Genetic and clinical markers for predicting treatment responsiveness in rheumatoid arthritis.

abstract：:Swallowing multiple magnets is not uncommon worldwide and it frequently leads to serious consequences. However, most patients fail to receive timely and correct diagnosis and treatment. A literature search was performed to establish an algorithm for these accidents by the authors to identify relevant articles publishe...

journal_title：Frontiers of medicine

authors： Liu S,Li J,Lv Y

更新日期：2012-09-01 00:00:00

abstract：:Single incision laparoscopic surgery (SILS) is a novel minimally invasive surgical technique that is gaining popularity around the world. One of the most commonly performed procedures is single incision laparoscopic cholecystectomy (SILC). Most reported techniques utilize special purpose-made access port and articulat...

journal_title：Frontiers of medicine

authors： Cui H

更新日期：2011-09-01 00:00:00

abstract：:Traditional Chinese medicine (TCM) investigates the clinical diagnosis and treatment regularities in a typical schema of personalized medicine, which means that individualized patients with same diseases would obtain distinct diagnosis and optimal treatment from different TCM physicians. This principle has been recogn...

journal_title：Frontiers of medicine

authors： Zhou X,Li Y,Peng Y,Hu J,Zhang R,He L,Wang Y,Jiang L,Yan S,Li P,Xie Q,Liu B

更新日期：2014-09-01 00:00:00

abstract：:Chromosomal aberrations have been associated with cancer development since their discovery more than a hundred years ago. Chromosomal translocations, a type of particular structural changes involving heterologous chromosomes, have made a critical impact on diagnosis, prognosis and treatment of cancers. For example, th...

journal_title：Frontiers of medicine

authors： Wang JH

更新日期：2012-09-01 00:00:00

abstract：:This study evaluated the immunogenicity and protective immunity of a Hemophilus influenzae b (Hib) polysaccharide conjugate vaccine with the pneumococcal surface adhesin A (PsaA) protein carrier in young mice. The Hib polysaccharide was conjugated with the rPsaA protein carrier, which was produced using recombinant DN...

journal_title：Frontiers of medicine

authors： Chen Z,Guo R,Xu J,Qiu C

更新日期：2016-12-01 00:00:00

abstract：:NUP98 fuses with approximately 34 different partner genes via translocation in hematological malignancies. Transgenic or retrovirus-mediated bone marrow transplanted mouse models reveal the leukemogenesis of some NUP98-related fusion genes. We previously reported the fusion protein NUP98-IQ motif containing G (IQCG) i...

journal_title：Frontiers of medicine

authors： Pan M,Zhang Q,Liu P,Huang J,Wang Y,Chen S

更新日期：2016-12-01 00:00:00

abstract：:An effective eradication therapy of Helicobacter pylori (H. pylori) should be used for the first time. In this study, we assessed whether tailored therapy based on antibiotic susceptibility testing is more effective than traditional therapy. We also evaluated the factors that cause treatment failure in high-resistance...

journal_title：Frontiers of medicine

authors： Pan J,Shi Z,Lin D,Yang N,Meng F,Lin L,Jin Z,Zhou Q,Wu J,Zhang J,Li Y

更新日期：2020-02-01 00:00:00

abstract：:Growing evidence suggests that somatic hypermutational status and programmed cell death-1 overexpression are potential predictive biomarkers indicating treatment benefits from immunotherapy using immune checkpoint inhibitors. However, biomarker-matched trials are still limited, and many of the genomic alterations rema...

journal_title：Frontiers of medicine

authors： Chen A,Zhang S,Li J,Ji C,Chen J,Li C

更新日期：2020-02-01 00:00:00

abstract：:A total of 251 patients with epithelial ovarian cancer (EOC) treated between 2002 and 2008 was retrospectively analyzed to investigate the long-term outcomes and prognostic factors of these patients, particularly those who underwent primary debulking surgery followed by platinum-based chemotherapy. Clinicopathological...

journal_title：Frontiers of medicine

authors： Fu Y,Wang X,Pan Z,Xie X

更新日期：2014-03-01 00:00:00

abstract：:Childhood obesity and obesity-related metabolic complications are induced by a high-fat postnatal diet. The lack of a suitable animal model, however, remains a considerable challenge in obesity studies. In the current study, we provided high-fat diet (HFD) to dams during lactation and to pups after weaning. We also de...

journal_title：Frontiers of medicine

authors： Ullah R,Su Y,Shen Y,Li C,Xu X,Zhang J,Huang K,Rauf N,He Y,Cheng J,Qin H,Zhou YD,Fu J

