Abstract：
:Growing evidence suggests that somatic hypermutational status and programmed cell death-1 overexpression are potential predictive biomarkers indicating treatment benefits from immunotherapy using immune checkpoint inhibitors. However, biomarker-matched trials are still limited, and many of the genomic alterations remain difficult to target. To isolate the potential somatic hypermutational tumor from microsatellite instability low/microsatellite stability (MSI-L/MSS) cases, we employed two commercial kits to determine MSI and forensic short tandem repeat (STR) alternations in 250 gastrointestinal (GI) tumors. Three types of forensic STR alternations, namely, allelic loss, Aadd, and Anew, were identified. 62.4% (156/250) of the patients with GI exhibited STR alternation, including 100% (15/15) and 60% (141/235) of the microsatellite high instability and MSI-L/MSS cases, respectively. 30% (75/250) of the patients exhibited STR instability with more than 26.32% (26.32%-84.21%) STR alternation. The cutoff with 26.32% of the STR alternations covered all 15 MSI cases and suggested that it might be a potential threshold. Given the similar mechanism of the mutations of MSI and forensic STR, the widely used forensic identifier STR kit might provide potential usage for identifying hypermutational status in GI cancers.
journal_name
Front Medjournal_title
Frontiers of medicineauthors
Chen A,Zhang S,Li J,Ji C,Chen J,Li Cdoi
10.1007/s11684-019-0698-4subject
Has Abstractpub_date
2020-02-01 00:00:00pages
101-111issue
1eissn
2095-0217issn
2095-0225pii
10.1007/s11684-019-0698-4journal_volume
14pub_type
杂志文章,多中心研究abstract：:γδ T cells display unique developmental, distributional, and functional patterns and can rapidly respond to various insults and contribute to diverse diseases. Different subtypes of γδ T cells are produced in the thymus prior to their migration to peripheral tissues. γδ T cells are enriched in the liver and exhibit li...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-017-0584-x
更新日期：2018-06-01 00:00:00
abstract：:Zinc (Zn) is an essential mineral that is required for various cellular functions. Zn dyshomeostasis always is related to certain disorders such as metabolic syndrome, diabetes and diabetic complications. The associations of Zn with metabolic syndrome, diabetes and diabetic complications, thus, stem from the multiple ...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-013-0251-9
更新日期：2013-03-01 00:00:00
abstract：:Disorders of sex development (DSD) are a group of rare complex clinical syndromes with multiple etiologies. Distinguishing the various causes of DSD is quite difficult in clinical practice, even for senior general physicians because of the similar and atypical clinical manifestations of these conditions. In addition, ...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-020-0791-8
更新日期：2020-08-01 00:00:00
abstract：:Inappropriate cell proliferation during oncogenesis is often accompanied by inactivation of components involved in the cell cycle machinery. Here, we report that cyclin-dependent kinase inhibitor 2C (CDKN2C) as a member of the cyclin-dependent kinase inhibitors is a target of the PML/RARα oncofusion protein in leukemo...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-016-0478-3
更新日期：2016-12-01 00:00:00
abstract：:We observed the effect of Dianxianning, which was used as additive treatment to treat 206 epilepsy patients, on the epilepsy seizure rate. Based on a multicenter, prospective, randomized, and controlled clinical trial design, we used the seizure rate of epilepsy as the main index. For the treatment group comprising 13...
