Classification and treatment of orbital venous malformations: an updated review.

abstract：:Infection with Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 as an important respiratory disease with high fatality rates of 40%-60%. Despite the increased number of cases over subsequent years, the number of pediatric cases remained low. A review of studies conducted from June 2012 to April ...

journal_title：Frontiers of medicine

authors： Alfaraj SH,Al-Tawfiq JA,Altuwaijri TA,Memish ZA

更新日期：2019-02-01 00:00:00

abstract：:Although type 2 diabetes is a disease often associated with aging, the global prevalence of early-onset diabetes has been increasing due to man's sedentary lifestyle, low-physical activity, obesity, and some nonmodifiable risk factors. Many studies have found that individuals with early-onset type 2 diabetes were at h...

journal_title：Frontiers of medicine

authors： Pan J,Jia W

更新日期：2018-12-01 00:00:00

abstract：:China recently instituted a two-child policy in response to its aging population, declining workforce and demographic dividend, and the need to develop asocial economy. Additionally, women generally delay having a second child because of the overwhelming pressure in their lives. With the improvements in assisted ferti...

journal_title：Frontiers of medicine

authors： Li Q,Deng D

更新日期：2017-12-01 00:00:00

abstract：:Sickle cell disease (SCD) is an inherited disorder of hemoglobin in which the abnormal hemoglobin S polymerizes when deoxygenated. This polymerization of hemoglobin S not only results in hemolysis and vasoocclusion but also precipitates inflammation, oxidative stress and chronic organ dysfunction. Oxidative stress is ...

journal_title：Frontiers of medicine

authors： Owusu-Ansah A,Choi SH,Petrosiute A,Letterio JJ,Huang AY

更新日期：2015-03-01 00:00:00

abstract：:Foodborne disease is one of the most important public health issues worldwide. China faces various and unprecedented challenges in all aspects of the food chain. Data from laboratory-based foodborne disease surveillance systems from 2013 to 2016, as well as different regions and ages, can be found along with differenc...

journal_title：Frontiers of medicine

authors： Liu J,Bai L,Li W,Han H,Fu P,Ma X,Bi Z,Yang X,Zhang X,Zhen S,Deng X,Liu X,Guo Y

更新日期：2018-02-01 00:00:00

abstract：:Chromosomal aberrations have been associated with cancer development since their discovery more than a hundred years ago. Chromosomal translocations, a type of particular structural changes involving heterologous chromosomes, have made a critical impact on diagnosis, prognosis and treatment of cancers. For example, th...

journal_title：Frontiers of medicine

authors： Wang JH

更新日期：2012-09-01 00:00:00

abstract：:The N-end rule pathway is a unique branch of the ubiquitin-proteasome system in which the determination of a protein's half-life is dependent on its N-terminal residue. The N-terminal residue serves as the degradation signal of a protein and thus called N-degron. N-degron can be recognized and modifed by several steps...

journal_title：Frontiers of medicine

authors： Liu Y,Liu C,Dong W,Li W

更新日期：2016-09-01 00:00:00

abstract：:Single incision laparoscopic surgery (SILS) is a novel minimally invasive surgical technique that is gaining popularity around the world. One of the most commonly performed procedures is single incision laparoscopic cholecystectomy (SILC). Most reported techniques utilize special purpose-made access port and articulat...

journal_title：Frontiers of medicine

authors： Cui H

更新日期：2011-09-01 00:00:00

abstract：:This study evaluated the immunogenicity and protective immunity of a Hemophilus influenzae b (Hib) polysaccharide conjugate vaccine with the pneumococcal surface adhesin A (PsaA) protein carrier in young mice. The Hib polysaccharide was conjugated with the rPsaA protein carrier, which was produced using recombinant DN...

journal_title：Frontiers of medicine

authors： Chen Z,Guo R,Xu J,Qiu C

更新日期：2016-12-01 00:00:00

abstract：:Although many drugs and therapeutic strategies have been developed for rheumatoid arthritis (RA) treatment, numerous patients with RA fail to respond to currently available agents. In this review, we provide an overview of the complexity of this autoimmune disease by showing the rapidly increasing number of genes asso...

journal_title：Frontiers of medicine

authors： Wu X,Sheng X,Sheng R,Lu H,Xu H

更新日期：2019-08-01 00:00:00

abstract：:Grading of Recommendations Assessment, Development, and Evaluation (GRADE) offers a worldwide approach to guideline development for clinical practice. For the clinical practice of acupuncture therapy, 18 evidence-based guidelines have been developed in China using GRADE. In this study, we review the advantages and lim...

