Immunogenicity and protective immunity against otitis media caused by pneumococcus in mice of Hib conjugate vaccine with PsaA protein carrier.

abstract：:We observed the effect of Dianxianning, which was used as additive treatment to treat 206 epilepsy patients, on the epilepsy seizure rate. Based on a multicenter, prospective, randomized, and controlled clinical trial design, we used the seizure rate of epilepsy as the main index. For the treatment group comprising 13...

journal_title：Frontiers of medicine

authors： He L,Wen T,Yan S,Li R,Liu Z,Ren H,Liu J,Zhang F,Wu J,Liu J

更新日期：2011-06-01 00:00:00

abstract：:The prevalence of the risk factors and the risk of cardiac failure are both increasing in China. This might be the consequence of the changes of the life conditions (emigration to the urban areas, changes in the diet and life style, lack of physical exercise, etc.). The wide range of clinical presentations of cardiac ...

journal_title：Frontiers of medicine

authors： Loisance D

更新日期：2011-03-01 00:00:00

abstract：:Grading of Recommendations Assessment, Development, and Evaluation (GRADE) offers a worldwide approach to guideline development for clinical practice. For the clinical practice of acupuncture therapy, 18 evidence-based guidelines have been developed in China using GRADE. In this study, we review the advantages and lim...

journal_title：Frontiers of medicine

authors： Zhao H,Liang F,Fang Y,Liu B

更新日期：2017-12-01 00:00:00

abstract：:Recent evidences suggested that cyclic guanosine monophosphate-specific phosphodiesterase 5 (PDE5) inhibitor represents an important therapeutic target for cardiovascular diseases. Whether and how it ameliorates cardiac fibrosis, a major cause of diastolic dysfunction and heart failure, is unknown. The purpose of this...

journal_title：Frontiers of medicine

authors： Gong W,Yan M,Chen J,Chaugai S,Chen C,Wang D

更新日期：2014-12-01 00:00:00

abstract：:Obstructive sleep apnea syndrome (OSAS) increases the risk of post-surgery complications. This study uses Berlin Questionnaire (BQ) to identify Chinese adult surgical patients who are at a high risk of OSAS and to determine if the BQ could be used to detect potential high risk of adverse respiratory events in the post...

journal_title：Frontiers of medicine

authors： Liu F,Liu L,Zheng F,Tang X,Bao Y,Zuo Y

更新日期：2018-04-01 00:00:00

abstract：:γδ T cells display unique developmental, distributional, and functional patterns and can rapidly respond to various insults and contribute to diverse diseases. Different subtypes of γδ T cells are produced in the thymus prior to their migration to peripheral tissues. γδ T cells are enriched in the liver and exhibit li...

journal_title：Frontiers of medicine

authors： Wang X,Tian Z

更新日期：2018-06-01 00:00:00

abstract：:The ongoing pandemic of Coronavirus disease 19 (COVID-19) is caused by a newly discovered β Coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). How long the adaptive immunity triggered by SARS-CoV-2 can last is of critical clinical relevance in assessing the probability of second infection ...

journal_title：Frontiers of medicine

authors： Tan Y,Liu F,Xu X,Ling Y,Huang W,Zhu Z,Guo M,Lin Y,Fu Z,Liang D,Zhang T,Fan J,Xu M,Lu H,Chen S

更新日期：2020-12-01 00:00:00

abstract：:It has been known that, the novel coronavirus, 2019-nCoV, which is considered similar to SARS-CoV, invades human cells via the receptor angiotensin converting enzyme II (ACE2). Moreover, lung cells that have ACE2 expression may be the main target cells during 2019-nCoV infection. However, some patients also exhibit no...

journal_title：Frontiers of medicine

authors： Zou X,Chen K,Zou J,Han P,Hao J,Han Z

更新日期：2020-04-01 00:00:00

abstract：:Head and neck cancer (HNC) consists of a group of malignancies affecting closely related anatomical regions of the upper aerodigestive tract (UADT), including the oral cavity, salivary glands, upper and lower jaw bones and facial skin; the nasal cavity, paranasal sinuses, pharynx, larynx and thyroid gland (although th...

journal_title：Frontiers of medicine

authors： Gao J,Panizza B,Johnson NW,Coman S,Clough AR

更新日期：2012-12-01 00:00:00

abstract：:The ability of tumor cells to sustain continuous proliferation is one of the major characteristics of cancer. The activation of oncogenes and the mutation or inactivation of tumor suppressor genes ensure the rapid proliferation of tumor cells. The PI3K-Akt-mTOR axis is one of the most frequently modified signaling pat...

