Abstract：
:Identification of the driver mutations in cancer has resulted in the development of a new category of molecularly targeted anti-cancer drugs. However, as was the case with conventional chemotherapies, the effectiveness of these drugs is limited by the emergence of drug-resistant variants. While most cancer therapies are given in combinations that are designed to avoid drug resistance, we discuss here therapeutic approaches that take advantage of the changes in cancer cells that arise upon development of drug resistance. This approach is based on notion that drug resistance comes at a fitness cost to the cancer cell that can be exploited for therapeutic benefit.We discuss the development of sequential drug therapies in which the first therapy is not given with curative intent, but to induce a major new sensitivity that can be targeted with a second drug that selectively targets the acquired vulnerability. This concept of collateral sensitivity has hitherto not been used on a large scale in the clinic and holds great promise for future cancer therapy.
journal_name
Front Medjournal_title
Frontiers of medicineauthors
Wang L,Bernards Rdoi
10.1007/s11684-018-0647-7subject
Has Abstractpub_date
2018-08-01 00:00:00pages
490-495issue
4eissn
2095-0217issn
2095-0225pii
10.1007/s11684-018-0647-7journal_volume
12pub_type
杂志文章abstract：:Hepatocellular carcinoma (HCC) is a highly complex disease that is generally resistant to commonly used chemotherapy and radiotherapy. Consequently, there is an urgent need for the development of new treatment strategies for this devastating disease. In the past decade, tremendous progress has been achieved in the mol...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-012-0193-7
更新日期：2012-06-01 00:00:00
abstract：:Although type 2 diabetes is a disease often associated with aging, the global prevalence of early-onset diabetes has been increasing due to man's sedentary lifestyle, low-physical activity, obesity, and some nonmodifiable risk factors. Many studies have found that individuals with early-onset type 2 diabetes were at h...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-018-0669-1
更新日期：2018-12-01 00:00:00
abstract：:Pulmonary hypertension (PH), as a complication of bronchiectasis, is associated with increased mortality. However, hemodynamic characteristics and the efficacy of pulmonary arterial hypertension (PAH) therapies in patients with bronchiectasis and PH remain unknown. Patients with bilateral bronchiectasis and concurrent...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-016-0461-z
更新日期：2016-09-01 00:00:00
abstract：:We observed the effect of Dianxianning, which was used as additive treatment to treat 206 epilepsy patients, on the epilepsy seizure rate. Based on a multicenter, prospective, randomized, and controlled clinical trial design, we used the seizure rate of epilepsy as the main index. For the treatment group comprising 13...
journal_title：Frontiers of medicine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s11684-011-0139-5
更新日期：2011-06-01 00:00:00
abstract：:Netrin-1 (NT-1) is one of the axon-guiding molecules that are critical for neuronal development. Because of its structural homology to the endothelial mitogens, NT-1 may have similar effects on vascular network formation. NT-1 was shown to be able to stimulate the proliferation and migration of human cerebral endothel...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-011-0118-x
更新日期：2011-03-01 00:00:00
abstract：:This study aimed to evaluate the efficacy of Chinese herbal medicine (CHM) in patients with severe/critical coronavirus disease 2019 (COVID-19). In this retrospective study, data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVI...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-020-0813-6
更新日期：2020-12-01 00:00:00
abstract：:Herbal medicines have recently been recognized as the second most common cause of drug-induced liver injury (DILI) in the United States. However, reliable methods to identify the DILI causality of some herbs, such as Heshouwu (dried root of Polygonum multiflorum), remain lacking. In this study, a total of 12 307 inpat...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-015-0417-8