journal_title：Frontiers of medicine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s11684-011-0139-5
更新日期：2011-06-01 00:00:00
abstract：:Foodborne disease is one of the most important public health issues worldwide. China faces various and unprecedented challenges in all aspects of the food chain. Data from laboratory-based foodborne disease surveillance systems from 2013 to 2016, as well as different regions and ages, can be found along with differenc...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-017-0608-6
更新日期：2018-02-01 00:00:00
abstract：:Persistent vegetative state (PVS) is a clinical condition wherein the cerebral cortex loses its function although brain stem function remains relatively intact. It has high mortality and disability rates. Although treatment for PVS is extensively studied in developed countries, little breakthrough has been made. In Ch...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-017-0539-2
更新日期：2018-06-01 00:00:00
abstract：:The rationale for the antibiotic treatment of viral community-acquired pneumonia (CAP) in adults was analyzed to develop a clinical reference standard for this condition. Clinical data from 166 patients diagnosed with viral pneumonia across 14 hospitals in Beijing from November 2010 to December 2017 were collected. Th...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-019-0736-2
更新日期：2020-06-13 00:00:00
abstract：:Ventricular hypertrophy is a powerful and independent predictor of cardiovascular morbid events. The vascular properties of low-dose acetyl salicylic acid (aspirin) provide cardiovascular benefits through the irreversible inhibition of platelet cyclooxygenase 1; however, the possible anti-hypertrophic properties and p...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-015-0421-z
更新日期：2015-12-01 00:00:00
abstract：:Although type 2 diabetes is a disease often associated with aging, the global prevalence of early-onset diabetes has been increasing due to man's sedentary lifestyle, low-physical activity, obesity, and some nonmodifiable risk factors. Many studies have found that individuals with early-onset type 2 diabetes were at h...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-018-0669-1
更新日期：2018-12-01 00:00:00
abstract：:The inhibitory environment that surrounds the lesion site and the lack of intrinsic regenerative capacity of the adult mammalian central nervous system (CNS) impede the regrowth of injured axons and thereby the reestablishment of neural circuits required for functional recovery after spinal cord injuries (SCI). To cir...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-018-0642-z
更新日期：2019-04-01 00:00:00
abstract：:Swallowing multiple magnets is not uncommon worldwide and it frequently leads to serious consequences. However, most patients fail to receive timely and correct diagnosis and treatment. A literature search was performed to establish an algorithm for these accidents by the authors to identify relevant articles publishe...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-012-0207-5
更新日期：2012-09-01 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is a highly complex disease that is generally resistant to commonly used chemotherapy and radiotherapy. Consequently, there is an urgent need for the development of new treatment strategies for this devastating disease. In the past decade, tremendous progress has been achieved in the mol...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-012-0193-7
更新日期：2012-06-01 00:00:00
abstract：:A total of 251 patients with epithelial ovarian cancer (EOC) treated between 2002 and 2008 was retrospectively analyzed to investigate the long-term outcomes and prognostic factors of these patients, particularly those who underwent primary debulking surgery followed by platinum-based chemotherapy. Clinicopathological...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-014-0305-7
更新日期：2014-03-01 00:00:00
abstract：:This study aimed to explore the association of maternal depression with nutrient intake, growth, and development of preterm infants. A cohort study of 201 infants was conducted in Beijing. Based on the gestational age of an infant and status of the mother, the infants were divided into four groups: non-depression-full...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-017-0591-y
更新日期：2018-10-01 00:00:00
abstract：:Bronchiolitis obliterans syndrome (BOS) after hematopoietic stem cell transplantation (HSCT) is a major cause of morbidity and mortality with limited treatment options. Lung transplantation (LTX) has been rarely reported as a treatment option for selected HSCT recipients with this problem. In the present study, we rep...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-017-0538-3
更新日期：2018-04-01 00:00:00
abstract：:Perioperative parecoxib administration reduces postoperative pain, opioid consumption, and adverse events in adult patients. However, the efficacy and safety of parecoxib in children remain unclear. This metaanalysis included related published studies to address this concern. Eight databases in the literature until Fe...
