Abstract：
:Gliomas are the most common primary intracranial tumors in adults. Anaplastic gliomas (WHO grade III) and glioblastomas (WHO grade IV) represent the major groups of malignant gliomas in the brain. Several diagnostic, predictive, and prognostic biomarkers for malignant gliomas have been reported over the last few decades, and these markers have made great contributions to the accuracy of diagnosis, therapeutic decision making, and prognosis of patients. However, heterogeneity in patient outcomes may still be observed, which highlights the insufficiency of a classification system based purely on histopathology. Great efforts have been made to incorporate new information about the molecular landscape of gliomas into novel classifications that may potentially guide treatment. In this review, we summarize three distinctive biomarkers, three most commonly altered pathways, and three classifications based on microarray data in malignant gliomas.
journal_name
Front Medjournal_title
Frontiers of medicineauthors
Zhang C,Bao Z,Zhang W,Jiang Tdoi
10.1007/s11684-013-0267-1subject
Has Abstractpub_date
2013-06-01 00:00:00pages
150-6issue
2eissn
2095-0217issn
2095-0225journal_volume
7pub_type
杂志文章,评审abstract：:Identification of the driver mutations in cancer has resulted in the development of a new category of molecularly targeted anti-cancer drugs. However, as was the case with conventional chemotherapies, the effectiveness of these drugs is limited by the emergence of drug-resistant variants. While most cancer therapies a...
journal_title：Frontiers of medicine
pub_type： 杂志文章
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abstract：:Traditional Chinese medicine (TCM) investigates the clinical diagnosis and treatment regularities in a typical schema of personalized medicine, which means that individualized patients with same diseases would obtain distinct diagnosis and optimal treatment from different TCM physicians. This principle has been recogn...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
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abstract：:Inappropriate cell proliferation during oncogenesis is often accompanied by inactivation of components involved in the cell cycle machinery. Here, we report that cyclin-dependent kinase inhibitor 2C (CDKN2C) as a member of the cyclin-dependent kinase inhibitors is a target of the PML/RARα oncofusion protein in leukemo...
journal_title：Frontiers of medicine
pub_type： 杂志文章
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abstract：:Hepatocellular carcinoma (HCC) is currently the fifth most common malignancy and the third leading cause of cancer-related mortalities worldwide. In the last few years, treatments for HCC have significantly improved from a mere surgical resection to a series of minimally invasive therapies and targeted drugs. However,...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
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journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-014-0343-1
更新日期：2015-03-01 00:00:00
abstract：:Transforming growth factor (TGF)-β regulates a wide variety of cellular responses, including cell growth arrest, apoptosis, cell differentiation, motility, invasion, extracellular matrix production, tissue fibrosis, angiogenesis, and immune function. Although tumor-suppressive roles of TGF-β have been extensively stud...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-018-0646-8
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abstract：:Sepsis is a common cause of death in hospitalized patients worldwide. The early detection of sepsis remains a great challenge for clinicians, and delayed diagnosis frequently undermines treatment efforts, thereby contributing to high mortality. Omics technologies allow high-throughput screening of sepsis biomarkers. T...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
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更新日期：2012-12-01 00:00:00
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journal_title：Frontiers of medicine
pub_type： 杂志文章
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journal_title：Frontiers of medicine
pub_type： 杂志文章
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更新日期：2016-09-01 00:00:00
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
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更新日期：2017-03-01 00:00:00
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journal_title：Frontiers of medicine
pub_type： 杂志文章
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更新日期：2020-04-01 00:00:00
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journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-013-0299-6
更新日期：2013-12-01 00:00:00
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journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-019-0725-5
更新日期：2020-05-26 00:00:00
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journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-015-0376-0
更新日期：2015-03-01 00:00:00
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-012-0207-5
更新日期：2012-09-01 00:00:00
abstract：:Bronchiolitis obliterans syndrome (BOS) after hematopoietic stem cell transplantation (HSCT) is a major cause of morbidity and mortality with limited treatment options. Lung transplantation (LTX) has been rarely reported as a treatment option for selected HSCT recipients with this problem. In the present study, we rep...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-017-0538-3
更新日期：2018-04-01 00:00:00
abstract：:China recently instituted a two-child policy in response to its aging population, declining workforce and demographic dividend, and the need to develop asocial economy. Additionally, women generally delay having a second child because of the overwhelming pressure in their lives. With the improvements in assisted ferti...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-017-0552-5
更新日期：2017-12-01 00:00:00
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journal_title：Frontiers of medicine
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
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journal_title：Frontiers of medicine
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
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更新日期：2012-09-01 00:00:00
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journal_title：Frontiers of medicine
pub_type： 杂志文章,多中心研究,随机对照试验
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abstract：:Recent evidences suggested that cyclic guanosine monophosphate-specific phosphodiesterase 5 (PDE5) inhibitor represents an important therapeutic target for cardiovascular diseases. Whether and how it ameliorates cardiac fibrosis, a major cause of diastolic dysfunction and heart failure, is unknown. The purpose of this...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-014-0378-3
更新日期：2014-12-01 00:00:00
abstract：:An effective eradication therapy of Helicobacter pylori (H. pylori) should be used for the first time. In this study, we assessed whether tailored therapy based on antibiotic susceptibility testing is more effective than traditional therapy. We also evaluated the factors that cause treatment failure in high-resistance...
journal_title：Frontiers of medicine
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2020-02-01 00:00:00
abstract：:The ongoing pandemic of Coronavirus disease 19 (COVID-19) is caused by a newly discovered β Coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). How long the adaptive immunity triggered by SARS-CoV-2 can last is of critical clinical relevance in assessing the probability of second infection ...
journal_title：Frontiers of medicine
pub_type： 杂志文章
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journal_title：Frontiers of medicine
pub_type： 杂志文章
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更新日期：2020-12-01 00:00:00
abstract：:It is well documented that patients can show significant heterogeneous responses to treatments so the best treatment strategies may require adaptation over individuals and time. Recently, a number of new statistical methods have been developed to tackle the important problem of estimating personalized treatment rules ...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-013-0245-7
更新日期：2013-03-01 00:00:00
