Mechanisms and impacts of chromosomal translocations in cancers.

abstract：:S100A9, a calcium-binding protein, participates in the inflammatory process and development of various tumors, thus attracting much attention in the field of cancer biology. This study aimed to investigate the regulatory mechanism of S100A9 and its function involvement in APL. We used real-time quantitative PCR to det...

journal_title：Frontiers of medicine

authors： Zhu Y,Zhang F,Zhang S,Deng W,Fan H,Wang H,Zhang J

更新日期：2017-03-01 00:00:00

abstract：:The N-end rule pathway is a unique branch of the ubiquitin-proteasome system in which the determination of a protein's half-life is dependent on its N-terminal residue. The N-terminal residue serves as the degradation signal of a protein and thus called N-degron. N-degron can be recognized and modifed by several steps...

journal_title：Frontiers of medicine

authors： Liu Y,Liu C,Dong W,Li W

更新日期：2016-09-01 00:00:00

abstract：:Orbital venous malformation (OVM) is a congenital vascular disease. As a common type of vascular malformation in the orbit, OVM may result in vision deterioration and cosmetic defect. Classification of orbital vascular malformations, especially OVMs, is carried out on the basis of different categories, such as angioge...

journal_title：Frontiers of medicine

authors： Li T,Jia R,Fan X

更新日期：2019-10-01 00:00:00

abstract：:Hearing impairment is considered as the most prevalent impairment worldwide. Almost 600 million people in the world suffer from mild or moderate hearing impairment, an estimated 10% of the human population. Genetic factors play an important role in the pathogenesis of this disorder. Hereditary hearing loss is divided ...

journal_title：Frontiers of medicine

authors： Xia W,Liu F,Ma D

更新日期：2016-06-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a highly complex disease that is generally resistant to commonly used chemotherapy and radiotherapy. Consequently, there is an urgent need for the development of new treatment strategies for this devastating disease. In the past decade, tremendous progress has been achieved in the mol...

journal_title：Frontiers of medicine

authors： Gao Q,Shi Y,Wang X,Zhou J,Qiu S,Fan J

更新日期：2012-06-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is currently the fifth most common malignancy and the third leading cause of cancer-related mortalities worldwide. In the last few years, treatments for HCC have significantly improved from a mere surgical resection to a series of minimally invasive therapies and targeted drugs. However,...

journal_title：Frontiers of medicine

authors： Yu M,Li Z

更新日期：2017-12-01 00:00:00

abstract：:Real world study (RWS) has become a hotspot for clinical research. Data quality plays a vital role in research achievement and other clinical research fields. In this paper, the common quality problems in the RWS of traditional Chinese medicine are discussed, and a countermeasure is proposed. ...

journal_title：Frontiers of medicine

authors： Zhang R,Wang Y,Liu B,Song G,Zhou X,Fan S,Pan X

更新日期：2014-09-01 00:00:00

abstract：:MicroRNAs (miRNAs), an important class of small non-coding RNAs, regulate gene expression at the post-transcriptional level. miRNAs are involved in a wide range of biological processes and implicated in different diseases, including cancers. In this study, miRNA profiling and qRT-PCR validation revealed that miR-142-3...

journal_title：Frontiers of medicine

authors： Tsang FH,Au SL,Wei L,Fan DN,Lee JM,Wong CC,Ng IO,Wong CM

更新日期：2015-09-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is an idiopathic group of reactive proliferative diseases linked to aberrant immunity, pathologically characterized by clonal proliferation of Langerhans cells. LCH rarely involves the thymus. We report a case of thymic LCH with diabetes insipidus as the first presentation, without ...

journal_title：Frontiers of medicine

authors： Chen X,Huang X,Qiu Y,Chen H,Fu Y,Li X

更新日期：2013-03-01 00:00:00

abstract：:Ventricular hypertrophy is a powerful and independent predictor of cardiovascular morbid events. The vascular properties of low-dose acetyl salicylic acid (aspirin) provide cardiovascular benefits through the irreversible inhibition of platelet cyclooxygenase 1; however, the possible anti-hypertrophic properties and p...

journal_title：Frontiers of medicine

authors： Gitau SC,Li X,Zhao D,Guo Z,Liang H,Qian M,Lv L,Li T,Xu B,Wang Z,Zhang Y,Xu C,Lu Y,Du Z,Shan H,Yang B

