors： Liu W,Wang J,Li W,Zhou Z,Liu S,Rong Z

更新日期：2020-04-01 00:00:00

abstract：:Growing evidence suggests that somatic hypermutational status and programmed cell death-1 overexpression are potential predictive biomarkers indicating treatment benefits from immunotherapy using immune checkpoint inhibitors. However, biomarker-matched trials are still limited, and many of the genomic alterations rema...

journal_title：Frontiers of medicine

authors： Chen A,Zhang S,Li J,Ji C,Chen J,Li C

更新日期：2020-02-01 00:00:00

abstract：:An effective eradication therapy of Helicobacter pylori (H. pylori) should be used for the first time. In this study, we assessed whether tailored therapy based on antibiotic susceptibility testing is more effective than traditional therapy. We also evaluated the factors that cause treatment failure in high-resistance...

journal_title：Frontiers of medicine

authors： Pan J,Shi Z,Lin D,Yang N,Meng F,Lin L,Jin Z,Zhou Q,Wu J,Zhang J,Li Y

更新日期：2020-02-01 00:00:00

abstract：:Assisted reproduction provides a wide spectrum of treatments and strategies addressing infertility. However, distinct groups of infertile patients with unexplained infertility, congenital disorders, and other complex cases pose a challenge in in vitro fertilization (IVF) practices. This special cohort of patients is a...

journal_title：Frontiers of medicine

authors： Simopoulou M,Sfakianoudis K,Tsioulou P,Rapani A,Giannelou P,Kiriakopoulos N,Pantou A,Vlahos N,Anifandis G,Bolaris S,Pantos K,Koutsilieris M

更新日期：2019-12-01 00:00:00

abstract：:Orbital venous malformation (OVM) is a congenital vascular disease. As a common type of vascular malformation in the orbit, OVM may result in vision deterioration and cosmetic defect. Classification of orbital vascular malformations, especially OVMs, is carried out on the basis of different categories, such as angioge...

journal_title：Frontiers of medicine

authors： Li T,Jia R,Fan X

更新日期：2019-10-01 00:00:00

abstract：:Chimeric antigen receptor T (CAR-T) cell therapy is a novel cellular immunotherapy that is widely used to treat hematological malignancies, including acute leukemia, lymphoma, and multiple myeloma. Despite its remarkable clinical effects, this therapy has side effects that cannot be underestimated. Cytokine release sy...

journal_title：Frontiers of medicine

authors： Chen H,Wang F,Zhang P,Zhang Y,Chen Y,Fan X,Cao X,Liu J,Yang Y,Wang B,Lei B,Gu L,Bai J,Wei L,Zhang R,Zhuang Q,Zhang W,Zhao W,He A

更新日期：2019-10-01 00:00:00

abstract：:Although many drugs and therapeutic strategies have been developed for rheumatoid arthritis (RA) treatment, numerous patients with RA fail to respond to currently available agents. In this review, we provide an overview of the complexity of this autoimmune disease by showing the rapidly increasing number of genes asso...

journal_title：Frontiers of medicine

authors： Wu X,Sheng X,Sheng R,Lu H,Xu H

更新日期：2019-08-01 00:00:00

abstract：:The teeth are highly differentiated chewing organs formed by the development of tooth germ tissue located in the jaw and consist of the enamel, dentin, cementum, pulp, and periodontal tissue. Moreover, the teeth have a complicated regulatory mechanism, special histologic origin, diverse structure, and important functi...

journal_title：Frontiers of medicine

authors： Zhai Q,Dong Z,Wang W,Li B,Jin Y

更新日期：2019-04-01 00:00:00

abstract：:The inhibitory environment that surrounds the lesion site and the lack of intrinsic regenerative capacity of the adult mammalian central nervous system (CNS) impede the regrowth of injured axons and thereby the reestablishment of neural circuits required for functional recovery after spinal cord injuries (SCI). To cir...

journal_title：Frontiers of medicine

authors： Yu B,Gu X

更新日期：2019-04-01 00:00:00

abstract：:Infection with Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 as an important respiratory disease with high fatality rates of 40%-60%. Despite the increased number of cases over subsequent years, the number of pediatric cases remained low. A review of studies conducted from June 2012 to April ...

