Abstract:
:A phase II study (A2202) was performed to evaluate the efficacy and safety of JAK inhibitor ruxolitinib in 63 Chinese MF patients. Ruxolitinib was given twice a day (bid) at a starting dose of 15 mg (n = 25) or 20 mg (n = 38) based on a baseline platelet count. About 94.7% of the patients achieved a reduction in spleen size, 27.0% of which exhibited significant reduction (≥ 35%) at week 24. Significant improvement in debilitating constitutional symptoms, as assessed by MFSAF v2.0, was observed in patients treated with ruxolitinib. Ruxolitinib treatment was generally well tolerated by Chinese patients. Although the treatment was associated with an increase in certain adverse events (AEs) that were established as identified risks (anemia and thrombocytopenia), these AEs were considered manageable in this clinical setting. Ruxolitinib provided substantial reductions in splenomegaly and improvements in symptoms, and was well-tolerated by Chinese patients with MF.
journal_name
Front Medjournal_title
Frontiers of medicineauthors
Du X,Zhou Ddoi
10.1007/s11684-016-0472-9subject
Has Abstractpub_date
2016-12-01 00:00:00pages
437-443issue
4eissn
2095-0217issn
2095-0225pii
10.1007/s11684-016-0472-9journal_volume
10pub_type
杂志文章,多中心研究abstract::The inhibitory environment that surrounds the lesion site and the lack of intrinsic regenerative capacity of the adult mammalian central nervous system (CNS) impede the regrowth of injured axons and thereby the reestablishment of neural circuits required for functional recovery after spinal cord injuries (SCI). To cir...
journal_title:Frontiers of medicine
pub_type: 杂志文章,评审
doi:10.1007/s11684-018-0642-z
更新日期:2019-04-01 00:00:00
abstract::The prevalence of the risk factors and the risk of cardiac failure are both increasing in China. This might be the consequence of the changes of the life conditions (emigration to the urban areas, changes in the diet and life style, lack of physical exercise, etc.). The wide range of clinical presentations of cardiac ...
journal_title:Frontiers of medicine
pub_type: 杂志文章,评审
doi:10.1007/s11684-011-0106-1
更新日期:2011-03-01 00:00:00
abstract::Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer (NSCLC) risk, biological mechanisms of these variants remain largely unknown. By integrating a large-scale genotype data of 15 581 lung adenocarcinoma (AD) cases, 8350 squamous cell car...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-020-0779-4
更新日期:2020-09-05 00:00:00
abstract::Persistent vegetative state (PVS) is a clinical condition wherein the cerebral cortex loses its function although brain stem function remains relatively intact. It has high mortality and disability rates. Although treatment for PVS is extensively studied in developed countries, little breakthrough has been made. In Ch...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-017-0539-2
更新日期:2018-06-01 00:00:00
abstract::Traditional Chinese medicine (TCM) investigates the clinical diagnosis and treatment regularities in a typical schema of personalized medicine, which means that individualized patients with same diseases would obtain distinct diagnosis and optimal treatment from different TCM physicians. This principle has been recogn...
journal_title:Frontiers of medicine
pub_type: 杂志文章,评审
doi:10.1007/s11684-014-0349-8
更新日期:2014-09-01 00:00:00
abstract::Orbital venous malformation (OVM) is a congenital vascular disease. As a common type of vascular malformation in the orbit, OVM may result in vision deterioration and cosmetic defect. Classification of orbital vascular malformations, especially OVMs, is carried out on the basis of different categories, such as angioge...
journal_title:Frontiers of medicine
pub_type: 杂志文章,评审
doi:10.1007/s11684-018-0623-2
更新日期:2019-10-01 00:00:00
abstract::MicroRNAs (miRNAs), an important class of small non-coding RNAs, regulate gene expression at the post-transcriptional level. miRNAs are involved in a wide range of biological processes and implicated in different diseases, including cancers. In this study, miRNA profiling and qRT-PCR validation revealed that miR-142-3...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-015-0409-8
更新日期:2015-09-01 00:00:00
abstract::The teeth are highly differentiated chewing organs formed by the development of tooth germ tissue located in the jaw and consist of the enamel, dentin, cementum, pulp, and periodontal tissue. Moreover, the teeth have a complicated regulatory mechanism, special histologic origin, diverse structure, and important functi...