journal_title：Frontiers of medicine

authors： Zhang J,Yin Y,Wang J,Zhang J,Liu H,Feng W,Yang W,Zetter B,Xu Y

更新日期：2020-12-01 00:00:00

abstract：:The rationale for the antibiotic treatment of viral community-acquired pneumonia (CAP) in adults was analyzed to develop a clinical reference standard for this condition. Clinical data from 166 patients diagnosed with viral pneumonia across 14 hospitals in Beijing from November 2010 to December 2017 were collected. Th...

journal_title：Frontiers of medicine

authors： Jiang R,Han B,Dou C,Zhou F,Cao B,Li X

更新日期：2020-06-13 00:00:00

abstract：:A phase II study (A2202) was performed to evaluate the efficacy and safety of JAK inhibitor ruxolitinib in 63 Chinese MF patients. Ruxolitinib was given twice a day (bid) at a starting dose of 15 mg (n = 25) or 20 mg (n = 38) based on a baseline platelet count. About 94.7% of the patients achieved a reduction in splee...

journal_title：Frontiers of medicine

authors： Du X,Zhou D

更新日期：2016-12-01 00:00:00

abstract：:Swallowing multiple magnets is not uncommon worldwide and it frequently leads to serious consequences. However, most patients fail to receive timely and correct diagnosis and treatment. A literature search was performed to establish an algorithm for these accidents by the authors to identify relevant articles publishe...

journal_title：Frontiers of medicine

authors： Liu S,Li J,Lv Y

更新日期：2012-09-01 00:00:00

abstract：:As a promising method in artificial intelligence, deep learning has been proven successful in several domains ranging from acoustics and images to natural language processing. With medical imaging becoming an important part of disease screening and diagnosis, deep learning-based approaches have emerged as powerful tec...

journal_title：Frontiers of medicine

authors： Ma J,Song Y,Tian X,Hua Y,Zhang R,Wu J

更新日期：2020-08-01 00:00:00

abstract：:Alternative splicing plays a fundamental role in the development and physiological function of the inner ear. Inner-ear-specific gene splicing is necessary to establish the identity and maintain the function of the inner ear. For example, exon 68 of Cadherin 23 (Cdh23) gene is subject to inner-ear-specific alternative...

journal_title：Frontiers of medicine

authors： Wang Y,Liu Y,Nie H,Ma X,Xu Z

更新日期：2016-09-01 00:00:00

abstract：:The COVID-19 caused by a novel strain of coronavirus has been spreading rapidly since its occurrence in December 2019. It is highly communicable through human-to-human transmission. China has been making unprecedented efforts in treating the confirmed cases, identifying and isolating their close contacts and suspected...

journal_title：Frontiers of medicine

authors： Gong F,Xiong Y,Xiao J,Lin L,Liu X,Wang D,Li X

更新日期：2020-04-01 00:00:00

abstract：:Infection with Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 as an important respiratory disease with high fatality rates of 40%-60%. Despite the increased number of cases over subsequent years, the number of pediatric cases remained low. A review of studies conducted from June 2012 to April ...

journal_title：Frontiers of medicine

authors： Alfaraj SH,Al-Tawfiq JA,Altuwaijri TA,Memish ZA

更新日期：2019-02-01 00:00:00

abstract：:Growing evidence suggests that somatic hypermutational status and programmed cell death-1 overexpression are potential predictive biomarkers indicating treatment benefits from immunotherapy using immune checkpoint inhibitors. However, biomarker-matched trials are still limited, and many of the genomic alterations rema...

journal_title：Frontiers of medicine

authors： Chen A,Zhang S,Li J,Ji C,Chen J,Li C

更新日期：2020-02-01 00:00:00

abstract：:At the very time of global paying the highest attention to the worst insults of smoking as well as haze on the airway, everybody knows both are exogenous and noticeable. However, people mostly, including many medical personnel, do not know how badly the gastroesophageal reflux (GER) insults on our own airway. Symptoms...

journal_title：Frontiers of medicine

authors： Wang Z,Hu Z,Wu J,Ji F,Wang H,Lai Y,Gao X,Ning Y,Zhang C,Li Z,Liang W,Liu J

更新日期：2015-03-01 00:00:00

abstract：:Perioperative parecoxib administration reduces postoperative pain, opioid consumption, and adverse events in adult patients. However, the efficacy and safety of parecoxib in children remain unclear. This metaanalysis included related published studies to address this concern. Eight databases in the literature until Fe...