journal_title：Frontiers of medicine

authors： Alfaraj SH,Al-Tawfiq JA,Altuwaijri TA,Memish ZA

更新日期：2019-02-01 00:00:00

abstract：:Autoimmune diseases (ADs) increase the risk of non-Hodgkin's lymphoma and contribute to poor prognosis of patients. However, the association between immunologic markers and clinical outcome has rarely been investigated. This study aims to analyze the prognostic value of pretreatment immunologic markers in newly diagno...

journal_title：Frontiers of medicine

authors： Cao Y,Liu Z,Wu W,Qian Y,Shi Q,Shen R,Ouyang B,Xu P,Cheng S,Ye J,Lu Y,Wang C,Yang C,Wang L,Zhao W

更新日期：2019-02-01 00:00:00

abstract：:Although type 2 diabetes is a disease often associated with aging, the global prevalence of early-onset diabetes has been increasing due to man's sedentary lifestyle, low-physical activity, obesity, and some nonmodifiable risk factors. Many studies have found that individuals with early-onset type 2 diabetes were at h...

journal_title：Frontiers of medicine

authors： Pan J,Jia W

更新日期：2018-12-01 00:00:00

abstract：:This study aimed to explore the association of maternal depression with nutrient intake, growth, and development of preterm infants. A cohort study of 201 infants was conducted in Beijing. Based on the gestational age of an infant and status of the mother, the infants were divided into four groups: non-depression-full...

journal_title：Frontiers of medicine

authors： Wang H,Zhou H,Zhang Y,Wang Y,Sun J

更新日期：2018-10-01 00:00:00

abstract：:Identification of the driver mutations in cancer has resulted in the development of a new category of molecularly targeted anti-cancer drugs. However, as was the case with conventional chemotherapies, the effectiveness of these drugs is limited by the emergence of drug-resistant variants. While most cancer therapies a...

journal_title：Frontiers of medicine

authors： Wang L,Bernards R

更新日期：2018-08-01 00:00:00

abstract：:Transforming growth factor (TGF)-β regulates a wide variety of cellular responses, including cell growth arrest, apoptosis, cell differentiation, motility, invasion, extracellular matrix production, tissue fibrosis, angiogenesis, and immune function. Although tumor-suppressive roles of TGF-β have been extensively stud...

journal_title：Frontiers of medicine

authors： Miyazono K,Katsuno Y,Koinuma D,Ehata S,Morikawa M

更新日期：2018-08-01 00:00:00

abstract：:Persistent vegetative state (PVS) is a clinical condition wherein the cerebral cortex loses its function although brain stem function remains relatively intact. It has high mortality and disability rates. Although treatment for PVS is extensively studied in developed countries, little breakthrough has been made. In Ch...

journal_title：Frontiers of medicine

authors： Song H,Chen X,Yu Y,Zhang L

更新日期：2018-06-01 00:00:00

abstract：:γδ T cells display unique developmental, distributional, and functional patterns and can rapidly respond to various insults and contribute to diverse diseases. Different subtypes of γδ T cells are produced in the thymus prior to their migration to peripheral tissues. γδ T cells are enriched in the liver and exhibit li...

journal_title：Frontiers of medicine

authors： Wang X,Tian Z

更新日期：2018-06-01 00:00:00

abstract：:Obstructive sleep apnea syndrome (OSAS) increases the risk of post-surgery complications. This study uses Berlin Questionnaire (BQ) to identify Chinese adult surgical patients who are at a high risk of OSAS and to determine if the BQ could be used to detect potential high risk of adverse respiratory events in the post...

journal_title：Frontiers of medicine

authors： Liu F,Liu L,Zheng F,Tang X,Bao Y,Zuo Y

更新日期：2018-04-01 00:00:00

abstract：:Bronchiolitis obliterans syndrome (BOS) after hematopoietic stem cell transplantation (HSCT) is a major cause of morbidity and mortality with limited treatment options. Lung transplantation (LTX) has been rarely reported as a treatment option for selected HSCT recipients with this problem. In the present study, we rep...

journal_title：Frontiers of medicine

authors： Gao F,Chen J,Wei D,Wu B,Zhou M

更新日期：2018-04-01 00:00:00

abstract：:Foodborne disease is one of the most important public health issues worldwide. China faces various and unprecedented challenges in all aspects of the food chain. Data from laboratory-based foodborne disease surveillance systems from 2013 to 2016, as well as different regions and ages, can be found along with differenc...