journal_title:Frontiers of medicine
pub_type: 杂志文章,评审
doi:10.1007/s11684-018-0628-x
更新日期:2019-04-01 00:00:00
abstract::We observed the effect of Dianxianning, which was used as additive treatment to treat 206 epilepsy patients, on the epilepsy seizure rate. Based on a multicenter, prospective, randomized, and controlled clinical trial design, we used the seizure rate of epilepsy as the main index. For the treatment group comprising 13...
journal_title:Frontiers of medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s11684-011-0139-5
更新日期:2011-06-01 00:00:00
abstract::This study aims to investigate the effect of non-transecting anastomotic urethroplasty for treatment of posterior urethral stricture. A total of 23 patients with traumatic posterior urethral stricture were enrolled and then divided into two groups. In one group, 12 patients underwent non-transecting anastomotic urethr...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-017-0515-x
更新日期:2017-06-01 00:00:00
abstract::Ventricular hypertrophy is a powerful and independent predictor of cardiovascular morbid events. The vascular properties of low-dose acetyl salicylic acid (aspirin) provide cardiovascular benefits through the irreversible inhibition of platelet cyclooxygenase 1; however, the possible anti-hypertrophic properties and p...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-015-0421-z
更新日期:2015-12-01 00:00:00
abstract::This study aimed to define the most consistent white matter microarchitecture pattern in Parkinson's disease (PD) reflected by fractional anisotropy (FA), addressing clinical profiles and methodology-related heterogeneity. Web-based publication databases were searched to conduct a meta-analysis of whole-brain diffusio...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-019-0725-5
更新日期:2020-05-26 00:00:00
abstract::Childhood obesity and obesity-related metabolic complications are induced by a high-fat postnatal diet. The lack of a suitable animal model, however, remains a considerable challenge in obesity studies. In the current study, we provided high-fat diet (HFD) to dams during lactation and to pups after weaning. We also de...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-017-0530-y
更新日期:2017-06-01 00:00:00
abstract::Alternative splicing plays a fundamental role in the development and physiological function of the inner ear. Inner-ear-specific gene splicing is necessary to establish the identity and maintain the function of the inner ear. For example, exon 68 of Cadherin 23 (Cdh23) gene is subject to inner-ear-specific alternative...
journal_title:Frontiers of medicine
pub_type: 杂志文章,评审
doi:10.1007/s11684-016-0454-y
更新日期:2016-09-01 00:00:00
abstract::Identification of the driver mutations in cancer has resulted in the development of a new category of molecularly targeted anti-cancer drugs. However, as was the case with conventional chemotherapies, the effectiveness of these drugs is limited by the emergence of drug-resistant variants. While most cancer therapies a...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-018-0647-7
更新日期:2018-08-01 00:00:00
abstract::Zebrafish is an emerging animal model for studies on auditory system. This model presents high comparability with humans, good accessibility to the hearing organ, and high throughput capacity. To better utilize this animal model, methodologies need to be used to quantify the hearing function of the zebrafish. Zebrafis...
journal_title:Frontiers of medicine
pub_type: 杂志文章,评审
doi:10.1007/s11684-017-0507-x
更新日期:2017-06-01 00:00:00
abstract::Autoimmune diseases (ADs) increase the risk of non-Hodgkin's lymphoma and contribute to poor prognosis of patients. However, the association between immunologic markers and clinical outcome has rarely been investigated. This study aims to analyze the prognostic value of pretreatment immunologic markers in newly diagno...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-019-0680-1
更新日期:2019-02-01 00:00:00
abstract::Sickle cell disease (SCD) is an inherited disorder of hemoglobin in which the abnormal hemoglobin S polymerizes when deoxygenated. This polymerization of hemoglobin S not only results in hemolysis and vasoocclusion but also precipitates inflammation, oxidative stress and chronic organ dysfunction. Oxidative stress is ...