journal_title：Frontiers of medicine

authors： Zhao H,Liang F,Fang Y,Liu B

更新日期：2017-12-01 00:00:00

abstract：:Chimeric antigen receptor T (CAR-T) cell therapy is a novel cellular immunotherapy that is widely used to treat hematological malignancies, including acute leukemia, lymphoma, and multiple myeloma. Despite its remarkable clinical effects, this therapy has side effects that cannot be underestimated. Cytokine release sy...

journal_title：Frontiers of medicine

authors： Chen H,Wang F,Zhang P,Zhang Y,Chen Y,Fan X,Cao X,Liu J,Yang Y,Wang B,Lei B,Gu L,Bai J,Wei L,Zhang R,Zhuang Q,Zhang W,Zhao W,He A

更新日期：2019-10-01 00:00:00

abstract：:Recent evidences suggested that cyclic guanosine monophosphate-specific phosphodiesterase 5 (PDE5) inhibitor represents an important therapeutic target for cardiovascular diseases. Whether and how it ameliorates cardiac fibrosis, a major cause of diastolic dysfunction and heart failure, is unknown. The purpose of this...

journal_title：Frontiers of medicine

authors： Gong W,Yan M,Chen J,Chaugai S,Chen C,Wang D

更新日期：2014-12-01 00:00:00

abstract：:Hearing impairment is considered as the most prevalent impairment worldwide. Almost 600 million people in the world suffer from mild or moderate hearing impairment, an estimated 10% of the human population. Genetic factors play an important role in the pathogenesis of this disorder. Hereditary hearing loss is divided ...

journal_title：Frontiers of medicine

authors： Xia W,Liu F,Ma D

更新日期：2016-06-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is an idiopathic group of reactive proliferative diseases linked to aberrant immunity, pathologically characterized by clonal proliferation of Langerhans cells. LCH rarely involves the thymus. We report a case of thymic LCH with diabetes insipidus as the first presentation, without ...

journal_title：Frontiers of medicine

authors： Chen X,Huang X,Qiu Y,Chen H,Fu Y,Li X

更新日期：2013-03-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a highly complex disease that is generally resistant to commonly used chemotherapy and radiotherapy. Consequently, there is an urgent need for the development of new treatment strategies for this devastating disease. In the past decade, tremendous progress has been achieved in the mol...

journal_title：Frontiers of medicine

authors： Gao Q,Shi Y,Wang X,Zhou J,Qiu S,Fan J

更新日期：2012-06-01 00:00:00

abstract：:Persistent vegetative state (PVS) is a clinical condition wherein the cerebral cortex loses its function although brain stem function remains relatively intact. It has high mortality and disability rates. Although treatment for PVS is extensively studied in developed countries, little breakthrough has been made. In Ch...

journal_title：Frontiers of medicine

authors： Song H,Chen X,Yu Y,Zhang L

更新日期：2018-06-01 00:00:00

abstract：:Obstructive sleep apnea syndrome (OSAS) increases the risk of post-surgery complications. This study uses Berlin Questionnaire (BQ) to identify Chinese adult surgical patients who are at a high risk of OSAS and to determine if the BQ could be used to detect potential high risk of adverse respiratory events in the post...

journal_title：Frontiers of medicine

authors： Liu F,Liu L,Zheng F,Tang X,Bao Y,Zuo Y

更新日期：2018-04-01 00:00:00

abstract：:Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer (NSCLC) risk, biological mechanisms of these variants remain largely unknown. By integrating a large-scale genotype data of 15 581 lung adenocarcinoma (AD) cases, 8350 squamous cell car...

journal_title：Frontiers of medicine

authors： Qin N,Li Y,Wang C,Zhu M,Dai J,Hong T,Albanes D,Lam S,Tardon A,Chen C,Goodman G,Bojesen SE,Landi MT,Johansson M,Risch A,Wichmann HE,Bickeboller H,Rennert G,Arnold S,Brennan P,Field JK,Shete S,Le Marchand L,Me

更新日期：2020-09-05 00:00:00

abstract：:Perioperative parecoxib administration reduces postoperative pain, opioid consumption, and adverse events in adult patients. However, the efficacy and safety of parecoxib in children remain unclear. This metaanalysis included related published studies to address this concern. Eight databases in the literature until Fe...

journal_title：Frontiers of medicine

authors： Bu X,Yang L,Zuo Y

更新日期：2015-12-01 00:00:00

abstract：:The rationale for the antibiotic treatment of viral community-acquired pneumonia (CAP) in adults was analyzed to develop a clinical reference standard for this condition. Clinical data from 166 patients diagnosed with viral pneumonia across 14 hospitals in Beijing from November 2010 to December 2017 were collected. Th...