更新日期：2017-06-01 00:00:00

abstract：:Gliomas are the most common primary intracranial tumors in adults. Anaplastic gliomas (WHO grade III) and glioblastomas (WHO grade IV) represent the major groups of malignant gliomas in the brain. Several diagnostic, predictive, and prognostic biomarkers for malignant gliomas have been reported over the last few decad...

journal_title：Frontiers of medicine

authors： Zhang C,Bao Z,Zhang W,Jiang T

更新日期：2013-06-01 00:00:00

abstract：:Persistent vegetative state (PVS) is a clinical condition wherein the cerebral cortex loses its function although brain stem function remains relatively intact. It has high mortality and disability rates. Although treatment for PVS is extensively studied in developed countries, little breakthrough has been made. In Ch...

journal_title：Frontiers of medicine

authors： Song H,Chen X,Yu Y,Zhang L

更新日期：2018-06-01 00:00:00

abstract：:Identification of the driver mutations in cancer has resulted in the development of a new category of molecularly targeted anti-cancer drugs. However, as was the case with conventional chemotherapies, the effectiveness of these drugs is limited by the emergence of drug-resistant variants. While most cancer therapies a...

journal_title：Frontiers of medicine

authors： Wang L,Bernards R

更新日期：2018-08-01 00:00:00

abstract：:Bronchiolitis obliterans syndrome (BOS) after hematopoietic stem cell transplantation (HSCT) is a major cause of morbidity and mortality with limited treatment options. Lung transplantation (LTX) has been rarely reported as a treatment option for selected HSCT recipients with this problem. In the present study, we rep...

journal_title：Frontiers of medicine

authors： Gao F,Chen J,Wei D,Wu B,Zhou M

更新日期：2018-04-01 00:00:00

abstract：:At the very time of global paying the highest attention to the worst insults of smoking as well as haze on the airway, everybody knows both are exogenous and noticeable. However, people mostly, including many medical personnel, do not know how badly the gastroesophageal reflux (GER) insults on our own airway. Symptoms...

journal_title：Frontiers of medicine

authors： Wang Z,Hu Z,Wu J,Ji F,Wang H,Lai Y,Gao X,Ning Y,Zhang C,Li Z,Liang W,Liu J

更新日期：2015-03-01 00:00:00

abstract：:Ventricular hypertrophy is a powerful and independent predictor of cardiovascular morbid events. The vascular properties of low-dose acetyl salicylic acid (aspirin) provide cardiovascular benefits through the irreversible inhibition of platelet cyclooxygenase 1; however, the possible anti-hypertrophic properties and p...

journal_title：Frontiers of medicine

authors： Gitau SC,Li X,Zhao D,Guo Z,Liang H,Qian M,Lv L,Li T,Xu B,Wang Z,Zhang Y,Xu C,Lu Y,Du Z,Shan H,Yang B

更新日期：2015-12-01 00:00:00

abstract：:Recent evidences suggested that cyclic guanosine monophosphate-specific phosphodiesterase 5 (PDE5) inhibitor represents an important therapeutic target for cardiovascular diseases. Whether and how it ameliorates cardiac fibrosis, a major cause of diastolic dysfunction and heart failure, is unknown. The purpose of this...

journal_title：Frontiers of medicine

authors： Gong W,Yan M,Chen J,Chaugai S,Chen C,Wang D

更新日期：2014-12-01 00:00:00

abstract：:Cleft lip and palate (CLP) is the most common craniofacial congenital deformity. The etiology of CLP is multifactorial and involves complex interactions between environmental and genetic factors. Millard's rotation advancement technique has long been considered as state-of-the-art for unilateral cleft lip repair. Howe...

journal_title：Frontiers of medicine

authors： Xu Y,Li J,Shi B

更新日期：2013-12-01 00:00:00

abstract：:The inhibitory environment that surrounds the lesion site and the lack of intrinsic regenerative capacity of the adult mammalian central nervous system (CNS) impede the regrowth of injured axons and thereby the reestablishment of neural circuits required for functional recovery after spinal cord injuries (SCI). To cir...

journal_title：Frontiers of medicine

authors： Yu B,Gu X

更新日期：2019-04-01 00:00:00

abstract：:China recently instituted a two-child policy in response to its aging population, declining workforce and demographic dividend, and the need to develop asocial economy. Additionally, women generally delay having a second child because of the overwhelming pressure in their lives. With the improvements in assisted ferti...