更新日期：2015-12-01 00:00:00
abstract：:Zebrafish is an emerging animal model for studies on auditory system. This model presents high comparability with humans, good accessibility to the hearing organ, and high throughput capacity. To better utilize this animal model, methodologies need to be used to quantify the hearing function of the zebrafish. Zebrafis...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-017-0507-x
更新日期：2017-06-01 00:00:00
abstract：:Antitumor angiogenic therapy has been shown promising in the treatment of several advanced cancers since the approval of the first antiangiogenic drug Avastin in 2004. Although the current antiangiogenic drugs reduce the density of tumor blood vessels and result in tumor shrinkage at the early stage of treatment, rece...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-012-0176-8
更新日期：2012-03-01 00:00:00
abstract：:Obstructive sleep apnea syndrome (OSAS) increases the risk of post-surgery complications. This study uses Berlin Questionnaire (BQ) to identify Chinese adult surgical patients who are at a high risk of OSAS and to determine if the BQ could be used to detect potential high risk of adverse respiratory events in the post...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-017-0533-8
更新日期：2018-04-01 00:00:00
abstract：:Real world study (RWS) has become a hotspot for clinical research. Data quality plays a vital role in research achievement and other clinical research fields. In this paper, the common quality problems in the RWS of traditional Chinese medicine are discussed, and a countermeasure is proposed. ...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-014-0351-1
更新日期：2014-09-01 00:00:00
abstract：:Assisted reproduction provides a wide spectrum of treatments and strategies addressing infertility. However, distinct groups of infertile patients with unexplained infertility, congenital disorders, and other complex cases pose a challenge in in vitro fertilization (IVF) practices. This special cohort of patients is a...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-019-0697-5
更新日期：2019-12-01 00:00:00
abstract：:A phase II study (A2202) was performed to evaluate the efficacy and safety of JAK inhibitor ruxolitinib in 63 Chinese MF patients. Ruxolitinib was given twice a day (bid) at a starting dose of 15 mg (n = 25) or 20 mg (n = 38) based on a baseline platelet count. About 94.7% of the patients achieved a reduction in splee...
journal_title：Frontiers of medicine
pub_type： 杂志文章,多中心研究
doi：10.1007/s11684-016-0472-9
更新日期：2016-12-01 00:00:00
abstract：:A total of 251 patients with epithelial ovarian cancer (EOC) treated between 2002 and 2008 was retrospectively analyzed to investigate the long-term outcomes and prognostic factors of these patients, particularly those who underwent primary debulking surgery followed by platinum-based chemotherapy. Clinicopathological...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-014-0305-7
更新日期：2014-03-01 00:00:00
abstract：:Autoimmune diseases (ADs) increase the risk of non-Hodgkin's lymphoma and contribute to poor prognosis of patients. However, the association between immunologic markers and clinical outcome has rarely been investigated. This study aims to analyze the prognostic value of pretreatment immunologic markers in newly diagno...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-019-0680-1
更新日期：2019-02-01 00:00:00
abstract：:Perioperative parecoxib administration reduces postoperative pain, opioid consumption, and adverse events in adult patients. However, the efficacy and safety of parecoxib in children remain unclear. This metaanalysis included related published studies to address this concern. Eight databases in the literature until Fe...
journal_title：Frontiers of medicine
pub_type： 杂志文章,meta分析
doi：10.1007/s11684-015-0414-y
更新日期：2015-12-01 00:00:00
abstract：:Growing evidence suggests that somatic hypermutational status and programmed cell death-1 overexpression are potential predictive biomarkers indicating treatment benefits from immunotherapy using immune checkpoint inhibitors. However, biomarker-matched trials are still limited, and many of the genomic alterations rema...