journal_title：Frontiers of medicine

authors： Bu X,Yang L,Zuo Y

更新日期：2015-12-01 00:00:00

abstract：:At present, clinical pathway has become one of the most important health care reform measures in many countries. In this study, the authors introduced basic concepts and explored the application of the clinical pathway of evidence-based Chinese medicine incorporated with the methodology from the concepts of management...

journal_title：Frontiers of medicine

authors： Wang S,Yu H,Liu J,Liu B

更新日期：2011-06-01 00:00:00

abstract：:Laparoscopic liver surgery has been increasingly used for the treatment of pediatric liver diseases over the past decade due to the development of special laparoscopic instruments and improvements in the technique. A number of factors are considered when electing to undergo the surgical process, including age, type of...

journal_title：Frontiers of medicine

authors： Wei J,Feng J

更新日期：2011-12-01 00:00:00

abstract：:Chromosomal aberrations have been associated with cancer development since their discovery more than a hundred years ago. Chromosomal translocations, a type of particular structural changes involving heterologous chromosomes, have made a critical impact on diagnosis, prognosis and treatment of cancers. For example, th...

journal_title：Frontiers of medicine

authors： Wang JH

更新日期：2012-09-01 00:00:00

abstract：:Although many drugs and therapeutic strategies have been developed for rheumatoid arthritis (RA) treatment, numerous patients with RA fail to respond to currently available agents. In this review, we provide an overview of the complexity of this autoimmune disease by showing the rapidly increasing number of genes asso...

journal_title：Frontiers of medicine

authors： Wu X,Sheng X,Sheng R,Lu H,Xu H

更新日期：2019-08-01 00:00:00

abstract：:Electroacupuncture (EA) at Zhongliao (BL33) can improve the symptoms of overactive bladder (OAB), such as urinary frequency, urgency, and incontinence. However, its performance compared with other acupoints remains unclear. This study investigated the effects of EA at BL33 with deep needling on rats with OAB by detect...

journal_title：Frontiers of medicine

authors： Yang L,Wang Y,Mo Q,Liu Z

更新日期：2017-03-01 00:00:00

abstract：:Childhood obesity and obesity-related metabolic complications are induced by a high-fat postnatal diet. The lack of a suitable animal model, however, remains a considerable challenge in obesity studies. In the current study, we provided high-fat diet (HFD) to dams during lactation and to pups after weaning. We also de...

journal_title：Frontiers of medicine

authors： Ullah R,Su Y,Shen Y,Li C,Xu X,Zhang J,Huang K,Rauf N,He Y,Cheng J,Qin H,Zhou YD,Fu J

更新日期：2017-06-01 00:00:00

abstract：:Orbital venous malformation (OVM) is a congenital vascular disease. As a common type of vascular malformation in the orbit, OVM may result in vision deterioration and cosmetic defect. Classification of orbital vascular malformations, especially OVMs, is carried out on the basis of different categories, such as angioge...

journal_title：Frontiers of medicine

authors： Li T,Jia R,Fan X

更新日期：2019-10-01 00:00:00

abstract：:This study aimed to explore the association of maternal depression with nutrient intake, growth, and development of preterm infants. A cohort study of 201 infants was conducted in Beijing. Based on the gestational age of an infant and status of the mother, the infants were divided into four groups: non-depression-full...

journal_title：Frontiers of medicine

authors： Wang H,Zhou H,Zhang Y,Wang Y,Sun J

更新日期：2018-10-01 00:00:00

abstract：:Congenital heart disease (CHD) is the most common birth defect worldwide. Long non-coding RNAs (lncRNAs) have been implicated in many diseases. However, their involvement in CHD is not well understood. This study aimed to investigate the role of dysregulated lncRNAs in CHD. We used Gene Expression Omnibus data mining,...

journal_title：Frontiers of medicine

authors： Ma J,Chen S,Hao L,Sheng W,Chen W,Ma X,Zhang B,Ma D,Huang G

更新日期：2020-08-19 00:00:00

abstract：:Ventricular hypertrophy is a powerful and independent predictor of cardiovascular morbid events. The vascular properties of low-dose acetyl salicylic acid (aspirin) provide cardiovascular benefits through the irreversible inhibition of platelet cyclooxygenase 1; however, the possible anti-hypertrophic properties and p...

journal_title：Frontiers of medicine

authors： Gitau SC,Li X,Zhao D,Guo Z,Liang H,Qian M,Lv L,Li T,Xu B,Wang Z,Zhang Y,Xu C,Lu Y,Du Z,Shan H,Yang B

更新日期：2015-12-01 00:00:00