Abstract：
:To date, gastric carcinoma (GC) is one of the common and fatal digestive malignancies worldwide. The prognosis of GC is not always satisfactory because of late diagnosis. Scholars are keen on discovering novel accurate and economical biomarkers in body liquids for GC screening to detect and evaluate the lesion before the results of imaging techniques are obtained. While traditional serum assays have limited sensitivity and specificity, gastrointestinal juice may provide relevant specific biomarkers because of its close contact with the tumor. Herein, the current progress in the relationship between gastrointestinal fluid analyses and GC is systematically and comprehensively reviewed. The detection of gastric juice pH, fluorescence spectrum, cytology, Helicobacter pylori-associated markers, nitrosamines, conventional tumor markers, amino acids, proteomics, microRNAs, long noncoding RNAs, protein-coding genes, vitamin C, etc., and combination tests of different category markers could provide important diagnostic and prognostic clues for gastrointestinal diseases. Particularly, early GC may be efficiently screened using gastric juice. Gastrointestinal fluid examination could also predict the adverse effects of postgastrectomy, such as pancreatic leakage, fistula, and abscess. Gastric fluid markers should be further studied to reveal the early predicators of malignancy and complications. The methods for obtaining the samples of gastrointestinal juice with minimum incision should also be comprehensively investigated.
journal_name
Front Medjournal_title
Frontiers of medicineauthors
Huang L,Xu Adoi
10.1007/s11684-016-0493-4subject
Has Abstractpub_date
2017-03-01 00:00:00pages
20-31issue
1eissn
2095-0217issn
2095-0225pii
10.1007/s11684-016-0493-4journal_volume
11pub_type
杂志文章,评审abstract：:A total of 251 patients with epithelial ovarian cancer (EOC) treated between 2002 and 2008 was retrospectively analyzed to investigate the long-term outcomes and prognostic factors of these patients, particularly those who underwent primary debulking surgery followed by platinum-based chemotherapy. Clinicopathological...
journal_title：Frontiers of medicine
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
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journal_title：Frontiers of medicine
pub_type： 杂志文章
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journal_title：Frontiers of medicine
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2018-06-01 00:00:00
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journal_title：Frontiers of medicine
pub_type： 杂志文章,多中心研究
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更新日期：2020-02-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
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pub_type： 杂志文章,随机对照试验
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journal_title：Frontiers of medicine
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pub_type： 杂志文章,meta分析
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