journal_title：Frontiers of medicine

authors： Li Q,Deng D

更新日期：2017-12-01 00:00:00

abstract：:Zinc (Zn) is an essential mineral that is required for various cellular functions. Zn dyshomeostasis always is related to certain disorders such as metabolic syndrome, diabetes and diabetic complications. The associations of Zn with metabolic syndrome, diabetes and diabetic complications, thus, stem from the multiple ...

journal_title：Frontiers of medicine

authors： Miao X,Sun W,Fu Y,Miao L,Cai L

更新日期：2013-03-01 00:00:00

abstract：:Although type 2 diabetes is a disease often associated with aging, the global prevalence of early-onset diabetes has been increasing due to man's sedentary lifestyle, low-physical activity, obesity, and some nonmodifiable risk factors. Many studies have found that individuals with early-onset type 2 diabetes were at h...

journal_title：Frontiers of medicine

authors： Pan J,Jia W

更新日期：2018-12-01 00:00:00

abstract：:S100A9, a calcium-binding protein, participates in the inflammatory process and development of various tumors, thus attracting much attention in the field of cancer biology. This study aimed to investigate the regulatory mechanism of S100A9 and its function involvement in APL. We used real-time quantitative PCR to det...

journal_title：Frontiers of medicine

authors： Zhu Y,Zhang F,Zhang S,Deng W,Fan H,Wang H,Zhang J

更新日期：2017-03-01 00:00:00

abstract：:Inappropriate cell proliferation during oncogenesis is often accompanied by inactivation of components involved in the cell cycle machinery. Here, we report that cyclin-dependent kinase inhibitor 2C (CDKN2C) as a member of the cyclin-dependent kinase inhibitors is a target of the PML/RARα oncofusion protein in leukemo...

journal_title：Frontiers of medicine

authors： Wang X,Tan Y,Li Y,Li J,Jin W,Wang K

更新日期：2016-12-01 00:00:00

abstract：:It is well documented that patients can show significant heterogeneous responses to treatments so the best treatment strategies may require adaptation over individuals and time. Recently, a number of new statistical methods have been developed to tackle the important problem of estimating personalized treatment rules ...

journal_title：Frontiers of medicine

authors： Zhao Y,Zeng D

更新日期：2013-03-01 00:00:00

abstract：:Foodborne disease is one of the most important public health issues worldwide. China faces various and unprecedented challenges in all aspects of the food chain. Data from laboratory-based foodborne disease surveillance systems from 2013 to 2016, as well as different regions and ages, can be found along with differenc...

journal_title：Frontiers of medicine

authors： Liu J,Bai L,Li W,Han H,Fu P,Ma X,Bi Z,Yang X,Zhang X,Zhen S,Deng X,Liu X,Guo Y

更新日期：2018-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a highly complex disease that is generally resistant to commonly used chemotherapy and radiotherapy. Consequently, there is an urgent need for the development of new treatment strategies for this devastating disease. In the past decade, tremendous progress has been achieved in the mol...

journal_title：Frontiers of medicine

authors： Gao Q,Shi Y,Wang X,Zhou J,Qiu S,Fan J

更新日期：2012-06-01 00:00:00

abstract：:Recently, fibroblast growth factor 23 (FGF23) has sparked widespread interest because of its potential role in regulating phosphate and vitamin D metabolism. In this review, we summarized the FGF superfamily, the mechanism of FGF23 on phosphate and vitamin D metabolism, and the FGF23 related bone disease. ...

journal_title：Frontiers of medicine

authors： Liao E

更新日期：2013-03-01 00:00:00

abstract：:Chimeric antigen receptor T (CAR-T) cell therapy is a novel cellular immunotherapy that is widely used to treat hematological malignancies, including acute leukemia, lymphoma, and multiple myeloma. Despite its remarkable clinical effects, this therapy has side effects that cannot be underestimated. Cytokine release sy...

journal_title：Frontiers of medicine

authors： Chen H,Wang F,Zhang P,Zhang Y,Chen Y,Fan X,Cao X,Liu J,Yang Y,Wang B,Lei B,Gu L,Bai J,Wei L,Zhang R,Zhuang Q,Zhang W,Zhao W,He A

更新日期：2019-10-01 00:00:00

abstract：:It has been known that, the novel coronavirus, 2019-nCoV, which is considered similar to SARS-CoV, invades human cells via the receptor angiotensin converting enzyme II (ACE2). Moreover, lung cells that have ACE2 expression may be the main target cells during 2019-nCoV infection. However, some patients also exhibit no...

journal_title：Frontiers of medicine

authors： Zou X,Chen K,Zou J,Han P,Hao J,Han Z

更新日期：2020-04-01 00:00:00