journal_title：Frontiers of medicine

authors： Jiang R,Han B,Dou C,Zhou F,Cao B,Li X

更新日期：2020-06-13 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is currently the fifth most common malignancy and the third leading cause of cancer-related mortalities worldwide. In the last few years, treatments for HCC have significantly improved from a mere surgical resection to a series of minimally invasive therapies and targeted drugs. However,...

journal_title：Frontiers of medicine

authors： Yu M,Li Z

更新日期：2017-12-01 00:00:00

abstract：:Disorders of sex development (DSD) are a group of rare complex clinical syndromes with multiple etiologies. Distinguishing the various causes of DSD is quite difficult in clinical practice, even for senior general physicians because of the similar and atypical clinical manifestations of these conditions. In addition, ...

journal_title：Frontiers of medicine

authors： Ning D,Zhang Z,Qiu K,Lu L,Zhang Q,Zhu Y,Wang R

更新日期：2020-08-01 00:00:00

abstract：:Herbal medicines have recently been recognized as the second most common cause of drug-induced liver injury (DILI) in the United States. However, reliable methods to identify the DILI causality of some herbs, such as Heshouwu (dried root of Polygonum multiflorum), remain lacking. In this study, a total of 12 307 inpat...

journal_title：Frontiers of medicine

authors： Wang J,Ma Z,Niu M,Zhu Y,Liang Q,Zhao Y,Song J,Bai Z,Zhang Y,Zhang P,Li N,Meng Y,Li Q,Qin L,Teng G,Cao J,Li B,Chen S,Li Y,Zou Z,Zhou H,Xiao X

更新日期：2015-12-01 00:00:00

abstract：:Sepsis is a common cause of death in hospitalized patients worldwide. The early detection of sepsis remains a great challenge for clinicians, and delayed diagnosis frequently undermines treatment efforts, thereby contributing to high mortality. Omics technologies allow high-throughput screening of sepsis biomarkers. T...

journal_title：Frontiers of medicine

authors： Liu X,Ren H,Peng D

更新日期：2014-03-01 00:00:00

abstract：:This study aimed to evaluate the efficacy of Chinese herbal medicine (CHM) in patients with severe/critical coronavirus disease 2019 (COVID-19). In this retrospective study, data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVI...

journal_title：Frontiers of medicine

authors： Chen G,Su W,Yang J,Luo D,Xia P,Jia W,Li X,Wang C,Lang S,Meng Q,Zhang Y,Ke Y,Fan A,Yang S,Zheng Y,Fan X,Qiao J,Lian F,Wei L,Tong X

更新日期：2020-12-01 00:00:00

abstract：:The ability of tumor cells to sustain continuous proliferation is one of the major characteristics of cancer. The activation of oncogenes and the mutation or inactivation of tumor suppressor genes ensure the rapid proliferation of tumor cells. The PI3K-Akt-mTOR axis is one of the most frequently modified signaling pat...

journal_title：Frontiers of medicine

authors： Zhang J,Yin Y,Wang J,Zhang J,Liu H,Feng W,Yang W,Zetter B,Xu Y

更新日期：2020-12-01 00:00:00

abstract：:Real world study (RWS) has become a hotspot for clinical research. Data quality plays a vital role in research achievement and other clinical research fields. In this paper, the common quality problems in the RWS of traditional Chinese medicine are discussed, and a countermeasure is proposed. ...

journal_title：Frontiers of medicine

authors： Zhang R,Wang Y,Liu B,Song G,Zhou X,Fan S,Pan X

更新日期：2014-09-01 00:00:00

abstract：:The COVID-19 caused by a novel strain of coronavirus has been spreading rapidly since its occurrence in December 2019. It is highly communicable through human-to-human transmission. China has been making unprecedented efforts in treating the confirmed cases, identifying and isolating their close contacts and suspected...

journal_title：Frontiers of medicine

authors： Gong F,Xiong Y,Xiao J,Lin L,Liu X,Wang D,Li X

更新日期：2020-04-01 00:00:00

abstract：:Bronchiolitis obliterans syndrome (BOS) after hematopoietic stem cell transplantation (HSCT) is a major cause of morbidity and mortality with limited treatment options. Lung transplantation (LTX) has been rarely reported as a treatment option for selected HSCT recipients with this problem. In the present study, we rep...

journal_title：Frontiers of medicine

authors： Gao F,Chen J,Wei D,Wu B,Zhou M

更新日期：2018-04-01 00:00:00