journal_title：Frontiers of medicine
pub_type： 杂志文章,meta分析
doi：10.1007/s11684-015-0414-y
更新日期：2015-12-01 00:00:00
abstract：:The ongoing pandemic of Coronavirus disease 19 (COVID-19) is caused by a newly discovered β Coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). How long the adaptive immunity triggered by SARS-CoV-2 can last is of critical clinical relevance in assessing the probability of second infection ...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-020-0822-5
更新日期：2020-12-01 00:00:00
abstract：:Sepsis is a common cause of death in hospitalized patients worldwide. The early detection of sepsis remains a great challenge for clinicians, and delayed diagnosis frequently undermines treatment efforts, thereby contributing to high mortality. Omics technologies allow high-throughput screening of sepsis biomarkers. T...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-014-0318-2
更新日期：2014-03-01 00:00:00
abstract：:Gliomas are the most common primary intracranial tumors in adults. Anaplastic gliomas (WHO grade III) and glioblastomas (WHO grade IV) represent the major groups of malignant gliomas in the brain. Several diagnostic, predictive, and prognostic biomarkers for malignant gliomas have been reported over the last few decad...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-013-0267-1
更新日期：2013-06-01 00:00:00
abstract：:To date, gastric carcinoma (GC) is one of the common and fatal digestive malignancies worldwide. The prognosis of GC is not always satisfactory because of late diagnosis. Scholars are keen on discovering novel accurate and economical biomarkers in body liquids for GC screening to detect and evaluate the lesion before ...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-016-0493-4
更新日期：2017-03-01 00:00:00
abstract：:Recently, fibroblast growth factor 23 (FGF23) has sparked widespread interest because of its potential role in regulating phosphate and vitamin D metabolism. In this review, we summarized the FGF superfamily, the mechanism of FGF23 on phosphate and vitamin D metabolism, and the FGF23 related bone disease. ...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-013-0254-6
更新日期：2013-03-01 00:00:00
abstract：:It is well documented that patients can show significant heterogeneous responses to treatments so the best treatment strategies may require adaptation over individuals and time. Recently, a number of new statistical methods have been developed to tackle the important problem of estimating personalized treatment rules ...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-013-0245-7
更新日期：2013-03-01 00:00:00
abstract：:Although many drugs and therapeutic strategies have been developed for rheumatoid arthritis (RA) treatment, numerous patients with RA fail to respond to currently available agents. In this review, we provide an overview of the complexity of this autoimmune disease by showing the rapidly increasing number of genes asso...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-018-0659-3
更新日期：2019-08-01 00:00:00
abstract：:The N-end rule pathway is a unique branch of the ubiquitin-proteasome system in which the determination of a protein's half-life is dependent on its N-terminal residue. The N-terminal residue serves as the degradation signal of a protein and thus called N-degron. N-degron can be recognized and modifed by several steps...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-016-0458-7
更新日期：2016-09-01 00:00:00
abstract：:Real world study (RWS) has become a hotspot for clinical research. Data quality plays a vital role in research achievement and other clinical research fields. In this paper, the common quality problems in the RWS of traditional Chinese medicine are discussed, and a countermeasure is proposed. ...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-014-0351-1
更新日期：2014-09-01 00:00:00
abstract：:The COVID-19 caused by a novel strain of coronavirus has been spreading rapidly since its occurrence in December 2019. It is highly communicable through human-to-human transmission. China has been making unprecedented efforts in treating the confirmed cases, identifying and isolating their close contacts and suspected...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-020-0755-z
更新日期：2020-04-01 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is currently the fifth most common malignancy and the third leading cause of cancer-related mortalities worldwide. In the last few years, treatments for HCC have significantly improved from a mere surgical resection to a series of minimally invasive therapies and targeted drugs. However,...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-017-0546-3
更新日期：2017-12-01 00:00:00
abstract：:Herbal medicines have recently been recognized as the second most common cause of drug-induced liver injury (DILI) in the United States. However, reliable methods to identify the DILI causality of some herbs, such as Heshouwu (dried root of Polygonum multiflorum), remain lacking. In this study, a total of 12 307 inpat...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-015-0417-8
更新日期：2015-12-01 00:00:00
abstract：:Pulmonary hypertension (PH), as a complication of bronchiectasis, is associated with increased mortality. However, hemodynamic characteristics and the efficacy of pulmonary arterial hypertension (PAH) therapies in patients with bronchiectasis and PH remain unknown. Patients with bilateral bronchiectasis and concurrent...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-016-0461-z
更新日期：2016-09-01 00:00:00