journal_title:Frontiers of medicine
pub_type: 杂志文章,评审
doi:10.1007/s11684-015-0375-1
更新日期:2015-03-01 00:00:00
abstract::It has been known that, the novel coronavirus, 2019-nCoV, which is considered similar to SARS-CoV, invades human cells via the receptor angiotensin converting enzyme II (ACE2). Moreover, lung cells that have ACE2 expression may be the main target cells during 2019-nCoV infection. However, some patients also exhibit no...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-020-0754-0
更新日期:2020-04-01 00:00:00
abstract::This study aimed to compare the antimicrobial activities of topical agents against Propionibacterium acnes isolated from patients admitted to a hospital in Shanghai, China. The minimal inhibitory concentrations of the cultured P. acnes were determined in accordance with the Clinical and Laboratory Standards Institute....
journal_title:Frontiers of medicine
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11684-016-0480-9
更新日期:2016-12-01 00:00:00
abstract::S100A9, a calcium-binding protein, participates in the inflammatory process and development of various tumors, thus attracting much attention in the field of cancer biology. This study aimed to investigate the regulatory mechanism of S100A9 and its function involvement in APL. We used real-time quantitative PCR to det...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-016-0469-4
更新日期:2017-03-01 00:00:00
abstract::Langerhans cell histiocytosis (LCH) is an idiopathic group of reactive proliferative diseases linked to aberrant immunity, pathologically characterized by clonal proliferation of Langerhans cells. LCH rarely involves the thymus. We report a case of thymic LCH with diabetes insipidus as the first presentation, without ...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-013-0238-6
更新日期:2013-03-01 00:00:00
abstract::A total of 251 patients with epithelial ovarian cancer (EOC) treated between 2002 and 2008 was retrospectively analyzed to investigate the long-term outcomes and prognostic factors of these patients, particularly those who underwent primary debulking surgery followed by platinum-based chemotherapy. Clinicopathological...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-014-0305-7
更新日期:2014-03-01 00:00:00
abstract::At the very time of global paying the highest attention to the worst insults of smoking as well as haze on the airway, everybody knows both are exogenous and noticeable. However, people mostly, including many medical personnel, do not know how badly the gastroesophageal reflux (GER) insults on our own airway. Symptoms...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-014-0343-1
更新日期:2015-03-01 00:00:00
abstract::Cleft lip and palate (CLP) is the most common craniofacial congenital deformity. The etiology of CLP is multifactorial and involves complex interactions between environmental and genetic factors. Millard's rotation advancement technique has long been considered as state-of-the-art for unilateral cleft lip repair. Howe...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-013-0299-6
更新日期:2013-12-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is currently the fifth most common malignancy and the third leading cause of cancer-related mortalities worldwide. In the last few years, treatments for HCC have significantly improved from a mere surgical resection to a series of minimally invasive therapies and targeted drugs. However,...
journal_title:Frontiers of medicine
pub_type: 杂志文章,评审
doi:10.1007/s11684-017-0546-3
更新日期:2017-12-01 00:00:00
abstract::Grading of Recommendations Assessment, Development, and Evaluation (GRADE) offers a worldwide approach to guideline development for clinical practice. For the clinical practice of acupuncture therapy, 18 evidence-based guidelines have been developed in China using GRADE. In this study, we review the advantages and lim...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-017-0537-4
更新日期:2017-12-01 00:00:00
abstract::Netrin-1 (NT-1) is one of the axon-guiding molecules that are critical for neuronal development. Because of its structural homology to the endothelial mitogens, NT-1 may have similar effects on vascular network formation. NT-1 was shown to be able to stimulate the proliferation and migration of human cerebral endothel...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-011-0118-x
更新日期:2011-03-01 00:00:00
abstract::Disorders of sex development (DSD) are a group of rare complex clinical syndromes with multiple etiologies. Distinguishing the various causes of DSD is quite difficult in clinical practice, even for senior general physicians because of the similar and atypical clinical manifestations of these conditions. In addition, ...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-020-0791-8
更新日期:2020-08-01 00:00:00
abstract::Inappropriate cell proliferation during oncogenesis is often accompanied by inactivation of components involved in the cell cycle machinery. Here, we report that cyclin-dependent kinase inhibitor 2C (CDKN2C) as a member of the cyclin-dependent kinase inhibitors is a target of the PML/RARα oncofusion protein in leukemo...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-016-0478-3
更新日期:2016-12-01 00:00:00