journal_title：Frontiers of medicine
pub_type： 杂志文章,多中心研究
doi：10.1007/s11684-019-0698-4
更新日期：2020-02-01 00:00:00
abstract：:Sickle cell disease (SCD) is an inherited disorder of hemoglobin in which the abnormal hemoglobin S polymerizes when deoxygenated. This polymerization of hemoglobin S not only results in hemolysis and vasoocclusion but also precipitates inflammation, oxidative stress and chronic organ dysfunction. Oxidative stress is ...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-015-0375-1
更新日期：2015-03-01 00:00:00
abstract：:Hearing impairment is considered as the most prevalent impairment worldwide. Almost 600 million people in the world suffer from mild or moderate hearing impairment, an estimated 10% of the human population. Genetic factors play an important role in the pathogenesis of this disorder. Hereditary hearing loss is divided ...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-016-0449-8
更新日期：2016-06-01 00:00:00
abstract：:Although many drugs and therapeutic strategies have been developed for rheumatoid arthritis (RA) treatment, numerous patients with RA fail to respond to currently available agents. In this review, we provide an overview of the complexity of this autoimmune disease by showing the rapidly increasing number of genes asso...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-018-0659-3
更新日期：2019-08-01 00:00:00
abstract：:Orbital venous malformation (OVM) is a congenital vascular disease. As a common type of vascular malformation in the orbit, OVM may result in vision deterioration and cosmetic defect. Classification of orbital vascular malformations, especially OVMs, is carried out on the basis of different categories, such as angioge...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-018-0623-2
更新日期：2019-10-01 00:00:00
abstract：:As a promising method in artificial intelligence, deep learning has been proven successful in several domains ranging from acoustics and images to natural language processing. With medical imaging becoming an important part of disease screening and diagnosis, deep learning-based approaches have emerged as powerful tec...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-019-0726-4
更新日期：2020-08-01 00:00:00
abstract：:Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor-mediated coagulation. TFPI is expressed by endothelial and smooth muscle cells in the vasculature. Endothelium-derived TFPI has been reported to play a regulatory role in arterial thrombosis. However, the role of endogenous TFPI in vascular ...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-017-0522-y
更新日期：2017-09-01 00:00:00
abstract：:Traditional Chinese medicine (TCM) investigates the clinical diagnosis and treatment regularities in a typical schema of personalized medicine, which means that individualized patients with same diseases would obtain distinct diagnosis and optimal treatment from different TCM physicians. This principle has been recogn...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-014-0349-8
更新日期：2014-09-01 00:00:00
abstract：:This study aimed to define the most consistent white matter microarchitecture pattern in Parkinson's disease (PD) reflected by fractional anisotropy (FA), addressing clinical profiles and methodology-related heterogeneity. Web-based publication databases were searched to conduct a meta-analysis of whole-brain diffusio...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-019-0725-5
更新日期：2020-05-26 00:00:00
abstract：:Disorders of sex development (DSD) are a group of rare complex clinical syndromes with multiple etiologies. Distinguishing the various causes of DSD is quite difficult in clinical practice, even for senior general physicians because of the similar and atypical clinical manifestations of these conditions. In addition, ...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-020-0791-8
更新日期：2020-08-01 00:00:00
abstract：:The aim of this study was to investigate the clinical characteristics of neonates born to SARS-CoV-2 infected mothers and increase the current knowledge on the perinatal consequences of COVID-19. Nineteen neonates were admitted to Tongji Hospital from January 31 to February 29, 2020. Their mothers were clinically diag...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-020-0772-y
更新日期：2020-04-01 00:00:00
abstract：:NUP98 fuses with approximately 34 different partner genes via translocation in hematological malignancies. Transgenic or retrovirus-mediated bone marrow transplanted mouse models reveal the leukemogenesis of some NUP98-related fusion genes. We previously reported the fusion protein NUP98-IQ motif containing G (IQCG) i...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-016-0489-0
更新日期：2016-12-01 00:00:00
abstract：:A high level of social support can improve long-term diabetes self-management. Support from a single source has been evaluated. This study aims to analyze support from multiple and multilevel sources for diabetic patients by using the Chronic Illness Resources Survey (CIRS). Factors influencing the utilization of the ...
journal_title：Frontiers of medicine
pub_type： 杂志文章,多中心研究
doi：10.1007/s11684-016-0441-3
更新日期：2016-06-01 00:00:00
abstract：:Single incision laparoscopic surgery (SILS) is a novel minimally invasive surgical technique that is gaining popularity around the world. One of the most commonly performed procedures is single incision laparoscopic cholecystectomy (SILC). Most reported techniques utilize special purpose-made access port and articulat...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-011-0151-9
更新日期：2011-09-01 00:00:00