更新日期：2015-12-01 00:00:00

abstract：:Swallowing multiple magnets is not uncommon worldwide and it frequently leads to serious consequences. However, most patients fail to receive timely and correct diagnosis and treatment. A literature search was performed to establish an algorithm for these accidents by the authors to identify relevant articles publishe...

journal_title：Frontiers of medicine

authors： Liu S,Li J,Lv Y

更新日期：2012-09-01 00:00:00

abstract：:As a promising method in artificial intelligence, deep learning has been proven successful in several domains ranging from acoustics and images to natural language processing. With medical imaging becoming an important part of disease screening and diagnosis, deep learning-based approaches have emerged as powerful tec...

journal_title：Frontiers of medicine

authors： Ma J,Song Y,Tian X,Hua Y,Zhang R,Wu J

更新日期：2020-08-01 00:00:00

abstract：:Grading of Recommendations Assessment, Development, and Evaluation (GRADE) offers a worldwide approach to guideline development for clinical practice. For the clinical practice of acupuncture therapy, 18 evidence-based guidelines have been developed in China using GRADE. In this study, we review the advantages and lim...

journal_title：Frontiers of medicine

authors： Zhao H,Liang F,Fang Y,Liu B

更新日期：2017-12-01 00:00:00

abstract：:Cleft lip and palate (CLP) is the most common craniofacial congenital deformity. The etiology of CLP is multifactorial and involves complex interactions between environmental and genetic factors. Millard's rotation advancement technique has long been considered as state-of-the-art for unilateral cleft lip repair. Howe...

journal_title：Frontiers of medicine

authors： Xu Y,Li J,Shi B

更新日期：2013-12-01 00:00:00

abstract：:Although many drugs and therapeutic strategies have been developed for rheumatoid arthritis (RA) treatment, numerous patients with RA fail to respond to currently available agents. In this review, we provide an overview of the complexity of this autoimmune disease by showing the rapidly increasing number of genes asso...

journal_title：Frontiers of medicine

authors： Wu X,Sheng X,Sheng R,Lu H,Xu H

更新日期：2019-08-01 00:00:00

abstract：:Sepsis is a common cause of death in hospitalized patients worldwide. The early detection of sepsis remains a great challenge for clinicians, and delayed diagnosis frequently undermines treatment efforts, thereby contributing to high mortality. Omics technologies allow high-throughput screening of sepsis biomarkers. T...

journal_title：Frontiers of medicine

authors： Liu X,Ren H,Peng D

更新日期：2014-03-01 00:00:00

abstract：:Infection with Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 as an important respiratory disease with high fatality rates of 40%-60%. Despite the increased number of cases over subsequent years, the number of pediatric cases remained low. A review of studies conducted from June 2012 to April ...

journal_title：Frontiers of medicine

authors： Alfaraj SH,Al-Tawfiq JA,Altuwaijri TA,Memish ZA

更新日期：2019-02-01 00:00:00

abstract：:This study aimed to evaluate the efficacy of Chinese herbal medicine (CHM) in patients with severe/critical coronavirus disease 2019 (COVID-19). In this retrospective study, data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVI...

journal_title：Frontiers of medicine

authors： Chen G,Su W,Yang J,Luo D,Xia P,Jia W,Li X,Wang C,Lang S,Meng Q,Zhang Y,Ke Y,Fan A,Yang S,Zheng Y,Fan X,Qiao J,Lian F,Wei L,Tong X

更新日期：2020-12-01 00:00:00

abstract：:It has been known that, the novel coronavirus, 2019-nCoV, which is considered similar to SARS-CoV, invades human cells via the receptor angiotensin converting enzyme II (ACE2). Moreover, lung cells that have ACE2 expression may be the main target cells during 2019-nCoV infection. However, some patients also exhibit no...

journal_title：Frontiers of medicine

authors： Zou X,Chen K,Zou J,Han P,Hao J,Han Z

更新日期：2020-04-01 00:00:00

abstract：:We observed the effect of Dianxianning, which was used as additive treatment to treat 206 epilepsy patients, on the epilepsy seizure rate. Based on a multicenter, prospective, randomized, and controlled clinical trial design, we used the seizure rate of epilepsy as the main index. For the treatment group comprising 13...

