Abstract：
:A total of 251 patients with epithelial ovarian cancer (EOC) treated between 2002 and 2008 was retrospectively analyzed to investigate the long-term outcomes and prognostic factors of these patients, particularly those who underwent primary debulking surgery followed by platinum-based chemotherapy. Clinicopathological parameters, including progression-free survival (PFS) and overall survival (OS), were also analyzed. The median follow-up period from the end of initial treatment to June 2010 was 58 months. The three-year PFS rate was 61.7% for International Federation of Gynecology and Obstetrics (FIGO) I-II, 19.9% for FIGO III-IV, and 33.9% for all stages. By comparison, the five-year PFS rate was 44.6% for FIGO I-II, 17.7% for FIGO III-IV, and 28.3% for all stages. The three-year OS rate was 67.9% for FIGO I-II, 41.7% for FIGO III-IV, and 50.2% for all stages. The five-year OS rate was 52.7% for FIGO I-II, 30.8% for FIGO III-IV, and 39.2% for all stages. Univariate analysis revealed that advanced FIGO stage, serum CA125, and suboptimal debulking were significant factors affecting PFS and OS. In multivariate analysis, PFS was significantly influenced by FIGO stage and suboptimal debulking. However, OS was significantly influenced by advanced FIGO stage only. Our study confirms the efficacy of surgery followed by platinum-based chemotherapy for EOC. FIGO stage is considered as one of the most reliable predictors of the prognosis of patients with EOC.
journal_name
Front Medjournal_title
Frontiers of medicineauthors
Fu Y,Wang X,Pan Z,Xie Xdoi
10.1007/s11684-014-0305-7subject
Has Abstractpub_date
2014-03-01 00:00:00pages
91-5issue
1eissn
2095-0217issn
2095-0225journal_volume
8pub_type
杂志文章abstract：:Electroacupuncture (EA) at Zhongliao (BL33) can improve the symptoms of overactive bladder (OAB), such as urinary frequency, urgency, and incontinence. However, its performance compared with other acupoints remains unclear. This study investigated the effects of EA at BL33 with deep needling on rats with OAB by detect...
journal_title：Frontiers of medicine
pub_type： 杂志文章
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abstract：:Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor-mediated coagulation. TFPI is expressed by endothelial and smooth muscle cells in the vasculature. Endothelium-derived TFPI has been reported to play a regulatory role in arterial thrombosis. However, the role of endogenous TFPI in vascular ...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-017-0522-y
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abstract：:A phase II study (A2202) was performed to evaluate the efficacy and safety of JAK inhibitor ruxolitinib in 63 Chinese MF patients. Ruxolitinib was given twice a day (bid) at a starting dose of 15 mg (n = 25) or 20 mg (n = 38) based on a baseline platelet count. About 94.7% of the patients achieved a reduction in splee...
journal_title：Frontiers of medicine
pub_type： 杂志文章,多中心研究
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abstract：:Traditional Chinese medicine (TCM) investigates the clinical diagnosis and treatment regularities in a typical schema of personalized medicine, which means that individualized patients with same diseases would obtain distinct diagnosis and optimal treatment from different TCM physicians. This principle has been recogn...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
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journal_title：Frontiers of medicine
pub_type： 杂志文章
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abstract：:Zebrafish is an emerging animal model for studies on auditory system. This model presents high comparability with humans, good accessibility to the hearing organ, and high throughput capacity. To better utilize this animal model, methodologies need to be used to quantify the hearing function of the zebrafish. Zebrafis...
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pub_type： 杂志文章,评审
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journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-014-0343-1
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pub_type： 杂志文章
doi：10.1007/s11684-017-0539-2
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journal_title：Frontiers of medicine
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doi：10.1007/s11684-020-0778-5
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journal_title：Frontiers of medicine
pub_type： 杂志文章
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journal_title：Frontiers of medicine
pub_type： 杂志文章
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更新日期：2015-12-01 00:00:00
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-012-0207-5
更新日期：2012-09-01 00:00:00
abstract：:This study aims to investigate the effect of non-transecting anastomotic urethroplasty for treatment of posterior urethral stricture. A total of 23 patients with traumatic posterior urethral stricture were enrolled and then divided into two groups. In one group, 12 patients underwent non-transecting anastomotic urethr...
journal_title：Frontiers of medicine
pub_type： 杂志文章
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journal_title：Frontiers of medicine
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doi：10.1007/s11684-020-0772-y
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
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journal_title：Frontiers of medicine
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
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journal_title：Frontiers of medicine
pub_type： 杂志文章
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journal_title：Frontiers of medicine
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
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journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-019-0714-8
更新日期：2019-10-01 00:00:00