journal_title：Frontiers of medicine

authors： Liu J,Bai L,Li W,Han H,Fu P,Ma X,Bi Z,Yang X,Zhang X,Zhen S,Deng X,Liu X,Guo Y

更新日期：2018-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is currently the fifth most common malignancy and the third leading cause of cancer-related mortalities worldwide. In the last few years, treatments for HCC have significantly improved from a mere surgical resection to a series of minimally invasive therapies and targeted drugs. However,...

journal_title：Frontiers of medicine

authors： Yu M,Li Z

更新日期：2017-12-01 00:00:00

abstract：:Grading of Recommendations Assessment, Development, and Evaluation (GRADE) offers a worldwide approach to guideline development for clinical practice. For the clinical practice of acupuncture therapy, 18 evidence-based guidelines have been developed in China using GRADE. In this study, we review the advantages and lim...

journal_title：Frontiers of medicine

authors： Zhao H,Liang F,Fang Y,Liu B

更新日期：2017-12-01 00:00:00

abstract：:China recently instituted a two-child policy in response to its aging population, declining workforce and demographic dividend, and the need to develop asocial economy. Additionally, women generally delay having a second child because of the overwhelming pressure in their lives. With the improvements in assisted ferti...

journal_title：Frontiers of medicine

authors： Li Q,Deng D

更新日期：2017-12-01 00:00:00

abstract：:Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor-mediated coagulation. TFPI is expressed by endothelial and smooth muscle cells in the vasculature. Endothelium-derived TFPI has been reported to play a regulatory role in arterial thrombosis. However, the role of endogenous TFPI in vascular ...

journal_title：Frontiers of medicine

authors： Yang J,Jin K,Xiao J,Ma J,Ma D

更新日期：2017-09-01 00:00:00

abstract：:Zebrafish is an emerging animal model for studies on auditory system. This model presents high comparability with humans, good accessibility to the hearing organ, and high throughput capacity. To better utilize this animal model, methodologies need to be used to quantify the hearing function of the zebrafish. Zebrafis...

journal_title：Frontiers of medicine

authors： Yang Q,Sun P,Chen S,Li H,Chen F

更新日期：2017-06-01 00:00:00

abstract：:This study aims to investigate the effect of non-transecting anastomotic urethroplasty for treatment of posterior urethral stricture. A total of 23 patients with traumatic posterior urethral stricture were enrolled and then divided into two groups. In one group, 12 patients underwent non-transecting anastomotic urethr...

journal_title：Frontiers of medicine

authors： Le W,Li C,Zhang J,Wu D,Liu B

更新日期：2017-06-01 00:00:00

abstract：:Childhood obesity and obesity-related metabolic complications are induced by a high-fat postnatal diet. The lack of a suitable animal model, however, remains a considerable challenge in obesity studies. In the current study, we provided high-fat diet (HFD) to dams during lactation and to pups after weaning. We also de...

journal_title：Frontiers of medicine

authors： Ullah R,Su Y,Shen Y,Li C,Xu X,Zhang J,Huang K,Rauf N,He Y,Cheng J,Qin H,Zhou YD,Fu J

更新日期：2017-06-01 00:00:00

abstract：:S100A9, a calcium-binding protein, participates in the inflammatory process and development of various tumors, thus attracting much attention in the field of cancer biology. This study aimed to investigate the regulatory mechanism of S100A9 and its function involvement in APL. We used real-time quantitative PCR to det...

journal_title：Frontiers of medicine

authors： Zhu Y,Zhang F,Zhang S,Deng W,Fan H,Wang H,Zhang J

更新日期：2017-03-01 00:00:00

abstract：:Electroacupuncture (EA) at Zhongliao (BL33) can improve the symptoms of overactive bladder (OAB), such as urinary frequency, urgency, and incontinence. However, its performance compared with other acupoints remains unclear. This study investigated the effects of EA at BL33 with deep needling on rats with OAB by detect...

journal_title：Frontiers of medicine

authors： Yang L,Wang Y,Mo Q,Liu Z

更新日期：2017-03-01 00:00:00