journal_title：Frontiers of medicine

authors： He L,Wen T,Yan S,Li R,Liu Z,Ren H,Liu J,Zhang F,Wu J,Liu J

更新日期：2011-06-01 00:00:00

abstract：:This study aimed to evaluate the efficacy of comprehensive therapy based on traditional Chinese medicine (TCM) patterns on older patients with chronic obstructive pulmonary disease (COPD) through a fourcenter, open-label, randomized controlled trial. Patients were divided into the trial group treated using conventiona...

journal_title：Frontiers of medicine

authors： Wang M,Li J,Li S,Xie Y

更新日期：2014-09-01 00:00:00

abstract：:The mammalian MOF (male absent on the first), a member of the MYST (MOZ, YBF2, SAS2, and Tip60) family of histone acetyltransferases (HATs), is the major enzyme that catalyzes the acetylation of histone H4 on lysine 16. Acetylation of K16 is a prevalent mark associated with chromatin decondensation. MOF has recently b...

journal_title：Frontiers of medicine

authors： Yang Y,Han X,Guan J,Li X

更新日期：2014-03-01 00:00:00

abstract：:This study aimed to evaluate the therapeutic effect of traditional Chinese medicine (TCM) by observing the changes in CD4 T-lymphocyte cell count of 110 cases with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) treated continuously with TCM for 84 months. Information of 110 HIV/AIDS patie...

journal_title：Frontiers of medicine

authors： Wang J,Liang B,Zhang X,Xu L,Deng X,Li X,Fang L,Tan X,Mao Y,Zhang G,Wang Y

更新日期：2014-09-01 00:00:00

abstract：:γδ T cells display unique developmental, distributional, and functional patterns and can rapidly respond to various insults and contribute to diverse diseases. Different subtypes of γδ T cells are produced in the thymus prior to their migration to peripheral tissues. γδ T cells are enriched in the liver and exhibit li...

journal_title：Frontiers of medicine

authors： Wang X,Tian Z

更新日期：2018-06-01 00:00:00

abstract：:Bronchiolitis obliterans syndrome (BOS) after hematopoietic stem cell transplantation (HSCT) is a major cause of morbidity and mortality with limited treatment options. Lung transplantation (LTX) has been rarely reported as a treatment option for selected HSCT recipients with this problem. In the present study, we rep...

journal_title：Frontiers of medicine

authors： Gao F,Chen J,Wei D,Wu B,Zhou M

更新日期：2018-04-01 00:00:00

abstract：:It is well documented that patients can show significant heterogeneous responses to treatments so the best treatment strategies may require adaptation over individuals and time. Recently, a number of new statistical methods have been developed to tackle the important problem of estimating personalized treatment rules ...

journal_title：Frontiers of medicine

authors： Zhao Y,Zeng D

更新日期：2013-03-01 00:00:00

abstract：:A total of 251 patients with epithelial ovarian cancer (EOC) treated between 2002 and 2008 was retrospectively analyzed to investigate the long-term outcomes and prognostic factors of these patients, particularly those who underwent primary debulking surgery followed by platinum-based chemotherapy. Clinicopathological...

journal_title：Frontiers of medicine

authors： Fu Y,Wang X,Pan Z,Xie X

更新日期：2014-03-01 00:00:00

abstract：:Identification of the driver mutations in cancer has resulted in the development of a new category of molecularly targeted anti-cancer drugs. However, as was the case with conventional chemotherapies, the effectiveness of these drugs is limited by the emergence of drug-resistant variants. While most cancer therapies a...

journal_title：Frontiers of medicine

authors： Wang L,Bernards R

更新日期：2018-08-01 00:00:00

abstract：:The teeth are highly differentiated chewing organs formed by the development of tooth germ tissue located in the jaw and consist of the enamel, dentin, cementum, pulp, and periodontal tissue. Moreover, the teeth have a complicated regulatory mechanism, special histologic origin, diverse structure, and important functi...

journal_title：Frontiers of medicine

authors： Zhai Q,Dong Z,Wang W,Li B,Jin Y

更新日期：2019-04-01 00:00:00

abstract：:This study aims to investigate the effect of non-transecting anastomotic urethroplasty for treatment of posterior urethral stricture. A total of 23 patients with traumatic posterior urethral stricture were enrolled and then divided into two groups. In one group, 12 patients underwent non-transecting anastomotic urethr...

journal_title：Frontiers of medicine

authors： Le W,Li C,Zhang J,Wu D,Liu B

更新日期：2017-06-01 00:00:00